Incidental Mutation 'R8137:Ifi204'
| ID |
632284 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ifi204
|
| Ensembl Gene |
ENSMUSG00000073489 |
| Gene Name |
interferon activated gene 204 |
| Synonyms |
p204 |
| MMRRC Submission |
067565-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R8137 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
173574859-173594509 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 173589188 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 81
(I81T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106845
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000111214]
|
| AlphaFold |
P0DOV2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111214
AA Change: I81T
PolyPhen 2
Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000106845
Gene: ENSMUSG00000073489
AA Change: I81T
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
6 |
84 |
8.33e-14 |
SMART |
|
low complexity region
|
120 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
206 |
N/A |
INTRINSIC |
|
Pfam:HIN
|
225 |
393 |
6.2e-78 |
PFAM |
|
Pfam:HIN
|
429 |
595 |
9.8e-78 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.6%
- 10x: 98.8%
- 20x: 96.4%
|
| Validation Efficiency |
100% (56/56) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankfn1 |
T |
G |
11: 89,344,003 (GRCm39) |
Q326H |
probably benign |
Het |
| Carf |
G |
A |
1: 60,187,124 (GRCm39) |
V576I |
probably benign |
Het |
| Ccnl1 |
C |
T |
3: 65,865,291 (GRCm39) |
D87N |
possibly damaging |
Het |
| Cgref1 |
T |
A |
5: 31,091,749 (GRCm39) |
D111V |
possibly damaging |
Het |
| Cnot4 |
G |
A |
6: 35,023,222 (GRCm39) |
P567S |
unknown |
Het |
| Cyp7b1 |
A |
T |
3: 18,151,765 (GRCm39) |
D149E |
probably benign |
Het |
| Dcc |
A |
T |
18: 71,511,783 (GRCm39) |
D877E |
probably benign |
Het |
| Dhx8 |
T |
A |
11: 101,654,808 (GRCm39) |
I1032N |
probably damaging |
Het |
| Dnah7b |
A |
G |
1: 46,272,913 (GRCm39) |
Y2347C |
probably damaging |
Het |
| Dtx3 |
A |
G |
10: 127,029,041 (GRCm39) |
S63P |
possibly damaging |
Het |
| Dyrk2 |
C |
T |
10: 118,695,789 (GRCm39) |
E490K |
probably benign |
Het |
| Fcgbp |
A |
C |
7: 27,804,496 (GRCm39) |
Y1868S |
probably damaging |
Het |
| Foxa2 |
T |
C |
2: 147,885,768 (GRCm39) |
H355R |
probably benign |
Het |
| Fpr-rs7 |
A |
G |
17: 20,334,055 (GRCm39) |
V145A |
possibly damaging |
Het |
| Gm14137 |
A |
T |
2: 119,005,837 (GRCm39) |
E132V |
probably benign |
Het |
| Gpn2 |
T |
C |
4: 133,315,873 (GRCm39) |
S211P |
possibly damaging |
Het |
| Greb1l |
A |
T |
18: 10,474,357 (GRCm39) |
Q224L |
possibly damaging |
Het |
| Gspt1 |
A |
G |
16: 11,058,532 (GRCm39) |
V144A |
probably benign |
Het |
| Il27ra |
T |
A |
8: 84,767,720 (GRCm39) |
|
probably null |
Het |
| Kif21a |
T |
C |
15: 90,852,645 (GRCm39) |
T862A |
probably benign |
Het |
| Klf2 |
T |
C |
8: 73,074,088 (GRCm39) |
|
probably null |
Het |
| Kmt2e |
A |
G |
5: 23,706,952 (GRCm39) |
Y1505C |
probably damaging |
Het |
| Mcm9 |
T |
C |
10: 53,499,076 (GRCm39) |
T216A |
|
Het |
| Muc16 |
T |
C |
9: 18,556,972 (GRCm39) |
E3107G |
unknown |
Het |
| Ncor2 |
C |
T |
5: 125,114,957 (GRCm39) |
V169I |
|
Het |
| Oas3 |
T |
C |
5: 120,915,565 (GRCm39) |
Q42R |
probably benign |
Het |
| Or2l5 |
A |
G |
16: 19,333,846 (GRCm39) |
V180A |
possibly damaging |
Het |
| Or4p8 |
T |
C |
2: 88,727,013 (GRCm39) |
*309W |
probably null |
Het |
| Pde10a |
A |
G |
17: 9,193,647 (GRCm39) |
Y693C |
possibly damaging |
Het |
| Pde11a |
T |
C |
2: 76,041,383 (GRCm39) |
E429G |
possibly damaging |
Het |
| Pramel23 |
A |
G |
4: 143,425,835 (GRCm39) |
F36S |
probably damaging |
Het |
| Pygo1 |
A |
G |
9: 72,852,140 (GRCm39) |
H109R |
probably damaging |
Het |
| Rbsn |
A |
T |
6: 92,167,003 (GRCm39) |
V547D |
probably benign |
Het |
| Ros1 |
A |
G |
10: 52,001,933 (GRCm39) |
I1084T |
possibly damaging |
Het |
| Sis |
T |
C |
3: 72,796,378 (GRCm39) |
D1801G |
probably benign |
Het |
| Slco4c1 |
C |
T |
1: 96,748,970 (GRCm39) |
G649E |
probably damaging |
Het |
| Spmip10 |
A |
G |
18: 56,727,653 (GRCm39) |
D117G |
probably damaging |
Het |
| Sptbn2 |
A |
T |
19: 4,787,431 (GRCm39) |
I914F |
possibly damaging |
Het |
| Srebf2 |
C |
T |
15: 82,062,966 (GRCm39) |
R468C |
probably damaging |
Het |
| Strc |
C |
T |
2: 121,197,219 (GRCm39) |
G1503R |
probably damaging |
Het |
| Sv2c |
T |
A |
13: 96,225,171 (GRCm39) |
Y46F |
probably damaging |
Het |
| Tctn3 |
A |
T |
19: 40,593,785 (GRCm39) |
W462R |
probably damaging |
Het |
| Tjp3 |
T |
C |
10: 81,109,525 (GRCm39) |
D857G |
probably benign |
Het |
| Tor1aip2 |
C |
T |
1: 155,939,414 (GRCm39) |
T242I |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,800,273 (GRCm39) |
I312F |
unknown |
Het |
| Vezt |
T |
C |
10: 93,775,154 (GRCm39) |
N94D |
|
Het |
| Vmn2r105 |
T |
C |
17: 20,454,966 (GRCm39) |
N57D |
probably benign |
Het |
| Wdr59 |
T |
C |
8: 112,212,011 (GRCm39) |
D353G |
|
Het |
| Ykt6 |
T |
C |
11: 5,909,368 (GRCm39) |
V59A |
probably damaging |
Het |
| Ypel3 |
T |
G |
7: 126,377,269 (GRCm39) |
V54G |
possibly damaging |
Het |
| Zfp386 |
T |
A |
12: 116,023,268 (GRCm39) |
C329S |
possibly damaging |
Het |
| Zfp451 |
A |
T |
1: 33,821,156 (GRCm39) |
L232H |
possibly damaging |
Het |
| Zfp648 |
A |
G |
1: 154,081,110 (GRCm39) |
H423R |
probably damaging |
Het |
| Zfp729b |
T |
C |
13: 67,740,861 (GRCm39) |
Y468C |
probably damaging |
Het |
|
| Other mutations in Ifi204 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00906:Ifi204
|
APN |
1 |
173,587,197 (GRCm39) |
splice site |
probably benign |
|
|
IGL01922:Ifi204
|
APN |
1 |
173,589,288 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02296:Ifi204
|
APN |
1 |
173,576,880 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02419:Ifi204
|
APN |
1 |
173,576,946 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02505:Ifi204
|
APN |
1 |
173,583,220 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0938:Ifi204
|
UTSW |
1 |
173,579,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1363:Ifi204
|
UTSW |
1 |
173,576,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1834:Ifi204
|
UTSW |
1 |
173,575,172 (GRCm39) |
missense |
unknown |
|
|
R2031:Ifi204
|
UTSW |
1 |
173,580,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2254:Ifi204
|
UTSW |
1 |
173,589,296 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2379:Ifi204
|
UTSW |
1 |
173,583,559 (GRCm39) |
nonsense |
probably null |
|
|
R2408:Ifi204
|
UTSW |
1 |
173,583,198 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3011:Ifi204
|
UTSW |
1 |
173,579,217 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3617:Ifi204
|
UTSW |
1 |
173,583,283 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R3894:Ifi204
|
UTSW |
1 |
173,576,774 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Ifi204
|
UTSW |
1 |
173,583,341 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4656:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4657:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4694:Ifi204
|
UTSW |
1 |
173,576,825 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4703:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4704:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4894:Ifi204
|
UTSW |
1 |
173,587,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4947:Ifi204
|
UTSW |
1 |
173,583,316 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5023:Ifi204
|
UTSW |
1 |
173,579,306 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5036:Ifi204
|
UTSW |
1 |
173,580,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5119:Ifi204
|
UTSW |
1 |
173,583,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5194:Ifi204
|
UTSW |
1 |
173,576,910 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5762:Ifi204
|
UTSW |
1 |
173,580,325 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6063:Ifi204
|
UTSW |
1 |
173,579,223 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6808:Ifi204
|
UTSW |
1 |
173,589,269 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7311:Ifi204
|
UTSW |
1 |
173,587,134 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7338:Ifi204
|
UTSW |
1 |
173,587,703 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7430:Ifi204
|
UTSW |
1 |
173,583,247 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7528:Ifi204
|
UTSW |
1 |
173,579,406 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7985:Ifi204
|
UTSW |
1 |
173,587,772 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8021:Ifi204
|
UTSW |
1 |
173,586,919 (GRCm39) |
intron |
probably benign |
|
|
R8141:Ifi204
|
UTSW |
1 |
173,583,189 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8191:Ifi204
|
UTSW |
1 |
173,579,226 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8487:Ifi204
|
UTSW |
1 |
173,587,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9075:Ifi204
|
UTSW |
1 |
173,589,282 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9124:Ifi204
|
UTSW |
1 |
173,579,193 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9311:Ifi204
|
UTSW |
1 |
173,589,215 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9498:Ifi204
|
UTSW |
1 |
173,583,537 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9712:Ifi204
|
UTSW |
1 |
173,576,924 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Ifi204
|
UTSW |
1 |
173,579,194 (GRCm39) |
missense |
probably null |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAAGACAAACGTCCTCAGTAG -3'
(R):5'- AGAATTGTTCTGCTGAGAGGAC -3'
Sequencing Primer
(F):5'- CGTCCTCAGTAGCTAATCCAAAG -3'
(R):5'- CTGCTGAGAGGACTTGAATGTATC -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation