Incidental Mutation 'R8136:Treml4'
ID 632276
Institutional Source Beutler Lab
Gene Symbol Treml4
Ensembl Gene ENSMUSG00000051682
Gene Name triggering receptor expressed on myeloid cells-like 4
Synonyms 5031403H21Rik
MMRRC Submission 067564-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R8136 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 48571323-48582388 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 48571745 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 49 (Y49*)
Ref Sequence ENSEMBL: ENSMUSP00000118772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059873] [ENSMUST00000125426] [ENSMUST00000136272] [ENSMUST00000153420] [ENSMUST00000154335]
AlphaFold Q3LRV9
Predicted Effect probably null
Transcript: ENSMUST00000059873
AA Change: Y49*
SMART Domains Protein: ENSMUSP00000054121
Gene: ENSMUSG00000051682
AA Change: Y49*

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000125426
AA Change: Y45*
SMART Domains Protein: ENSMUSP00000119177
Gene: ENSMUSG00000051682
AA Change: Y45*

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 28 133 6.51e-3 SMART
transmembrane domain 196 218 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000136272
AA Change: Y49*
SMART Domains Protein: ENSMUSP00000120550
Gene: ENSMUSG00000051682
AA Change: Y49*

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
transmembrane domain 192 214 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000153420
AA Change: Y49*
SMART Domains Protein: ENSMUSP00000115290
Gene: ENSMUSG00000051682
AA Change: Y49*

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000154335
AA Change: Y49*
SMART Domains Protein: ENSMUSP00000118772
Gene: ENSMUSG00000051682
AA Change: Y49*

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
transmembrane domain 201 223 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.9%
  • 20x: 96.7%
Validation Efficiency 98% (40/41)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele do not exhibit any significant alterations in the uptake and cross-presentation of dying cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T A 1: 71,287,556 (GRCm39) M2462L probably benign Het
Aptx A G 4: 40,688,107 (GRCm39) probably null Het
Bmpr1b A G 3: 141,562,143 (GRCm39) I348T probably damaging Het
Btnl1 T A 17: 34,599,014 (GRCm39) probably null Het
Col27a1 T A 4: 63,202,190 (GRCm39) D960E probably benign Het
Crygn G T 5: 24,956,090 (GRCm39) R172S probably benign Het
Cyp26a1 T C 19: 37,689,654 (GRCm39) I450T probably benign Het
Emc2 A G 15: 43,375,202 (GRCm39) Y233C probably benign Het
Esyt2 C A 12: 116,327,079 (GRCm39) T549K probably benign Het
Garin5a T C 7: 44,149,704 (GRCm39) F142L probably damaging Het
Gatm T C 2: 122,426,018 (GRCm39) D411G probably damaging Het
Gpr65 T C 12: 98,241,415 (GRCm39) Y23H probably damaging Het
Itpr1 A G 6: 108,415,321 (GRCm39) R1752G probably benign Het
Krtap4-1 GGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGC GGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGCTGCAGCAAGGGCTGCAGCAGGGGC 11: 99,518,660 (GRCm39) probably benign Het
Map3k19 A C 1: 127,751,492 (GRCm39) S620A probably damaging Het
Mcm9 A G 10: 53,487,439 (GRCm39) *543Q probably null Het
Mfsd2a A T 4: 122,845,660 (GRCm39) C164S probably benign Het
Mta1 C A 12: 113,095,298 (GRCm39) R484S probably damaging Het
Nlrp9a T G 7: 26,256,678 (GRCm39) F99V probably benign Het
Notch2 G A 3: 98,031,537 (GRCm39) C1137Y probably damaging Het
Or51a6 A T 7: 102,604,448 (GRCm39) M120K probably damaging Het
Pcnx1 A G 12: 81,964,780 (GRCm39) T316A probably benign Het
Peds1 A C 2: 167,486,879 (GRCm39) Y167D probably benign Het
Phf11a A G 14: 59,515,018 (GRCm39) V221A probably benign Het
Pigb A G 9: 72,929,602 (GRCm39) L327P possibly damaging Het
Rab3c A T 13: 110,317,554 (GRCm39) Y110* probably null Het
Sdk2 G A 11: 113,742,539 (GRCm39) T790M probably damaging Het
Skic3 A G 13: 76,261,222 (GRCm39) K131R probably benign Het
Slc22a2 C T 17: 12,824,917 (GRCm39) P260S probably damaging Het
Sppl2a T C 2: 126,755,201 (GRCm39) probably null Het
Tnn T A 1: 159,934,630 (GRCm39) Q1261L probably damaging Het
Ubr3 T C 2: 69,851,523 (GRCm39) I1827T probably damaging Het
Vrtn C T 12: 84,696,809 (GRCm39) R520C probably damaging Het
Wipf1 G A 2: 73,267,879 (GRCm39) P173L possibly damaging Het
Wls C A 3: 159,578,761 (GRCm39) Q108K probably damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp39 A T 11: 58,782,228 (GRCm39) V178D probably damaging Het
Zfp777 C A 6: 48,021,559 (GRCm39) R21L probably benign Het
Other mutations in Treml4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01407:Treml4 APN 17 48,571,877 (GRCm39) missense possibly damaging 0.82
IGL01451:Treml4 APN 17 48,572,023 (GRCm39) splice site probably benign
IGL01787:Treml4 APN 17 48,571,732 (GRCm39) missense probably damaging 1.00
R0027:Treml4 UTSW 17 48,571,962 (GRCm39) missense possibly damaging 0.82
R1975:Treml4 UTSW 17 48,579,821 (GRCm39) missense probably damaging 1.00
R4013:Treml4 UTSW 17 48,571,837 (GRCm39) missense probably benign 0.09
R4327:Treml4 UTSW 17 48,581,417 (GRCm39) missense probably damaging 0.98
R5586:Treml4 UTSW 17 48,571,927 (GRCm39) missense probably damaging 1.00
R6220:Treml4 UTSW 17 48,571,876 (GRCm39) missense possibly damaging 0.91
R6510:Treml4 UTSW 17 48,581,472 (GRCm39) missense probably benign
R6964:Treml4 UTSW 17 48,579,847 (GRCm39) critical splice donor site probably null
R8289:Treml4 UTSW 17 48,581,456 (GRCm39) missense probably benign 0.23
R9070:Treml4 UTSW 17 48,576,781 (GRCm39) missense probably damaging 1.00
R9574:Treml4 UTSW 17 48,571,672 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGTTGGAAGTCATTGCCTC -3'
(R):5'- ACAGTTACTTCTCTGAGGGAAGG -3'

Sequencing Primer
(F):5'- ACCTCTGACCTGACAGTT -3'
(R):5'- AGTAGAACGCTGAGTCATCCTCTG -3'
Posted On 2020-06-30