Incidental Mutation 'R8111:Sike1'
ID 630858
Institutional Source Beutler Lab
Gene Symbol Sike1
Ensembl Gene ENSMUSG00000027854
Gene Name suppressor of IKBKE 1
Synonyms 2810005O12Rik, 5730470L24Rik
MMRRC Submission 067540-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8111 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 102903056-102911230 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to C at 102909123 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Glutamine at position 208 (*208Q)
Ref Sequence ENSEMBL: ENSMUSP00000029447 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029447] [ENSMUST00000119450]
AlphaFold Q9CPR7
Predicted Effect probably null
Transcript: ENSMUST00000029447
AA Change: *208Q
SMART Domains Protein: ENSMUSP00000029447
Gene: ENSMUSG00000027854
AA Change: *208Q

DomainStartEndE-ValueType
Pfam:DUF837 2 187 1.3e-70 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000119450
AA Change: *125Q
SMART Domains Protein: ENSMUSP00000112886
Gene: ENSMUSG00000027854
AA Change: *125Q

DomainStartEndE-ValueType
Pfam:DUF837 1 49 5.2e-20 PFAM
Pfam:DUF837 46 106 3.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000197601
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik C T 14: 32,382,266 (GRCm39) W1233* probably null Het
4930590J08Rik A G 6: 91,894,691 (GRCm39) I247V probably benign Het
8030423J24Rik T A 13: 71,032,077 (GRCm39) C50S unknown Het
Adam29 T G 8: 56,324,585 (GRCm39) H623P probably benign Het
Adamts5 A G 16: 85,696,203 (GRCm39) V318A probably damaging Het
Ano3 T C 2: 110,614,058 (GRCm39) D215G possibly damaging Het
Ap3b2 A G 7: 81,113,530 (GRCm39) I893T unknown Het
Apob G A 12: 8,058,801 (GRCm39) A2428T probably benign Het
Armc3 T C 2: 19,301,674 (GRCm39) V660A probably benign Het
Atf7 G T 15: 102,471,769 (GRCm39) T42K probably damaging Het
Atg9a A T 1: 75,164,366 (GRCm39) I160N probably damaging Het
Atp2b1 T C 10: 98,832,786 (GRCm39) V429A possibly damaging Het
Bpifb3 A C 2: 153,764,609 (GRCm39) H167P probably benign Het
Cacna1f G T X: 7,487,326 (GRCm39) E921D probably damaging Het
Ccdc57 T A 11: 120,769,713 (GRCm39) L713F probably damaging Het
Chd1l C T 3: 97,494,526 (GRCm39) E385K possibly damaging Het
Csmd1 C T 8: 15,967,306 (GRCm39) V3186I probably benign Het
Dclre1c T A 2: 3,448,185 (GRCm39) D349E probably benign Het
Dlg1 C T 16: 31,661,620 (GRCm39) T657M possibly damaging Het
Dync2h1 T C 9: 7,148,688 (GRCm39) I919V probably benign Het
Dync2i2 C A 2: 29,921,859 (GRCm39) A501S possibly damaging Het
Eml5 A G 12: 98,758,773 (GRCm39) probably null Het
Epas1 C A 17: 87,125,860 (GRCm39) S286* probably null Het
Fat1 G A 8: 45,479,095 (GRCm39) V2714I possibly damaging Het
Fuca2 T C 10: 13,390,545 (GRCm39) M447T probably benign Het
Gm10800 CAAGAAAACTGAAAATCAAAGAAAACTGAAAATCA CAAGAAAACTGAAAATCA 2: 98,497,361 (GRCm39) probably null Het
Gm11110 A C 17: 57,410,427 (GRCm39) C24G probably null Het
Gm6176 T A 7: 21,750,593 (GRCm39) I113F probably benign Het
Gmcl1 G T 6: 86,698,408 (GRCm39) A163E probably damaging Het
Gpat2 G T 2: 127,275,777 (GRCm39) L518F probably damaging Het
Gpr137b T C 13: 13,533,991 (GRCm39) Y355C Het
Hgsnat C T 8: 26,458,440 (GRCm39) V195I probably benign Het
Hivep3 T A 4: 119,955,583 (GRCm39) S1300T probably damaging Het
Hs3st2 A T 7: 120,992,362 (GRCm39) H137L probably damaging Het
Iffo1 T C 6: 125,122,781 (GRCm39) S188P possibly damaging Het
Itih1 T C 14: 30,654,225 (GRCm39) D684G probably damaging Het
Lrba C A 3: 86,235,012 (GRCm39) N852K probably damaging Het
Lrriq4 T C 3: 30,709,930 (GRCm39) S425P possibly damaging Het
Mdn1 T A 4: 32,674,003 (GRCm39) S562T possibly damaging Het
Mex3a T C 3: 88,444,064 (GRCm39) V380A probably benign Het
Mgat4d A T 8: 84,094,776 (GRCm39) N271I probably damaging Het
Mmp24 T A 2: 155,649,345 (GRCm39) V254E possibly damaging Het
Muc16 T A 9: 18,503,925 (GRCm39) R6455S possibly damaging Het
Npffr1 T A 10: 61,459,128 (GRCm39) V127E probably damaging Het
Obox5 T A 7: 15,492,541 (GRCm39) N165K probably damaging Het
Or10g3b G A 14: 52,587,344 (GRCm39) T53M possibly damaging Het
Otulin A C 15: 27,606,381 (GRCm39) V344G probably damaging Het
Pappa A G 4: 65,180,229 (GRCm39) D1030G probably damaging Het
Pdzd2 G A 15: 12,373,592 (GRCm39) S2181L probably benign Het
Ppp2r3c C A 12: 55,344,634 (GRCm39) M111I probably benign Het
Prss37 T C 6: 40,494,747 (GRCm39) T13A probably benign Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Sgo2b T A 8: 64,396,138 (GRCm39) K39N probably damaging Het
Spire1 A G 18: 67,652,391 (GRCm39) S229P probably damaging Het
Tmem132b A G 5: 125,699,857 (GRCm39) I132V probably benign Het
Umodl1 T C 17: 31,190,792 (GRCm39) V213A probably damaging Het
Washc1 C G 17: 66,423,033 (GRCm39) Q116E probably benign Het
Zfp553 T A 7: 126,836,093 (GRCm39) C549* probably null Het
Zfp9 G A 6: 118,441,561 (GRCm39) P367L probably damaging Het
Other mutations in Sike1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1368:Sike1 UTSW 3 102,903,500 (GRCm39) missense possibly damaging 0.68
R2280:Sike1 UTSW 3 102,904,694 (GRCm39) missense possibly damaging 0.89
R4868:Sike1 UTSW 3 102,904,730 (GRCm39) splice site probably null
R5356:Sike1 UTSW 3 102,909,106 (GRCm39) missense possibly damaging 0.51
Z1177:Sike1 UTSW 3 102,904,565 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTCTTTCTGGGCCAAAATAGTATG -3'
(R):5'- AAATGTCATCTCTGTCCCAGCAATG -3'

Sequencing Primer
(F):5'- CTGGGCCAAAATAGTATGTTCTGAC -3'
(R):5'- CCAGCAATGGGGGACTTGTCTAG -3'
Posted On 2020-06-30