|Institutional Source||Beutler Lab|
|Gene Name||GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein|
|Is this an essential gene?||Probably non essential (E-score: 0.135)|
|Stock #||R8141 (G1)|
|Chromosomal Location||101224188-101232756 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 101231909 bp|
|Amino Acid Change||Cysteine to Serine at position 358 (C358S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000000543 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000000543]|
|Predicted Effect||possibly damaging
AA Change: C358S
PolyPhen 2 Score 0.724 (Sensitivity: 0.86; Specificity: 0.92)
AA Change: C358S
|Coding Region Coverage||
|Validation Efficiency||100% (59/59)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for targeted null mutations develop and behave normally under ordinary conditions but display a marked reduction in sensitivity to acute morphine responses and impaired adaptive responses to morphine and cocaine. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Grasp||
(F):5'- TACCACACGTGCTTCTTTGGG -3'
(R):5'- TGTTCAGCAGACAAGCCAATG -3'
(F):5'- CTTCTTTGGGGGCGCCG -3'
(R):5'- GTCCTTGGACCGACACTAC -3'