Incidental Mutation 'R8111:Armc3'
ID 630847
Institutional Source Beutler Lab
Gene Symbol Armc3
Ensembl Gene ENSMUSG00000037683
Gene Name armadillo repeat containing 3
Synonyms 4921513G22Rik
MMRRC Submission 067540-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R8111 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 19204113-19315052 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19301674 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 660 (V660A)
Ref Sequence ENSEMBL: ENSMUSP00000110287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000114640]
AlphaFold A2AU72
Predicted Effect probably benign
Transcript: ENSMUST00000049255
AA Change: V664A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683
AA Change: V664A

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114640
AA Change: V660A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683
AA Change: V660A

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
Pfam:EDR1 549 868 1.4e-41 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik C T 14: 32,382,266 (GRCm39) W1233* probably null Het
4930590J08Rik A G 6: 91,894,691 (GRCm39) I247V probably benign Het
8030423J24Rik T A 13: 71,032,077 (GRCm39) C50S unknown Het
Adam29 T G 8: 56,324,585 (GRCm39) H623P probably benign Het
Adamts5 A G 16: 85,696,203 (GRCm39) V318A probably damaging Het
Ano3 T C 2: 110,614,058 (GRCm39) D215G possibly damaging Het
Ap3b2 A G 7: 81,113,530 (GRCm39) I893T unknown Het
Apob G A 12: 8,058,801 (GRCm39) A2428T probably benign Het
Atf7 G T 15: 102,471,769 (GRCm39) T42K probably damaging Het
Atg9a A T 1: 75,164,366 (GRCm39) I160N probably damaging Het
Atp2b1 T C 10: 98,832,786 (GRCm39) V429A possibly damaging Het
Bpifb3 A C 2: 153,764,609 (GRCm39) H167P probably benign Het
Cacna1f G T X: 7,487,326 (GRCm39) E921D probably damaging Het
Ccdc57 T A 11: 120,769,713 (GRCm39) L713F probably damaging Het
Chd1l C T 3: 97,494,526 (GRCm39) E385K possibly damaging Het
Csmd1 C T 8: 15,967,306 (GRCm39) V3186I probably benign Het
Dclre1c T A 2: 3,448,185 (GRCm39) D349E probably benign Het
Dlg1 C T 16: 31,661,620 (GRCm39) T657M possibly damaging Het
Dync2h1 T C 9: 7,148,688 (GRCm39) I919V probably benign Het
Dync2i2 C A 2: 29,921,859 (GRCm39) A501S possibly damaging Het
Eml5 A G 12: 98,758,773 (GRCm39) probably null Het
Epas1 C A 17: 87,125,860 (GRCm39) S286* probably null Het
Fat1 G A 8: 45,479,095 (GRCm39) V2714I possibly damaging Het
Fuca2 T C 10: 13,390,545 (GRCm39) M447T probably benign Het
Gm10800 CAAGAAAACTGAAAATCAAAGAAAACTGAAAATCA CAAGAAAACTGAAAATCA 2: 98,497,361 (GRCm39) probably null Het
Gm11110 A C 17: 57,410,427 (GRCm39) C24G probably null Het
Gm6176 T A 7: 21,750,593 (GRCm39) I113F probably benign Het
Gmcl1 G T 6: 86,698,408 (GRCm39) A163E probably damaging Het
Gpat2 G T 2: 127,275,777 (GRCm39) L518F probably damaging Het
Gpr137b T C 13: 13,533,991 (GRCm39) Y355C Het
Hgsnat C T 8: 26,458,440 (GRCm39) V195I probably benign Het
Hivep3 T A 4: 119,955,583 (GRCm39) S1300T probably damaging Het
Hs3st2 A T 7: 120,992,362 (GRCm39) H137L probably damaging Het
Iffo1 T C 6: 125,122,781 (GRCm39) S188P possibly damaging Het
Itih1 T C 14: 30,654,225 (GRCm39) D684G probably damaging Het
Lrba C A 3: 86,235,012 (GRCm39) N852K probably damaging Het
Lrriq4 T C 3: 30,709,930 (GRCm39) S425P possibly damaging Het
Mdn1 T A 4: 32,674,003 (GRCm39) S562T possibly damaging Het
Mex3a T C 3: 88,444,064 (GRCm39) V380A probably benign Het
Mgat4d A T 8: 84,094,776 (GRCm39) N271I probably damaging Het
Mmp24 T A 2: 155,649,345 (GRCm39) V254E possibly damaging Het
Muc16 T A 9: 18,503,925 (GRCm39) R6455S possibly damaging Het
Npffr1 T A 10: 61,459,128 (GRCm39) V127E probably damaging Het
Obox5 T A 7: 15,492,541 (GRCm39) N165K probably damaging Het
Or10g3b G A 14: 52,587,344 (GRCm39) T53M possibly damaging Het
Otulin A C 15: 27,606,381 (GRCm39) V344G probably damaging Het
Pappa A G 4: 65,180,229 (GRCm39) D1030G probably damaging Het
Pdzd2 G A 15: 12,373,592 (GRCm39) S2181L probably benign Het
Ppp2r3c C A 12: 55,344,634 (GRCm39) M111I probably benign Het
Prss37 T C 6: 40,494,747 (GRCm39) T13A probably benign Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Sgo2b T A 8: 64,396,138 (GRCm39) K39N probably damaging Het
Sike1 T C 3: 102,909,123 (GRCm39) *208Q probably null Het
Spire1 A G 18: 67,652,391 (GRCm39) S229P probably damaging Het
Tmem132b A G 5: 125,699,857 (GRCm39) I132V probably benign Het
Umodl1 T C 17: 31,190,792 (GRCm39) V213A probably damaging Het
Washc1 C G 17: 66,423,033 (GRCm39) Q116E probably benign Het
Zfp553 T A 7: 126,836,093 (GRCm39) C549* probably null Het
Zfp9 G A 6: 118,441,561 (GRCm39) P367L probably damaging Het
Other mutations in Armc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Armc3 APN 2 19,308,669 (GRCm39) missense possibly damaging 0.48
IGL01123:Armc3 APN 2 19,206,616 (GRCm39) missense possibly damaging 0.87
IGL01142:Armc3 APN 2 19,302,709 (GRCm39) splice site probably benign
IGL01556:Armc3 APN 2 19,273,957 (GRCm39) missense probably damaging 1.00
IGL02145:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02145:Armc3 APN 2 19,301,671 (GRCm39) missense possibly damaging 0.81
IGL02152:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02154:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02243:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02244:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02516:Armc3 APN 2 19,305,317 (GRCm39) missense possibly damaging 0.94
IGL02691:Armc3 APN 2 19,240,295 (GRCm39) missense probably damaging 1.00
IGL03151:Armc3 APN 2 19,243,509 (GRCm39) missense probably damaging 1.00
IGL03190:Armc3 APN 2 19,293,761 (GRCm39) missense probably damaging 0.99
IGL03288:Armc3 APN 2 19,240,293 (GRCm39) missense probably damaging 1.00
IGL03338:Armc3 APN 2 19,253,512 (GRCm39) missense possibly damaging 0.88
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0256:Armc3 UTSW 2 19,274,027 (GRCm39) missense probably damaging 1.00
R0621:Armc3 UTSW 2 19,300,204 (GRCm39) missense probably damaging 0.96
R1326:Armc3 UTSW 2 19,314,935 (GRCm39) makesense probably null
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1489:Armc3 UTSW 2 19,314,858 (GRCm39) missense probably benign 0.01
R1990:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1991:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1992:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R2002:Armc3 UTSW 2 19,293,747 (GRCm39) missense probably benign 0.01
R2095:Armc3 UTSW 2 19,293,740 (GRCm39) missense possibly damaging 0.65
R2127:Armc3 UTSW 2 19,206,622 (GRCm39) missense probably damaging 1.00
R2158:Armc3 UTSW 2 19,253,444 (GRCm39) missense probably damaging 0.99
R2697:Armc3 UTSW 2 19,308,746 (GRCm39) missense probably damaging 1.00
R3809:Armc3 UTSW 2 19,305,476 (GRCm39) missense probably damaging 1.00
R3897:Armc3 UTSW 2 19,273,988 (GRCm39) missense probably damaging 1.00
R4107:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.13
R4326:Armc3 UTSW 2 19,305,284 (GRCm39) missense probably damaging 0.97
R4464:Armc3 UTSW 2 19,253,470 (GRCm39) missense probably damaging 0.99
R4702:Armc3 UTSW 2 19,314,792 (GRCm39) missense probably damaging 1.00
R4923:Armc3 UTSW 2 19,297,791 (GRCm39) critical splice acceptor site probably null
R5370:Armc3 UTSW 2 19,290,873 (GRCm39) missense probably benign 0.00
R5518:Armc3 UTSW 2 19,302,739 (GRCm39) missense probably benign 0.28
R5718:Armc3 UTSW 2 19,308,610 (GRCm39) nonsense probably null
R5739:Armc3 UTSW 2 19,258,728 (GRCm39) missense possibly damaging 0.67
R5913:Armc3 UTSW 2 19,314,858 (GRCm39) missense possibly damaging 0.65
R6211:Armc3 UTSW 2 19,301,614 (GRCm39) critical splice acceptor site probably null
R6245:Armc3 UTSW 2 19,253,516 (GRCm39) missense probably damaging 1.00
R6841:Armc3 UTSW 2 19,206,630 (GRCm39) splice site probably null
R7003:Armc3 UTSW 2 19,274,839 (GRCm39) missense probably damaging 1.00
R7190:Armc3 UTSW 2 19,297,947 (GRCm39) missense probably damaging 1.00
R7499:Armc3 UTSW 2 19,290,790 (GRCm39) missense probably benign 0.03
R7738:Armc3 UTSW 2 19,293,761 (GRCm39) missense probably damaging 0.99
R7844:Armc3 UTSW 2 19,258,829 (GRCm39) missense possibly damaging 0.90
R7919:Armc3 UTSW 2 19,290,906 (GRCm39) missense probably benign 0.00
R8060:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.08
R8406:Armc3 UTSW 2 19,240,365 (GRCm39) missense probably damaging 0.98
R8485:Armc3 UTSW 2 19,297,945 (GRCm39) missense probably damaging 1.00
R8773:Armc3 UTSW 2 19,293,667 (GRCm39) missense probably benign 0.01
R8940:Armc3 UTSW 2 19,240,393 (GRCm39) missense probably damaging 1.00
R9441:Armc3 UTSW 2 19,253,426 (GRCm39) missense possibly damaging 0.89
Z1177:Armc3 UTSW 2 19,290,802 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAACTGCAGTGGTGATTGAATCC -3'
(R):5'- AGGGGTGCCAACTAACTAGG -3'

Sequencing Primer
(F):5'- TTGAATCCAATCATGCTGGAAGAG -3'
(R):5'- TTGCCCACTATGGAGACCC -3'
Posted On 2020-06-30