Incidental Mutation 'R8127:Olfr424'
ID 631792
Institutional Source Beutler Lab
Gene Symbol Olfr424
Ensembl Gene ENSMUSG00000051528
Gene Name olfactory receptor 424
Synonyms MOR105-2, GA_x6K02T2P20D-21025190-21024243
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.184) question?
Stock # R8127 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 174131517-174138257 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 174137589 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 282 (P282S)
Ref Sequence ENSEMBL: ENSMUSP00000150840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053941] [ENSMUST00000214751]
AlphaFold E9Q0Q2
Predicted Effect probably damaging
Transcript: ENSMUST00000053941
AA Change: P282S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054305
Gene: ENSMUSG00000051528
AA Change: P282S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-63 PFAM
Pfam:7tm_1 41 289 1.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214751
AA Change: P282S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.9%
  • 20x: 97.0%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T C 5: 145,043,439 M66T possibly damaging Het
Acvr1 A T 2: 58,477,626 N174K probably benign Het
Ago1 A T 4: 126,454,421 C342S possibly damaging Het
Anapc1 A G 2: 128,632,627 S1423P probably damaging Het
Antxr2 A T 5: 97,980,017 C218* probably null Het
Arsa A G 15: 89,474,864 Y200H probably damaging Het
Atad3a C T 4: 155,753,939 R207Q probably damaging Het
Carmil3 A G 14: 55,498,244 D551G probably damaging Het
Cdk9 A G 2: 32,707,997 I349T probably benign Het
Cmya5 A T 13: 93,094,614 V1322E probably damaging Het
Col4a3 T A 1: 82,649,760 I95K unknown Het
Dab2ip T C 2: 35,644,126 probably benign Het
Dok7 A G 5: 35,087,001 S530G probably benign Het
Dst C T 1: 34,178,229 T1250M probably damaging Het
Dzank1 A C 2: 144,488,816 W439G probably damaging Het
Evx1 T A 6: 52,313,917 S25T possibly damaging Het
Fut10 G A 8: 31,194,971 probably benign Het
Gatad1 T C 5: 3,643,540 R210G probably benign Het
Hyal5 C A 6: 24,891,488 R434S probably benign Het
Lrrc43 C T 5: 123,492,271 P66S probably damaging Het
Mib1 T A 18: 10,741,031 I93N probably damaging Het
Mug2 G A 6: 122,075,608 E1038K probably benign Het
Nsd2 T A 5: 33,885,490 C1033S probably damaging Het
Olfr985 T A 9: 40,127,064 H299L probably benign Het
Otogl A T 10: 107,895,752 F176Y probably damaging Het
Pih1d3 T C 1: 31,223,120 F61S probably benign Het
Polr3b A G 10: 84,679,789 K609E probably benign Het
Prdm15 T C 16: 97,837,710 N50S probably benign Het
Rlf G T 4: 121,147,896 Q1406K possibly damaging Het
Rusc2 T C 4: 43,423,747 V1023A possibly damaging Het
Scn11a C T 9: 119,804,512 G385D probably damaging Het
Slc44a1 T C 4: 53,528,714 S155P probably benign Het
Spam1 T A 6: 24,796,971 V307D possibly damaging Het
Srgap1 A C 10: 121,855,366 M321R probably null Het
Stam A G 2: 14,117,473 I128V probably damaging Het
Sytl2 A G 7: 90,375,590 D262G possibly damaging Het
Taf2 G A 15: 55,059,988 R298C probably damaging Het
Tcl1b5 A T 12: 105,180,003 T112S probably benign Het
Trim33 T C 3: 103,331,727 S674P possibly damaging Het
Trip12 T C 1: 84,738,742 N1602S probably damaging Het
Vmn1r44 T C 6: 89,893,863 I197T probably benign Het
Wdtc1 C T 4: 133,302,382 probably null Het
Zfp583 G T 7: 6,323,822 probably null Het
Zfyve16 T A 13: 92,505,677 I1213F probably damaging Het
Other mutations in Olfr424
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01453:Olfr424 APN 1 174137113 missense possibly damaging 0.46
IGL01651:Olfr424 APN 1 174137341 missense probably damaging 0.96
R0194:Olfr424 UTSW 1 174136761 missense probably benign 0.04
R0357:Olfr424 UTSW 1 174137299 nonsense probably null
R0732:Olfr424 UTSW 1 174137415 missense possibly damaging 0.85
R1103:Olfr424 UTSW 1 174136891 missense probably benign 0.07
R1623:Olfr424 UTSW 1 174137317 missense probably damaging 0.98
R1829:Olfr424 UTSW 1 174137194 missense probably benign 0.12
R6617:Olfr424 UTSW 1 174137248 missense probably damaging 1.00
R7060:Olfr424 UTSW 1 174136810 missense probably benign 0.00
R7203:Olfr424 UTSW 1 174137114 nonsense probably null
R7625:Olfr424 UTSW 1 174137167 missense probably benign 0.13
R7994:Olfr424 UTSW 1 174136707 start gained probably benign
R8035:Olfr424 UTSW 1 174136924 missense probably damaging 1.00
R8802:Olfr424 UTSW 1 174137050 missense probably damaging 1.00
R9102:Olfr424 UTSW 1 174136756 missense
R9296:Olfr424 UTSW 1 174137269 missense probably benign 0.02
R9374:Olfr424 UTSW 1 174137319 missense probably benign 0.34
R9551:Olfr424 UTSW 1 174137319 missense probably benign 0.34
R9552:Olfr424 UTSW 1 174137319 missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- GCAGTGGCCATCATCTTCTC -3'
(R):5'- CAGTCTTCTGATAAATGAGTTGTGTGC -3'

Sequencing Primer
(F):5'- TGAGAATCATCACCGTGATCCTGAG -3'
(R):5'- AAATGAGTTGTGTGCTAATTTTAGGG -3'
Posted On 2020-06-30