Incidental Mutation 'R8141:Prss41'
ID 632557
Institutional Source Beutler Lab
Gene Symbol Prss41
Ensembl Gene ENSMUSG00000024114
Gene Name serine protease 41
Synonyms Tessp1, 4931440B09Rik
MMRRC Submission 067569-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R8141 (G1)
Quality Score 221.178
Status Validated
Chromosome 17
Chromosomal Location 24055759-24063146 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 24056607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 196 (P196L)
Ref Sequence ENSEMBL: ENSMUSP00000024926 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024926] [ENSMUST00000059906] [ENSMUST00000115444] [ENSMUST00000122936] [ENSMUST00000151797]
AlphaFold Q920S2
Predicted Effect probably damaging
Transcript: ENSMUST00000024926
AA Change: P196L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000024926
Gene: ENSMUSG00000024114
AA Change: P196L

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Tryp_SPc 52 289 2.48e-79 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000059906
SMART Domains Protein: ENSMUSP00000059491
Gene: ENSMUSG00000049620

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Tryp_SPc 33 271 9.03e-91 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115444
SMART Domains Protein: ENSMUSP00000111104
Gene: ENSMUSG00000049620

DomainStartEndE-ValueType
Tryp_SPc 15 253 4.5e-93 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000122936
AA Change: P156L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000120141
Gene: ENSMUSG00000024114
AA Change: P156L

DomainStartEndE-ValueType
Tryp_SPc 12 249 2.48e-79 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151797
SMART Domains Protein: ENSMUSP00000122453
Gene: ENSMUSG00000024114

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Tryp_SPc 52 204 2.91e-12 SMART
low complexity region 228 244 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 90.7%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik T C 9: 57,165,688 (GRCm39) T229A probably benign Het
4930438A08Rik A G 11: 58,177,411 (GRCm39) E40G Het
Actn2 T C 13: 12,303,516 (GRCm39) D428G probably damaging Het
Arl14epl C A 18: 47,059,410 (GRCm39) N8K probably benign Het
Bend7 T C 2: 4,757,636 (GRCm39) V226A probably benign Het
C1s1 A T 6: 124,508,321 (GRCm39) L556Q probably damaging Het
Casr T C 16: 36,315,173 (GRCm39) K966E probably damaging Het
Ccm2l T C 2: 152,912,791 (GRCm39) L110P probably damaging Het
Cdhr4 G A 9: 107,873,991 (GRCm39) R59H Het
Celf3 C A 3: 94,395,850 (GRCm39) N410K probably damaging Het
Cfap251 T G 5: 123,424,493 (GRCm39) V726G possibly damaging Het
Cpne6 T C 14: 55,750,066 (GRCm39) C66R possibly damaging Het
Cyp2f2 G A 7: 26,828,678 (GRCm39) V183I probably benign Het
Eln CTCCAGCTCCGAT C 5: 134,758,003 (GRCm39) probably benign Het
Fam53b A C 7: 132,361,758 (GRCm39) V90G probably damaging Het
Fat3 T A 9: 15,908,362 (GRCm39) I2547F possibly damaging Het
Foxk1 A G 5: 142,439,716 (GRCm39) Y524C probably damaging Het
Gpr87 A G 3: 59,087,020 (GRCm39) S162P probably damaging Het
Ifi204 A G 1: 173,583,189 (GRCm39) V343A possibly damaging Het
Igsf10 A G 3: 59,237,949 (GRCm39) L744P probably damaging Het
Iqub T A 6: 24,491,608 (GRCm39) K359N probably benign Het
Kdm3b A T 18: 34,961,599 (GRCm39) K1459* probably null Het
Kirrel1 C T 3: 86,993,735 (GRCm39) W507* probably null Het
Klra17 T C 6: 129,849,292 (GRCm39) D94G probably damaging Het
Llgl1 G C 11: 60,601,142 (GRCm39) E693D probably benign Het
Lrrc37 T C 11: 103,511,855 (GRCm39) T38A unknown Het
Lypd4 A T 7: 24,564,254 (GRCm39) D201E possibly damaging Het
Nin A G 12: 70,076,795 (GRCm39) S1794P Het
Oog2 T C 4: 143,920,777 (GRCm39) L70P probably damaging Het
Or6n2 T C 1: 173,897,488 (GRCm39) L208P probably damaging Het
Pacsin1 G T 17: 27,926,034 (GRCm39) R282S possibly damaging Het
Pcdhb9 T A 18: 37,535,361 (GRCm39) Y452N probably damaging Het
Pdgfra T C 5: 75,338,387 (GRCm39) V547A possibly damaging Het
Plcb4 T C 2: 135,781,169 (GRCm39) F209L probably damaging Het
Pnpla6 T C 8: 3,571,384 (GRCm39) S158P probably benign Het
Prlhr C G 19: 60,455,747 (GRCm39) R273P probably damaging Het
Ptgr3 T C 18: 84,112,651 (GRCm39) L109P probably benign Het
Ptpn22 A G 3: 103,793,643 (GRCm39) E598G possibly damaging Het
Rasal2 T C 1: 156,992,240 (GRCm39) D569G possibly damaging Het
Sf3b3 A C 8: 111,547,483 (GRCm39) M715R possibly damaging Het
Ska1 T C 18: 74,339,907 (GRCm39) N13S probably benign Het
Spocd1 A C 4: 129,823,497 (GRCm39) E98A Het
Sycp1 G T 3: 102,842,885 (GRCm39) A28E possibly damaging Het
Syf2 C T 4: 134,664,182 (GRCm39) R199C probably damaging Het
Syne2 A G 12: 76,108,442 (GRCm39) D942G possibly damaging Het
Tamalin T A 15: 101,129,790 (GRCm39) C358S possibly damaging Het
Tmem63a A G 1: 180,801,776 (GRCm39) T764A probably benign Het
Ttf1 C T 2: 28,957,238 (GRCm39) Q503* probably null Het
Usp13 T C 3: 32,949,025 (GRCm39) V454A possibly damaging Het
Usp47 A G 7: 111,652,472 (GRCm39) T50A possibly damaging Het
Zfyve26 A T 12: 79,315,331 (GRCm39) C1382S possibly damaging Het
Other mutations in Prss41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02215:Prss41 APN 17 24,062,830 (GRCm39) missense probably benign 0.01
IGL03031:Prss41 APN 17 24,061,396 (GRCm39) missense probably damaging 1.00
IGL03131:Prss41 APN 17 24,061,498 (GRCm39) missense probably benign 0.00
FR4737:Prss41 UTSW 17 24,063,071 (GRCm39) small deletion probably benign
R0491:Prss41 UTSW 17 24,061,477 (GRCm39) missense possibly damaging 0.91
R2014:Prss41 UTSW 17 24,056,464 (GRCm39) critical splice donor site probably null
R3813:Prss41 UTSW 17 24,056,596 (GRCm39) nonsense probably null
R4888:Prss41 UTSW 17 24,055,977 (GRCm39) missense probably benign 0.08
R5707:Prss41 UTSW 17 24,061,390 (GRCm39) missense probably benign 0.00
R6904:Prss41 UTSW 17 24,056,622 (GRCm39) missense probably benign 0.15
R7486:Prss41 UTSW 17 24,063,072 (GRCm39) small deletion probably benign
R7782:Prss41 UTSW 17 24,056,087 (GRCm39) missense probably benign 0.40
R8087:Prss41 UTSW 17 24,056,076 (GRCm39) missense probably damaging 1.00
R9189:Prss41 UTSW 17 24,061,361 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCCAGCCTGAAGTGAAGGAG -3'
(R):5'- CCACCCTTATGTAAGAGGTGTAC -3'

Sequencing Primer
(F):5'- CCTGAAGTGAAGGAGAGGGG -3'
(R):5'- CTCTTGCCCTTAAGAGTAGAGGAG -3'
Posted On 2020-06-30