Incidental Mutation 'R8124:Or5p1'
ID 631643
Institutional Source Beutler Lab
Gene Symbol Or5p1
Ensembl Gene ENSMUSG00000094612
Gene Name olfactory receptor family 5 subfamily P member 1
Synonyms MOR204-11, GA_x6K02T2PBJ9-10646917-10647849, Olfr491
MMRRC Submission 067553-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R8124 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107916103-107917035 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 107916984 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 294 (N294K)
Ref Sequence ENSEMBL: ENSMUSP00000150694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053179] [ENSMUST00000079865] [ENSMUST00000209545] [ENSMUST00000214605]
AlphaFold Q8VG06
Predicted Effect possibly damaging
Transcript: ENSMUST00000053179
AA Change: N294K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000061188
Gene: ENSMUSG00000094612
AA Change: N294K

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.4e-50 PFAM
Pfam:7tm_1 41 290 5.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079865
Predicted Effect possibly damaging
Transcript: ENSMUST00000209545
AA Change: N294K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214605
AA Change: N294K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.6%
  • 20x: 94.5%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agap3 T A 5: 24,683,128 (GRCm39) I320N probably benign Het
Ahnak G A 19: 8,984,487 (GRCm39) G1924S probably damaging Het
Ap2a2 G A 7: 141,178,757 (GRCm39) R141H probably benign Het
Atf7ip2 T C 16: 10,026,999 (GRCm39) V89A possibly damaging Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Csnk2a2 G A 8: 96,182,575 (GRCm39) P296L Het
Dab2 T A 15: 6,458,878 (GRCm39) C263* probably null Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Ddx60 C T 8: 62,436,945 (GRCm39) A965V probably benign Het
Dennd5a A T 7: 109,497,142 (GRCm39) I1119N probably damaging Het
Dpy30 A G 17: 74,623,099 (GRCm39) probably benign Het
Epg5 G A 18: 78,008,211 (GRCm39) A780T probably benign Het
Etl4 A G 2: 20,811,451 (GRCm39) D1546G probably benign Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
F13a1 T C 13: 37,209,779 (GRCm39) K62R probably damaging Het
Gm2832 T C 14: 41,000,894 (GRCm39) M44T Het
Gm9195 T C 14: 72,680,063 (GRCm39) I2249V probably benign Het
Hmcn2 T C 2: 31,290,136 (GRCm39) V2323A probably benign Het
Ice2 T A 9: 69,307,777 (GRCm39) N20K probably damaging Het
Klf15 T C 6: 90,443,863 (GRCm39) F146S probably damaging Het
Lgi3 A G 14: 70,772,178 (GRCm39) Y241C probably damaging Het
Lig4 A T 8: 10,022,954 (GRCm39) D275E probably damaging Het
Lrit1 T A 14: 36,784,005 (GRCm39) S444R probably benign Het
Lrrc37 A G 11: 103,511,257 (GRCm39) V237A unknown Het
Mip T C 10: 128,062,070 (GRCm39) V107A possibly damaging Het
Mtrex A C 13: 113,063,871 (GRCm39) D7E probably benign Het
Myo15a G A 11: 60,398,279 (GRCm39) V1581M Het
Nckap1l A G 15: 103,382,248 (GRCm39) D481G possibly damaging Het
Obox3 A T 7: 15,323,874 (GRCm39) probably null Het
Or11h4 C T 14: 50,973,743 (GRCm39) R292H probably benign Het
Or2d3 G A 7: 106,491,088 (GRCm39) T76I possibly damaging Het
Or5a21 T A 19: 12,310,834 (GRCm39) N129Y probably damaging Het
Or8g27 T C 9: 39,128,967 (GRCm39) F105L probably benign Het
Pilrb2 T A 5: 137,869,306 (GRCm39) E98V probably damaging Het
Plekhm1 A G 11: 103,257,775 (GRCm39) V1053A probably benign Het
Prdm2 A T 4: 142,861,835 (GRCm39) V485E probably damaging Het
Riox2 G A 16: 59,306,954 (GRCm39) E282K probably benign Het
Rps6ka2 T A 17: 7,549,228 (GRCm39) V379E possibly damaging Het
Slc4a7 G A 14: 14,729,211 (GRCm38) E20K possibly damaging Het
Sned1 G A 1: 93,210,711 (GRCm39) probably null Het
Spata3 C T 1: 85,952,075 (GRCm39) R110C unknown Het
St6gal1 G A 16: 23,176,585 (GRCm39) A393T probably benign Het
Tent4a G A 13: 69,681,716 (GRCm39) probably benign Het
Tmem132d T C 5: 127,869,624 (GRCm39) Q570R probably damaging Het
Tmem87a T C 2: 120,222,676 (GRCm39) T168A probably benign Het
Trank1 A G 9: 111,207,995 (GRCm39) R1747G probably benign Het
Txk C T 5: 72,860,606 (GRCm39) probably null Het
Vcan T A 13: 89,852,373 (GRCm39) L862F possibly damaging Het
Wdr64 A T 1: 175,626,844 (GRCm39) probably null Het
Zfp106 G T 2: 120,354,812 (GRCm39) Q1343K probably benign Het
Zfp719 A G 7: 43,239,314 (GRCm39) T301A probably benign Het
Other mutations in Or5p1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01672:Or5p1 APN 7 107,916,725 (GRCm39) missense probably benign 0.02
IGL01731:Or5p1 APN 7 107,916,682 (GRCm39) missense probably benign 0.01
IGL02227:Or5p1 APN 7 107,916,408 (GRCm39) nonsense probably null
IGL02624:Or5p1 APN 7 107,916,130 (GRCm39) missense probably benign 0.38
IGL03164:Or5p1 APN 7 107,916,901 (GRCm39) missense probably damaging 1.00
R0143:Or5p1 UTSW 7 107,916,202 (GRCm39) missense probably benign 0.00
R0217:Or5p1 UTSW 7 107,916,505 (GRCm39) missense probably benign 0.00
R0295:Or5p1 UTSW 7 107,916,892 (GRCm39) missense probably benign 0.42
R2100:Or5p1 UTSW 7 107,916,761 (GRCm39) missense probably benign 0.04
R2379:Or5p1 UTSW 7 107,916,499 (GRCm39) missense probably benign 0.25
R4178:Or5p1 UTSW 7 107,916,565 (GRCm39) missense probably damaging 1.00
R4365:Or5p1 UTSW 7 107,916,313 (GRCm39) missense probably benign 0.02
R4734:Or5p1 UTSW 7 107,916,959 (GRCm39) missense probably damaging 1.00
R4828:Or5p1 UTSW 7 107,916,677 (GRCm39) missense probably benign 0.00
R6424:Or5p1 UTSW 7 107,916,412 (GRCm39) missense probably benign 0.01
R6784:Or5p1 UTSW 7 107,916,989 (GRCm39) missense probably damaging 0.98
R7109:Or5p1 UTSW 7 107,916,959 (GRCm39) missense probably damaging 1.00
R7348:Or5p1 UTSW 7 107,916,920 (GRCm39) missense possibly damaging 0.58
R7590:Or5p1 UTSW 7 107,916,386 (GRCm39) missense probably benign 0.00
R8782:Or5p1 UTSW 7 107,916,296 (GRCm39) missense probably damaging 0.99
X0060:Or5p1 UTSW 7 107,916,427 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- GCTGGCTCCATTATTGTAGTGACAG -3'
(R):5'- CACACAGCAAGGGTACATTATTG -3'

Sequencing Primer
(F):5'- ATCCTGAAGATGCGCTCCACTG -3'
(R):5'- CACAGCAAGGGTACATTATTGTTTAG -3'
Posted On 2020-06-30