Incidental Mutation 'R8104:Ing5'
ID 630626
Institutional Source Beutler Lab
Gene Symbol Ing5
Ensembl Gene ENSMUSG00000026283
Gene Name inhibitor of growth family, member 5
Synonyms 1810018M11Rik, 1700027H23Rik
MMRRC Submission 067535-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.350) question?
Stock # R8104 (G1)
Quality Score 185.009
Status Validated
Chromosome 1
Chromosomal Location 93731687-93749823 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93744166 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 184 (N184K)
Ref Sequence ENSEMBL: ENSMUSP00000027505 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027505] [ENSMUST00000188402] [ENSMUST00000190476]
AlphaFold Q9D8Y8
Predicted Effect probably damaging
Transcript: ENSMUST00000027505
AA Change: N184K

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000027505
Gene: ENSMUSG00000026283
AA Change: N184K

DomainStartEndE-ValueType
Pfam:ING 6 107 1.6e-34 PFAM
low complexity region 129 150 N/A INTRINSIC
PHD 188 233 7.34e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188402
Predicted Effect probably damaging
Transcript: ENSMUST00000190476
AA Change: N157K

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000140498
Gene: ENSMUSG00000026283
AA Change: N157K

DomainStartEndE-ValueType
Pfam:ING 1 80 2.4e-18 PFAM
low complexity region 102 123 N/A INTRINSIC
PHD 161 206 4.7e-14 SMART
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 98.6%
  • 20x: 94.6%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg2 C A 17: 57,152,443 (GRCm39) L666F probably benign Het
Adgrv1 A T 13: 81,588,344 (GRCm39) V4414E possibly damaging Het
Apoc3 T G 9: 46,144,585 (GRCm39) D79A probably damaging Het
Arfgap1 T A 2: 180,621,022 (GRCm39) probably null Het
Ascc1 T C 10: 59,843,551 (GRCm39) S38P probably benign Het
Asl C T 5: 130,040,791 (GRCm39) E389K probably benign Het
Atat1 A T 17: 36,215,008 (GRCm39) I215K probably benign Het
Bod1l A T 5: 41,991,075 (GRCm39) L160* probably null Het
Cbl C A 9: 44,069,836 (GRCm39) S637I possibly damaging Het
Ccdc112 A C 18: 46,420,720 (GRCm39) S343R probably benign Het
Cr1l A G 1: 194,799,925 (GRCm39) S250P possibly damaging Het
Cspg4b T A 13: 113,456,263 (GRCm39) F770I Het
Dlgap3 A G 4: 127,129,947 (GRCm39) E907G probably damaging Het
Dsp A T 13: 38,352,600 (GRCm39) E159D probably benign Het
Ech1 G A 7: 28,524,728 (GRCm39) probably benign Het
Erbin G T 13: 103,971,485 (GRCm39) N710K possibly damaging Het
Fbxw28 A T 9: 109,155,357 (GRCm39) probably null Het
Gm4871 G C 5: 144,969,012 (GRCm39) D100E probably damaging Het
Got1l1 A G 8: 27,687,619 (GRCm39) I388T probably damaging Het
Izumo3 A T 4: 92,035,145 (GRCm39) L24* probably null Het
Lig1 T C 7: 13,020,491 (GRCm39) V99A possibly damaging Het
Mbtps1 A G 8: 120,255,794 (GRCm39) Y488H possibly damaging Het
Muc5ac A G 7: 141,358,520 (GRCm39) Y1240C possibly damaging Het
Nav3 T C 10: 109,594,828 (GRCm39) T1458A probably damaging Het
Nedd1 T C 10: 92,527,778 (GRCm39) E472G probably damaging Het
Nod2 A T 8: 89,391,685 (GRCm39) H664L possibly damaging Het
Ntrk3 A G 7: 78,227,450 (GRCm39) S28P probably damaging Het
Or14a257 A G 7: 86,138,231 (GRCm39) F176S probably damaging Het
Or1i2 C T 10: 78,448,242 (GRCm39) V78I probably benign Het
Or2ag17 T A 7: 106,390,338 (GRCm39) probably benign Het
Or2ag17 C A 7: 106,390,337 (GRCm39) probably benign Het
Or6c66b T A 10: 129,376,826 (GRCm39) M140K probably benign Het
Pcdha4 G T 18: 37,087,106 (GRCm39) G430W probably damaging Het
Pcnx1 T A 12: 82,030,385 (GRCm39) Y1114* probably null Het
Pde6a T A 18: 61,364,566 (GRCm39) D207E probably damaging Het
Plekhg1 T A 10: 3,902,326 (GRCm39) I540N Het
Pnp2 A T 14: 51,197,099 (GRCm39) I62F probably benign Het
Rarg C A 15: 102,148,334 (GRCm39) D258Y probably damaging Het
Rnps1 T A 17: 24,643,484 (GRCm39) M262K unknown Het
Scaf11 T C 15: 96,316,483 (GRCm39) D1027G probably benign Het
Serpina3a A T 12: 104,079,110 (GRCm39) probably benign Het
Slc25a1 A G 16: 17,744,297 (GRCm39) probably null Het
Slc44a3 A C 3: 121,291,521 (GRCm39) V365G probably benign Het
Slc45a3 T C 1: 131,904,754 (GRCm39) F26L probably benign Het
Slc9a2 T A 1: 40,757,809 (GRCm39) I116K probably damaging Het
Stk36 T A 1: 74,665,756 (GRCm39) S700T probably benign Het
Tekt3 A G 11: 62,968,945 (GRCm39) D224G probably benign Het
Tgtp1 A T 11: 48,877,841 (GRCm39) I288N probably damaging Het
Ttn C T 2: 76,710,567 (GRCm39) V8485M unknown Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Uso1 T A 5: 92,306,280 (GRCm39) I79K probably damaging Het
Utp20 C T 10: 88,593,766 (GRCm39) D2215N probably damaging Het
Wdr43 C T 17: 71,923,350 (GRCm39) A32V probably benign Het
Zfp704 T C 3: 9,630,301 (GRCm39) D170G probably benign Het
Other mutations in Ing5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Ing5 APN 1 93,733,816 (GRCm39) start codon destroyed probably null 0.92
IGL02067:Ing5 APN 1 93,739,648 (GRCm39) missense probably damaging 1.00
IGL02699:Ing5 APN 1 93,744,164 (GRCm39) missense possibly damaging 0.81
IGL02744:Ing5 APN 1 93,744,210 (GRCm39) missense probably damaging 0.99
Albion UTSW 1 93,744,166 (GRCm39) missense probably damaging 0.97
cordelia UTSW 1 93,740,154 (GRCm39) missense probably damaging 1.00
Dover UTSW 1 93,740,155 (GRCm39) missense probably damaging 1.00
PIT4458001:Ing5 UTSW 1 93,739,668 (GRCm39) missense possibly damaging 0.64
R0372:Ing5 UTSW 1 93,740,142 (GRCm39) missense probably damaging 0.98
R2903:Ing5 UTSW 1 93,731,710 (GRCm39) unclassified probably benign
R3742:Ing5 UTSW 1 93,740,398 (GRCm39) missense probably damaging 1.00
R5713:Ing5 UTSW 1 93,740,452 (GRCm39) missense probably benign 0.00
R7514:Ing5 UTSW 1 93,744,164 (GRCm39) missense possibly damaging 0.81
R7643:Ing5 UTSW 1 93,740,155 (GRCm39) missense probably damaging 1.00
R8783:Ing5 UTSW 1 93,740,154 (GRCm39) missense probably damaging 1.00
R9211:Ing5 UTSW 1 93,740,409 (GRCm39) missense possibly damaging 0.93
R9231:Ing5 UTSW 1 93,739,505 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTTTCCTTGGAAGCTGCAAGC -3'
(R):5'- TGTGTCACACCCATGCAAGC -3'

Sequencing Primer
(F):5'- CAAGCATCCTTTGTTCCAGGGTAAAG -3'
(R):5'- GCTGCACATTAAACACAGAAAGG -3'
Posted On 2020-06-30