Incidental Mutation 'R8136:Zfp39'
ID 632263
Institutional Source Beutler Lab
Gene Symbol Zfp39
Ensembl Gene ENSMUSG00000037001
Gene Name zinc finger protein 39
Synonyms Zfp-39, CTfin33
MMRRC Submission 067564-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # R8136 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 58778979-58795051 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58782228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 178 (V178D)
Ref Sequence ENSEMBL: ENSMUSP00000099764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102703]
AlphaFold Q02525
Predicted Effect probably damaging
Transcript: ENSMUST00000102703
AA Change: V178D

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000099764
Gene: ENSMUSG00000037001
AA Change: V178D

DomainStartEndE-ValueType
KRAB 59 119 8.23e-34 SMART
low complexity region 171 180 N/A INTRINSIC
ZnF_C2H2 298 320 9.58e-3 SMART
ZnF_C2H2 326 347 2.2e2 SMART
ZnF_C2H2 353 373 1.18e2 SMART
ZnF_C2H2 409 431 8.34e-3 SMART
ZnF_C2H2 437 459 7.26e-3 SMART
ZnF_C2H2 465 487 1.53e-1 SMART
ZnF_C2H2 493 515 9.08e-4 SMART
ZnF_C2H2 521 543 2.61e-4 SMART
ZnF_C2H2 549 571 1.12e-3 SMART
ZnF_C2H2 577 599 4.94e-5 SMART
ZnF_C2H2 605 627 5.14e-3 SMART
ZnF_C2H2 633 655 1.38e-3 SMART
ZnF_C2H2 661 683 6.78e-3 SMART
ZnF_C2H2 689 711 5.14e-3 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.9%
  • 20x: 96.7%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T A 1: 71,287,556 (GRCm39) M2462L probably benign Het
Aptx A G 4: 40,688,107 (GRCm39) probably null Het
Bmpr1b A G 3: 141,562,143 (GRCm39) I348T probably damaging Het
Btnl1 T A 17: 34,599,014 (GRCm39) probably null Het
Col27a1 T A 4: 63,202,190 (GRCm39) D960E probably benign Het
Crygn G T 5: 24,956,090 (GRCm39) R172S probably benign Het
Cyp26a1 T C 19: 37,689,654 (GRCm39) I450T probably benign Het
Emc2 A G 15: 43,375,202 (GRCm39) Y233C probably benign Het
Esyt2 C A 12: 116,327,079 (GRCm39) T549K probably benign Het
Garin5a T C 7: 44,149,704 (GRCm39) F142L probably damaging Het
Gatm T C 2: 122,426,018 (GRCm39) D411G probably damaging Het
Gpr65 T C 12: 98,241,415 (GRCm39) Y23H probably damaging Het
Itpr1 A G 6: 108,415,321 (GRCm39) R1752G probably benign Het
Krtap4-1 GGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGC GGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGC 11: 99,518,660 (GRCm39) probably benign Het
Map3k19 A C 1: 127,751,492 (GRCm39) S620A probably damaging Het
Mcm9 A G 10: 53,487,439 (GRCm39) *543Q probably null Het
Mfsd2a A T 4: 122,845,660 (GRCm39) C164S probably benign Het
Mta1 C A 12: 113,095,298 (GRCm39) R484S probably damaging Het
Nlrp9a T G 7: 26,256,678 (GRCm39) F99V probably benign Het
Notch2 G A 3: 98,031,537 (GRCm39) C1137Y probably damaging Het
Or51a6 A T 7: 102,604,448 (GRCm39) M120K probably damaging Het
Pcnx1 A G 12: 81,964,780 (GRCm39) T316A probably benign Het
Peds1 A C 2: 167,486,879 (GRCm39) Y167D probably benign Het
Phf11a A G 14: 59,515,018 (GRCm39) V221A probably benign Het
Pigb A G 9: 72,929,602 (GRCm39) L327P possibly damaging Het
Rab3c A T 13: 110,317,554 (GRCm39) Y110* probably null Het
Sdk2 G A 11: 113,742,539 (GRCm39) T790M probably damaging Het
Skic3 A G 13: 76,261,222 (GRCm39) K131R probably benign Het
Slc22a2 C T 17: 12,824,917 (GRCm39) P260S probably damaging Het
Sppl2a T C 2: 126,755,201 (GRCm39) probably null Het
Tnn T A 1: 159,934,630 (GRCm39) Q1261L probably damaging Het
Treml4 C A 17: 48,571,745 (GRCm39) Y49* probably null Het
Ubr3 T C 2: 69,851,523 (GRCm39) I1827T probably damaging Het
Vrtn C T 12: 84,696,809 (GRCm39) R520C probably damaging Het
Wipf1 G A 2: 73,267,879 (GRCm39) P173L possibly damaging Het
Wls C A 3: 159,578,761 (GRCm39) Q108K probably damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp777 C A 6: 48,021,559 (GRCm39) R21L probably benign Het
Other mutations in Zfp39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Zfp39 APN 11 58,783,885 (GRCm39) splice site probably benign
IGL01597:Zfp39 APN 11 58,782,369 (GRCm39) missense probably damaging 0.96
IGL02055:Zfp39 APN 11 58,782,156 (GRCm39) missense probably benign
IGL02456:Zfp39 APN 11 58,793,626 (GRCm39) nonsense probably null
IGL02873:Zfp39 APN 11 58,781,848 (GRCm39) missense probably benign 0.12
H8562:Zfp39 UTSW 11 58,791,512 (GRCm39) missense probably damaging 1.00
R0462:Zfp39 UTSW 11 58,781,232 (GRCm39) missense probably benign 0.03
R0513:Zfp39 UTSW 11 58,780,813 (GRCm39) missense probably benign 0.09
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1401:Zfp39 UTSW 11 58,781,149 (GRCm39) missense probably benign 0.01
R1797:Zfp39 UTSW 11 58,791,486 (GRCm39) missense probably damaging 0.96
R2146:Zfp39 UTSW 11 58,781,158 (GRCm39) missense probably benign 0.05
R3903:Zfp39 UTSW 11 58,781,001 (GRCm39) missense probably benign 0.44
R4303:Zfp39 UTSW 11 58,780,843 (GRCm39) missense probably damaging 1.00
R4706:Zfp39 UTSW 11 58,793,633 (GRCm39) missense probably benign 0.41
R4957:Zfp39 UTSW 11 58,782,057 (GRCm39) missense possibly damaging 0.63
R5092:Zfp39 UTSW 11 58,782,028 (GRCm39) missense possibly damaging 0.71
R5158:Zfp39 UTSW 11 58,780,671 (GRCm39) missense possibly damaging 0.81
R5292:Zfp39 UTSW 11 58,791,415 (GRCm39) missense probably damaging 0.97
R5697:Zfp39 UTSW 11 58,780,661 (GRCm39) missense probably benign 0.08
R5906:Zfp39 UTSW 11 58,793,717 (GRCm39) missense probably benign
R5925:Zfp39 UTSW 11 58,782,099 (GRCm39) missense possibly damaging 0.94
R6174:Zfp39 UTSW 11 58,782,213 (GRCm39) missense probably benign 0.01
R6177:Zfp39 UTSW 11 58,781,887 (GRCm39) missense probably benign 0.27
R6968:Zfp39 UTSW 11 58,782,306 (GRCm39) missense probably benign 0.00
R7045:Zfp39 UTSW 11 58,781,269 (GRCm39) missense unknown
R7139:Zfp39 UTSW 11 58,781,385 (GRCm39) missense probably damaging 1.00
R7421:Zfp39 UTSW 11 58,780,933 (GRCm39) missense probably damaging 1.00
R7493:Zfp39 UTSW 11 58,781,869 (GRCm39) missense possibly damaging 0.82
R7689:Zfp39 UTSW 11 58,781,469 (GRCm39) missense probably damaging 1.00
R8061:Zfp39 UTSW 11 58,793,573 (GRCm39) missense probably benign
R8955:Zfp39 UTSW 11 58,780,946 (GRCm39) nonsense probably null
Z1186:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1186:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1186:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1186:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1186:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1186:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1186:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1186:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1186:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1186:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1186:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1187:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1187:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1187:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1187:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1187:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1187:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1187:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1187:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1187:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1187:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1187:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1187:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1188:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1188:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1188:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1188:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1188:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1188:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1188:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1188:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1188:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1188:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1188:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1188:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1189:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1189:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1189:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1189:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1189:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1189:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1189:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1189:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1189:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1189:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1189:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1190:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1190:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1190:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1190:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1190:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1190:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1190:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1190:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1190:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1190:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1190:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1190:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1191:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1191:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1191:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1191:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1191:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1191:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1191:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1191:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1191:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1191:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1191:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1191:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1192:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1192:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1192:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1192:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1192:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1192:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1192:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1192:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1192:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1192:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1192:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1192:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTGCATACAACACTGAAACTGC -3'
(R):5'- CTGTAACATGAGCTTGGCGAC -3'

Sequencing Primer
(F):5'- GCCTGGAGCTCTGCTATACAAC -3'
(R):5'- TGGCACCATGCAATTACC -3'
Posted On 2020-06-30