Incidental Mutation 'R8142:Dtd2'
ID 632596
Institutional Source Beutler Lab
Gene Symbol Dtd2
Ensembl Gene ENSMUSG00000020956
Gene Name D-tyrosyl-tRNA deacylase 2
Synonyms 6530401N04Rik, B830049N13Rik, 4930578F06Rik
MMRRC Submission 067570-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R8142 (G1)
Quality Score 225.009
Status Not validated
Chromosome 12
Chromosomal Location 52035095-52053284 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 52046593 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 82 (D82V)
Ref Sequence ENSEMBL: ENSMUSP00000021339 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021339] [ENSMUST00000085404]
AlphaFold Q8BHA3
Predicted Effect probably damaging
Transcript: ENSMUST00000021339
AA Change: D82V

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000021339
Gene: ENSMUSG00000020956
AA Change: D82V

DomainStartEndE-ValueType
Pfam:Tyr_Deacylase 11 167 1.1e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000085404
AA Change: D82V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000082525
Gene: ENSMUSG00000020956
AA Change: D82V

DomainStartEndE-ValueType
Pfam:Tyr_Deacylase 11 158 6.7e-39 PFAM
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.5%
  • 10x: 98.0%
  • 20x: 91.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp6v1e2 A T 17: 87,252,083 (GRCm39) I105N possibly damaging Het
Azi2 A G 9: 117,878,475 (GRCm39) D105G probably damaging Het
Bmpr2 T C 1: 59,909,465 (GRCm39) S980P probably damaging Het
Ccno T G 13: 113,125,489 (GRCm39) L151R probably damaging Het
Cdh2 A C 18: 16,734,791 (GRCm39) I801S probably benign Het
Cyp2f2 G A 7: 26,828,678 (GRCm39) V183I probably benign Het
Dab1 T A 4: 104,535,921 (GRCm39) V110D probably damaging Het
Dnah3 T C 7: 119,660,189 (GRCm39) T828A probably benign Het
Dnah5 G T 15: 28,384,519 (GRCm39) V3088L probably benign Het
Dusp5 T C 19: 53,525,912 (GRCm39) F185L probably damaging Het
Epha10 A G 4: 124,779,639 (GRCm39) T162A probably damaging Het
Fat4 A T 3: 38,945,352 (GRCm39) D1415V probably damaging Het
Fitm1 T C 14: 55,813,247 (GRCm39) Y37H possibly damaging Het
Flg2 G T 3: 93,122,782 (GRCm39) E1651* probably null Het
Ifit3 G T 19: 34,564,901 (GRCm39) C149F probably damaging Het
Lepr C A 4: 101,622,616 (GRCm39) H465Q possibly damaging Het
Ltn1 A C 16: 87,178,529 (GRCm39) S1567A probably benign Het
Marchf1 T C 8: 66,908,778 (GRCm39) V166A probably benign Het
Marveld2 T C 13: 100,737,448 (GRCm39) H424R possibly damaging Het
Mypop A G 7: 18,735,051 (GRCm39) T383A unknown Het
Ngef G C 1: 87,468,463 (GRCm39) R99G probably benign Het
Nherf4 A G 9: 44,162,078 (GRCm39) probably null Het
Npepps G T 11: 97,109,398 (GRCm39) A726D probably damaging Het
Or6c63-ps1 T A 10: 128,900,519 (GRCm39) D9V probably benign Het
Pcdhgb4 A G 18: 37,854,166 (GRCm39) D187G probably damaging Het
Per2 T C 1: 91,349,269 (GRCm39) E1034G possibly damaging Het
Pira1 A G 7: 3,739,842 (GRCm39) S418P possibly damaging Het
Pkhd1l1 G A 15: 44,378,327 (GRCm39) R1027H probably benign Het
Pon2 A T 6: 5,266,239 (GRCm39) V260D probably benign Het
Rnase13 A G 14: 52,159,893 (GRCm39) I82T probably damaging Het
Sbno1 A G 5: 124,546,608 (GRCm39) S194P probably benign Het
Serpinb6c T A 13: 34,064,096 (GRCm39) I320L probably benign Het
Sh3rf3 C T 10: 58,885,205 (GRCm39) R363* probably null Het
Slc11a1 T C 1: 74,424,418 (GRCm39) F500L probably benign Het
Slc1a4 A G 11: 20,257,890 (GRCm39) probably null Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Sorcs2 T C 5: 36,219,958 (GRCm39) N362S possibly damaging Het
Stau2 A G 1: 16,530,575 (GRCm39) S115P unknown Het
Stk38l A G 6: 146,660,070 (GRCm39) N34S probably benign Het
Tmem201 T C 4: 149,803,114 (GRCm39) T585A probably benign Het
Ttc6 A T 12: 57,744,258 (GRCm39) I1297F possibly damaging Het
Uncx A G 5: 139,532,655 (GRCm39) D240G possibly damaging Het
Vmn2r88 A G 14: 51,651,564 (GRCm39) I293V Het
Vps11 T C 9: 44,265,852 (GRCm39) T476A probably benign Het
Vrtn T C 12: 84,697,395 (GRCm39) L715P probably damaging Het
Wdr72 T G 9: 74,046,949 (GRCm39) V65G probably damaging Het
Zbtb21 T C 16: 97,752,675 (GRCm39) E536G probably damaging Het
Zbtb34 G T 2: 33,302,493 (GRCm39) S16* probably null Het
Zfhx2 G A 14: 55,310,895 (GRCm39) L600F possibly damaging Het
Other mutations in Dtd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02182:Dtd2 APN 12 52,046,492 (GRCm39) missense probably benign
IGL02626:Dtd2 APN 12 52,051,708 (GRCm39) nonsense probably null
PIT4366001:Dtd2 UTSW 12 52,046,582 (GRCm39) missense probably damaging 1.00
R0519:Dtd2 UTSW 12 52,051,742 (GRCm39) splice site probably benign
R0741:Dtd2 UTSW 12 52,046,455 (GRCm39) missense probably benign 0.07
R2421:Dtd2 UTSW 12 52,046,638 (GRCm39) missense probably benign 0.25
R3922:Dtd2 UTSW 12 52,051,734 (GRCm39) splice site probably null
R3923:Dtd2 UTSW 12 52,051,734 (GRCm39) splice site probably null
R3924:Dtd2 UTSW 12 52,051,734 (GRCm39) splice site probably null
R5666:Dtd2 UTSW 12 52,046,643 (GRCm39) missense probably damaging 1.00
R5670:Dtd2 UTSW 12 52,046,643 (GRCm39) missense probably damaging 1.00
R8488:Dtd2 UTSW 12 52,046,344 (GRCm39) missense probably benign 0.26
Predicted Primers PCR Primer
(F):5'- GTCCAGCTTTAACACTTGCCTG -3'
(R):5'- ATCTACAGACTGGGGTTGAAAAC -3'

Sequencing Primer
(F):5'- TGTTCCCGTACGTGCCGTG -3'
(R):5'- AGACTGGGGTTGAAAACTAGGTTTTG -3'
Posted On 2020-06-30