Incidental Mutation 'R8119:Zranb2'
ID 631386
Institutional Source Beutler Lab
Gene Symbol Zranb2
Ensembl Gene ENSMUSG00000028180
Gene Name zinc finger, RAN-binding domain containing 2
Synonyms Zfp265, Zis, Znf265
MMRRC Submission 067548-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8119 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 157239797-157254047 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to G at 157241969 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029831] [ENSMUST00000106057] [ENSMUST00000106058] [ENSMUST00000184802] [ENSMUST00000198915]
AlphaFold Q9R020
Predicted Effect probably null
Transcript: ENSMUST00000029831
SMART Domains Protein: ENSMUSP00000029831
Gene: ENSMUSG00000028180

DomainStartEndE-ValueType
ZnF_RBZ 11 35 1.02e-2 SMART
ZnF_RBZ 36 54 2.09e-1 SMART
low complexity region 70 82 N/A INTRINSIC
low complexity region 108 145 N/A INTRINSIC
low complexity region 156 293 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106057
SMART Domains Protein: ENSMUSP00000101672
Gene: ENSMUSG00000028180

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 312 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106058
SMART Domains Protein: ENSMUSP00000101673
Gene: ENSMUSG00000028180

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 340 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106063
SMART Domains Protein: ENSMUSP00000101678
Gene: ENSMUSG00000028180

DomainStartEndE-ValueType
ZnF_RBZ 11 37 8.79e-7 SMART
ZnF_RBZ 67 91 3.11e-7 SMART
low complexity region 107 119 N/A INTRINSIC
low complexity region 145 182 N/A INTRINSIC
low complexity region 193 330 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184802
Predicted Effect probably benign
Transcript: ENSMUST00000198915
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.7%
  • 20x: 95.2%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T C 11: 110,087,930 (GRCm39) I1066V probably benign Het
Abcd2 T C 15: 91,033,197 (GRCm39) T740A probably benign Het
Amigo1 T C 3: 108,094,852 (GRCm39) L117P probably damaging Het
Ankar A T 1: 72,686,160 (GRCm39) S1347T probably damaging Het
Apol7e T C 15: 77,601,956 (GRCm39) S185P probably damaging Het
Ash1l G A 3: 88,942,734 (GRCm39) C2088Y probably damaging Het
Atrnl1 A G 19: 57,630,895 (GRCm39) T221A probably benign Het
Caln1 A G 5: 130,851,825 (GRCm39) S205G probably damaging Het
Cfap54 T C 10: 92,704,672 (GRCm39) I2803V unknown Het
Cfh A C 1: 140,047,753 (GRCm39) F477V possibly damaging Het
Cldn23 A G 8: 36,293,056 (GRCm39) V144A probably damaging Het
Csmd1 A G 8: 17,077,310 (GRCm39) S116P probably damaging Het
Dgkd A T 1: 87,845,689 (GRCm39) T299S possibly damaging Het
Fam20b T G 1: 156,518,072 (GRCm39) T241P probably damaging Het
Fndc3b A T 3: 27,505,493 (GRCm39) M925K probably benign Het
Ftdc1 C A 16: 58,437,211 (GRCm39) M32I probably benign Het
Ints3 C T 3: 90,299,607 (GRCm39) R987Q probably damaging Het
Kctd10 A G 5: 114,505,316 (GRCm39) V226A probably damaging Het
Lypd2 A G 15: 74,604,881 (GRCm39) V38A probably benign Het
Map3k1 T C 13: 111,909,156 (GRCm39) R265G possibly damaging Het
Mcc C T 18: 44,601,500 (GRCm39) V610M possibly damaging Het
Mocs1 C T 17: 49,756,547 (GRCm39) R244C probably damaging Het
Nav2 A G 7: 49,103,232 (GRCm39) T677A probably damaging Het
Ngp A G 9: 110,251,421 (GRCm39) N150D probably benign Het
Nipbl C T 15: 8,388,696 (GRCm39) R308Q probably benign Het
Nsrp1 A G 11: 76,939,177 (GRCm39) probably null Het
Or2y16 A T 11: 49,334,953 (GRCm39) I92F probably damaging Het
Or4f47 T A 2: 111,972,908 (GRCm39) I206N probably damaging Het
Or52n20 A T 7: 104,320,061 (GRCm39) I51F probably damaging Het
Pbld2 A T 10: 62,889,656 (GRCm39) D146V probably benign Het
Prss22 T A 17: 24,213,701 (GRCm39) K197* probably null Het
Ptprd G T 4: 76,047,263 (GRCm39) S87R probably benign Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Slc25a35 T C 11: 68,862,798 (GRCm39) L251S probably benign Het
Slx4 A T 16: 3,803,136 (GRCm39) L1226* probably null Het
Smarca4 T C 9: 21,558,922 (GRCm39) V651A possibly damaging Het
Smarcad1 T C 6: 65,071,303 (GRCm39) F583L probably benign Het
Taf2 T C 15: 54,894,526 (GRCm39) K932E probably benign Het
Trav8d-1 A T 14: 53,016,425 (GRCm39) T104S probably benign Het
Trmt9b G A 8: 36,965,576 (GRCm39) W32* probably null Het
Trpm4 A T 7: 44,976,552 (GRCm39) V155D probably damaging Het
Ttc6 A T 12: 57,752,429 (GRCm39) Y1445F possibly damaging Het
Ttll5 C A 12: 86,067,322 (GRCm39) N1270K probably damaging Het
Usp40 G T 1: 87,895,400 (GRCm39) probably null Het
Vmn2r74 T C 7: 85,610,690 (GRCm39) M1V probably null Het
Wwox T C 8: 115,433,108 (GRCm39) V258A probably damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp770 G A 2: 114,027,508 (GRCm39) T187I probably damaging Het
Zscan4-ps3 A G 7: 11,344,267 (GRCm39) Q75R probably damaging Het
Other mutations in Zranb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Zranb2 APN 3 157,252,328 (GRCm39) unclassified probably benign
IGL01528:Zranb2 APN 3 157,250,602 (GRCm39) unclassified probably benign
IGL03008:Zranb2 APN 3 157,252,302 (GRCm39) splice site probably null
R0528:Zranb2 UTSW 3 157,240,096 (GRCm39) missense probably benign 0.26
R0659:Zranb2 UTSW 3 157,247,400 (GRCm39) missense probably benign 0.23
R1170:Zranb2 UTSW 3 157,247,502 (GRCm39) utr 3 prime probably benign
R1673:Zranb2 UTSW 3 157,243,277 (GRCm39) missense probably damaging 1.00
R1885:Zranb2 UTSW 3 157,248,793 (GRCm39) critical splice acceptor site probably null
R4127:Zranb2 UTSW 3 157,243,227 (GRCm39) nonsense probably null
R4610:Zranb2 UTSW 3 157,247,521 (GRCm39) splice site probably benign
R4981:Zranb2 UTSW 3 157,252,378 (GRCm39) unclassified probably benign
R5053:Zranb2 UTSW 3 157,246,796 (GRCm39) missense probably damaging 0.96
R5742:Zranb2 UTSW 3 157,246,340 (GRCm39) nonsense probably null
R5873:Zranb2 UTSW 3 157,242,020 (GRCm39) nonsense probably null
R6086:Zranb2 UTSW 3 157,248,883 (GRCm39) critical splice donor site probably null
R7015:Zranb2 UTSW 3 157,242,370 (GRCm39) critical splice acceptor site probably null
R7547:Zranb2 UTSW 3 157,246,806 (GRCm39) missense possibly damaging 0.93
R7579:Zranb2 UTSW 3 157,246,309 (GRCm39) missense probably damaging 1.00
R8237:Zranb2 UTSW 3 157,250,677 (GRCm39) missense probably null
R8296:Zranb2 UTSW 3 157,247,412 (GRCm39) missense unknown
R8345:Zranb2 UTSW 3 157,251,731 (GRCm39) missense unknown
R8414:Zranb2 UTSW 3 157,252,312 (GRCm39) missense unknown
R8478:Zranb2 UTSW 3 157,251,745 (GRCm39) makesense probably null
R8768:Zranb2 UTSW 3 157,247,327 (GRCm39) splice site probably benign
R9021:Zranb2 UTSW 3 157,250,720 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACAGTAACTGTAAGCACAAGGTTG -3'
(R):5'- TGGCACTAAATAAGCCCCGG -3'

Sequencing Primer
(F):5'- CACAAGGTTGAGATTTTTACCCAGC -3'
(R):5'- CCCCAGCTTTCATCATCTTGG -3'
Posted On 2020-06-30