Incidental Mutation 'R8096:Or8u9'
ID 630181
Institutional Source Beutler Lab
Gene Symbol Or8u9
Ensembl Gene ENSMUSG00000075200
Gene Name olfactory receptor family 8 subfamily U member 9
Synonyms GA_x6K02T2Q125-47640742-47639798, MOR185-4, Olfr1044
MMRRC Submission 067528-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R8096 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86001215-86002159 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86002056 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 35 (Y35F)
Ref Sequence ENSEMBL: ENSMUSP00000150199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099906] [ENSMUST00000213886] [ENSMUST00000213949] [ENSMUST00000215171] [ENSMUST00000216028]
AlphaFold Q8VGR9
Predicted Effect probably damaging
Transcript: ENSMUST00000099906
AA Change: Y35F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097490
Gene: ENSMUSG00000075200
AA Change: Y35F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.7e-59 PFAM
Pfam:7tm_1 41 290 2.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213886
Predicted Effect probably benign
Transcript: ENSMUST00000213949
Predicted Effect probably damaging
Transcript: ENSMUST00000215171
AA Change: Y35F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216028
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.1%
  • 20x: 97.3%
Validation Efficiency 98% (44/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 G A 14: 54,882,726 (GRCm39) A999V possibly damaging Het
Actn4 A G 7: 28,594,008 (GRCm39) I833T possibly damaging Het
Actn4 C A 7: 28,601,338 (GRCm39) R470L probably damaging Het
Adgre4 T A 17: 56,127,700 (GRCm39) I580N probably damaging Het
Arid5b T A 10: 68,021,982 (GRCm39) T203S probably benign Het
Astn1 A G 1: 158,436,890 (GRCm39) Y824C probably damaging Het
Cacna2d3 A G 14: 28,825,657 (GRCm39) V506A possibly damaging Het
Cdk17 T G 10: 93,052,229 (GRCm39) M103R probably damaging Het
Clca3a1 T A 3: 144,455,446 (GRCm39) E449V probably damaging Het
Cux2 A G 5: 122,007,160 (GRCm39) Y834H possibly damaging Het
Dynlrb2 A G 8: 117,234,256 (GRCm39) T7A possibly damaging Het
Ggcx G A 6: 72,406,976 (GRCm39) R704Q probably benign Het
Gpr87 A T 3: 59,087,229 (GRCm39) L92Q possibly damaging Het
Grik1 C T 16: 87,803,355 (GRCm39) G279E Het
Igsf10 G T 3: 59,236,380 (GRCm39) T1267N probably damaging Het
Mrc2 G T 11: 105,234,333 (GRCm39) R951L probably damaging Het
Muc4 T A 16: 32,575,764 (GRCm39) S1755T unknown Het
Muc5b T C 7: 141,403,292 (GRCm39) V751A unknown Het
Or10a3 A T 7: 108,480,248 (GRCm39) C188* probably null Het
Or1l4 T A 2: 37,092,078 (GRCm39) V275E probably damaging Het
Pclo A G 5: 14,762,975 (GRCm39) Y531C Het
Pigr A G 1: 130,774,247 (GRCm39) E409G probably damaging Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Rsph14 T A 10: 74,795,493 (GRCm39) I231F possibly damaging Het
Ryr1 A G 7: 28,708,626 (GRCm39) S4812P unknown Het
Scgb2b24 T A 7: 33,438,646 (GRCm39) probably null Het
Scn2a T A 2: 65,594,366 (GRCm39) H1738Q probably damaging Het
Scrib A T 15: 75,934,558 (GRCm39) D678E probably benign Het
Slc39a8 T C 3: 135,590,417 (GRCm39) F370S probably damaging Het
Sphkap A T 1: 83,255,279 (GRCm39) D823E probably damaging Het
Srrm3 T A 5: 135,898,094 (GRCm39) I555N unknown Het
Stx19 A C 16: 62,642,524 (GRCm39) E113D possibly damaging Het
Tex30 A T 1: 44,127,663 (GRCm39) Y91N probably damaging Het
Tnfsf13 A G 11: 69,575,983 (GRCm39) C35R probably damaging Het
Tnik G A 3: 28,715,927 (GRCm39) M1180I possibly damaging Het
Tnn C T 1: 159,950,411 (GRCm39) A732T probably damaging Het
Tpra1 C T 6: 88,888,699 (GRCm39) Q294* probably null Het
Trim24 G T 6: 37,935,592 (GRCm39) S895I probably benign Het
Trim68 A G 7: 102,327,649 (GRCm39) S435P probably damaging Het
Vrtn C T 12: 84,696,809 (GRCm39) R520C probably damaging Het
Zfp280d T C 9: 72,226,560 (GRCm39) C335R probably damaging Het
Zfp958 G T 8: 4,663,273 (GRCm39) probably benign Het
Other mutations in Or8u9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01614:Or8u9 APN 2 86,001,741 (GRCm39) missense possibly damaging 0.90
IGL02562:Or8u9 APN 2 86,001,384 (GRCm39) missense probably damaging 1.00
R0230:Or8u9 UTSW 2 86,001,886 (GRCm39) missense probably benign 0.22
R0306:Or8u9 UTSW 2 86,002,060 (GRCm39) missense possibly damaging 0.80
R0373:Or8u9 UTSW 2 86,002,050 (GRCm39) missense probably damaging 0.98
R0539:Or8u9 UTSW 2 86,001,387 (GRCm39) missense probably damaging 0.98
R1925:Or8u9 UTSW 2 86,001,354 (GRCm39) missense probably benign 0.22
R2367:Or8u9 UTSW 2 86,001,981 (GRCm39) missense probably damaging 1.00
R4114:Or8u9 UTSW 2 86,001,759 (GRCm39) missense possibly damaging 0.90
R4850:Or8u9 UTSW 2 86,002,015 (GRCm39) missense probably damaging 1.00
R4851:Or8u9 UTSW 2 86,002,015 (GRCm39) missense probably damaging 1.00
R7402:Or8u9 UTSW 2 86,001,546 (GRCm39) missense probably benign 0.34
R7439:Or8u9 UTSW 2 86,001,354 (GRCm39) missense probably damaging 1.00
R7441:Or8u9 UTSW 2 86,001,354 (GRCm39) missense probably damaging 1.00
R7624:Or8u9 UTSW 2 86,001,564 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CAGCACATGCATTGAAGGATATC -3'
(R):5'- TTTGATGGACAAGCTTTGAGC -3'

Sequencing Primer
(F):5'- ACAAAAGCCAGGTTGCTG -3'
(R):5'- CATGTTAACAGTGTAATGTGTTTCAC -3'
Posted On 2020-06-30