|Institutional Source||Beutler Lab|
|Gene Name||prostaglandin D receptor|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8139 (G1)|
|Chromosomal Location||44851235-44859375 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 44858685 bp|
|Amino Acid Change||Glutamic Acid to Glycine at position 190 (E190G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000093653 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000095959]|
|Predicted Effect||probably benign
AA Change: E190G
PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)
AA Change: E190G
|Coding Region Coverage||
|Validation Efficiency||100% (84/84)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for disruptions in this gene display a reduced inflammatory response to airborn allergens and reduced susceptibility to passive cutaneous anaphylaxis induced by IgE antigen challenge due to impaired mast cell degranulation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptgdr||
(F):5'- CTGTAGTCTGAGCCTGACTG -3'
(R):5'- TAGCCTCGACCTTACAGCTG -3'
(F):5'- CTGACTGGGCGCGGTCC -3'
(R):5'- CGACCTTACAGCTGTTGGC -3'