Incidental Mutation 'R8097:Zfp764l1'
ID 630243
Institutional Source Beutler Lab
Gene Symbol Zfp764l1
Ensembl Gene ENSMUSG00000078580
Gene Name zinc finger protein 764 like 1
Synonyms E430018J23Rik
MMRRC Submission 067529-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R8097 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 126988845-126992801 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 126992496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 38 (C38Y)
Ref Sequence ENSEMBL: ENSMUSP00000073867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074249] [ENSMUST00000106303] [ENSMUST00000165495]
AlphaFold E9PZQ8
Predicted Effect probably null
Transcript: ENSMUST00000074249
AA Change: C38Y

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073867
Gene: ENSMUSG00000078580
AA Change: C38Y

DomainStartEndE-ValueType
KRAB 22 79 4.43e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000106303
AA Change: C38Y

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000101910
Gene: ENSMUSG00000078580
AA Change: C38Y

DomainStartEndE-ValueType
KRAB 22 81 9.25e-28 SMART
Predicted Effect probably null
Transcript: ENSMUST00000165495
AA Change: C38Y

PolyPhen 2 Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000126288
Gene: ENSMUSG00000078580
AA Change: C38Y

DomainStartEndE-ValueType
KRAB 22 82 4.09e-29 SMART
ZnF_C2H2 168 190 2.2e-2 SMART
ZnF_C2H2 196 218 4.79e-3 SMART
ZnF_C2H2 224 246 4.3e-5 SMART
ZnF_C2H2 252 274 7.9e-4 SMART
ZnF_C2H2 280 302 9.58e-3 SMART
ZnF_C2H2 308 331 2.36e-2 SMART
ZnF_C2H2 337 359 2.57e-3 SMART
ZnF_C2H2 365 387 1.69e-3 SMART
ZnF_C2H2 393 415 2.2e-2 SMART
Meta Mutation Damage Score 0.3601 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.6%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 G A 19: 43,805,394 (GRCm39) M749I probably benign Het
Adcy8 A T 15: 64,743,711 (GRCm39) probably null Het
Adgrb2 G A 4: 129,901,690 (GRCm39) C438Y probably damaging Het
Amn1 G A 6: 149,070,853 (GRCm39) probably benign Het
Atxn2 C T 5: 121,887,286 (GRCm39) R319W probably damaging Het
Ccdc162 T C 10: 41,510,115 (GRCm39) E830G probably benign Het
Ccdc71 T C 9: 108,340,751 (GRCm39) V188A probably benign Het
Ceacam11 A T 7: 17,709,455 (GRCm39) R218* probably null Het
Col18a1 A C 10: 76,948,342 (GRCm39) L390R unknown Het
Cps1 A G 1: 67,267,429 (GRCm39) N1399S probably benign Het
Ctnnal1 T C 4: 56,847,845 (GRCm39) E98G probably damaging Het
Cyp1a2 T A 9: 57,586,836 (GRCm39) probably null Het
Cyp2d11 C A 15: 82,274,581 (GRCm39) probably null Het
Cyp2j7 G A 4: 96,103,647 (GRCm39) T296I possibly damaging Het
Dcc C T 18: 71,812,573 (GRCm39) G407D probably damaging Het
E330034G19Rik T C 14: 24,356,920 (GRCm39) L217S unknown Het
Eea1 A G 10: 95,862,516 (GRCm39) K813E probably benign Het
Ell3 TCTCCTC TCTC 2: 121,269,937 (GRCm39) probably benign Het
Etf1 T C 18: 35,064,697 (GRCm39) D4G probably benign Het
F830045P16Rik T C 2: 129,305,505 (GRCm39) T290A possibly damaging Het
Filip1 T C 9: 79,725,541 (GRCm39) D1026G probably benign Het
Flad1 A T 3: 89,316,442 (GRCm39) L40H probably damaging Het
Fpr3 C A 17: 18,191,054 (GRCm39) N108K probably damaging Het
Galntl6 A G 8: 58,415,407 (GRCm39) probably null Het
Hmgcll1 T C 9: 75,922,421 (GRCm39) L22P probably benign Het
Iars2 C T 1: 185,061,586 (GRCm39) probably benign Het
Ifna15 A T 4: 88,475,938 (GRCm39) L182Q probably benign Het
Kcna6 A T 6: 126,715,575 (GRCm39) V438E probably damaging Het
Kcnma1 T A 14: 23,381,032 (GRCm39) D1012V probably damaging Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Lama2 G A 10: 27,066,660 (GRCm39) Q1074* probably null Het
Lhx9 T C 1: 138,766,089 (GRCm39) Y242C probably damaging Het
Lrrc37a T A 11: 103,394,925 (GRCm39) I167F probably benign Het
Lrrc49 T A 9: 60,522,331 (GRCm39) T351S probably benign Het
Lrrc56 A G 7: 140,775,819 (GRCm39) probably null Het
Mlh1 C A 9: 111,085,160 (GRCm39) probably null Het
Msh4 C T 3: 153,583,545 (GRCm39) probably null Het
Nav2 A G 7: 49,237,525 (GRCm39) D1999G probably damaging Het
Ncapd2 A T 6: 125,145,945 (GRCm39) I1272K possibly damaging Het
Neurl1a A G 19: 47,245,958 (GRCm39) D530G probably damaging Het
Nid2 T C 14: 19,848,657 (GRCm39) V1019A possibly damaging Het
Nlrp2 A T 7: 5,330,650 (GRCm39) L582Q probably damaging Het
Or1o4 A T 17: 37,590,818 (GRCm39) Y164* probably null Het
Or4c121 A T 2: 89,023,976 (GRCm39) I134N probably damaging Het
Or51a39 A G 7: 102,363,197 (GRCm39) V141A possibly damaging Het
Or8k1 A T 2: 86,048,010 (GRCm39) F15I probably damaging Het
Pde6c G T 19: 38,150,414 (GRCm39) E520* probably null Het
Pdzk1 C T 3: 96,757,556 (GRCm39) T4I probably benign Het
Pxdn C T 12: 30,056,601 (GRCm39) L1271F probably damaging Het
Rap1gap G T 4: 137,455,597 (GRCm39) V667F probably benign Het
Recql A T 6: 142,320,637 (GRCm39) I137N probably damaging Het
Ryr2 T C 13: 11,960,881 (GRCm39) E19G probably damaging Het
Ryr3 T C 2: 112,500,615 (GRCm39) probably null Het
Six1 A G 12: 73,090,524 (GRCm39) S214P possibly damaging Het
Slc24a1 T C 9: 64,831,734 (GRCm39) D1121G probably damaging Het
Slc30a6 T A 17: 74,719,693 (GRCm39) C218S possibly damaging Het
Spata31e1 T A 13: 49,943,676 (GRCm39) M1L probably benign Het
Stab2 T C 10: 86,704,959 (GRCm39) D1803G possibly damaging Het
Sult2a3 A T 7: 13,816,635 (GRCm39) V181E possibly damaging Het
Ubc C T 5: 125,466,982 (GRCm39) probably benign Het
Usp8 A G 2: 126,596,800 (GRCm39) N870S probably benign Het
Vmn1r225 A G 17: 20,722,611 (GRCm39) I17M possibly damaging Het
Vps13b T C 15: 35,709,492 (GRCm39) I1813T probably benign Het
Wdr11 C T 7: 129,209,611 (GRCm39) P473L probably damaging Het
Zcchc4 T A 5: 52,953,333 (GRCm39) I114N probably benign Het
Zfp516 C A 18: 83,005,295 (GRCm39) S733* probably null Het
Other mutations in Zfp764l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01716:Zfp764l1 APN 7 126,991,208 (GRCm39) missense possibly damaging 0.92
IGL01782:Zfp764l1 APN 7 126,992,476 (GRCm39) missense probably benign 0.02
IGL02174:Zfp764l1 APN 7 126,991,525 (GRCm39) missense possibly damaging 0.54
IGL02882:Zfp764l1 APN 7 126,991,424 (GRCm39) missense probably damaging 1.00
IGL03152:Zfp764l1 APN 7 126,991,469 (GRCm39) missense probably damaging 1.00
R0552:Zfp764l1 UTSW 7 126,991,504 (GRCm39) missense possibly damaging 0.92
R1828:Zfp764l1 UTSW 7 126,991,081 (GRCm39) missense probably damaging 1.00
R1843:Zfp764l1 UTSW 7 126,990,660 (GRCm39) missense probably benign 0.32
R1866:Zfp764l1 UTSW 7 126,992,503 (GRCm39) missense probably damaging 1.00
R3429:Zfp764l1 UTSW 7 126,990,914 (GRCm39) missense possibly damaging 0.79
R4433:Zfp764l1 UTSW 7 126,992,174 (GRCm39) missense possibly damaging 0.75
R4933:Zfp764l1 UTSW 7 126,992,521 (GRCm39) missense probably damaging 1.00
R5292:Zfp764l1 UTSW 7 126,991,659 (GRCm39) missense possibly damaging 0.48
R6218:Zfp764l1 UTSW 7 126,992,581 (GRCm39) missense possibly damaging 0.85
R6667:Zfp764l1 UTSW 7 126,992,595 (GRCm39) missense probably benign 0.35
R6712:Zfp764l1 UTSW 7 126,991,482 (GRCm39) missense probably damaging 1.00
R7108:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7214:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7215:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7216:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7313:Zfp764l1 UTSW 7 126,990,856 (GRCm39) missense probably benign 0.23
R7396:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7397:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7398:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7478:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7479:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7480:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7481:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7512:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7652:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7716:Zfp764l1 UTSW 7 126,991,259 (GRCm39) missense probably benign
R7820:Zfp764l1 UTSW 7 126,990,608 (GRCm39) missense possibly damaging 0.84
R7923:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7999:Zfp764l1 UTSW 7 126,991,600 (GRCm39) missense probably damaging 0.98
R8098:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8100:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8182:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8184:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8185:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8309:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8389:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8433:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8436:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R9196:Zfp764l1 UTSW 7 126,990,761 (GRCm39) missense probably benign 0.02
R9779:Zfp764l1 UTSW 7 126,991,469 (GRCm39) missense probably damaging 1.00
X0022:Zfp764l1 UTSW 7 126,992,442 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGACCCACTTGTTACGACC -3'
(R):5'- CACGGACCTGATATATGTCCTTTC -3'

Sequencing Primer
(F):5'- ACTTGTTACGACCACCCGTAC -3'
(R):5'- GGCAACCTAGGATCTGGCAG -3'
Posted On 2020-06-30