|Institutional Source||Beutler Lab|
|Gene Name||ATP-binding cassette, sub-family B (MDR/TAP), member 10|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R8132 (G1)|
|Chromosomal Location||123952459-123983122 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 123965018 bp|
|Amino Acid Change||Alanine to Threonine at position 403 (A403T)|
|Ref Sequence||ENSEMBL: ENSMUSP00000075011 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000075578] [ENSMUST00000127664]|
AA Change: A403T
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.0704|
|Coding Region Coverage||
FUNCTION: This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased response to ischemia and reperfusion. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Abcb10||
(F):5'- ACTCAGGCTGGGAAACACAG -3'
(R):5'- GCCGAGATCTAGTTTATACTCTTGTC -3'
(F):5'- TCCTAAGCTGTGGGAGGACAC -3'
(R):5'- TTGTCCCAAGAAGCCTTCGG -3'