Incidental Mutation 'R0042:Ccnb2'
ID 63249
Institutional Source Beutler Lab
Gene Symbol Ccnb2
Ensembl Gene ENSMUSG00000032218
Gene Name cyclin B2
Synonyms CycB2
MMRRC Submission 038336-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.574) question?
Stock # R0042 (G1)
Quality Score 102
Status Validated
Chromosome 9
Chromosomal Location 70314974-70328829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70326335 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 34 (V34A)
Ref Sequence ENSEMBL: ENSMUSP00000034742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034742]
AlphaFold P30276
Predicted Effect probably benign
Transcript: ENSMUST00000034742
AA Change: V34A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034742
Gene: ENSMUSG00000032218
AA Change: V34A

DomainStartEndE-ValueType
CYCLIN 171 255 8.58e-28 SMART
Cyclin_C 264 382 9.83e-34 SMART
CYCLIN 268 349 2.73e-21 SMART
Meta Mutation Damage Score 0.0634 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 C T 4: 53,059,245 (GRCm39) probably benign Het
Acr T A 15: 89,458,535 (GRCm39) H405Q probably benign Het
Adad1 T C 3: 37,137,322 (GRCm39) probably benign Het
Alox5ap T C 5: 149,216,069 (GRCm39) probably benign Het
Ank2 T C 3: 126,730,280 (GRCm39) D3568G probably damaging Het
Atl3 T G 19: 7,506,388 (GRCm39) I306S probably damaging Het
Atr T A 9: 95,809,409 (GRCm39) probably benign Het
Cdh12 A C 15: 21,537,763 (GRCm39) probably benign Het
Cib1 C T 7: 79,880,126 (GRCm39) V45M probably benign Het
Col6a6 T C 9: 105,657,896 (GRCm39) E772G possibly damaging Het
Dmxl1 C A 18: 49,997,102 (GRCm39) T466K probably benign Het
Dym T C 18: 75,258,610 (GRCm39) probably null Het
Enpp3 A C 10: 24,650,722 (GRCm39) F805V probably damaging Het
Eya1 T C 1: 14,254,713 (GRCm39) D373G probably damaging Het
Gpr179 C T 11: 97,225,757 (GRCm39) V2133I probably benign Het
Grb10 G T 11: 11,886,798 (GRCm39) H435Q probably damaging Het
Gzmm T C 10: 79,530,399 (GRCm39) I190T probably benign Het
Helt T C 8: 46,745,433 (GRCm39) Y150C probably damaging Het
Hrg A T 16: 22,779,886 (GRCm39) probably benign Het
Il17ra T C 6: 120,449,086 (GRCm39) probably benign Het
Inhbc A G 10: 127,193,302 (GRCm39) I238T probably benign Het
Itgb3 A G 11: 104,557,966 (GRCm39) T787A possibly damaging Het
Jakmip2 T G 18: 43,685,210 (GRCm39) probably benign Het
Krt4 T G 15: 101,831,187 (GRCm39) probably benign Het
Lgsn C T 1: 31,229,534 (GRCm39) T85I probably benign Het
Metap1 C T 3: 138,177,918 (GRCm39) V217I probably benign Het
Mib2 A T 4: 155,743,897 (GRCm39) C48* probably null Het
Mroh4 T A 15: 74,482,154 (GRCm39) I768F probably damaging Het
Npas3 T A 12: 54,095,624 (GRCm39) D361E probably damaging Het
Obscn A G 11: 58,943,411 (GRCm39) L4246P probably damaging Het
Or4a78 A C 2: 89,497,798 (GRCm39) V144G probably benign Het
Or7e169 A G 9: 19,757,075 (GRCm39) M280T probably benign Het
Or8h7 A G 2: 86,720,835 (GRCm39) I228T probably damaging Het
P4hb G A 11: 120,459,092 (GRCm39) R134C probably damaging Het
Plcb3 T C 19: 6,943,788 (GRCm39) D71G probably damaging Het
Prex2 T A 1: 11,150,305 (GRCm39) V159E probably damaging Het
Prpsap1 T A 11: 116,370,482 (GRCm39) K158N probably benign Het
Prr35 C A 17: 26,166,956 (GRCm39) E194* probably null Het
Ptger1 G T 8: 84,394,795 (GRCm39) V91L probably benign Het
Rdh10 T C 1: 16,178,260 (GRCm39) probably benign Het
Rgs9bp C A 7: 35,284,458 (GRCm39) R63L probably damaging Het
Slc13a5 A T 11: 72,149,940 (GRCm39) V173E probably benign Het
Spata31 A T 13: 65,070,377 (GRCm39) I842L probably benign Het
Stk32b A C 5: 37,874,092 (GRCm39) D13E probably benign Het
Svep1 T C 4: 58,123,192 (GRCm39) D708G possibly damaging Het
Taar6 T C 10: 23,861,021 (GRCm39) D175G probably benign Het
Thbs1 A C 2: 117,953,358 (GRCm39) D925A probably damaging Het
Tnr A T 1: 159,714,595 (GRCm39) T825S probably benign Het
Ttc23l A C 15: 10,551,627 (GRCm39) L33W probably damaging Het
Ttc39d T C 17: 80,523,379 (GRCm39) Y13H probably benign Het
Vmn2r102 C A 17: 19,880,851 (GRCm39) P64Q probably damaging Het
Vps11 G T 9: 44,267,588 (GRCm39) Y341* probably null Het
Vsig8 T C 1: 172,387,925 (GRCm39) V5A possibly damaging Het
Vwce C T 19: 10,624,177 (GRCm39) A356V probably benign Het
Other mutations in Ccnb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Ccnb2 APN 9 70,326,189 (GRCm39) missense probably damaging 0.96
IGL01474:Ccnb2 APN 9 70,326,305 (GRCm39) missense probably benign
IGL03097:Ccnb2 APN 9 70,316,678 (GRCm39) splice site probably benign
IGL03298:Ccnb2 APN 9 70,326,156 (GRCm39) missense probably benign
R0042:Ccnb2 UTSW 9 70,326,335 (GRCm39) missense probably benign
R1585:Ccnb2 UTSW 9 70,317,559 (GRCm39) splice site probably null
R1756:Ccnb2 UTSW 9 70,318,070 (GRCm39) missense probably benign 0.41
R2046:Ccnb2 UTSW 9 70,316,629 (GRCm39) missense probably benign 0.11
R6045:Ccnb2 UTSW 9 70,326,375 (GRCm39) missense probably benign
R7202:Ccnb2 UTSW 9 70,318,128 (GRCm39) missense probably damaging 1.00
R7623:Ccnb2 UTSW 9 70,326,170 (GRCm39) missense probably benign
R8515:Ccnb2 UTSW 9 70,320,382 (GRCm39) critical splice donor site probably null
R9072:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9073:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9235:Ccnb2 UTSW 9 70,318,163 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CTCCATCTGCACTGGTTTCACAGAG -3'
(R):5'- CAGCATATTCACCTTACCAGGGTAGC -3'

Sequencing Primer
(F):5'- CACTTTGGTGGGCAGAGC -3'
(R):5'- ACCTTACCAGGGTAGCTCTGAC -3'
Posted On 2013-07-30