Mutagenetix > Incidental Mutation

Incidental Mutation 'R8133:Cd200l1'

632133

Institutional Source

Beutler Lab

Gene Symbol

Cd200l1

Ensembl Gene

ENSMUSG00000053182

Gene Name

CD200 molecule like 1

Synonyms

iSEC1, LOC208166, LOC385647, Gm609

MMRRC Submission

067561-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R8133 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

45232131-45313332 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 45264304 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 85 (T85A)

Ref Sequence

ENSEMBL: ENSMUSP00000110233 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114585] [ENSMUST00000232138]

AlphaFold

E9Q573

Predicted Effect

probably benign
Transcript: ENSMUST00000114585
AA Change: T85A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000110233
Gene: ENSMUSG00000053182
AA Change: T85A

Domain	Start	End	E-Value	Type
IG	18	125	2.21e-5	SMART
transmembrane domain	233	255	N/A	INTRINSIC
low complexity region	275	289	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000232138

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.9%
20x: 96.3%

Validation Efficiency

98% (48/49)

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	T	11: 110,018,289 (GRCm39)	S1110R	possibly damaging	Het
Adam15	C	T	3: 89,254,513 (GRCm39)	R123Q	probably benign	Het
AI987944	A	G	7: 41,024,489 (GRCm39)		probably null	Het
Ankrd31	T	C	13: 97,003,003 (GRCm39)		probably null	Het
Arfgef3	C	A	10: 18,486,951 (GRCm39)		probably null	Het
Atp6v0c	C	T	17: 24,383,553 (GRCm39)	S98N	possibly damaging	Het
Camsap1	T	C	2: 25,824,309 (GRCm39)	N1417S	probably damaging	Het
Cct7	T	C	6: 85,438,045 (GRCm39)	S96P	probably damaging	Het
Cd38	C	A	5: 44,058,790 (GRCm39)	L135M	probably damaging	Het
Cib4	T	C	5: 30,691,562 (GRCm39)	D53G	probably benign	Het
Cntn6	T	A	6: 104,705,298 (GRCm39)	S244T	probably benign	Het
Cubn	G	T	2: 13,393,659 (GRCm39)	D1447E	probably damaging	Het
Ebf3	T	C	7: 136,914,872 (GRCm39)	E102G	probably damaging	Het
Elmo1	T	A	13: 20,557,256 (GRCm39)	V399E	probably damaging	Het
Etl4	A	G	2: 20,811,082 (GRCm39)	E1423G	possibly damaging	Het
Glis3	A	G	19: 28,327,406 (GRCm39)	S669P	probably benign	Het
Hipk1	T	C	3: 103,660,710 (GRCm39)	T742A	possibly damaging	Het
Igdcc4	C	A	9: 65,039,023 (GRCm39)	T890N	possibly damaging	Het
Jcad	C	T	18: 4,649,384 (GRCm39)	T85I	probably benign	Het
Kmt2d	T	C	15: 98,762,823 (GRCm39)	K316E	probably damaging	Het
Lrig1	T	C	6: 94,588,610 (GRCm39)	D513G	possibly damaging	Het
Lrrn4	T	C	2: 132,719,934 (GRCm39)	N289D	probably damaging	Het
Mcf2l	A	G	8: 13,061,487 (GRCm39)	M829V	probably damaging	Het
Mib2	C	T	4: 155,741,458 (GRCm39)	R495H	probably benign	Het
Nqo2	T	C	13: 34,169,461 (GRCm39)	Y228H	probably benign	Het
Nrg2	T	A	18: 36,165,430 (GRCm39)	E394V	probably benign	Het
Oas1e	T	C	5: 120,926,060 (GRCm39)	N336S	probably benign	Het
Obi1	G	T	14: 104,716,681 (GRCm39)	S564*	probably null	Het
Or51i2	G	T	7: 103,689,122 (GRCm39)	G40W	probably benign	Het
Or52b4i	T	A	7: 102,192,065 (GRCm39)	H307Q	probably benign	Het
Or5b95	T	G	19: 12,657,844 (GRCm39)	V124G	probably damaging	Het
Pax4	T	C	6: 28,442,513 (GRCm39)	D305G	probably benign	Het
Pcdhb16	T	A	18: 37,611,185 (GRCm39)	N48K	probably damaging	Het
Pcdhb20	G	T	18: 37,639,663 (GRCm39)	E730*	probably null	Het
Pde4a	A	T	9: 21,102,673 (GRCm39)	D119V	possibly damaging	Het
Pgam1	T	C	19: 41,904,149 (GRCm39)	V82A	probably benign	Het
Phf11a	C	T	14: 59,521,773 (GRCm39)	G133S	probably damaging	Het
Phlpp1	TGCGCGCGCGC	TGCGCGCGC	1: 106,100,522 (GRCm39)		probably null	Het
Piwil1	T	C	5: 128,826,914 (GRCm39)	V558A	probably damaging	Het
Prpf40b	T	C	15: 99,202,319 (GRCm39)	V59A	unknown	Het
Psd4	T	A	2: 24,286,701 (GRCm39)	S353T	probably benign	Het
Ryr2	A	T	13: 11,618,584 (GRCm39)	L3877H	probably damaging	Het
S100a2	T	C	3: 90,498,616 (GRCm39)	V39A	possibly damaging	Het
Tanc2	T	A	11: 105,814,048 (GRCm39)	S1831T	probably damaging	Het
Zfhx4	A	G	3: 5,465,554 (GRCm39)	K1904R	probably damaging	Het
Zfp141	A	G	7: 42,124,481 (GRCm39)	C664R	probably damaging	Het

Other mutations in Cd200l1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00435:Cd200l1	APN	16	45,264,483 (GRCm39)	missense	probably damaging	1.00
IGL02822:Cd200l1	APN	16	45,262,968 (GRCm39)	missense	probably damaging	0.99
PIT4618001:Cd200l1	UTSW	16	45,264,297 (GRCm39)	missense	probably benign	0.08
R0565:Cd200l1	UTSW	16	45,264,536 (GRCm39)	intron	probably benign
R1561:Cd200l1	UTSW	16	45,262,875 (GRCm39)	missense	possibly damaging	0.90
R4632:Cd200l1	UTSW	16	45,238,271 (GRCm39)	missense	probably benign	0.34
R4667:Cd200l1	UTSW	16	45,264,526 (GRCm39)	missense	probably benign	0.01
R5887:Cd200l1	UTSW	16	45,238,279 (GRCm39)	missense	probably damaging	0.99
R6181:Cd200l1	UTSW	16	45,238,260 (GRCm39)	missense	probably benign	0.01
R6562:Cd200l1	UTSW	16	45,264,442 (GRCm39)	missense	probably benign	0.03
R6922:Cd200l1	UTSW	16	45,264,294 (GRCm39)	missense	probably benign	0.31
R6961:Cd200l1	UTSW	16	45,264,366 (GRCm39)	missense	probably benign	0.32
R7830:Cd200l1	UTSW	16	45,262,917 (GRCm39)	missense	probably damaging	1.00
R8459:Cd200l1	UTSW	16	45,238,271 (GRCm39)	missense	probably benign	0.06
R8483:Cd200l1	UTSW	16	45,240,235 (GRCm39)	missense	possibly damaging	0.92
R8810:Cd200l1	UTSW	16	45,264,199 (GRCm39)	missense	probably benign	0.04
R8950:Cd200l1	UTSW	16	45,263,007 (GRCm39)	missense	possibly damaging	0.46
R8988:Cd200l1	UTSW	16	45,238,271 (GRCm39)	missense	probably benign	0.01
R9040:Cd200l1	UTSW	16	45,264,509 (GRCm39)	missense	possibly damaging	0.82
R9729:Cd200l1	UTSW	16	45,264,237 (GRCm39)	missense	possibly damaging	0.63
X0011:Cd200l1	UTSW	16	45,240,234 (GRCm39)	missense	possibly damaging	0.92
X0019:Cd200l1	UTSW	16	45,263,008 (GRCm39)	missense	probably benign

Predicted Primers

Posted On

2020-06-30