Incidental Mutation 'R8132:Ncapg2'
ID 632084
Institutional Source Beutler Lab
Gene Symbol Ncapg2
Ensembl Gene ENSMUSG00000042029
Gene Name non-SMC condensin II complex, subunit G2
Synonyms 5830426I05Rik, Mtb, mCAP-G2, Luzp5
MMRRC Submission 067895-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8132 (G1)
Quality Score 194.009
Status Not validated
Chromosome 12
Chromosomal Location 116368969-116427152 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 116407967 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 989 (I989N)
Ref Sequence ENSEMBL: ENSMUSP00000081889 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084828]
AlphaFold Q6DFV1
Predicted Effect possibly damaging
Transcript: ENSMUST00000084828
AA Change: I989N

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000081889
Gene: ENSMUSG00000042029
AA Change: I989N

DomainStartEndE-ValueType
low complexity region 14 25 N/A INTRINSIC
Pfam:Condensin2nSMC 212 361 7.2e-62 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.6%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,691,757 (GRCm39) A403T Het
Abhd16b G A 2: 181,135,760 (GRCm39) A221T probably damaging Het
Arhgef1 C T 7: 24,607,087 (GRCm39) probably benign Het
Arhgef1 C T 7: 24,619,174 (GRCm39) Q472* probably null Het
Calr3 C T 8: 73,181,023 (GRCm39) G298S probably damaging Het
Chrng A G 1: 87,133,718 (GRCm39) T15A unknown Het
CK137956 T A 4: 127,845,075 (GRCm39) K223* probably null Het
Clca3b A T 3: 144,552,935 (GRCm39) S97T probably benign Het
Cops7b G T 1: 86,514,916 (GRCm39) G102V probably damaging Het
Dennd1a T A 2: 37,748,072 (GRCm39) S382C probably damaging Het
Fdps G A 3: 89,006,693 (GRCm39) Q66* probably null Het
Gemin4 T C 11: 76,103,739 (GRCm39) T341A probably benign Het
Grk3 A G 5: 113,109,355 (GRCm39) S201P unknown Het
Hgf C T 5: 16,807,329 (GRCm39) T407I probably damaging Het
Hip1r C T 5: 124,135,290 (GRCm39) R446C probably damaging Het
Hyal6 A T 6: 24,740,827 (GRCm39) I327L possibly damaging Het
Ifna15 T C 4: 88,475,920 (GRCm39) E188G possibly damaging Het
Igip A G 18: 36,434,266 (GRCm39) S11G probably benign Het
Igkv5-39 A G 6: 69,877,589 (GRCm39) Y56H probably damaging Het
Jph1 G A 1: 17,086,379 (GRCm39) T381I probably damaging Het
Lrrc55 T C 2: 85,022,259 (GRCm39) I311V probably benign Het
Mrps35 T A 6: 146,949,661 (GRCm39) D58E probably benign Het
Ms4a4d C A 19: 11,535,310 (GRCm39) P203T probably benign Het
Naip1 T G 13: 100,573,883 (GRCm39) E225D possibly damaging Het
Nek3 A T 8: 22,647,036 (GRCm39) Y166* probably null Het
Nphs1 A G 7: 30,181,478 (GRCm39) E1169G probably benign Het
Nudt15 G A 14: 73,759,099 (GRCm39) P123L probably benign Het
Or10c1 T A 17: 37,522,207 (GRCm39) E179V probably damaging Het
Or10q1b G A 19: 13,682,584 (GRCm39) C131Y probably damaging Het
Or5ac22 T C 16: 59,134,907 (GRCm39) I288V possibly damaging Het
Or6k14 T A 1: 173,927,737 (GRCm39) S238T probably damaging Het
Or8a1b C T 9: 37,623,369 (GRCm39) V69M probably benign Het
Pcdha5 T C 18: 37,093,694 (GRCm39) S68P possibly damaging Het
Plec G T 15: 76,074,773 (GRCm39) A330E unknown Het
Rpa3 A C 6: 8,256,790 (GRCm39) I63S probably damaging Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Het
Snap25 A T 2: 136,611,748 (GRCm39) K83N probably benign Het
Sos1 T G 17: 80,716,031 (GRCm39) Q977P probably damaging Het
Spag16 A G 1: 70,420,461 (GRCm39) Y483C probably damaging Het
Speg A G 1: 75,399,639 (GRCm39) E2362G probably damaging Het
Swap70 A G 7: 109,855,084 (GRCm39) D128G probably damaging Het
Syngap1 G A 17: 27,177,154 (GRCm39) M545I probably damaging Het
Tdpoz6 G A 3: 93,599,452 (GRCm39) Q306* probably null Het
Tmem147 T C 7: 30,427,872 (GRCm39) E110G probably damaging Het
Tmem156 T A 5: 65,233,098 (GRCm39) I155F probably benign Het
Trim25 C A 11: 88,907,432 (GRCm39) A597E probably damaging Het
Ttc7b T C 12: 100,413,131 (GRCm39) Y229C probably damaging Het
Utrn T A 10: 12,558,154 (GRCm39) Q1435L probably damaging Het
Zbtb41 T C 1: 139,350,955 (GRCm39) S23P probably benign Het
Zeb2 T A 2: 44,879,142 (GRCm39) I1075F probably damaging Het
Other mutations in Ncapg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Ncapg2 APN 12 116,388,270 (GRCm39) missense possibly damaging 0.54
IGL01694:Ncapg2 APN 12 116,370,850 (GRCm39) utr 5 prime probably benign
IGL01724:Ncapg2 APN 12 116,390,331 (GRCm39) missense probably damaging 1.00
IGL01792:Ncapg2 APN 12 116,389,438 (GRCm39) missense probably damaging 0.99
IGL02098:Ncapg2 APN 12 116,407,952 (GRCm39) missense possibly damaging 0.59
IGL02136:Ncapg2 APN 12 116,424,203 (GRCm39) missense probably benign
IGL02409:Ncapg2 APN 12 116,384,337 (GRCm39) missense probably damaging 1.00
IGL02580:Ncapg2 APN 12 116,384,309 (GRCm39) missense probably damaging 1.00
IGL02653:Ncapg2 APN 12 116,389,526 (GRCm39) critical splice donor site probably null
IGL03073:Ncapg2 APN 12 116,415,894 (GRCm39) missense probably benign 0.01
IGL03114:Ncapg2 APN 12 116,415,993 (GRCm39) splice site probably benign
IGL03199:Ncapg2 APN 12 116,382,856 (GRCm39) missense probably damaging 1.00
IGL03328:Ncapg2 APN 12 116,403,677 (GRCm39) missense possibly damaging 0.90
P0033:Ncapg2 UTSW 12 116,402,255 (GRCm39) missense probably benign 0.03
R0008:Ncapg2 UTSW 12 116,393,455 (GRCm39) missense probably damaging 1.00
R0194:Ncapg2 UTSW 12 116,384,303 (GRCm39) splice site probably null
R0379:Ncapg2 UTSW 12 116,406,695 (GRCm39) missense probably damaging 1.00
R0568:Ncapg2 UTSW 12 116,386,835 (GRCm39) missense probably damaging 1.00
R0771:Ncapg2 UTSW 12 116,376,779 (GRCm39) nonsense probably null
R1016:Ncapg2 UTSW 12 116,402,295 (GRCm39) missense probably damaging 1.00
R1507:Ncapg2 UTSW 12 116,424,186 (GRCm39) missense probably benign 0.00
R1524:Ncapg2 UTSW 12 116,398,198 (GRCm39) splice site probably benign
R1596:Ncapg2 UTSW 12 116,382,856 (GRCm39) missense probably damaging 1.00
R1635:Ncapg2 UTSW 12 116,398,305 (GRCm39) frame shift probably null
R1752:Ncapg2 UTSW 12 116,390,338 (GRCm39) missense probably damaging 1.00
R2164:Ncapg2 UTSW 12 116,414,095 (GRCm39) splice site probably null
R2266:Ncapg2 UTSW 12 116,393,296 (GRCm39) missense probably damaging 1.00
R2366:Ncapg2 UTSW 12 116,384,349 (GRCm39) nonsense probably null
R2924:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R2925:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R3828:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R3829:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R4384:Ncapg2 UTSW 12 116,403,497 (GRCm39) critical splice donor site probably null
R4651:Ncapg2 UTSW 12 116,389,407 (GRCm39) missense probably damaging 1.00
R4701:Ncapg2 UTSW 12 116,404,238 (GRCm39) missense probably benign
R4821:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R4845:Ncapg2 UTSW 12 116,404,208 (GRCm39) missense probably damaging 0.96
R5135:Ncapg2 UTSW 12 116,391,406 (GRCm39) missense possibly damaging 0.64
R5294:Ncapg2 UTSW 12 116,391,414 (GRCm39) missense possibly damaging 0.54
R5334:Ncapg2 UTSW 12 116,390,257 (GRCm39) missense probably damaging 1.00
R5588:Ncapg2 UTSW 12 116,376,697 (GRCm39) missense possibly damaging 0.95
R5888:Ncapg2 UTSW 12 116,389,420 (GRCm39) missense possibly damaging 0.84
R5938:Ncapg2 UTSW 12 116,393,277 (GRCm39) missense probably damaging 1.00
R5978:Ncapg2 UTSW 12 116,388,291 (GRCm39) missense possibly damaging 0.68
R6016:Ncapg2 UTSW 12 116,390,227 (GRCm39) missense probably damaging 1.00
R6026:Ncapg2 UTSW 12 116,406,641 (GRCm39) missense possibly damaging 0.73
R6155:Ncapg2 UTSW 12 116,401,631 (GRCm39) missense possibly damaging 0.83
R6509:Ncapg2 UTSW 12 116,391,376 (GRCm39) missense probably damaging 1.00
R6675:Ncapg2 UTSW 12 116,398,281 (GRCm39) missense possibly damaging 0.71
R6912:Ncapg2 UTSW 12 116,390,202 (GRCm39) missense probably benign
R7069:Ncapg2 UTSW 12 116,388,337 (GRCm39) splice site probably null
R7339:Ncapg2 UTSW 12 116,378,454 (GRCm39) missense probably damaging 0.96
R7440:Ncapg2 UTSW 12 116,414,033 (GRCm39) missense possibly damaging 0.89
R7445:Ncapg2 UTSW 12 116,382,888 (GRCm39) missense possibly damaging 0.50
R7704:Ncapg2 UTSW 12 116,382,897 (GRCm39) missense probably damaging 1.00
R8061:Ncapg2 UTSW 12 116,390,197 (GRCm39) missense probably benign
R8166:Ncapg2 UTSW 12 116,376,036 (GRCm39) missense probably benign 0.00
R8351:Ncapg2 UTSW 12 116,403,647 (GRCm39) missense possibly damaging 0.80
R8526:Ncapg2 UTSW 12 116,403,679 (GRCm39) missense probably benign 0.00
R8692:Ncapg2 UTSW 12 116,414,049 (GRCm39) missense probably damaging 1.00
R8739:Ncapg2 UTSW 12 116,379,098 (GRCm39) missense possibly damaging 0.75
R8766:Ncapg2 UTSW 12 116,390,356 (GRCm39) missense probably damaging 1.00
R8929:Ncapg2 UTSW 12 116,415,983 (GRCm39) missense probably damaging 1.00
R9046:Ncapg2 UTSW 12 116,376,145 (GRCm39) missense probably benign 0.01
R9187:Ncapg2 UTSW 12 116,402,287 (GRCm39) missense probably damaging 1.00
R9344:Ncapg2 UTSW 12 116,388,273 (GRCm39) missense probably damaging 1.00
R9444:Ncapg2 UTSW 12 116,370,863 (GRCm39) missense probably damaging 1.00
R9580:Ncapg2 UTSW 12 116,424,228 (GRCm39) missense probably damaging 1.00
R9634:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R9749:Ncapg2 UTSW 12 116,411,368 (GRCm39) nonsense probably null
X0020:Ncapg2 UTSW 12 116,388,327 (GRCm39) missense probably damaging 1.00
Z1177:Ncapg2 UTSW 12 116,402,225 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TATCCTGCCTGAGCTGATGG -3'
(R):5'- GATGGCATCCTCAGCACATG -3'

Sequencing Primer
(F):5'- TTGGCCTGGAACTCACAATG -3'
(R):5'- AGCCAACCAGCTGAATGG -3'
Posted On 2020-06-30