Incidental Mutation 'R8095:Fabp6'
ID 630158
Institutional Source Beutler Lab
Gene Symbol Fabp6
Ensembl Gene ENSMUSG00000020405
Gene Name fatty acid binding protein 6
Synonyms Illbp, I-BABP, gastrotropin, ILBP3, I-15P
MMRRC Submission 067527-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8095 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 43486876-43492367 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 43489543 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 33 (R33C)
Ref Sequence ENSEMBL: ENSMUSP00000020672 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020672]
AlphaFold P51162
Predicted Effect probably damaging
Transcript: ENSMUST00000020672
AA Change: R33C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000020672
Gene: ENSMUSG00000020405
AA Change: R33C

DomainStartEndE-ValueType
Pfam:Lipocalin_7 1 128 6.8e-83 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.1%
  • 20x: 97.6%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit sex-specific altered bile acid absorption and transport. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,536,196 (GRCm39) I490M possibly damaging Het
Abcc9 T C 6: 142,590,048 (GRCm39) I817V probably benign Het
Atp11b T C 3: 35,888,565 (GRCm39) L945P probably damaging Het
Coa8 C A 12: 111,689,218 (GRCm39) A100D probably damaging Het
Crem T C 18: 3,295,106 (GRCm39) T108A probably benign Het
Cttnbp2 T A 6: 18,435,432 (GRCm39) K142M probably damaging Het
Cyp51 C T 5: 4,136,490 (GRCm39) E435K probably benign Het
Dnah14 G T 1: 181,633,597 (GRCm39) E11* probably null Het
Dpy19l1 T C 9: 24,396,160 (GRCm39) probably null Het
Dym A G 18: 75,247,872 (GRCm39) T259A possibly damaging Het
E030018B13Rik T G 7: 63,569,049 (GRCm39) H32Q unknown Het
Ehmt2 T G 17: 35,126,745 (GRCm39) H809Q probably damaging Het
Fam98a C A 17: 75,845,766 (GRCm39) D327Y probably damaging Het
Foxf1 C T 8: 121,813,551 (GRCm39) T357I probably benign Het
Foxh1 T A 15: 76,553,208 (GRCm39) R169* probably null Het
Hydin T C 8: 111,295,991 (GRCm39) F3568S probably damaging Het
Il22 T C 10: 118,041,028 (GRCm39) S45P possibly damaging Het
Isyna1 C A 8: 71,049,035 (GRCm39) Y371* probably null Het
Lingo3 T C 10: 80,671,255 (GRCm39) H225R probably benign Het
Lmo7 T A 14: 102,124,855 (GRCm39) V560E possibly damaging Het
Mab21l2 A G 3: 86,454,769 (GRCm39) V77A probably benign Het
Mapkbp1 A G 2: 119,848,131 (GRCm39) K595R probably benign Het
Mfsd2a A T 4: 122,845,064 (GRCm39) C216S probably damaging Het
Muc16 A T 9: 18,496,126 (GRCm39) Y6688* probably null Het
Or12j5 T C 7: 140,084,192 (GRCm39) Y60C probably damaging Het
Otud6b T C 4: 14,825,614 (GRCm39) D72G probably damaging Het
Pcdhgb6 A G 18: 37,875,924 (GRCm39) I211V probably benign Het
Ryr3 A G 2: 112,498,388 (GRCm39) probably null Het
Sardh T C 2: 27,132,730 (GRCm39) Y166C probably damaging Het
Scn1a T A 2: 66,132,809 (GRCm39) K171N possibly damaging Het
Scyl2 G T 10: 89,476,965 (GRCm39) T720K probably damaging Het
Slc9a8 T A 2: 167,310,891 (GRCm39) V384D probably damaging Het
Slco1a8 T A 6: 141,933,415 (GRCm39) I457F probably benign Het
Smg1 T C 7: 117,772,285 (GRCm39) Y1490C unknown Het
Snx16 A T 3: 10,503,244 (GRCm39) M1K probably null Het
Sqle A G 15: 59,193,276 (GRCm39) S218G probably benign Het
Strip1 A G 3: 107,525,455 (GRCm39) I527T possibly damaging Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tnfsf13 A G 11: 69,575,983 (GRCm39) C35R probably damaging Het
Trf T C 9: 103,087,735 (GRCm39) Y673C probably damaging Het
Ttc39b C T 4: 83,164,557 (GRCm39) A252T probably benign Het
Tubgcp6 A T 15: 89,006,977 (GRCm39) L15H probably benign Het
Uspl1 C T 5: 149,150,992 (GRCm39) Q731* probably null Het
Vmn1r193 T C 13: 22,403,231 (GRCm39) R254G possibly damaging Het
Vrtn C T 12: 84,696,809 (GRCm39) R520C probably damaging Het
Wipf1 G A 2: 73,267,879 (GRCm39) P173L possibly damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp644 A C 5: 106,766,280 (GRCm39) V1234G possibly damaging Het
Other mutations in Fabp6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Fabp6 APN 11 43,489,543 (GRCm39) missense probably damaging 1.00
R1448:Fabp6 UTSW 11 43,486,992 (GRCm39) missense probably benign 0.01
R1907:Fabp6 UTSW 11 43,486,994 (GRCm39) critical splice acceptor site probably null
R8910:Fabp6 UTSW 11 43,492,335 (GRCm39) missense possibly damaging 0.65
R9220:Fabp6 UTSW 11 43,489,572 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- GCAGAGGGCTCATATCTGAAATAG -3'
(R):5'- CATTGCAGAGCTGGGCTTTG -3'

Sequencing Primer
(F):5'- AAGCTGACTTCTGGCCTGG -3'
(R):5'- CAGTCACTGTATTCAGCC -3'
Posted On 2020-06-30