Incidental Mutation 'R8099:Cfap74'
ID 630386
Institutional Source Beutler Lab
Gene Symbol Cfap74
Ensembl Gene ENSMUSG00000078490
Gene Name cilia and flagella associated protein 74
Synonyms 2010015L04Rik
MMRRC Submission 067531-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8099 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 155493647-155551280 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 155539489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 938 (N938S)
Ref Sequence ENSEMBL: ENSMUSP00000123626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105619] [ENSMUST00000151083]
AlphaFold Q3UY96
Predicted Effect probably benign
Transcript: ENSMUST00000105619
Predicted Effect unknown
Transcript: ENSMUST00000151083
AA Change: N938S
SMART Domains Protein: ENSMUSP00000123626
Gene: ENSMUSG00000078490
AA Change: N938S

DomainStartEndE-ValueType
low complexity region 44 59 N/A INTRINSIC
coiled coil region 134 162 N/A INTRINSIC
coiled coil region 333 378 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.1%
Validation Efficiency 97% (60/62)
Allele List at MGI

All alleles(7) : Targeted(2) Gene trapped(5)

Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930012K11Rik T C 14: 70,394,969 (GRCm39) R62G probably benign Het
Abcb9 A G 5: 124,215,308 (GRCm39) F478L probably benign Het
Abcc9 A T 6: 142,621,257 (GRCm39) N494K probably damaging Het
Atp11a T G 8: 12,911,973 (GRCm39) M124R Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Ccdc110 T A 8: 46,395,130 (GRCm39) H340Q probably damaging Het
Celsr1 A G 15: 85,915,801 (GRCm39) L724P probably damaging Het
Chil3 T G 3: 106,055,984 (GRCm39) D363A probably damaging Het
Ciart G A 3: 95,788,656 (GRCm39) P61L probably damaging Het
Cpne3 A G 4: 19,525,169 (GRCm39) V442A possibly damaging Het
Ctsh T C 9: 89,946,300 (GRCm39) V130A probably damaging Het
Cyp3a44 T C 5: 145,725,212 (GRCm39) K330E probably benign Het
Dgcr2 A T 16: 17,667,633 (GRCm39) D275E probably damaging Het
Dnah1 A T 14: 31,024,321 (GRCm39) D919E probably benign Het
Ell3 TCTCCTC TCTC 2: 121,269,937 (GRCm39) probably benign Het
Entrep3 T C 3: 89,091,250 (GRCm39) F74L probably damaging Het
Epb41l3 T A 17: 69,554,683 (GRCm39) F261Y possibly damaging Het
Fbxo3 A C 2: 103,885,280 (GRCm39) H383P probably damaging Het
Foxp1 C T 6: 98,922,510 (GRCm39) V441M unknown Het
Gm29106 C T 1: 118,126,521 (GRCm39) S71F probably benign Het
Golga3 T A 5: 110,336,573 (GRCm39) L364* probably null Het
H1f1 C T 13: 23,947,832 (GRCm39) L45F probably damaging Het
Herc1 T A 9: 66,279,422 (GRCm39) L110H probably damaging Het
Igkv4-53 A T 6: 69,625,898 (GRCm39) S90T possibly damaging Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Kti12 G T 4: 108,705,571 (GRCm39) G162W probably damaging Het
Lama3 T A 18: 12,667,120 (GRCm39) I763N probably damaging Het
Macf1 A T 4: 123,369,922 (GRCm39) I1613K probably benign Het
Mkrn1 T C 6: 39,387,031 (GRCm39) D102G probably benign Het
Muc2 T A 7: 141,299,175 (GRCm39) probably null Het
Nipal4 T C 11: 46,052,848 (GRCm39) E39G probably benign Het
Nr1h2 T C 7: 44,199,746 (GRCm39) Y391C possibly damaging Het
Odam T C 5: 88,040,299 (GRCm39) I255T possibly damaging Het
Or11m3 A G 15: 98,395,694 (GRCm39) M114V probably benign Het
Or6c35 T A 10: 129,168,996 (GRCm39) I82K probably damaging Het
Or9m1 T A 2: 87,733,852 (GRCm39) H56L probably damaging Het
Per3 A T 4: 151,097,014 (GRCm39) M837K possibly damaging Het
Pitpnm3 T A 11: 71,961,144 (GRCm39) H357L possibly damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Plcb1 T C 2: 135,093,654 (GRCm39) Y156H possibly damaging Het
Ppm1d C T 11: 85,230,492 (GRCm39) P370L possibly damaging Het
Prrc2b T C 2: 32,098,686 (GRCm39) V666A probably benign Het
Ptpn3 A T 4: 57,204,985 (GRCm39) C725* probably null Het
Rapgefl1 T C 11: 98,738,209 (GRCm39) W437R probably damaging Het
Sema4g T C 19: 44,980,967 (GRCm39) L5P probably damaging Het
Sipa1l1 C T 12: 82,480,600 (GRCm39) P1529L probably benign Het
Slc12a2 T C 18: 58,032,464 (GRCm39) L388P probably damaging Het
Sltm T A 9: 70,493,360 (GRCm39) S786T probably damaging Het
Srsf1 T C 11: 87,940,082 (GRCm39) I198T probably benign Het
Ssh2 C T 11: 77,345,755 (GRCm39) R1247* probably null Het
Ssu2 T C 6: 112,353,438 (GRCm39) T229A probably benign Het
Stra6 T A 9: 58,059,777 (GRCm39) H579Q probably damaging Het
Tanc2 T A 11: 105,754,833 (GRCm39) V559E probably benign Het
Trp53bp1 A G 2: 121,030,230 (GRCm39) Y1762H probably damaging Het
Usp15 T C 10: 122,982,826 (GRCm39) Y263C possibly damaging Het
Usp17ld A T 7: 102,899,495 (GRCm39) V479E probably damaging Het
Vmn2r15 A T 5: 109,441,185 (GRCm39) S224R possibly damaging Het
Vmn2r8 A T 5: 108,949,700 (GRCm39) N382K probably benign Het
Vmn2r94 T C 17: 18,477,659 (GRCm39) I251V probably benign Het
Wnt2b A T 3: 104,854,408 (GRCm39) V350D possibly damaging Het
Other mutations in Cfap74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01607:Cfap74 APN 4 155,503,443 (GRCm39) missense possibly damaging 0.95
paranoid UTSW 4 155,538,481 (GRCm39) utr 5 prime probably benign
sensibile UTSW 4 155,525,743 (GRCm39) missense probably null 0.03
touchy UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
FR4304:Cfap74 UTSW 4 155,500,217 (GRCm39) missense possibly damaging 0.93
P0007:Cfap74 UTSW 4 155,506,685 (GRCm39) missense possibly damaging 0.83
PIT4434001:Cfap74 UTSW 4 155,548,421 (GRCm39) missense unknown
R0025:Cfap74 UTSW 4 155,510,572 (GRCm39) missense probably benign 0.22
R0034:Cfap74 UTSW 4 155,545,344 (GRCm39) splice site probably benign
R0193:Cfap74 UTSW 4 155,510,572 (GRCm39) missense probably benign 0.22
R0306:Cfap74 UTSW 4 155,549,896 (GRCm39) unclassified probably benign
R0427:Cfap74 UTSW 4 155,525,734 (GRCm39) missense probably benign 0.02
R0905:Cfap74 UTSW 4 155,503,153 (GRCm39) critical splice donor site probably null
R1116:Cfap74 UTSW 4 155,518,453 (GRCm39) missense probably benign 0.15
R1548:Cfap74 UTSW 4 155,518,502 (GRCm39) missense probably benign 0.45
R1950:Cfap74 UTSW 4 155,511,887 (GRCm39) critical splice donor site probably null
R2009:Cfap74 UTSW 4 155,504,724 (GRCm39) missense possibly damaging 0.77
R2029:Cfap74 UTSW 4 155,526,538 (GRCm39) missense possibly damaging 0.74
R2135:Cfap74 UTSW 4 155,514,408 (GRCm39) missense probably damaging 1.00
R2135:Cfap74 UTSW 4 155,514,397 (GRCm39) missense probably damaging 0.97
R2154:Cfap74 UTSW 4 155,513,753 (GRCm39) missense possibly damaging 0.94
R2413:Cfap74 UTSW 4 155,503,081 (GRCm39) missense possibly damaging 0.76
R2418:Cfap74 UTSW 4 155,540,166 (GRCm39) utr 5 prime probably benign
R2930:Cfap74 UTSW 4 155,522,627 (GRCm39) missense probably damaging 0.97
R3965:Cfap74 UTSW 4 155,531,174 (GRCm39) missense probably damaging 1.00
R4078:Cfap74 UTSW 4 155,540,128 (GRCm39) missense probably damaging 0.98
R4238:Cfap74 UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
R4239:Cfap74 UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
R4240:Cfap74 UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
R4491:Cfap74 UTSW 4 155,513,628 (GRCm39) missense probably benign 0.22
R4731:Cfap74 UTSW 4 155,548,059 (GRCm39) intron probably benign
R5333:Cfap74 UTSW 4 155,521,197 (GRCm39) missense probably damaging 0.99
R5362:Cfap74 UTSW 4 155,522,623 (GRCm39) missense probably damaging 0.98
R5425:Cfap74 UTSW 4 155,540,149 (GRCm39) utr 5 prime probably benign
R5468:Cfap74 UTSW 4 155,510,498 (GRCm39) missense probably benign 0.27
R5839:Cfap74 UTSW 4 155,507,207 (GRCm39) critical splice donor site probably null
R6010:Cfap74 UTSW 4 155,538,495 (GRCm39) missense possibly damaging 0.83
R6284:Cfap74 UTSW 4 155,536,253 (GRCm39) missense probably damaging 0.96
R6323:Cfap74 UTSW 4 155,548,395 (GRCm39) missense possibly damaging 0.54
R6389:Cfap74 UTSW 4 155,507,793 (GRCm39) missense possibly damaging 0.69
R6513:Cfap74 UTSW 4 155,525,743 (GRCm39) missense probably null 0.03
R6527:Cfap74 UTSW 4 155,506,722 (GRCm39) splice site probably null
R6785:Cfap74 UTSW 4 155,538,481 (GRCm39) utr 5 prime probably benign
R6980:Cfap74 UTSW 4 155,550,809 (GRCm39) unclassified probably benign
R7039:Cfap74 UTSW 4 155,538,565 (GRCm39) critical splice donor site probably null
R7077:Cfap74 UTSW 4 155,540,134 (GRCm39) missense unknown
R7116:Cfap74 UTSW 4 155,539,518 (GRCm39) missense unknown
R7202:Cfap74 UTSW 4 155,510,654 (GRCm39) splice site probably null
R7227:Cfap74 UTSW 4 155,545,405 (GRCm39) nonsense probably null
R7228:Cfap74 UTSW 4 155,549,507 (GRCm39) missense unknown
R7261:Cfap74 UTSW 4 155,549,831 (GRCm39) missense unknown
R7315:Cfap74 UTSW 4 155,547,476 (GRCm39) missense unknown
R7337:Cfap74 UTSW 4 155,544,472 (GRCm39) missense unknown
R7354:Cfap74 UTSW 4 155,549,804 (GRCm39) missense unknown
R7533:Cfap74 UTSW 4 155,500,200 (GRCm39) missense
R7673:Cfap74 UTSW 4 155,547,513 (GRCm39) missense unknown
R7798:Cfap74 UTSW 4 155,507,079 (GRCm39) missense
R7829:Cfap74 UTSW 4 155,513,694 (GRCm39) missense
R7897:Cfap74 UTSW 4 155,514,351 (GRCm39) missense
R8126:Cfap74 UTSW 4 155,511,831 (GRCm39) missense
R8769:Cfap74 UTSW 4 155,503,105 (GRCm39) missense
R8873:Cfap74 UTSW 4 155,539,465 (GRCm39) missense unknown
R8893:Cfap74 UTSW 4 155,531,152 (GRCm39) missense unknown
R8900:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R8954:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R8957:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R8982:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R9008:Cfap74 UTSW 4 155,503,121 (GRCm39) missense
R9406:Cfap74 UTSW 4 155,510,626 (GRCm39) nonsense probably null
R9606:Cfap74 UTSW 4 155,509,133 (GRCm39) missense
R9641:Cfap74 UTSW 4 155,549,054 (GRCm39) missense unknown
R9647:Cfap74 UTSW 4 155,549,373 (GRCm39) missense unknown
R9655:Cfap74 UTSW 4 155,522,665 (GRCm39) missense
R9761:Cfap74 UTSW 4 155,550,844 (GRCm39) missense unknown
R9797:Cfap74 UTSW 4 155,514,402 (GRCm39) missense
T0970:Cfap74 UTSW 4 155,547,574 (GRCm39) splice site probably null
X0066:Cfap74 UTSW 4 155,548,421 (GRCm39) missense probably damaging 1.00
Z1176:Cfap74 UTSW 4 155,510,575 (GRCm39) missense
Z1177:Cfap74 UTSW 4 155,539,370 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AAAGCTTCCAGTGGCTGAG -3'
(R):5'- GCAGCTCTTTTGGGTGTACC -3'

Sequencing Primer
(F):5'- CTTCCAGTGGCTGAGAACGTTC -3'
(R):5'- CAGCTCTTTTGGGTGTACCTTACAG -3'
Posted On 2020-06-30