Incidental Mutation 'R8129:Wdtc1'
ID 631897
Institutional Source Beutler Lab
Gene Symbol Wdtc1
Ensembl Gene ENSMUSG00000037622
Gene Name WD and tetratricopeptide repeats 1
Synonyms adp, adipose, LOC230796
MMRRC Submission 067558-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8129 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 133019770-133080792 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 133031460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000040647 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043305] [ENSMUST00000105906]
AlphaFold Q80ZK9
Predicted Effect probably null
Transcript: ENSMUST00000043305
SMART Domains Protein: ENSMUSP00000040647
Gene: ENSMUSG00000037622

DomainStartEndE-ValueType
WD40 36 75 4.58e-8 SMART
WD40 79 120 1.24e-4 SMART
WD40 123 163 2.58e-1 SMART
WD40 170 213 4.42e1 SMART
Pfam:TPR_11 362 429 1.1e-15 PFAM
Pfam:TPR_2 432 457 1.1e-3 PFAM
low complexity region 488 499 N/A INTRINSIC
WD40 523 566 7.16e-1 SMART
WD40 569 608 1.55e-5 SMART
low complexity region 655 670 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105906
SMART Domains Protein: ENSMUSP00000101526
Gene: ENSMUSG00000037622

DomainStartEndE-ValueType
WD40 36 75 4.58e-8 SMART
WD40 79 120 1.24e-4 SMART
WD40 123 163 2.58e-1 SMART
WD40 170 213 4.42e1 SMART
Blast:WD40 261 296 5e-12 BLAST
Pfam:TPR_11 361 429 2.9e-16 PFAM
Pfam:TPR_2 432 457 1.4e-3 PFAM
low complexity region 488 499 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 85.2%
Validation Efficiency 98% (99/101)
MGI Phenotype PHENOTYPE: Mice heterozygous for a gene trapped allele are obese and insulin resistant with significantly elevated plasma insulin and leptin levels. Although a number of adult homozygotes are also described as obese, the majority of homozygotes die in utero thus precluding statistically significant analyses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik T C 2: 35,266,187 (GRCm39) D161G probably damaging Het
Adamts19 T C 18: 59,140,559 (GRCm39) probably null Het
Ahnak A T 19: 8,977,464 (GRCm39) M1L not run Het
Appl1 A G 14: 26,671,466 (GRCm39) S329P possibly damaging Het
Bach1 C T 16: 87,519,314 (GRCm39) R535W possibly damaging Het
Bicc1 T C 10: 70,915,033 (GRCm39) D77G probably benign Het
Bub1b T A 2: 118,468,975 (GRCm39) D913E probably benign Het
Cdhr2 G T 13: 54,864,208 (GRCm39) probably null Het
Col25a1 T C 3: 130,290,050 (GRCm39) S247P probably damaging Het
Commd8 T C 5: 72,320,164 (GRCm39) M126V unknown Het
Dpysl4 C T 7: 138,666,076 (GRCm39) T13M probably benign Het
Epc1 A G 18: 6,439,634 (GRCm39) V776A possibly damaging Het
Fancg G T 4: 43,005,036 (GRCm39) probably null Het
Fdx1 T C 9: 51,859,926 (GRCm39) T135A probably benign Het
Fgf7 T C 2: 125,877,765 (GRCm39) V44A probably benign Het
Fgfr3 A T 5: 33,891,250 (GRCm39) M523L probably damaging Het
Focad A T 4: 88,151,000 (GRCm39) H548L unknown Het
Ftsj3 C A 11: 106,144,657 (GRCm39) V111F probably benign Het
Gm28168 T A 1: 117,857,483 (GRCm39) D12E probably damaging Het
Gprin3 T C 6: 59,330,844 (GRCm39) T488A probably benign Het
Hormad2 C A 11: 4,296,648 (GRCm39) V279L probably benign Het
Hs6st1 A G 1: 36,108,105 (GRCm39) K123E probably damaging Het
Ice1 A G 13: 70,754,320 (GRCm39) S589P probably benign Het
Il1r1 T A 1: 40,341,447 (GRCm39) H286Q probably benign Het
Il1rl1 T A 1: 40,490,987 (GRCm39) C423S probably damaging Het
L1td1 A T 4: 98,621,563 (GRCm39) M42L probably benign Het
Large1 T C 8: 73,542,585 (GRCm39) D713G probably damaging Het
Llgl2 C A 11: 115,741,737 (GRCm39) probably null Het
Lrp2 C T 2: 69,260,624 (GRCm39) V4536M possibly damaging Het
Map3k19 A C 1: 127,750,420 (GRCm39) L977R possibly damaging Het
Myo15a A T 11: 60,399,026 (GRCm39) D1617V Het
Nek3 A G 8: 22,639,908 (GRCm39) I189T probably damaging Het
Nrap C T 19: 56,355,068 (GRCm39) probably null Het
Omd A C 13: 49,745,565 (GRCm39) D325A probably damaging Het
Or1x6 G A 11: 50,939,210 (GRCm39) R92K probably benign Het
Or4a76 C A 2: 89,460,792 (GRCm39) G150V probably damaging Het
Or52h7 A G 7: 104,213,584 (GRCm39) Y52C probably benign Het
Or5b118 A T 19: 13,448,508 (GRCm39) Y16F probably damaging Het
Pabpc6 C T 17: 9,887,427 (GRCm39) V375I possibly damaging Het
Pcdha5 A G 18: 37,094,832 (GRCm39) D447G probably damaging Het
Pla2r1 A T 2: 60,262,944 (GRCm39) W1032R probably damaging Het
Ppp2r5d T C 17: 46,995,263 (GRCm39) Y524C probably benign Het
Ppp4r3b T C 11: 29,159,364 (GRCm39) Y573H probably damaging Het
Prune2 T C 19: 17,096,200 (GRCm39) I568T probably benign Het
Ptpn22 G A 3: 103,797,600 (GRCm39) probably null Het
Rbm12b1 A G 4: 12,145,549 (GRCm39) D507G probably damaging Het
Rdh7 A G 10: 127,723,370 (GRCm39) S162P probably benign Het
Rreb1 C T 13: 38,113,775 (GRCm39) A378V probably benign Het
Scaf11 A G 15: 96,317,350 (GRCm39) F738S probably damaging Het
Sdk1 C A 5: 142,177,648 (GRCm39) N2031K probably benign Het
Serpina3c A T 12: 104,118,056 (GRCm39) L94Q probably damaging Het
Sgo2b T C 8: 64,381,834 (GRCm39) S333G possibly damaging Het
Slc22a15 A G 3: 101,822,658 (GRCm39) V88A possibly damaging Het
Smarcad1 G T 6: 65,044,078 (GRCm39) D217Y probably benign Het
Sppl2a A G 2: 126,765,390 (GRCm39) F244S probably damaging Het
Sspo G A 6: 48,443,959 (GRCm39) D2156N possibly damaging Het
Taf2 G A 15: 54,923,384 (GRCm39) R298C probably damaging Het
Tap2 C T 17: 34,424,672 (GRCm39) T135I probably benign Het
Tbx15 G T 3: 99,161,254 (GRCm39) V20F probably damaging Het
Tes A T 6: 17,065,242 (GRCm39) probably benign Het
Tmem39b A T 4: 129,572,468 (GRCm39) M378K probably damaging Het
Trim44 A G 2: 102,230,848 (GRCm39) V61A unknown Het
Ttll5 T C 12: 85,937,858 (GRCm39) probably null Het
Tubgcp4 C T 2: 121,004,109 (GRCm39) T50I possibly damaging Het
Txndc17 G A 11: 72,098,588 (GRCm39) V47M probably damaging Het
Ubp1 A G 9: 113,804,417 (GRCm39) E494G possibly damaging Het
Utp20 A T 10: 88,628,487 (GRCm39) S936T probably benign Het
Wdr64 A G 1: 175,603,154 (GRCm39) D585G probably damaging Het
Zfp292 A G 4: 34,807,386 (GRCm39) M1891T probably damaging Het
Zfp84 A C 7: 29,475,862 (GRCm39) I185L probably benign Het
Zmym4 A G 4: 126,808,956 (GRCm39) F364L possibly damaging Het
Other mutations in Wdtc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01653:Wdtc1 APN 4 133,022,543 (GRCm39) missense probably damaging 1.00
IGL02005:Wdtc1 APN 4 133,036,225 (GRCm39) missense probably benign 0.14
IGL02078:Wdtc1 APN 4 133,033,271 (GRCm39) missense probably damaging 1.00
IGL02146:Wdtc1 APN 4 133,029,076 (GRCm39) missense probably benign 0.00
IGL02724:Wdtc1 APN 4 133,024,789 (GRCm39) missense possibly damaging 0.78
IGL03196:Wdtc1 APN 4 133,022,648 (GRCm39) missense probably damaging 1.00
Furry UTSW 4 133,029,693 (GRCm39) critical splice donor site probably null
pear UTSW 4 133,021,702 (GRCm39) splice site probably null
Piliated UTSW 4 133,023,782 (GRCm39) missense probably damaging 1.00
R0448:Wdtc1 UTSW 4 133,024,811 (GRCm39) missense probably damaging 1.00
R0501:Wdtc1 UTSW 4 133,036,151 (GRCm39) missense possibly damaging 0.88
R0743:Wdtc1 UTSW 4 133,027,972 (GRCm39) missense probably damaging 0.99
R1170:Wdtc1 UTSW 4 133,024,857 (GRCm39) missense probably damaging 0.99
R1439:Wdtc1 UTSW 4 133,029,118 (GRCm39) missense probably benign
R1456:Wdtc1 UTSW 4 133,024,739 (GRCm39) missense possibly damaging 0.83
R1833:Wdtc1 UTSW 4 133,036,053 (GRCm39) splice site probably benign
R4506:Wdtc1 UTSW 4 133,036,130 (GRCm39) missense probably damaging 1.00
R4687:Wdtc1 UTSW 4 133,023,742 (GRCm39) missense probably damaging 1.00
R4739:Wdtc1 UTSW 4 133,029,110 (GRCm39) missense possibly damaging 0.68
R4967:Wdtc1 UTSW 4 133,021,654 (GRCm39) missense probably damaging 0.99
R5032:Wdtc1 UTSW 4 133,036,162 (GRCm39) missense possibly damaging 0.89
R5193:Wdtc1 UTSW 4 133,021,678 (GRCm39) nonsense probably null
R5448:Wdtc1 UTSW 4 133,021,608 (GRCm39) missense probably benign
R5593:Wdtc1 UTSW 4 133,021,702 (GRCm39) splice site probably null
R5890:Wdtc1 UTSW 4 133,021,673 (GRCm39) missense unknown
R7536:Wdtc1 UTSW 4 133,022,561 (GRCm39) missense probably damaging 1.00
R7609:Wdtc1 UTSW 4 133,023,748 (GRCm39) missense probably damaging 1.00
R8127:Wdtc1 UTSW 4 133,029,693 (GRCm39) critical splice donor site probably null
R8431:Wdtc1 UTSW 4 133,049,481 (GRCm39) critical splice donor site probably null
R8725:Wdtc1 UTSW 4 133,041,114 (GRCm39) missense probably damaging 1.00
R8735:Wdtc1 UTSW 4 133,031,511 (GRCm39) nonsense probably null
R8937:Wdtc1 UTSW 4 133,031,470 (GRCm39) missense probably damaging 1.00
R9357:Wdtc1 UTSW 4 133,023,782 (GRCm39) missense probably damaging 1.00
R9387:Wdtc1 UTSW 4 133,036,058 (GRCm39) critical splice donor site probably null
R9415:Wdtc1 UTSW 4 133,022,684 (GRCm39) missense possibly damaging 0.91
R9476:Wdtc1 UTSW 4 133,049,529 (GRCm39) missense probably damaging 0.96
R9510:Wdtc1 UTSW 4 133,049,529 (GRCm39) missense probably damaging 0.96
R9738:Wdtc1 UTSW 4 133,022,604 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGTCAACAGGTCAGCAGCC -3'
(R):5'- GGACATAACCCTGGGTTTTCTC -3'

Sequencing Primer
(F):5'- GTCTTGCTGAGAAGTCCAGAC -3'
(R):5'- ATAACCCTGGGTTTTCTCTCTGGAG -3'
Posted On 2020-06-30