Incidental Mutation 'R8135:Vmn1r74'
| ID |
632219 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r74
|
| Ensembl Gene |
ENSMUSG00000047655 |
| Gene Name |
vomeronasal 1 receptor 74 |
| Synonyms |
V1rg5 |
| MMRRC Submission |
067563-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R8135 (G1)
|
| Quality Score |
205.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
11580702-11581616 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 11581530 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 277
(C277S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000055148
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050416]
[ENSMUST00000228471]
|
| AlphaFold |
Q8R290 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000050416
AA Change: C277S
PolyPhen 2
Score 0.356 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000055148
Gene: ENSMUSG00000047655
AA Change: C277S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
22 |
290 |
1.3e-7 |
PFAM |
|
Pfam:V1R
|
34 |
296 |
1.2e-31 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228471
AA Change: C277S
PolyPhen 2
Score 0.356 (Sensitivity: 0.90; Specificity: 0.89)
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.6%
- 10x: 98.7%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsl3 |
A |
G |
1: 78,674,712 (GRCm39) |
I420V |
probably benign |
Het |
| Adam7 |
A |
T |
14: 68,754,022 (GRCm39) |
M359K |
probably damaging |
Het |
| Adra1d |
C |
T |
2: 131,403,692 (GRCm39) |
A133T |
probably damaging |
Het |
| B3galnt2 |
T |
A |
13: 14,145,454 (GRCm39) |
|
probably null |
Het |
| Camk1g |
A |
G |
1: 193,036,335 (GRCm39) |
V175A |
possibly damaging |
Het |
| Cfi |
A |
G |
3: 129,648,649 (GRCm39) |
N178D |
probably benign |
Het |
| Csf2rb |
T |
A |
15: 78,232,319 (GRCm39) |
I542K |
possibly damaging |
Het |
| Ctsz |
T |
C |
2: 174,270,946 (GRCm39) |
T183A |
probably benign |
Het |
| Dhx8 |
A |
G |
11: 101,629,090 (GRCm39) |
D213G |
unknown |
Het |
| Dph7 |
T |
C |
2: 24,859,556 (GRCm39) |
I271T |
probably benign |
Het |
| Edem1 |
G |
T |
6: 108,806,022 (GRCm39) |
E108* |
probably null |
Het |
| Enpp4 |
T |
C |
17: 44,412,226 (GRCm39) |
T328A |
probably benign |
Het |
| Fasl |
A |
G |
1: 161,614,697 (GRCm39) |
V122A |
probably benign |
Het |
| Fut2 |
T |
C |
7: 45,300,566 (GRCm39) |
T69A |
probably damaging |
Het |
| Gaa |
T |
C |
11: 119,169,210 (GRCm39) |
|
probably null |
Het |
| Galnt5 |
T |
A |
2: 57,904,880 (GRCm39) |
V481D |
probably damaging |
Het |
| Gsdma2 |
A |
G |
11: 98,542,872 (GRCm39) |
I211V |
probably benign |
Het |
| H2-M10.4 |
T |
C |
17: 36,772,662 (GRCm39) |
T107A |
probably benign |
Het |
| Iqcg |
T |
A |
16: 32,849,394 (GRCm39) |
K297N |
probably benign |
Het |
| Map2 |
A |
G |
1: 66,452,828 (GRCm39) |
T573A |
probably damaging |
Het |
| Nhsl1 |
A |
G |
10: 18,407,180 (GRCm39) |
D1438G |
probably damaging |
Het |
| Nipal2 |
A |
T |
15: 34,678,719 (GRCm39) |
Y41N |
possibly damaging |
Het |
| Obscn |
A |
T |
11: 58,922,703 (GRCm39) |
S5878T |
possibly damaging |
Het |
| Pde6a |
T |
C |
18: 61,418,996 (GRCm39) |
F791L |
probably damaging |
Het |
| Phip |
A |
T |
9: 82,812,427 (GRCm39) |
N308K |
probably benign |
Het |
| Pigc |
A |
G |
1: 161,798,134 (GRCm39) |
K39E |
possibly damaging |
Het |
| Robo2 |
T |
G |
16: 73,730,048 (GRCm39) |
I1050L |
probably benign |
Het |
| Rps2 |
A |
G |
17: 24,939,409 (GRCm39) |
K54E |
probably benign |
Het |
| Set |
T |
A |
2: 29,959,439 (GRCm39) |
D137E |
probably benign |
Het |
| Sipa1l1 |
A |
G |
12: 82,388,075 (GRCm39) |
I100M |
probably benign |
Het |
| Spdye4b |
T |
C |
5: 143,180,777 (GRCm39) |
V81A |
probably damaging |
Het |
| Tbc1d2 |
T |
C |
4: 46,609,071 (GRCm39) |
D722G |
probably benign |
Het |
| Tecpr1 |
T |
A |
5: 144,135,420 (GRCm39) |
D1011V |
probably damaging |
Het |
| Unc80 |
A |
T |
1: 66,548,446 (GRCm39) |
I573F |
possibly damaging |
Het |
| Vwa1 |
T |
A |
4: 155,857,351 (GRCm39) |
D149V |
probably damaging |
Het |
| Zfp397 |
T |
A |
18: 24,089,564 (GRCm39) |
V23E |
probably damaging |
Het |
| Zmynd8 |
T |
C |
2: 165,654,346 (GRCm39) |
D722G |
probably damaging |
Het |
|
| Other mutations in Vmn1r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01608:Vmn1r74
|
APN |
7 |
11,581,560 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01673:Vmn1r74
|
APN |
7 |
11,581,317 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03023:Vmn1r74
|
APN |
7 |
11,581,257 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03409:Vmn1r74
|
APN |
7 |
11,581,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0393:Vmn1r74
|
UTSW |
7 |
11,581,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1488:Vmn1r74
|
UTSW |
7 |
11,581,510 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1707:Vmn1r74
|
UTSW |
7 |
11,581,504 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1998:Vmn1r74
|
UTSW |
7 |
11,581,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1999:Vmn1r74
|
UTSW |
7 |
11,581,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2139:Vmn1r74
|
UTSW |
7 |
11,581,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Vmn1r74
|
UTSW |
7 |
11,580,898 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4576:Vmn1r74
|
UTSW |
7 |
11,580,696 (GRCm39) |
splice site |
probably null |
|
|
R4619:Vmn1r74
|
UTSW |
7 |
11,581,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Vmn1r74
|
UTSW |
7 |
11,581,398 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5371:Vmn1r74
|
UTSW |
7 |
11,580,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5606:Vmn1r74
|
UTSW |
7 |
11,580,822 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6464:Vmn1r74
|
UTSW |
7 |
11,581,131 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6901:Vmn1r74
|
UTSW |
7 |
11,581,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn1r74
|
UTSW |
7 |
11,581,575 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7223:Vmn1r74
|
UTSW |
7 |
11,580,894 (GRCm39) |
nonsense |
probably null |
|
|
R7231:Vmn1r74
|
UTSW |
7 |
11,580,888 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7418:Vmn1r74
|
UTSW |
7 |
11,581,081 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8692:Vmn1r74
|
UTSW |
7 |
11,580,972 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8748:Vmn1r74
|
UTSW |
7 |
11,580,903 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9004:Vmn1r74
|
UTSW |
7 |
11,580,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9258:Vmn1r74
|
UTSW |
7 |
11,580,999 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9564:Vmn1r74
|
UTSW |
7 |
11,581,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF049:Vmn1r74
|
UTSW |
7 |
11,581,067 (GRCm39) |
frame shift |
probably null |
|
|
RF063:Vmn1r74
|
UTSW |
7 |
11,581,067 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn1r74
|
UTSW |
7 |
11,580,936 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCCATGGTGAGTATTCTCTACAGAC -3'
(R):5'- ATGTCATAGCATTGCACAACAG -3'
Sequencing Primer
(F):5'- TGGTGAGTATTCTCTACAGACATAAG -3'
(R):5'- TGTCATAGCATTGCACAACAGATAAC -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation