Mutagenetix > Incidental Mutation

Incidental Mutation 'R8110:Olfr102'

630841

Institutional Source

Beutler Lab

Gene Symbol

Olfr102

Ensembl Gene

ENSMUSG00000091531

Gene Name

olfactory receptor 102

Synonyms

MOR250-4, GA_x6K02T2PSCP-1775063-1774137

MMRRC Submission

067539-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R8110 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

37311795-37317054 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 37313713 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 224 (F224L)

Ref Sequence

ENSEMBL: ENSMUSP00000149168 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169373] [ENSMUST00000217590]

AlphaFold

B2RT33

Predicted Effect

probably benign
Transcript: ENSMUST00000169373
AA Change: F224L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000126737
Gene: ENSMUSG00000091531
AA Change: F224L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	2.6e-52	PFAM
Pfam:7tm_1	39	289	8.3e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217590
AA Change: F224L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 93.1%

Validation Efficiency

99% (73/74)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	G	T	11: 23,576,764	T696N	probably benign	Het
Ankrd45	T	C	1: 161,151,319		probably null	Het
Appl1	C	A	14: 26,927,794	G592*	probably null	Het
Arfgef2	T	A	2: 166,878,544	M1501K	probably benign	Het
Calcrl	C	T	2: 84,339,339	A333T	probably damaging	Het
Cd200r3	T	A	16: 44,951,472	I33N	probably benign	Het
Ceacam15	A	G	7: 16,673,409	L61P	probably benign	Het
Cfap69	T	A	5: 5,582,515	H827L	possibly damaging	Het
Csmd3	T	A	15: 47,644,270	E2780V	probably damaging	Het
Cyp2u1	G	A	3: 131,293,654	T426I	probably damaging	Het
Eefsec	A	C	6: 88,376,330	I119S	probably damaging	Het
Fem1b	T	C	9: 62,796,268	N570S	probably damaging	Het
Fmo9	A	G	1: 166,663,526	M461T	probably benign	Het
Fryl	A	G	5: 73,133,277	Y95H	probably benign	Het
Fsip2	T	C	2: 82,958,673	I346T	probably benign	Het
Fto	T	C	8: 91,485,190	F381S	probably damaging	Het
Gabbr1	G	C	17: 37,048,583	S150T	probably benign	Het
Galnt9	G	T	5: 110,615,473	W448L	probably damaging	Het
Gcnt2	G	T	13: 40,917,722		probably benign	Het
Gm10800	CAAGAAAACTGAAAATCAAAGAAAACTGAAAATCA	CAAGAAAACTGAAAATCA	2: 98,667,016		probably null	Het
Gm17727	T	C	9: 35,778,033	*84W	probably null	Het
Gm8882	C	T	6: 132,361,568	G229D	unknown	Het
Gmcl1	G	T	6: 86,721,426	A163E	probably damaging	Het
Hectd4	A	G	5: 121,332,949	Y2633C	possibly damaging	Het
Hsd11b2	A	G	8: 105,522,634	I214V	probably damaging	Het
Hspa12a	T	A	19: 58,821,013	E217V	possibly damaging	Het
Itih2	A	G	2: 10,097,137	F845L	probably damaging	Het
Kcnn3	T	A	3: 89,661,233	L606H	probably damaging	Het
Krt6b	G	A	15: 101,680,142	R28C	probably damaging	Het
Lama2	T	A	10: 26,990,870	D2876V	probably damaging	Het
Lmbrd2	T	C	15: 9,175,192	S397P	probably damaging	Het
Lmf2	C	T	15: 89,352,358		probably null	Het
Lrp2	A	G	2: 69,506,453	I1325T	probably benign	Het
Ltbp2	A	T	12: 84,803,902	C879*	probably null	Het
Map3k1	A	G	13: 111,755,313	V1136A	probably damaging	Het
Mettl3	G	T	14: 52,300,252	H84N	probably benign	Het
Mia2	A	G	12: 59,109,087		probably null	Het
Mlip	G	T	9: 77,239,579	T92K	probably damaging	Het
Nalcn	T	A	14: 123,464,701	Y466F	probably benign	Het
Nav2	T	A	7: 49,551,950	L235*	probably null	Het
Nbn	T	C	4: 15,981,588	V560A	probably benign	Het
Ncln	A	T	10: 81,493,153	Y144N	possibly damaging	Het
Nfe2l2	A	C	2: 75,679,421	D18E	probably benign	Het
Olfr1131	T	C	2: 87,628,607	I48T	possibly damaging	Het
Olfr356	T	C	2: 36,937,709	C197R	possibly damaging	Het
Olfr432	G	A	1: 174,050,525	A51T	probably benign	Het
Otop3	A	T	11: 115,339,395	M33L	probably benign	Het
Pdzd2	G	A	15: 12,373,506	S2181L	probably benign	Het
Phf14	T	C	6: 11,953,423	I387T	possibly damaging	Het
Prdm9	T	A	17: 15,554,698	N318Y	probably damaging	Het
Proca1	A	G	11: 78,204,911	D123G	probably damaging	Het
Prune2	G	A	19: 17,120,719	G1196S	probably benign	Het
Psd3	T	A	8: 68,121,056	S158C	probably damaging	Het
Rps18	A	G	17: 33,955,136	V15A	probably benign	Het
Sharpin	C	A	15: 76,347,765	R271L	possibly damaging	Het
Smad5	C	A	13: 56,723,888	Q99K	probably damaging	Het
Sox5	T	C	6: 144,116,474	M151V	possibly damaging	Het
Sphkap	A	T	1: 83,278,771	F419Y	possibly damaging	Het
Tbx20	T	A	9: 24,725,525	Y422F	probably damaging	Het
Tcirg1	A	C	19: 3,899,099	F397V	probably damaging	Het
Tex36	G	A	7: 133,595,283	S35F	possibly damaging	Het
Tsen54	G	T	11: 115,814,934	A26S	unknown	Het
Usp50	T	A	2: 126,780,330		probably null	Het
Vmn2r5	A	T	3: 64,491,288	F757I	probably benign	Het
Zbbx	T	C	3: 75,155,442	T3A	possibly damaging	Het
Zfp28	T	A	7: 6,389,829	M168K	probably benign	Het
Zfp568	G	T	7: 30,023,126	G499W	probably damaging	Het
Zfp7	C	G	15: 76,890,931	P391R	possibly damaging	Het

Other mutations in Olfr102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00901:Olfr102	APN	17	37313707	missense	possibly damaging	0.90
IGL01947:Olfr102	APN	17	37313665	missense	probably damaging	1.00
IGL02164:Olfr102	APN	17	37313687	missense	probably benign	0.01
IGL02465:Olfr102	APN	17	37313911	missense	probably damaging	0.99
IGL03095:Olfr102	APN	17	37313773	missense	probably benign	0.01
R0712:Olfr102	UTSW	17	37314084	missense	probably damaging	0.96
R1572:Olfr102	UTSW	17	37313480	missense	probably benign
R1749:Olfr102	UTSW	17	37314061	missense	probably benign	0.05
R3083:Olfr102	UTSW	17	37314195	missense	probably damaging	1.00
R4022:Olfr102	UTSW	17	37314274	missense	probably benign
R5203:Olfr102	UTSW	17	37314201	missense	probably damaging	1.00
R5367:Olfr102	UTSW	17	37314256	missense	probably damaging	1.00
R5387:Olfr102	UTSW	17	37314292	missense	probably benign	0.22
R5488:Olfr102	UTSW	17	37313668	missense	probably damaging	1.00
R6804:Olfr102	UTSW	17	37314130	missense	probably damaging	1.00
R7442:Olfr102	UTSW	17	37313925	missense	possibly damaging	0.89
R7473:Olfr102	UTSW	17	37313631	missense	probably benign	0.03
R8887:Olfr102	UTSW	17	37313751	missense	probably damaging	1.00
R9400:Olfr102	UTSW	17	37313663	nonsense	probably null

Predicted Primers

Posted On

2020-06-30