Incidental Mutation 'R8124:Csnk2a2'
ID 631648
Institutional Source Beutler Lab
Gene Symbol Csnk2a2
Ensembl Gene ENSMUSG00000046707
Gene Name casein kinase 2, alpha prime polypeptide
Synonyms 1110035J23Rik, CK2
MMRRC Submission 067553-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.716) question?
Stock # R8124 (G1)
Quality Score 212.009
Status Validated
Chromosome 8
Chromosomal Location 96172724-96215505 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 96182575 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 296 (P296L)
Ref Sequence ENSEMBL: ENSMUSP00000055919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056919] [ENSMUST00000212214] [ENSMUST00000212952]
AlphaFold O54833
Predicted Effect
SMART Domains Protein: ENSMUSP00000055919
Gene: ENSMUSG00000046707
AA Change: P296L

DomainStartEndE-ValueType
S_TKc 40 325 1.85e-77 SMART
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000212441
Predicted Effect
Predicted Effect
Predicted Effect possibly damaging
Transcript: ENSMUST00000212952
AA Change: P201L

PolyPhen 2 Score 0.924 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.6%
  • 20x: 94.5%
Validation Efficiency 98% (51/52)
MGI Phenotype PHENOTYPE: Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agap3 T A 5: 24,683,128 (GRCm39) I320N probably benign Het
Ahnak G A 19: 8,984,487 (GRCm39) G1924S probably damaging Het
Ap2a2 G A 7: 141,178,757 (GRCm39) R141H probably benign Het
Atf7ip2 T C 16: 10,026,999 (GRCm39) V89A possibly damaging Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Dab2 T A 15: 6,458,878 (GRCm39) C263* probably null Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Ddx60 C T 8: 62,436,945 (GRCm39) A965V probably benign Het
Dennd5a A T 7: 109,497,142 (GRCm39) I1119N probably damaging Het
Dpy30 A G 17: 74,623,099 (GRCm39) probably benign Het
Epg5 G A 18: 78,008,211 (GRCm39) A780T probably benign Het
Etl4 A G 2: 20,811,451 (GRCm39) D1546G probably benign Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
F13a1 T C 13: 37,209,779 (GRCm39) K62R probably damaging Het
Gm2832 T C 14: 41,000,894 (GRCm39) M44T Het
Gm9195 T C 14: 72,680,063 (GRCm39) I2249V probably benign Het
Hmcn2 T C 2: 31,290,136 (GRCm39) V2323A probably benign Het
Ice2 T A 9: 69,307,777 (GRCm39) N20K probably damaging Het
Klf15 T C 6: 90,443,863 (GRCm39) F146S probably damaging Het
Lgi3 A G 14: 70,772,178 (GRCm39) Y241C probably damaging Het
Lig4 A T 8: 10,022,954 (GRCm39) D275E probably damaging Het
Lrit1 T A 14: 36,784,005 (GRCm39) S444R probably benign Het
Lrrc37 A G 11: 103,511,257 (GRCm39) V237A unknown Het
Mip T C 10: 128,062,070 (GRCm39) V107A possibly damaging Het
Mtrex A C 13: 113,063,871 (GRCm39) D7E probably benign Het
Myo15a G A 11: 60,398,279 (GRCm39) V1581M Het
Nckap1l A G 15: 103,382,248 (GRCm39) D481G possibly damaging Het
Obox3 A T 7: 15,323,874 (GRCm39) probably null Het
Or11h4 C T 14: 50,973,743 (GRCm39) R292H probably benign Het
Or2d3 G A 7: 106,491,088 (GRCm39) T76I possibly damaging Het
Or5a21 T A 19: 12,310,834 (GRCm39) N129Y probably damaging Het
Or5p1 C A 7: 107,916,984 (GRCm39) N294K possibly damaging Het
Or8g27 T C 9: 39,128,967 (GRCm39) F105L probably benign Het
Pilrb2 T A 5: 137,869,306 (GRCm39) E98V probably damaging Het
Plekhm1 A G 11: 103,257,775 (GRCm39) V1053A probably benign Het
Prdm2 A T 4: 142,861,835 (GRCm39) V485E probably damaging Het
Riox2 G A 16: 59,306,954 (GRCm39) E282K probably benign Het
Rps6ka2 T A 17: 7,549,228 (GRCm39) V379E possibly damaging Het
Slc4a7 G A 14: 14,729,211 (GRCm38) E20K possibly damaging Het
Sned1 G A 1: 93,210,711 (GRCm39) probably null Het
Spata3 C T 1: 85,952,075 (GRCm39) R110C unknown Het
St6gal1 G A 16: 23,176,585 (GRCm39) A393T probably benign Het
Tent4a G A 13: 69,681,716 (GRCm39) probably benign Het
Tmem132d T C 5: 127,869,624 (GRCm39) Q570R probably damaging Het
Tmem87a T C 2: 120,222,676 (GRCm39) T168A probably benign Het
Trank1 A G 9: 111,207,995 (GRCm39) R1747G probably benign Het
Txk C T 5: 72,860,606 (GRCm39) probably null Het
Vcan T A 13: 89,852,373 (GRCm39) L862F possibly damaging Het
Wdr64 A T 1: 175,626,844 (GRCm39) probably null Het
Zfp106 G T 2: 120,354,812 (GRCm39) Q1343K probably benign Het
Zfp719 A G 7: 43,239,314 (GRCm39) T301A probably benign Het
Other mutations in Csnk2a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02466:Csnk2a2 APN 8 96,203,859 (GRCm39) missense possibly damaging 0.87
R1452:Csnk2a2 UTSW 8 96,184,003 (GRCm39) splice site probably benign
R1717:Csnk2a2 UTSW 8 96,182,436 (GRCm39) splice site probably null
R4260:Csnk2a2 UTSW 8 96,184,027 (GRCm39) missense probably benign 0.01
R6062:Csnk2a2 UTSW 8 96,184,097 (GRCm39) missense possibly damaging 0.93
R7169:Csnk2a2 UTSW 8 96,215,006 (GRCm39) missense
R8125:Csnk2a2 UTSW 8 96,182,575 (GRCm39) missense
R8126:Csnk2a2 UTSW 8 96,182,575 (GRCm39) missense
R8253:Csnk2a2 UTSW 8 96,215,005 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TCTAGTGTTCTGACTGACCTTG -3'
(R):5'- ACAGTGCACCGTTCTAAGG -3'

Sequencing Primer
(F):5'- CCTGGTCTACAAAGTGAGTTCCAG -3'
(R):5'- CACCGTTCTAAGGGGTCCTTG -3'
Posted On 2020-06-30