Mutagenetix > Incidental Mutation

Incidental Mutation 'R8126:Vmn2r102'

631785

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

MMRRC Submission

067555-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8126 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19880661-19915010 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19880712 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 18 (S18P)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

probably benign
Transcript: ENSMUST00000171741
AA Change: S18P

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: S18P

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.0%
20x: 97.3%

Validation Efficiency

95% (42/44)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,588,344 (GRCm39)	V4414E	possibly damaging	Het
Aplp1	T	A	7: 30,141,164 (GRCm39)	D299V	probably damaging	Het
Atad2	T	C	15: 57,968,987 (GRCm39)	I841M	probably benign	Het
Bdp1	T	C	13: 100,192,790 (GRCm39)	E1348G	probably damaging	Het
Cacna1a	A	G	8: 85,359,881 (GRCm39)	T1948A	probably benign	Het
Cdh12	T	C	15: 21,558,393 (GRCm39)	Y431H	probably benign	Het
Cfap74	C	A	4: 155,511,831 (GRCm39)	D446E		Het
Clpsl2	G	A	17: 28,769,702 (GRCm39)	G55R	probably damaging	Het
Col4a4	T	C	1: 82,431,007 (GRCm39)	T1632A	unknown	Het
Csnk2a2	G	A	8: 96,182,575 (GRCm39)	P296L		Het
Cspg4b	T	A	13: 113,504,697 (GRCm39)	I1942N		Het
Cstl1	A	G	2: 148,596,591 (GRCm39)	E98G	probably benign	Het
Ddx49	A	T	8: 70,748,246 (GRCm39)	I303N	probably damaging	Het
Ddx60	C	T	8: 62,436,945 (GRCm39)	A965V	probably benign	Het
Evl	C	T	12: 108,647,783 (GRCm39)	R295*	probably null	Het
Gm14295	A	G	2: 176,502,658 (GRCm39)	D716G	probably benign	Het
Gsap	T	A	5: 21,475,010 (GRCm39)	H556Q	probably benign	Het
Hsp90b1	T	C	10: 86,530,246 (GRCm39)	I538V	probably damaging	Het
Ighv1-49	C	T	12: 115,019,230 (GRCm39)		probably benign	Het
Lrrk1	T	C	7: 65,942,063 (GRCm39)	N725S	probably damaging	Het
Mfsd4b2	A	G	10: 39,797,984 (GRCm39)	S124P	probably benign	Het
Ncoa1	A	T	12: 4,340,951 (GRCm39)	L827Q	probably damaging	Het
Ncor2	T	C	5: 125,183,268 (GRCm39)	N59D	unknown	Het
Nfkbid	T	A	7: 30,123,799 (GRCm39)	S120T	probably benign	Het
Nktr	T	C	9: 121,575,514 (GRCm39)	Y341H	probably damaging	Het
Npat	T	C	9: 53,463,634 (GRCm39)	V139A	probably benign	Het
Or5ae1	T	A	7: 84,565,114 (GRCm39)	N42K	probably damaging	Het
Plxnb2	T	C	15: 89,047,506 (GRCm39)	D721G	probably benign	Het
Ppl	C	T	16: 4,906,725 (GRCm39)	R1190H	probably damaging	Het
Ppp3ca	T	A	3: 136,608,952 (GRCm39)	D348E	probably damaging	Het
Pramel21	T	A	4: 143,343,635 (GRCm39)	C312S	possibly damaging	Het
Rnf146	T	C	10: 29,223,372 (GRCm39)	I171M	probably damaging	Het
Snrpa	G	T	7: 26,892,373 (GRCm39)	F62L	possibly damaging	Het
Spata3	C	T	1: 85,952,075 (GRCm39)	R110C	unknown	Het
Tbc1d2b	T	C	9: 90,104,369 (GRCm39)	H591R	probably benign	Het
Tnfsf8	T	G	4: 63,752,423 (GRCm39)	D214A	possibly damaging	Het
Trdmt1	C	T	2: 13,524,816 (GRCm39)	R213H	probably benign	Het
Uspl1	C	T	5: 149,151,430 (GRCm39)	L877F	probably damaging	Het
Vmn1r22	C	A	6: 57,877,669 (GRCm39)	V103F	possibly damaging	Het
Vmn2r-ps117	A	T	17: 19,042,814 (GRCm39)	Y74F	probably benign	Het
Wdr90	A	G	17: 26,067,951 (GRCm39)	F1429S	possibly damaging	Het
Zdhhc20	C	A	14: 58,084,402 (GRCm39)	V238F	probably damaging	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19,899,154 (GRCm39)	missense	probably damaging	1.00
IGL00974:Vmn2r102	APN	17	19,897,771 (GRCm39)	missense	possibly damaging	0.93
IGL00978:Vmn2r102	APN	17	19,899,185 (GRCm39)	splice site	probably null
IGL01589:Vmn2r102	APN	17	19,899,066 (GRCm39)	missense	probably benign
IGL01738:Vmn2r102	APN	17	19,898,020 (GRCm39)	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19,880,731 (GRCm39)	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19,914,191 (GRCm39)	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19,901,447 (GRCm39)	missense	probably benign
IGL02589:Vmn2r102	APN	17	19,901,480 (GRCm39)	missense	probably damaging	1.00
IGL02814:Vmn2r102	APN	17	19,898,170 (GRCm39)	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19,914,328 (GRCm39)	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19,914,286 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19,896,958 (GRCm39)	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19,880,851 (GRCm39)	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19,898,112 (GRCm39)	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19,914,630 (GRCm39)	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19,897,043 (GRCm39)	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19,898,277 (GRCm39)	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19,899,106 (GRCm39)	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19,914,454 (GRCm39)	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19,880,887 (GRCm39)	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19,914,843 (GRCm39)	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19,899,032 (GRCm39)	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19,897,770 (GRCm39)	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19,914,755 (GRCm39)	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19,897,006 (GRCm39)	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19,896,949 (GRCm39)	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19,914,930 (GRCm39)	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19,899,093 (GRCm39)	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19,914,787 (GRCm39)	missense	probably damaging	1.00
R4159:Vmn2r102	UTSW	17	19,898,088 (GRCm39)	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19,880,845 (GRCm39)	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4535:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4662:Vmn2r102	UTSW	17	19,901,424 (GRCm39)	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19,914,576 (GRCm39)	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19,897,795 (GRCm39)	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19,898,203 (GRCm39)	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19,880,661 (GRCm39)	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19,897,834 (GRCm39)	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19,914,393 (GRCm39)	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19,914,415 (GRCm39)	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19,897,804 (GRCm39)	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19,914,943 (GRCm39)	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19,914,402 (GRCm39)	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19,899,007 (GRCm39)	missense	probably benign
R6432:Vmn2r102	UTSW	17	19,901,483 (GRCm39)	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19,898,169 (GRCm39)	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19,914,450 (GRCm39)	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19,880,694 (GRCm39)	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19,914,456 (GRCm39)	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19,914,670 (GRCm39)	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19,897,749 (GRCm39)	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19,896,886 (GRCm39)	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19,901,405 (GRCm39)	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19,914,363 (GRCm39)	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19,898,093 (GRCm39)	missense	probably benign
R8385:Vmn2r102	UTSW	17	19,914,088 (GRCm39)	missense	possibly damaging	0.89
R8410:Vmn2r102	UTSW	17	19,898,196 (GRCm39)	missense	possibly damaging	0.85
R9045:Vmn2r102	UTSW	17	19,880,841 (GRCm39)	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19,896,928 (GRCm39)	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19,897,558 (GRCm39)	missense	probably damaging	1.00
R9363:Vmn2r102	UTSW	17	19,897,614 (GRCm39)	missense	probably benign	0.04
R9524:Vmn2r102	UTSW	17	19,897,564 (GRCm39)	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19,914,305 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TCGAAATTCCCAATGGCATTCTC -3'
(R):5'- CCAAGTCATAAGAATTCTGAGTCTG -3'

Sequencing Primer
(F):5'- AAATTCCCAATGGCATTCTCAATCTC -3'
(R):5'- GTGGCATTTTCTTCTCAGTG -3'

Posted On

2020-06-30