Incidental Mutation 'R8097:Dcc'
ID 630272
Institutional Source Beutler Lab
Gene Symbol Dcc
Ensembl Gene ENSMUSG00000060534
Gene Name deleted in colorectal carcinoma
Synonyms Igdcc1, C030036D22Rik
MMRRC Submission 067529-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8097 (G1)
Quality Score 119.008
Status Validated
Chromosome 18
Chromosomal Location 71386705-72484140 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 71812573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 407 (G407D)
Ref Sequence ENSEMBL: ENSMUSP00000110593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073379] [ENSMUST00000114943]
AlphaFold P70211
Predicted Effect probably damaging
Transcript: ENSMUST00000073379
AA Change: G407D

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000073094
Gene: ENSMUSG00000060534
AA Change: G407D

DomainStartEndE-ValueType
transmembrane domain 5 27 N/A INTRINSIC
IG 46 137 9.12e-7 SMART
IGc2 152 219 1.75e-17 SMART
IGc2 252 317 4.12e-14 SMART
IGc2 343 407 8e-12 SMART
IG_like 424 520 1.06e2 SMART
FN3 429 511 6.69e-12 SMART
FN3 528 607 6.53e-15 SMART
FN3 622 705 2.09e-13 SMART
FN3 726 805 8.43e-9 SMART
FN3 824 909 2.48e-6 SMART
FN3 925 1011 1.35e-7 SMART
transmembrane domain 1079 1101 N/A INTRINSIC
Pfam:Neogenin_C 1126 1425 5.5e-129 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000114943
AA Change: G407D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110593
Gene: ENSMUSG00000060534
AA Change: G407D

DomainStartEndE-ValueType
transmembrane domain 5 27 N/A INTRINSIC
IG 46 137 9.12e-7 SMART
IGc2 152 219 1.75e-17 SMART
IGc2 252 317 4.12e-14 SMART
IGc2 343 407 8e-12 SMART
IG_like 424 520 1.06e2 SMART
FN3 429 511 6.69e-12 SMART
FN3 528 607 6.53e-15 SMART
FN3 622 705 2.09e-13 SMART
FN3 726 805 8.43e-9 SMART
FN3 844 929 2.48e-6 SMART
FN3 945 1031 1.35e-7 SMART
transmembrane domain 1099 1121 N/A INTRINSIC
Pfam:Neogenin_C 1148 1445 3.4e-113 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.6%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems. Incidence of tumors increases in mutations preventing netrin-1 binding. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 G A 19: 43,805,394 (GRCm39) M749I probably benign Het
Adcy8 A T 15: 64,743,711 (GRCm39) probably null Het
Adgrb2 G A 4: 129,901,690 (GRCm39) C438Y probably damaging Het
Amn1 G A 6: 149,070,853 (GRCm39) probably benign Het
Atxn2 C T 5: 121,887,286 (GRCm39) R319W probably damaging Het
Ccdc162 T C 10: 41,510,115 (GRCm39) E830G probably benign Het
Ccdc71 T C 9: 108,340,751 (GRCm39) V188A probably benign Het
Ceacam11 A T 7: 17,709,455 (GRCm39) R218* probably null Het
Col18a1 A C 10: 76,948,342 (GRCm39) L390R unknown Het
Cps1 A G 1: 67,267,429 (GRCm39) N1399S probably benign Het
Ctnnal1 T C 4: 56,847,845 (GRCm39) E98G probably damaging Het
Cyp1a2 T A 9: 57,586,836 (GRCm39) probably null Het
Cyp2d11 C A 15: 82,274,581 (GRCm39) probably null Het
Cyp2j7 G A 4: 96,103,647 (GRCm39) T296I possibly damaging Het
E330034G19Rik T C 14: 24,356,920 (GRCm39) L217S unknown Het
Eea1 A G 10: 95,862,516 (GRCm39) K813E probably benign Het
Ell3 TCTCCTC TCTC 2: 121,269,937 (GRCm39) probably benign Het
Etf1 T C 18: 35,064,697 (GRCm39) D4G probably benign Het
F830045P16Rik T C 2: 129,305,505 (GRCm39) T290A possibly damaging Het
Filip1 T C 9: 79,725,541 (GRCm39) D1026G probably benign Het
Flad1 A T 3: 89,316,442 (GRCm39) L40H probably damaging Het
Fpr3 C A 17: 18,191,054 (GRCm39) N108K probably damaging Het
Galntl6 A G 8: 58,415,407 (GRCm39) probably null Het
Hmgcll1 T C 9: 75,922,421 (GRCm39) L22P probably benign Het
Iars2 C T 1: 185,061,586 (GRCm39) probably benign Het
Ifna15 A T 4: 88,475,938 (GRCm39) L182Q probably benign Het
Kcna6 A T 6: 126,715,575 (GRCm39) V438E probably damaging Het
Kcnma1 T A 14: 23,381,032 (GRCm39) D1012V probably damaging Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Lama2 G A 10: 27,066,660 (GRCm39) Q1074* probably null Het
Lhx9 T C 1: 138,766,089 (GRCm39) Y242C probably damaging Het
Lrrc37a T A 11: 103,394,925 (GRCm39) I167F probably benign Het
Lrrc49 T A 9: 60,522,331 (GRCm39) T351S probably benign Het
Lrrc56 A G 7: 140,775,819 (GRCm39) probably null Het
Mlh1 C A 9: 111,085,160 (GRCm39) probably null Het
Msh4 C T 3: 153,583,545 (GRCm39) probably null Het
Nav2 A G 7: 49,237,525 (GRCm39) D1999G probably damaging Het
Ncapd2 A T 6: 125,145,945 (GRCm39) I1272K possibly damaging Het
Neurl1a A G 19: 47,245,958 (GRCm39) D530G probably damaging Het
Nid2 T C 14: 19,848,657 (GRCm39) V1019A possibly damaging Het
Nlrp2 A T 7: 5,330,650 (GRCm39) L582Q probably damaging Het
Or1o4 A T 17: 37,590,818 (GRCm39) Y164* probably null Het
Or4c121 A T 2: 89,023,976 (GRCm39) I134N probably damaging Het
Or51a39 A G 7: 102,363,197 (GRCm39) V141A possibly damaging Het
Or8k1 A T 2: 86,048,010 (GRCm39) F15I probably damaging Het
Pde6c G T 19: 38,150,414 (GRCm39) E520* probably null Het
Pdzk1 C T 3: 96,757,556 (GRCm39) T4I probably benign Het
Pxdn C T 12: 30,056,601 (GRCm39) L1271F probably damaging Het
Rap1gap G T 4: 137,455,597 (GRCm39) V667F probably benign Het
Recql A T 6: 142,320,637 (GRCm39) I137N probably damaging Het
Ryr2 T C 13: 11,960,881 (GRCm39) E19G probably damaging Het
Ryr3 T C 2: 112,500,615 (GRCm39) probably null Het
Six1 A G 12: 73,090,524 (GRCm39) S214P possibly damaging Het
Slc24a1 T C 9: 64,831,734 (GRCm39) D1121G probably damaging Het
Slc30a6 T A 17: 74,719,693 (GRCm39) C218S possibly damaging Het
Spata31e1 T A 13: 49,943,676 (GRCm39) M1L probably benign Het
Stab2 T C 10: 86,704,959 (GRCm39) D1803G possibly damaging Het
Sult2a3 A T 7: 13,816,635 (GRCm39) V181E possibly damaging Het
Ubc C T 5: 125,466,982 (GRCm39) probably benign Het
Usp8 A G 2: 126,596,800 (GRCm39) N870S probably benign Het
Vmn1r225 A G 17: 20,722,611 (GRCm39) I17M possibly damaging Het
Vps13b T C 15: 35,709,492 (GRCm39) I1813T probably benign Het
Wdr11 C T 7: 129,209,611 (GRCm39) P473L probably damaging Het
Zcchc4 T A 5: 52,953,333 (GRCm39) I114N probably benign Het
Zfp516 C A 18: 83,005,295 (GRCm39) S733* probably null Het
Zfp764l1 C T 7: 126,992,496 (GRCm39) C38Y probably null Het
Other mutations in Dcc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Dcc APN 18 71,517,296 (GRCm39) critical splice acceptor site probably null
IGL00781:Dcc APN 18 71,942,266 (GRCm39) missense probably benign 0.25
IGL00818:Dcc APN 18 72,088,083 (GRCm39) missense probably benign
IGL00895:Dcc APN 18 71,943,871 (GRCm39) missense probably damaging 0.98
IGL00969:Dcc APN 18 71,589,954 (GRCm39) missense probably benign 0.25
IGL01019:Dcc APN 18 71,942,161 (GRCm39) missense probably benign 0.00
IGL01132:Dcc APN 18 71,815,245 (GRCm39) nonsense probably null
IGL01349:Dcc APN 18 71,503,808 (GRCm39) missense probably damaging 1.00
IGL01355:Dcc APN 18 71,942,185 (GRCm39) missense probably benign 0.00
IGL01374:Dcc APN 18 71,507,624 (GRCm39) missense probably damaging 1.00
IGL01947:Dcc APN 18 71,959,280 (GRCm39) missense probably benign
IGL02470:Dcc APN 18 72,088,153 (GRCm39) splice site probably benign
IGL02508:Dcc APN 18 71,503,773 (GRCm39) missense probably benign 0.00
IGL02999:Dcc APN 18 71,511,749 (GRCm39) missense possibly damaging 0.68
IGL03034:Dcc APN 18 71,708,214 (GRCm39) nonsense probably null
IGL03118:Dcc APN 18 71,553,344 (GRCm39) missense probably benign 0.00
IGL03133:Dcc APN 18 71,396,026 (GRCm39) splice site probably benign
IGL03357:Dcc APN 18 71,460,625 (GRCm39) missense probably damaging 1.00
Hyperrev UTSW 18 71,392,086 (GRCm39) missense probably damaging 1.00
LCD18:Dcc UTSW 18 72,430,518 (GRCm39) intron probably benign
P0031:Dcc UTSW 18 71,517,299 (GRCm39) splice site probably benign
PIT4142001:Dcc UTSW 18 71,517,297 (GRCm39) splice site probably null
R0076:Dcc UTSW 18 71,454,117 (GRCm39) nonsense probably null
R0355:Dcc UTSW 18 71,708,279 (GRCm39) missense possibly damaging 0.75
R0370:Dcc UTSW 18 71,721,056 (GRCm39) missense possibly damaging 0.92
R0383:Dcc UTSW 18 71,553,334 (GRCm39) missense probably damaging 0.99
R0541:Dcc UTSW 18 71,392,086 (GRCm39) missense probably damaging 1.00
R0690:Dcc UTSW 18 71,942,275 (GRCm39) splice site probably benign
R0762:Dcc UTSW 18 71,475,776 (GRCm39) splice site probably benign
R0765:Dcc UTSW 18 71,496,061 (GRCm39) missense probably damaging 1.00
R0846:Dcc UTSW 18 71,959,283 (GRCm39) missense probably benign 0.06
R1230:Dcc UTSW 18 71,815,384 (GRCm39) missense probably damaging 1.00
R1662:Dcc UTSW 18 71,553,409 (GRCm39) missense probably benign 0.00
R1663:Dcc UTSW 18 71,959,123 (GRCm39) missense probably damaging 1.00
R1697:Dcc UTSW 18 71,503,808 (GRCm39) missense probably damaging 1.00
R1770:Dcc UTSW 18 71,579,470 (GRCm39) missense probably benign 0.01
R1781:Dcc UTSW 18 71,511,788 (GRCm39) missense probably benign 0.41
R1797:Dcc UTSW 18 71,500,232 (GRCm39) missense probably damaging 1.00
R2101:Dcc UTSW 18 71,943,941 (GRCm39) missense possibly damaging 0.62
R2190:Dcc UTSW 18 71,680,491 (GRCm39) missense possibly damaging 0.89
R2248:Dcc UTSW 18 71,959,239 (GRCm39) missense probably benign 0.00
R2262:Dcc UTSW 18 71,507,622 (GRCm39) missense probably damaging 1.00
R2442:Dcc UTSW 18 71,589,954 (GRCm39) missense probably damaging 0.98
R3844:Dcc UTSW 18 71,959,257 (GRCm39) missense probably benign 0.01
R4037:Dcc UTSW 18 72,483,468 (GRCm39) missense possibly damaging 0.57
R4085:Dcc UTSW 18 71,959,240 (GRCm39) missense probably benign 0.00
R4344:Dcc UTSW 18 71,507,561 (GRCm39) missense probably damaging 0.99
R4499:Dcc UTSW 18 71,680,388 (GRCm39) missense probably benign 0.07
R4611:Dcc UTSW 18 71,682,069 (GRCm39) splice site probably null
R4811:Dcc UTSW 18 71,432,554 (GRCm39) missense probably benign 0.31
R4937:Dcc UTSW 18 71,675,320 (GRCm39) nonsense probably null
R5125:Dcc UTSW 18 71,589,948 (GRCm39) missense probably benign 0.02
R5292:Dcc UTSW 18 71,439,159 (GRCm39) missense probably damaging 1.00
R5297:Dcc UTSW 18 71,511,809 (GRCm39) missense probably benign 0.00
R5317:Dcc UTSW 18 71,517,226 (GRCm39) missense possibly damaging 0.78
R5691:Dcc UTSW 18 71,708,154 (GRCm39) missense probably damaging 1.00
R5693:Dcc UTSW 18 71,708,153 (GRCm39) missense probably damaging 1.00
R6091:Dcc UTSW 18 71,942,185 (GRCm39) missense probably benign 0.00
R6291:Dcc UTSW 18 71,815,238 (GRCm39) missense probably benign 0.06
R6307:Dcc UTSW 18 71,943,826 (GRCm39) missense probably benign 0.15
R6343:Dcc UTSW 18 71,469,106 (GRCm39) missense probably damaging 1.00
R6508:Dcc UTSW 18 71,439,144 (GRCm39) missense probably damaging 1.00
R6701:Dcc UTSW 18 71,942,191 (GRCm39) missense probably benign 0.02
R6810:Dcc UTSW 18 71,503,764 (GRCm39) missense probably damaging 0.99
R7078:Dcc UTSW 18 71,680,469 (GRCm39) missense probably benign 0.05
R7172:Dcc UTSW 18 71,511,755 (GRCm39) missense probably benign 0.04
R7345:Dcc UTSW 18 71,511,895 (GRCm39) missense probably benign 0.00
R7365:Dcc UTSW 18 71,959,194 (GRCm39) missense probably damaging 0.98
R7395:Dcc UTSW 18 71,507,640 (GRCm39) nonsense probably null
R7455:Dcc UTSW 18 71,553,394 (GRCm39) missense probably benign 0.00
R7461:Dcc UTSW 18 71,439,105 (GRCm39) missense probably damaging 1.00
R7485:Dcc UTSW 18 71,553,317 (GRCm39) missense probably benign 0.00
R7732:Dcc UTSW 18 71,579,506 (GRCm39) missense probably benign 0.24
R7886:Dcc UTSW 18 72,087,939 (GRCm39) nonsense probably null
R8137:Dcc UTSW 18 71,511,783 (GRCm39) missense probably benign 0.00
R8188:Dcc UTSW 18 71,943,928 (GRCm39) missense probably benign
R8236:Dcc UTSW 18 72,088,089 (GRCm39) missense probably benign
R8802:Dcc UTSW 18 71,959,125 (GRCm39) missense probably damaging 1.00
R8869:Dcc UTSW 18 71,511,755 (GRCm39) missense probably benign 0.04
R9221:Dcc UTSW 18 71,553,433 (GRCm39) missense possibly damaging 0.66
R9282:Dcc UTSW 18 71,815,249 (GRCm39) missense possibly damaging 0.85
R9366:Dcc UTSW 18 71,708,281 (GRCm39) missense probably damaging 1.00
R9566:Dcc UTSW 18 71,943,866 (GRCm39) missense possibly damaging 0.92
R9607:Dcc UTSW 18 71,721,072 (GRCm39) missense probably damaging 1.00
W0251:Dcc UTSW 18 71,959,154 (GRCm39) missense probably damaging 1.00
X0020:Dcc UTSW 18 71,454,171 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GCAAGAATGTTCCTAAGGTGCTG -3'
(R):5'- AGAACATATAGGCTCTATAGACTCGTG -3'

Sequencing Primer
(F):5'- AGAATGTTCCTAAGGTGCTGATTTC -3'
(R):5'- TTTTCCCTAGGGAGGAAG -3'
Posted On 2020-06-30