Incidental Mutation 'R8108:Olfr177'
ID 630763
Institutional Source Beutler Lab
Gene Symbol Olfr177
Ensembl Gene ENSMUSG00000063137
Gene Name olfactory receptor 177
Synonyms GA_x54KRFPKG5P-55091371-55090442, MOR184-7
MMRRC Submission 067537-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R8108 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 58870955-58874768 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58872236 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 305 (M305V)
Ref Sequence ENSEMBL: ENSMUSP00000150269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072853] [ENSMUST00000217377]
AlphaFold E9Q7W1
Predicted Effect probably benign
Transcript: ENSMUST00000072853
AA Change: M305V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072631
Gene: ENSMUSG00000063137
AA Change: M305V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 254 8.3e-6 PFAM
Pfam:7tm_1 41 290 1.2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217377
AA Change: M305V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.0%
  • 20x: 97.3%
Validation Efficiency 99% (72/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot1 T A 12: 84,017,361 (GRCm38) H414Q probably benign Het
Actrt2 A T 4: 154,667,036 (GRCm38) D214E probably benign Het
Ccdc7a T C 8: 128,980,153 (GRCm38) T332A unknown Het
Chd9 C T 8: 90,933,224 (GRCm38) H271Y unknown Het
Depdc5 T G 5: 32,945,049 (GRCm38) D966E probably benign Het
Dolpp1 A G 2: 30,396,246 (GRCm38) Y119C probably benign Het
Dscam G C 16: 96,643,879 (GRCm38) D1537E probably benign Het
Dusp16 A G 6: 134,739,873 (GRCm38) I157T probably benign Het
Dyrk2 T C 10: 118,859,829 (GRCm38) D508G probably benign Het
Endov T C 11: 119,507,411 (GRCm38) V334A probably benign Het
Ep400 A T 5: 110,687,883 (GRCm38) V1956E unknown Het
Erich3 A T 3: 154,720,115 (GRCm38) Y83F possibly damaging Het
Fbrsl1 T C 5: 110,378,379 (GRCm38) probably null Het
Gm1110 T C 9: 26,920,661 (GRCm38) I65V probably damaging Het
Gm28374 A G 19: 6,082,200 (GRCm38) V19A Het
Gm436 A T 4: 144,670,669 (GRCm38) N164K probably benign Het
Gpr107 C A 2: 31,184,869 (GRCm38) H336Q probably damaging Het
Gpr137b T C 13: 13,359,406 (GRCm38) Y355C Het
Grm1 C A 10: 10,720,132 (GRCm38) R584L probably benign Het
Gse1 T C 8: 120,229,810 (GRCm38) S347P unknown Het
Ier3ip1 T A 18: 76,940,525 (GRCm38) I69K possibly damaging Het
Impact T G 18: 12,984,331 (GRCm38) L154V probably benign Het
Katnb1 T C 8: 95,093,945 (GRCm38) F141S possibly damaging Het
Kifap3 T A 1: 163,797,362 (GRCm38) N162K probably damaging Het
Klhl5 A G 5: 65,148,587 (GRCm38) probably null Het
Klre1 A G 6: 129,584,222 (GRCm38) D182G probably benign Het
Krt42 T A 11: 100,266,957 (GRCm38) Y227F probably benign Het
Lhcgr T A 17: 88,742,050 (GRCm38) K683* probably null Het
Lrrc37a G A 11: 103,503,057 (GRCm38) S514F probably benign Het
Lrrc9 G T 12: 72,454,059 (GRCm38) L186F probably damaging Het
Metrn A G 17: 25,795,030 (GRCm38) V274A probably benign Het
Mettl25 A T 10: 105,823,179 (GRCm38) F414L possibly damaging Het
Mixl1 A G 1: 180,696,702 (GRCm38) V104A probably damaging Het
Myo9b T A 8: 71,348,342 (GRCm38) M1047K probably damaging Het
Nbea G A 3: 55,819,315 (GRCm38) A2081V probably benign Het
Ndufs1 A T 1: 63,150,012 (GRCm38) D551E possibly damaging Het
Nectin3 T C 16: 46,464,121 (GRCm38) T67A possibly damaging Het
Nme8 C T 13: 19,650,960 (GRCm38) V519I probably benign Het
Npat G T 9: 53,571,129 (GRCm38) G1379V probably benign Het
Obscn T A 11: 59,061,634 (GRCm38) T3870S probably benign Het
Olfr1000 T C 2: 85,608,749 (GRCm38) R54G possibly damaging Het
Olfr1288 T C 2: 111,479,234 (GRCm38) V150A possibly damaging Het
Olfr379-ps1 T A 11: 73,433,854 (GRCm38) H124L unknown Het
Olfr871 T A 9: 20,212,451 (GRCm38) M34K possibly damaging Het
Olfr910 A G 9: 38,539,410 (GRCm38) N172D probably damaging Het
Parp8 A T 13: 116,867,073 (GRCm38) Y769* probably null Het
Pcnx C T 12: 81,918,819 (GRCm38) R59* probably null Het
Pdzd2 G A 15: 12,373,506 (GRCm38) S2181L probably benign Het
Phldb1 T C 9: 44,711,161 (GRCm38) E65G probably damaging Het
Ppif C T 14: 25,698,326 (GRCm38) T157M probably damaging Het
Ppp3ca T A 3: 136,932,225 (GRCm38) probably null Het
Proser1 T A 3: 53,472,088 (GRCm38) probably null Het
Reg3d T A 6: 78,376,079 (GRCm38) K174* probably null Het
Rubcn A T 16: 32,856,950 (GRCm38) L55Q probably damaging Het
Sec14l3 T C 11: 4,066,198 (GRCm38) L39P probably damaging Het
Ska3 A G 14: 57,826,102 (GRCm38) I4T probably damaging Het
Slc30a10 A G 1: 185,464,154 (GRCm38) I338V possibly damaging Het
Slc35g1 T A 19: 38,402,831 (GRCm38) L187H probably damaging Het
Slc35g1 C G 19: 38,402,829 (GRCm38) S186R probably damaging Het
Spata5 T C 3: 37,431,782 (GRCm38) S218P probably benign Het
Tbc1d5 T C 17: 50,742,086 (GRCm38) I659V probably benign Het
Tbl3 G T 17: 24,700,916 (GRCm38) D751E probably benign Het
Tdrd3 T A 14: 87,486,266 (GRCm38) D311E possibly damaging Het
Tenm4 T C 7: 96,854,728 (GRCm38) F1335S probably benign Het
Tm2d1 A T 4: 98,375,023 (GRCm38) C83S probably damaging Het
Tnfrsf22 A T 7: 143,638,373 (GRCm38) V192D unknown Het
Trpm6 A G 19: 18,811,790 (GRCm38) T575A probably damaging Het
Uri1 T C 7: 37,981,673 (GRCm38) D102G possibly damaging Het
Vmn2r1 T A 3: 64,103,050 (GRCm38) C570S probably damaging Het
Vps13a C T 19: 16,640,787 (GRCm38) V2906I probably damaging Het
Zfp472 T C 17: 32,978,003 (GRCm38) Y351H possibly damaging Het
Zfp874a G T 13: 67,443,234 (GRCm38) Y110* probably null Het
Zfp986 T A 4: 145,899,305 (GRCm38) N178K probably benign Het
Other mutations in Olfr177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02084:Olfr177 APN 16 58,873,036 (GRCm38) missense probably damaging 1.00
IGL02223:Olfr177 APN 16 58,872,694 (GRCm38) missense probably damaging 1.00
R0131:Olfr177 UTSW 16 58,872,906 (GRCm38) missense probably benign 0.01
R0131:Olfr177 UTSW 16 58,872,906 (GRCm38) missense probably benign 0.01
R0132:Olfr177 UTSW 16 58,872,906 (GRCm38) missense probably benign 0.01
R0245:Olfr177 UTSW 16 58,872,866 (GRCm38) missense probably benign 0.01
R0717:Olfr177 UTSW 16 58,872,770 (GRCm38) missense probably damaging 1.00
R0975:Olfr177 UTSW 16 58,873,150 (GRCm38) splice site probably null
R1037:Olfr177 UTSW 16 58,872,970 (GRCm38) missense probably damaging 1.00
R1256:Olfr177 UTSW 16 58,872,843 (GRCm38) nonsense probably null
R1278:Olfr177 UTSW 16 58,872,977 (GRCm38) missense probably damaging 1.00
R1538:Olfr177 UTSW 16 58,872,898 (GRCm38) missense probably damaging 1.00
R1992:Olfr177 UTSW 16 58,872,511 (GRCm38) missense probably benign 0.43
R2173:Olfr177 UTSW 16 58,872,619 (GRCm38) missense probably damaging 0.99
R2392:Olfr177 UTSW 16 58,872,434 (GRCm38) missense probably damaging 1.00
R5651:Olfr177 UTSW 16 58,872,484 (GRCm38) missense probably damaging 0.99
R5652:Olfr177 UTSW 16 58,872,484 (GRCm38) missense probably damaging 0.99
R5653:Olfr177 UTSW 16 58,872,484 (GRCm38) missense probably damaging 0.99
R8031:Olfr177 UTSW 16 58,872,691 (GRCm38) missense probably benign 0.03
R8531:Olfr177 UTSW 16 58,872,653 (GRCm38) missense probably damaging 1.00
R8833:Olfr177 UTSW 16 58,872,596 (GRCm38) missense probably damaging 0.99
R9150:Olfr177 UTSW 16 58,872,642 (GRCm38) nonsense probably null
R9318:Olfr177 UTSW 16 58,872,385 (GRCm38) missense probably damaging 1.00
R9389:Olfr177 UTSW 16 58,872,613 (GRCm38) missense probably damaging 1.00
V8831:Olfr177 UTSW 16 58,873,075 (GRCm38) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- TGGTATGGGATCAAAAGTTGCAC -3'
(R):5'- TGTGTCAATATTCTATGGGTCTCTC -3'

Sequencing Primer
(F):5'- ATGCATGCTAATGTGTATTTCTAGG -3'
(R):5'- TCCTCTACATGTATATTCGACCAAG -3'
Posted On 2020-06-30