Incidental Mutation 'R8094:Sgo2a'
ID 630034
Institutional Source Beutler Lab
Gene Symbol Sgo2a
Ensembl Gene ENSMUSG00000026039
Gene Name shugoshin 2A
Synonyms Tripin, 5730576N04Rik, D1Ertd8e, Sgol2, Sgol2a, 1110007N04Rik
MMRRC Submission 067526-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8094 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 58035130-58065058 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58056300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 828 (I828T)
Ref Sequence ENSEMBL: ENSMUSP00000027202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027202] [ENSMUST00000163061]
AlphaFold Q7TSY8
Predicted Effect possibly damaging
Transcript: ENSMUST00000027202
AA Change: I828T

PolyPhen 2 Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000027202
Gene: ENSMUSG00000026039
AA Change: I828T

DomainStartEndE-ValueType
coiled coil region 54 109 N/A INTRINSIC
low complexity region 182 198 N/A INTRINSIC
low complexity region 371 381 N/A INTRINSIC
low complexity region 396 431 N/A INTRINSIC
low complexity region 583 597 N/A INTRINSIC
low complexity region 718 729 N/A INTRINSIC
low complexity region 1068 1078 N/A INTRINSIC
low complexity region 1112 1125 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163061
SMART Domains Protein: ENSMUSP00000124053
Gene: ENSMUSG00000054770

DomainStartEndE-ValueType
BTB 23 123 1.01e-2 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.2%
  • 20x: 98.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with abnormalities in meiosis but not in mitosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A230072I06Rik T A 8: 12,329,824 (GRCm39) L93H unknown Het
A2ml1 A G 6: 128,549,045 (GRCm39) Y246H probably damaging Het
Akap11 C A 14: 78,750,413 (GRCm39) C658F Het
Arid2 T G 15: 96,266,592 (GRCm39) S547A possibly damaging Het
Atf1 C A 15: 100,143,170 (GRCm39) D46E probably damaging Het
Brca2 T A 5: 150,459,634 (GRCm39) F303Y possibly damaging Het
Btbd18 T A 2: 84,498,260 (GRCm39) S633T possibly damaging Het
Btg4 T G 9: 51,030,445 (GRCm39) F182V probably benign Het
Cacna1e G A 1: 154,437,516 (GRCm39) S340F probably damaging Het
Camta2 A G 11: 70,576,903 (GRCm39) W41R probably damaging Het
Cbl A T 9: 44,074,696 (GRCm39) D455E probably benign Het
Ccdc162 A T 10: 41,488,864 (GRCm39) D1208E probably benign Het
Cd177 A T 7: 24,443,842 (GRCm39) M752K probably damaging Het
Cep290 A T 10: 100,380,793 (GRCm39) H100L possibly damaging Het
Chrnb2 T A 3: 89,668,698 (GRCm39) I206F probably damaging Het
Cyp2c40 A G 19: 39,791,009 (GRCm39) L274S probably benign Het
Cyp2c40 T A 19: 39,791,015 (GRCm39) Y272F probably benign Het
Cyp2d22 C A 15: 82,258,556 (GRCm39) A102S probably benign Het
Cyp51 C T 5: 4,136,490 (GRCm39) E435K probably benign Het
Dchs2 T C 3: 83,262,929 (GRCm39) F3066L probably benign Het
Disp1 C A 1: 182,869,192 (GRCm39) R1076L probably damaging Het
Dkk2 C T 3: 131,791,801 (GRCm39) A3V probably benign Het
Dnah7b T C 1: 46,165,964 (GRCm39) F543S probably benign Het
Dpt A T 1: 164,624,481 (GRCm39) S61C probably damaging Het
Drg2 A T 11: 60,353,096 (GRCm39) Y243F probably damaging Het
Dsg2 A G 18: 20,716,061 (GRCm39) probably benign Het
Dst T G 1: 34,228,040 (GRCm39) L1878V possibly damaging Het
F5 A G 1: 164,036,509 (GRCm39) Y1890C probably benign Het
Fat1 T C 8: 45,405,739 (GRCm39) V830A probably damaging Het
Fat2 C T 11: 55,186,965 (GRCm39) D1294N probably benign Het
Fbxo15 A G 18: 84,983,618 (GRCm39) Y322C probably benign Het
Fcsk A G 8: 111,622,604 (GRCm39) F108S probably damaging Het
Fhit A T 14: 10,751,666 (GRCm38) N7K unknown Het
Gabrb2 A G 11: 42,488,370 (GRCm39) I279V probably damaging Het
Galk2 T C 2: 125,773,189 (GRCm39) F207S probably damaging Het
Gtpbp3 C T 8: 71,941,480 (GRCm39) L17F possibly damaging Het
Gucy2c T A 6: 136,714,446 (GRCm39) D460V probably benign Het
Herc1 G A 9: 66,400,462 (GRCm39) V4329I probably damaging Het
Iqcn T C 8: 71,162,067 (GRCm39) V420A probably benign Het
Kirrel3 G A 9: 34,946,460 (GRCm39) V740M probably damaging Het
Macf1 C A 4: 123,263,660 (GRCm39) V6956L probably damaging Het
Mill1 C T 7: 17,989,835 (GRCm39) A39V probably benign Het
Mkln1 T A 6: 31,469,588 (GRCm39) Y599* probably null Het
Mrpl14 T A 17: 46,009,039 (GRCm39) L46Q possibly damaging Het
Myom2 G T 8: 15,119,418 (GRCm39) R103L possibly damaging Het
Naip2 A C 13: 100,298,290 (GRCm39) I582S probably benign Het
Ndst2 A T 14: 20,778,232 (GRCm39) V449D probably damaging Het
Nell1 T A 7: 49,770,335 (GRCm39) H131Q probably benign Het
Nos3 G C 5: 24,572,218 (GRCm39) R97P probably benign Het
Npc1 A T 18: 12,327,297 (GRCm39) F1099L probably benign Het
Nxpe5 T A 5: 138,249,802 (GRCm39) W531R probably damaging Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or1j1 A T 2: 36,702,330 (GRCm39) L258H probably damaging Het
Or4c110 T C 2: 88,832,712 (GRCm39) probably benign Het
Or5b98 A T 19: 12,931,366 (GRCm39) T138S probably benign Het
Or6c210 A G 10: 129,495,933 (GRCm39) D86G probably damaging Het
Osmr T C 15: 6,845,102 (GRCm39) N889S possibly damaging Het
Oxct2b A G 4: 123,010,301 (GRCm39) I74V possibly damaging Het
Pakap A G 4: 57,886,319 (GRCm39) T859A possibly damaging Het
Phldb3 C A 7: 24,326,134 (GRCm39) A572D probably damaging Het
Pigr A G 1: 130,774,247 (GRCm39) E409G probably damaging Het
Ptprs T C 17: 56,735,947 (GRCm39) E674G probably benign Het
Ptpru G A 4: 131,520,903 (GRCm39) T801I possibly damaging Het
Ralgapa1 T A 12: 55,829,631 (GRCm39) D200V probably damaging Het
Rb1cc1 A T 1: 6,333,448 (GRCm39) R1429* probably null Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Rnpep A T 1: 135,211,514 (GRCm39) L78Q probably damaging Het
Rtn2 A T 7: 19,027,791 (GRCm39) I394F probably damaging Het
Satb2 A T 1: 56,870,623 (GRCm39) V572D possibly damaging Het
Sds T C 5: 120,617,001 (GRCm39) probably benign Het
Serpina10 TTCCTCCTCCTCCTCCTCCTCCTCC TTCCTCCTCCTCCTCCTCCTCC 12: 103,595,032 (GRCm39) probably benign Het
Slc25a33 T A 4: 149,840,609 (GRCm39) K79N probably benign Het
Slc25a51 A C 4: 45,399,783 (GRCm39) F136V probably benign Het
Slfn14 T A 11: 83,174,119 (GRCm39) K291* probably null Het
Sp100 A G 1: 85,624,819 (GRCm39) K403E possibly damaging Het
Spaca1 C T 4: 34,049,837 (GRCm39) E54K possibly damaging Het
Sympk T G 7: 18,787,373 (GRCm39) probably null Het
Syne1 A T 10: 5,067,031 (GRCm39) V7078D probably damaging Het
Tas2r121 T A 6: 132,677,772 (GRCm39) I67L probably benign Het
Tha1 T C 11: 117,759,323 (GRCm39) K389E probably benign Het
Thbs2 T A 17: 14,900,584 (GRCm39) Q541L probably benign Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tmem94 T C 11: 115,679,218 (GRCm39) probably null Het
Tnfsf13 A G 11: 69,575,983 (GRCm39) C35R probably damaging Het
Trcg1 C A 9: 57,149,564 (GRCm39) Q379K probably benign Het
Ubr4 T C 4: 139,168,007 (GRCm39) S1507P probably damaging Het
Uckl1 A G 2: 181,215,049 (GRCm39) I268T probably damaging Het
Uvrag T C 7: 98,641,174 (GRCm39) K289E possibly damaging Het
Vmn2r104 C A 17: 20,250,483 (GRCm39) C596F possibly damaging Het
Vmn2r11 A T 5: 109,201,626 (GRCm39) F293I probably damaging Het
Vps13b T A 15: 35,669,052 (GRCm39) probably null Het
Wipf1 G A 2: 73,267,879 (GRCm39) P173L possibly damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zscan4f T A 7: 11,135,154 (GRCm39) C187S possibly damaging Het
Other mutations in Sgo2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Sgo2a APN 1 58,055,753 (GRCm39) missense probably damaging 1.00
IGL00534:Sgo2a APN 1 58,055,503 (GRCm39) missense probably damaging 1.00
IGL00902:Sgo2a APN 1 58,055,258 (GRCm39) missense probably benign 0.00
IGL01571:Sgo2a APN 1 58,057,133 (GRCm39) missense probably damaging 0.99
IGL02268:Sgo2a APN 1 58,056,881 (GRCm39) missense probably benign 0.10
IGL02756:Sgo2a APN 1 58,055,509 (GRCm39) missense probably damaging 1.00
IGL02887:Sgo2a APN 1 58,055,511 (GRCm39) missense probably damaging 0.99
IGL02991:Sgo2a APN 1 58,054,514 (GRCm39) intron probably benign
crazy UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
harpo UTSW 1 58,058,819 (GRCm39) nonsense probably null
mashugana UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
meshugas UTSW 1 58,042,092 (GRCm39) nonsense probably null
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0095:Sgo2a UTSW 1 58,054,714 (GRCm39) missense probably benign 0.11
R0325:Sgo2a UTSW 1 58,055,856 (GRCm39) missense probably benign
R0464:Sgo2a UTSW 1 58,039,253 (GRCm39) missense probably damaging 0.98
R0699:Sgo2a UTSW 1 58,037,308 (GRCm39) nonsense probably null
R1251:Sgo2a UTSW 1 58,039,121 (GRCm39) critical splice acceptor site probably null
R1355:Sgo2a UTSW 1 58,057,124 (GRCm39) missense possibly damaging 0.91
R1457:Sgo2a UTSW 1 58,054,965 (GRCm39) missense probably benign 0.00
R2244:Sgo2a UTSW 1 58,056,213 (GRCm39) missense probably benign 0.00
R3896:Sgo2a UTSW 1 58,052,805 (GRCm39) missense probably damaging 0.99
R4919:Sgo2a UTSW 1 58,037,293 (GRCm39) missense probably damaging 0.99
R5030:Sgo2a UTSW 1 58,056,918 (GRCm39) nonsense probably null
R5123:Sgo2a UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
R5317:Sgo2a UTSW 1 58,054,683 (GRCm39) missense probably benign
R5767:Sgo2a UTSW 1 58,058,819 (GRCm39) nonsense probably null
R5844:Sgo2a UTSW 1 58,055,556 (GRCm39) missense probably damaging 0.99
R6018:Sgo2a UTSW 1 58,056,118 (GRCm39) missense probably benign 0.01
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6450:Sgo2a UTSW 1 58,042,092 (GRCm39) nonsense probably null
R6998:Sgo2a UTSW 1 58,055,799 (GRCm39) missense probably damaging 0.99
R7073:Sgo2a UTSW 1 58,056,944 (GRCm39) missense possibly damaging 0.73
R7508:Sgo2a UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
R7722:Sgo2a UTSW 1 58,055,696 (GRCm39) missense probably benign 0.45
R8176:Sgo2a UTSW 1 58,056,252 (GRCm39) missense possibly damaging 0.93
R8782:Sgo2a UTSW 1 58,056,616 (GRCm39) start gained probably benign
R8899:Sgo2a UTSW 1 58,058,822 (GRCm39) missense possibly damaging 0.85
R8912:Sgo2a UTSW 1 58,056,560 (GRCm39) missense probably damaging 0.99
R9106:Sgo2a UTSW 1 58,037,283 (GRCm39) missense possibly damaging 0.59
R9256:Sgo2a UTSW 1 58,058,772 (GRCm39) missense possibly damaging 0.77
R9688:Sgo2a UTSW 1 58,056,737 (GRCm39) missense probably damaging 1.00
X0065:Sgo2a UTSW 1 58,055,517 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACCCTAATATGCAACCTGCTTG -3'
(R):5'- CTTAGCTCCTGCCAAACTGC -3'

Sequencing Primer
(F):5'- GCAACCTGCTTGTCAAGATG -3'
(R):5'- AAACTGCTCCCTGCTTTACATG -3'
Posted On 2020-06-30