Incidental Mutation 'R8124:Tmem87a'
ID 631633
Institutional Source Beutler Lab
Gene Symbol Tmem87a
Ensembl Gene ENSMUSG00000033808
Gene Name transmembrane protein 87A
Synonyms A930025J12Rik
MMRRC Submission 067553-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.266) question?
Stock # R8124 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 120185793-120234594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120222676 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 168 (T168A)
Ref Sequence ENSEMBL: ENSMUSP00000087500 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090042] [ENSMUST00000090046] [ENSMUST00000110729]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000090042
AA Change: T168A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000087496
Gene: ENSMUSG00000033808
AA Change: T168A

DomainStartEndE-ValueType
Pfam:Lung_7-TM_R 184 471 1.1e-87 PFAM
low complexity region 480 486 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000090046
AA Change: T168A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000087500
Gene: ENSMUSG00000033808
AA Change: T168A

DomainStartEndE-ValueType
Pfam:Lung_7-TM_R 185 472 1.5e-85 PFAM
low complexity region 481 487 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110729
AA Change: T168A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000106357
Gene: ENSMUSG00000033808
AA Change: T168A

DomainStartEndE-ValueType
Pfam:Lung_7-TM_R 184 472 2.4e-86 PFAM
low complexity region 481 487 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.6%
  • 20x: 94.5%
Validation Efficiency 98% (51/52)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agap3 T A 5: 24,683,128 (GRCm39) I320N probably benign Het
Ahnak G A 19: 8,984,487 (GRCm39) G1924S probably damaging Het
Ap2a2 G A 7: 141,178,757 (GRCm39) R141H probably benign Het
Atf7ip2 T C 16: 10,026,999 (GRCm39) V89A possibly damaging Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Csnk2a2 G A 8: 96,182,575 (GRCm39) P296L Het
Dab2 T A 15: 6,458,878 (GRCm39) C263* probably null Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Ddx60 C T 8: 62,436,945 (GRCm39) A965V probably benign Het
Dennd5a A T 7: 109,497,142 (GRCm39) I1119N probably damaging Het
Dpy30 A G 17: 74,623,099 (GRCm39) probably benign Het
Epg5 G A 18: 78,008,211 (GRCm39) A780T probably benign Het
Etl4 A G 2: 20,811,451 (GRCm39) D1546G probably benign Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
F13a1 T C 13: 37,209,779 (GRCm39) K62R probably damaging Het
Gm2832 T C 14: 41,000,894 (GRCm39) M44T Het
Gm9195 T C 14: 72,680,063 (GRCm39) I2249V probably benign Het
Hmcn2 T C 2: 31,290,136 (GRCm39) V2323A probably benign Het
Ice2 T A 9: 69,307,777 (GRCm39) N20K probably damaging Het
Klf15 T C 6: 90,443,863 (GRCm39) F146S probably damaging Het
Lgi3 A G 14: 70,772,178 (GRCm39) Y241C probably damaging Het
Lig4 A T 8: 10,022,954 (GRCm39) D275E probably damaging Het
Lrit1 T A 14: 36,784,005 (GRCm39) S444R probably benign Het
Lrrc37 A G 11: 103,511,257 (GRCm39) V237A unknown Het
Mip T C 10: 128,062,070 (GRCm39) V107A possibly damaging Het
Mtrex A C 13: 113,063,871 (GRCm39) D7E probably benign Het
Myo15a G A 11: 60,398,279 (GRCm39) V1581M Het
Nckap1l A G 15: 103,382,248 (GRCm39) D481G possibly damaging Het
Obox3 A T 7: 15,323,874 (GRCm39) probably null Het
Or11h4 C T 14: 50,973,743 (GRCm39) R292H probably benign Het
Or2d3 G A 7: 106,491,088 (GRCm39) T76I possibly damaging Het
Or5a21 T A 19: 12,310,834 (GRCm39) N129Y probably damaging Het
Or5p1 C A 7: 107,916,984 (GRCm39) N294K possibly damaging Het
Or8g27 T C 9: 39,128,967 (GRCm39) F105L probably benign Het
Pilrb2 T A 5: 137,869,306 (GRCm39) E98V probably damaging Het
Plekhm1 A G 11: 103,257,775 (GRCm39) V1053A probably benign Het
Prdm2 A T 4: 142,861,835 (GRCm39) V485E probably damaging Het
Riox2 G A 16: 59,306,954 (GRCm39) E282K probably benign Het
Rps6ka2 T A 17: 7,549,228 (GRCm39) V379E possibly damaging Het
Slc4a7 G A 14: 14,729,211 (GRCm38) E20K possibly damaging Het
Sned1 G A 1: 93,210,711 (GRCm39) probably null Het
Spata3 C T 1: 85,952,075 (GRCm39) R110C unknown Het
St6gal1 G A 16: 23,176,585 (GRCm39) A393T probably benign Het
Tent4a G A 13: 69,681,716 (GRCm39) probably benign Het
Tmem132d T C 5: 127,869,624 (GRCm39) Q570R probably damaging Het
Trank1 A G 9: 111,207,995 (GRCm39) R1747G probably benign Het
Txk C T 5: 72,860,606 (GRCm39) probably null Het
Vcan T A 13: 89,852,373 (GRCm39) L862F possibly damaging Het
Wdr64 A T 1: 175,626,844 (GRCm39) probably null Het
Zfp106 G T 2: 120,354,812 (GRCm39) Q1343K probably benign Het
Zfp719 A G 7: 43,239,314 (GRCm39) T301A probably benign Het
Other mutations in Tmem87a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00491:Tmem87a APN 2 120,210,261 (GRCm39) splice site probably benign
IGL00912:Tmem87a APN 2 120,234,417 (GRCm39) missense possibly damaging 0.54
IGL01301:Tmem87a APN 2 120,211,250 (GRCm39) missense probably benign 0.01
IGL01413:Tmem87a APN 2 120,216,351 (GRCm39) missense probably benign 0.06
IGL01418:Tmem87a APN 2 120,216,351 (GRCm39) missense probably benign 0.06
IGL02083:Tmem87a APN 2 120,227,861 (GRCm39) missense probably damaging 1.00
IGL02150:Tmem87a APN 2 120,190,557 (GRCm39) missense probably damaging 0.99
IGL02256:Tmem87a APN 2 120,208,377 (GRCm39) missense probably damaging 1.00
IGL02314:Tmem87a APN 2 120,234,502 (GRCm39) missense possibly damaging 0.57
IGL02501:Tmem87a APN 2 120,234,534 (GRCm39) missense probably damaging 0.98
IGL02550:Tmem87a APN 2 120,204,966 (GRCm39) splice site probably null
IGL03082:Tmem87a APN 2 120,227,847 (GRCm39) missense possibly damaging 0.81
Fugal UTSW 2 120,190,518 (GRCm39) critical splice donor site probably null
Ingenuity UTSW 2 120,224,841 (GRCm39) critical splice donor site probably null
ANU18:Tmem87a UTSW 2 120,211,250 (GRCm39) missense probably benign 0.01
R0254:Tmem87a UTSW 2 120,205,988 (GRCm39) missense probably damaging 1.00
R0285:Tmem87a UTSW 2 120,224,905 (GRCm39) missense probably benign 0.01
R0498:Tmem87a UTSW 2 120,224,946 (GRCm39) missense probably benign 0.01
R0611:Tmem87a UTSW 2 120,205,929 (GRCm39) missense possibly damaging 0.46
R0632:Tmem87a UTSW 2 120,190,023 (GRCm39) missense probably damaging 1.00
R0787:Tmem87a UTSW 2 120,200,965 (GRCm39) missense probably benign 0.22
R1599:Tmem87a UTSW 2 120,224,868 (GRCm39) missense probably damaging 1.00
R1977:Tmem87a UTSW 2 120,204,985 (GRCm39) missense probably benign 0.02
R2059:Tmem87a UTSW 2 120,199,773 (GRCm39) missense probably damaging 1.00
R2396:Tmem87a UTSW 2 120,234,540 (GRCm39) start codon destroyed probably null 0.02
R2496:Tmem87a UTSW 2 120,224,859 (GRCm39) missense probably damaging 0.96
R4478:Tmem87a UTSW 2 120,199,824 (GRCm39) nonsense probably null
R4621:Tmem87a UTSW 2 120,227,905 (GRCm39) missense probably benign 0.00
R4739:Tmem87a UTSW 2 120,190,518 (GRCm39) critical splice donor site probably null
R5138:Tmem87a UTSW 2 120,202,026 (GRCm39) missense possibly damaging 0.88
R5314:Tmem87a UTSW 2 120,208,407 (GRCm39) missense probably damaging 0.99
R5391:Tmem87a UTSW 2 120,193,358 (GRCm39) critical splice donor site probably null
R5536:Tmem87a UTSW 2 120,227,911 (GRCm39) missense probably damaging 0.96
R5618:Tmem87a UTSW 2 120,199,787 (GRCm39) missense probably benign 0.44
R5642:Tmem87a UTSW 2 120,234,427 (GRCm39) missense probably benign 0.00
R5884:Tmem87a UTSW 2 120,234,605 (GRCm39) unclassified probably benign
R6104:Tmem87a UTSW 2 120,224,905 (GRCm39) missense probably benign 0.01
R6158:Tmem87a UTSW 2 120,190,584 (GRCm39) splice site probably null
R6195:Tmem87a UTSW 2 120,222,656 (GRCm39) splice site probably null
R6233:Tmem87a UTSW 2 120,222,656 (GRCm39) splice site probably null
R6261:Tmem87a UTSW 2 120,234,502 (GRCm39) missense possibly damaging 0.57
R6403:Tmem87a UTSW 2 120,211,252 (GRCm39) missense possibly damaging 0.94
R6405:Tmem87a UTSW 2 120,210,231 (GRCm39) missense probably damaging 1.00
R6540:Tmem87a UTSW 2 120,234,400 (GRCm39) missense probably benign 0.00
R6583:Tmem87a UTSW 2 120,205,958 (GRCm39) missense possibly damaging 0.93
R6995:Tmem87a UTSW 2 120,193,409 (GRCm39) missense possibly damaging 0.91
R7081:Tmem87a UTSW 2 120,211,264 (GRCm39) missense possibly damaging 0.88
R7384:Tmem87a UTSW 2 120,202,004 (GRCm39) critical splice donor site probably null
R7558:Tmem87a UTSW 2 120,204,991 (GRCm39) missense probably benign 0.00
R7904:Tmem87a UTSW 2 120,210,198 (GRCm39) missense probably damaging 1.00
R8165:Tmem87a UTSW 2 120,200,959 (GRCm39) missense possibly damaging 0.95
R8259:Tmem87a UTSW 2 120,227,928 (GRCm39) missense possibly damaging 0.65
R8315:Tmem87a UTSW 2 120,234,441 (GRCm39) missense probably damaging 0.99
R8971:Tmem87a UTSW 2 120,190,541 (GRCm39) missense
R9124:Tmem87a UTSW 2 120,224,841 (GRCm39) critical splice donor site probably null
R9157:Tmem87a UTSW 2 120,210,093 (GRCm39) missense possibly damaging 0.66
R9188:Tmem87a UTSW 2 120,233,244 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GAGCCTCCACACAACTGTATTG -3'
(R):5'- CTTTTCTGGGGATTTTACACATCG -3'

Sequencing Primer
(F):5'- AAGGATTCCCAAGGTAATATGGG -3'
(R):5'- GGGGATTTTACACATCGACTTC -3'
Posted On 2020-06-30