Incidental Mutation 'R8096:Gpr87'
ID 630183
Institutional Source Beutler Lab
Gene Symbol Gpr87
Ensembl Gene ENSMUSG00000051431
Gene Name G protein-coupled receptor 87
Synonyms
MMRRC Submission 067528-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8096 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 59086344-59102525 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59087229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 92 (L92Q)
Ref Sequence ENSEMBL: ENSMUSP00000143683 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040325] [ENSMUST00000056898] [ENSMUST00000164225] [ENSMUST00000199659] [ENSMUST00000200095]
AlphaFold Q99MT7
Predicted Effect probably benign
Transcript: ENSMUST00000040325
SMART Domains Protein: ENSMUSP00000042269
Gene: ENSMUSG00000056476

DomainStartEndE-ValueType
Med12 101 161 1.71e-24 SMART
low complexity region 216 224 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:Med12-LCEWAV 282 730 2.6e-207 PFAM
low complexity region 744 758 N/A INTRINSIC
low complexity region 853 872 N/A INTRINSIC
low complexity region 1455 1466 N/A INTRINSIC
low complexity region 1728 1742 N/A INTRINSIC
low complexity region 1769 1783 N/A INTRINSIC
Pfam:Med12-PQL 1803 2029 2.3e-14 PFAM
low complexity region 2055 2076 N/A INTRINSIC
low complexity region 2083 2101 N/A INTRINSIC
low complexity region 2116 2136 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000056898
AA Change: L93Q

PolyPhen 2 Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000059272
Gene: ENSMUSG00000051431
AA Change: L93Q

DomainStartEndE-ValueType
Pfam:7tm_1 60 315 1.4e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164225
SMART Domains Protein: ENSMUSP00000127038
Gene: ENSMUSG00000056476

DomainStartEndE-ValueType
Med12 101 161 1.71e-24 SMART
low complexity region 216 224 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:Med12-LCEWAV 283 765 5e-187 PFAM
low complexity region 779 793 N/A INTRINSIC
low complexity region 888 907 N/A INTRINSIC
low complexity region 1490 1501 N/A INTRINSIC
low complexity region 1763 1777 N/A INTRINSIC
low complexity region 1804 1818 N/A INTRINSIC
Pfam:Med12-PQL 1840 2063 9.7e-66 PFAM
low complexity region 2090 2111 N/A INTRINSIC
low complexity region 2118 2136 N/A INTRINSIC
low complexity region 2151 2171 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000199659
SMART Domains Protein: ENSMUSP00000142903
Gene: ENSMUSG00000056476

DomainStartEndE-ValueType
Med12 101 161 1.71e-24 SMART
low complexity region 216 224 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:Med12-LCEWAV 282 765 5.5e-209 PFAM
low complexity region 779 793 N/A INTRINSIC
low complexity region 888 907 N/A INTRINSIC
low complexity region 1490 1501 N/A INTRINSIC
low complexity region 1761 1775 N/A INTRINSIC
low complexity region 1802 1816 N/A INTRINSIC
Pfam:Med12-PQL 1836 2062 1.7e-15 PFAM
low complexity region 2088 2130 N/A INTRINSIC
low complexity region 2144 2164 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000200095
AA Change: L92Q

PolyPhen 2 Score 0.700 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000143683
Gene: ENSMUSG00000051431
AA Change: L92Q

DomainStartEndE-ValueType
Pfam:7tm_1 59 314 3.5e-37 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.1%
  • 20x: 97.3%
Validation Efficiency 98% (44/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased mean vertebral and femoral bone measurements. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 G A 14: 54,882,726 (GRCm39) A999V possibly damaging Het
Actn4 A G 7: 28,594,008 (GRCm39) I833T possibly damaging Het
Actn4 C A 7: 28,601,338 (GRCm39) R470L probably damaging Het
Adgre4 T A 17: 56,127,700 (GRCm39) I580N probably damaging Het
Arid5b T A 10: 68,021,982 (GRCm39) T203S probably benign Het
Astn1 A G 1: 158,436,890 (GRCm39) Y824C probably damaging Het
Cacna2d3 A G 14: 28,825,657 (GRCm39) V506A possibly damaging Het
Cdk17 T G 10: 93,052,229 (GRCm39) M103R probably damaging Het
Clca3a1 T A 3: 144,455,446 (GRCm39) E449V probably damaging Het
Cux2 A G 5: 122,007,160 (GRCm39) Y834H possibly damaging Het
Dynlrb2 A G 8: 117,234,256 (GRCm39) T7A possibly damaging Het
Ggcx G A 6: 72,406,976 (GRCm39) R704Q probably benign Het
Grik1 C T 16: 87,803,355 (GRCm39) G279E Het
Igsf10 G T 3: 59,236,380 (GRCm39) T1267N probably damaging Het
Mrc2 G T 11: 105,234,333 (GRCm39) R951L probably damaging Het
Muc4 T A 16: 32,575,764 (GRCm39) S1755T unknown Het
Muc5b T C 7: 141,403,292 (GRCm39) V751A unknown Het
Or10a3 A T 7: 108,480,248 (GRCm39) C188* probably null Het
Or1l4 T A 2: 37,092,078 (GRCm39) V275E probably damaging Het
Or8u9 T A 2: 86,002,056 (GRCm39) Y35F probably damaging Het
Pclo A G 5: 14,762,975 (GRCm39) Y531C Het
Pigr A G 1: 130,774,247 (GRCm39) E409G probably damaging Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Rsph14 T A 10: 74,795,493 (GRCm39) I231F possibly damaging Het
Ryr1 A G 7: 28,708,626 (GRCm39) S4812P unknown Het
Scgb2b24 T A 7: 33,438,646 (GRCm39) probably null Het
Scn2a T A 2: 65,594,366 (GRCm39) H1738Q probably damaging Het
Scrib A T 15: 75,934,558 (GRCm39) D678E probably benign Het
Slc39a8 T C 3: 135,590,417 (GRCm39) F370S probably damaging Het
Sphkap A T 1: 83,255,279 (GRCm39) D823E probably damaging Het
Srrm3 T A 5: 135,898,094 (GRCm39) I555N unknown Het
Stx19 A C 16: 62,642,524 (GRCm39) E113D possibly damaging Het
Tex30 A T 1: 44,127,663 (GRCm39) Y91N probably damaging Het
Tnfsf13 A G 11: 69,575,983 (GRCm39) C35R probably damaging Het
Tnik G A 3: 28,715,927 (GRCm39) M1180I possibly damaging Het
Tnn C T 1: 159,950,411 (GRCm39) A732T probably damaging Het
Tpra1 C T 6: 88,888,699 (GRCm39) Q294* probably null Het
Trim24 G T 6: 37,935,592 (GRCm39) S895I probably benign Het
Trim68 A G 7: 102,327,649 (GRCm39) S435P probably damaging Het
Vrtn C T 12: 84,696,809 (GRCm39) R520C probably damaging Het
Zfp280d T C 9: 72,226,560 (GRCm39) C335R probably damaging Het
Zfp958 G T 8: 4,663,273 (GRCm39) probably benign Het
Other mutations in Gpr87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00496:Gpr87 APN 3 59,087,211 (GRCm39) missense probably damaging 1.00
IGL02309:Gpr87 APN 3 59,086,975 (GRCm39) missense possibly damaging 0.74
IGL02614:Gpr87 APN 3 59,086,738 (GRCm39) missense probably damaging 1.00
R0097:Gpr87 UTSW 3 59,086,506 (GRCm39) missense probably damaging 1.00
R0097:Gpr87 UTSW 3 59,086,506 (GRCm39) missense probably damaging 1.00
R0113:Gpr87 UTSW 3 59,086,932 (GRCm39) missense possibly damaging 0.86
R1801:Gpr87 UTSW 3 59,086,813 (GRCm39) missense possibly damaging 0.92
R2213:Gpr87 UTSW 3 59,086,465 (GRCm39) missense probably damaging 0.99
R2698:Gpr87 UTSW 3 59,086,587 (GRCm39) missense probably damaging 1.00
R5459:Gpr87 UTSW 3 59,087,148 (GRCm39) missense possibly damaging 0.89
R5490:Gpr87 UTSW 3 59,086,747 (GRCm39) missense probably damaging 0.99
R5963:Gpr87 UTSW 3 59,086,690 (GRCm39) nonsense probably null
R6189:Gpr87 UTSW 3 59,086,650 (GRCm39) missense probably damaging 1.00
R6251:Gpr87 UTSW 3 59,086,528 (GRCm39) missense probably damaging 0.99
R7863:Gpr87 UTSW 3 59,087,317 (GRCm39) missense probably damaging 1.00
R8008:Gpr87 UTSW 3 59,087,466 (GRCm39) missense probably benign
R8065:Gpr87 UTSW 3 59,087,308 (GRCm39) missense probably damaging 1.00
R8067:Gpr87 UTSW 3 59,087,308 (GRCm39) missense probably damaging 1.00
R8141:Gpr87 UTSW 3 59,087,020 (GRCm39) missense probably damaging 1.00
R8326:Gpr87 UTSW 3 59,102,395 (GRCm39) start gained probably benign
R9326:Gpr87 UTSW 3 59,086,609 (GRCm39) missense probably damaging 1.00
R9485:Gpr87 UTSW 3 59,087,005 (GRCm39) missense possibly damaging 0.85
Z1177:Gpr87 UTSW 3 59,087,491 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTCACCAAAGGGCTTTACCACC -3'
(R):5'- TGTACAGCCAAGCAAGTCAC -3'

Sequencing Primer
(F):5'- AAGGGCTTTACCACCTTTAGATACCG -3'
(R):5'- GGACATGGGAAGAACTCTACC -3'
Posted On 2020-06-30