Incidental Mutation 'R8120:Cdc5l'
ID 631471
Institutional Source Beutler Lab
Gene Symbol Cdc5l
Ensembl Gene ENSMUSG00000023932
Gene Name cell division cycle 5-like
Synonyms 1200002I02Rik, PCDC5RP
MMRRC Submission 067549-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.966) question?
Stock # R8120 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 45702809-45744633 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 45718796 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 607 (T607A)
Ref Sequence ENSEMBL: ENSMUSP00000024727 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024727]
AlphaFold Q6A068
Predicted Effect probably benign
Transcript: ENSMUST00000024727
AA Change: T607A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000024727
Gene: ENSMUSG00000023932
AA Change: T607A

DomainStartEndE-ValueType
SANT 7 56 4.41e-15 SMART
SANT 59 106 6.29e-11 SMART
coiled coil region 150 181 N/A INTRINSIC
Blast:SANT 187 233 5e-23 BLAST
low complexity region 258 271 N/A INTRINSIC
Pfam:Myb_Cef 404 655 3.1e-85 PFAM
low complexity region 706 718 N/A INTRINSIC
coiled coil region 764 802 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.6%
  • 20x: 95.1%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A T 4: 144,349,460 (GRCm39) Q239L probably benign Het
Abca12 T C 1: 71,298,540 (GRCm39) I2361V possibly damaging Het
Abcc8 T C 7: 45,786,108 (GRCm39) E655G probably benign Het
Ablim1 C T 19: 57,035,360 (GRCm39) V662I probably benign Het
Acte1 A G 7: 143,425,524 (GRCm39) T58A probably benign Het
Als2cl A C 9: 110,714,460 (GRCm39) I103L possibly damaging Het
Arhgef26 A T 3: 62,248,796 (GRCm39) D370V probably damaging Het
Brwd1 A C 16: 95,820,649 (GRCm39) D1292E probably benign Het
Cfhr1 T C 1: 139,475,583 (GRCm39) Y296C unknown Het
Cubn A T 2: 13,336,471 (GRCm39) C2452S probably damaging Het
Dgcr2 A T 16: 17,675,183 (GRCm39) Y187* probably null Het
Dhodh G A 8: 110,328,057 (GRCm39) T172I probably benign Het
Dnah6 G A 6: 73,002,769 (GRCm39) R3876C probably damaging Het
Dnai4 G A 4: 102,923,531 (GRCm39) R433W probably damaging Het
Farsb A T 1: 78,439,475 (GRCm39) N389K probably benign Het
Fryl T C 5: 73,228,527 (GRCm39) T1735A probably benign Het
Garin4 T G 1: 190,895,022 (GRCm39) Q540H probably damaging Het
Gpcpd1 C T 2: 132,395,943 (GRCm39) R136H probably damaging Het
Gpr171 T A 3: 59,005,406 (GRCm39) Y123F probably damaging Het
Hcar1 C A 5: 124,017,068 (GRCm39) V208F probably damaging Het
Hgf T A 5: 16,818,779 (GRCm39) L524M probably damaging Het
Itga2b A T 11: 102,360,368 (GRCm39) H57Q probably damaging Het
Itpripl2 G T 7: 118,089,508 (GRCm39) N350K probably damaging Het
Limk2 C T 11: 3,298,589 (GRCm39) probably null Het
Nae1 A T 8: 105,246,267 (GRCm39) V315E probably damaging Het
Nars1 T C 18: 64,637,422 (GRCm39) Y386C probably benign Het
Odr4 T C 1: 150,260,177 (GRCm39) probably null Het
Or10j3 C T 1: 173,031,502 (GRCm39) T193I probably benign Het
Or6z5 A T 7: 6,477,119 (GRCm39) R3S probably benign Het
Pcnx3 C T 19: 5,717,574 (GRCm39) A1512T probably benign Het
Pde1b A G 15: 103,430,524 (GRCm39) D176G possibly damaging Het
Pde4dip T A 3: 97,614,254 (GRCm39) T1855S probably null Het
Prr12 A G 7: 44,684,166 (GRCm39) Y1625H probably damaging Het
Psmc2 T C 5: 22,005,566 (GRCm39) Y216H probably damaging Het
Ptchd3 A T 11: 121,733,034 (GRCm39) E641D probably benign Het
Rtf1 A G 2: 119,531,602 (GRCm39) T110A probably damaging Het
Rusc1 C A 3: 88,996,513 (GRCm39) W690L probably damaging Het
Sardh A G 2: 27,108,863 (GRCm39) V624A possibly damaging Het
Slc17a9 G A 2: 180,374,308 (GRCm39) G125S probably benign Het
Smpdl3a A T 10: 57,683,547 (GRCm39) N219I probably damaging Het
Spo11 G T 2: 172,827,251 (GRCm39) D155Y probably damaging Het
Stk38l A G 6: 146,660,099 (GRCm39) T44A probably benign Het
Tceanc2 A T 4: 107,034,829 (GRCm39) I11N probably benign Het
Tead2 A T 7: 44,865,752 (GRCm39) probably benign Het
Tpk1 A G 6: 43,445,930 (GRCm39) probably null Het
Ttn T C 2: 76,593,835 (GRCm39) N20602D probably damaging Het
Tub T A 7: 108,624,803 (GRCm39) probably null Het
Uba2 A T 7: 33,867,812 (GRCm39) S42T probably benign Het
Vangl1 T A 3: 102,070,758 (GRCm39) R393* probably null Het
Washc3 G A 10: 88,037,159 (GRCm39) probably null Het
Wipf1 G A 2: 73,267,879 (GRCm39) P173L possibly damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp267 A T 3: 36,218,640 (GRCm39) N221I possibly damaging Het
Zfp386 C T 12: 116,018,573 (GRCm39) P81S unknown Het
Zw10 A T 9: 48,985,413 (GRCm39) E616D probably benign Het
Other mutations in Cdc5l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01589:Cdc5l APN 17 45,715,602 (GRCm39) missense probably damaging 0.98
IGL01629:Cdc5l APN 17 45,724,116 (GRCm39) missense probably benign 0.26
IGL02596:Cdc5l APN 17 45,735,530 (GRCm39) splice site probably benign
IGL02973:Cdc5l APN 17 45,715,573 (GRCm39) missense probably benign 0.31
IGL03102:Cdc5l APN 17 45,718,857 (GRCm39) missense probably damaging 0.99
IGL03113:Cdc5l APN 17 45,744,348 (GRCm39) missense possibly damaging 0.47
R0255:Cdc5l UTSW 17 45,726,610 (GRCm39) missense probably damaging 1.00
R0333:Cdc5l UTSW 17 45,704,142 (GRCm39) splice site probably benign
R0432:Cdc5l UTSW 17 45,726,610 (GRCm39) missense probably damaging 1.00
R0532:Cdc5l UTSW 17 45,726,610 (GRCm39) missense probably damaging 1.00
R0551:Cdc5l UTSW 17 45,726,610 (GRCm39) missense probably damaging 1.00
R0839:Cdc5l UTSW 17 45,704,073 (GRCm39) missense probably benign 0.10
R1462:Cdc5l UTSW 17 45,719,288 (GRCm39) missense possibly damaging 0.77
R1462:Cdc5l UTSW 17 45,719,288 (GRCm39) missense possibly damaging 0.77
R1483:Cdc5l UTSW 17 45,719,290 (GRCm39) missense possibly damaging 0.79
R1634:Cdc5l UTSW 17 45,715,632 (GRCm39) missense probably damaging 0.99
R1751:Cdc5l UTSW 17 45,718,731 (GRCm39) missense probably benign
R1954:Cdc5l UTSW 17 45,737,442 (GRCm39) splice site probably null
R1955:Cdc5l UTSW 17 45,737,442 (GRCm39) splice site probably null
R2197:Cdc5l UTSW 17 45,718,745 (GRCm39) missense probably benign 0.00
R2229:Cdc5l UTSW 17 45,718,772 (GRCm39) missense probably benign 0.04
R4060:Cdc5l UTSW 17 45,721,816 (GRCm39) missense probably benign 0.00
R4061:Cdc5l UTSW 17 45,721,816 (GRCm39) missense probably benign 0.00
R4064:Cdc5l UTSW 17 45,721,816 (GRCm39) missense probably benign 0.00
R4172:Cdc5l UTSW 17 45,730,698 (GRCm39) missense probably damaging 1.00
R4334:Cdc5l UTSW 17 45,721,712 (GRCm39) missense probably benign 0.00
R5093:Cdc5l UTSW 17 45,703,967 (GRCm39) missense possibly damaging 0.50
R5268:Cdc5l UTSW 17 45,726,511 (GRCm39) missense probably damaging 0.99
R5729:Cdc5l UTSW 17 45,737,495 (GRCm39) missense probably benign 0.39
R6190:Cdc5l UTSW 17 45,718,943 (GRCm39) missense probably benign 0.08
R6462:Cdc5l UTSW 17 45,703,975 (GRCm39) missense probably benign
R6540:Cdc5l UTSW 17 45,737,570 (GRCm39) missense probably damaging 1.00
R7232:Cdc5l UTSW 17 45,738,863 (GRCm39) critical splice donor site probably null
R7381:Cdc5l UTSW 17 45,722,849 (GRCm39) missense probably benign 0.00
R7589:Cdc5l UTSW 17 45,721,707 (GRCm39) missense probably benign 0.41
R8424:Cdc5l UTSW 17 45,726,526 (GRCm39) missense probably benign 0.27
R8495:Cdc5l UTSW 17 45,737,449 (GRCm39) missense probably damaging 1.00
R8875:Cdc5l UTSW 17 45,703,915 (GRCm39) splice site probably benign
R8884:Cdc5l UTSW 17 45,744,467 (GRCm39) start gained probably benign
R8927:Cdc5l UTSW 17 45,721,839 (GRCm39) missense
R8928:Cdc5l UTSW 17 45,721,839 (GRCm39) missense
R8958:Cdc5l UTSW 17 45,704,127 (GRCm39) missense probably benign 0.00
R8974:Cdc5l UTSW 17 45,715,621 (GRCm39) missense possibly damaging 0.83
R9259:Cdc5l UTSW 17 45,736,817 (GRCm39) missense possibly damaging 0.69
R9622:Cdc5l UTSW 17 45,715,709 (GRCm39) missense probably benign
R9716:Cdc5l UTSW 17 45,744,500 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CCTTTGGTTCGGAGTAGCAATG -3'
(R):5'- TAGGCACAGGATATTGCAGATG -3'

Sequencing Primer
(F):5'- TTCGGAGTAGCAATGTAGCCAC -3'
(R):5'- AGATGTGTCTGATCATTTTGCTTG -3'
Posted On 2020-06-30