Incidental Mutation 'R8145:Vmn2r79'
| ID |
632745 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r79
|
| Ensembl Gene |
ENSMUSG00000090362 |
| Gene Name |
vomeronasal 2, receptor 79 |
| Synonyms |
EG621430 |
| MMRRC Submission |
067573-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.093)
|
| Stock # |
R8145 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
86645673-86687176 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 86686862 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 748
(M748L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132478
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164462]
|
| AlphaFold |
E9Q067 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164462
AA Change: M748L
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: M748L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
1.9e-31 |
PFAM |
|
Pfam:NCD3G
|
506 |
559 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
2.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.7%
- 3x: 99.5%
- 10x: 97.9%
- 20x: 90.4%
|
| Validation Efficiency |
100% (79/79) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alg6 |
A |
T |
4: 99,634,564 (GRCm39) |
D273V |
probably damaging |
Het |
| Ankk1 |
T |
A |
9: 49,327,097 (GRCm39) |
H694L |
possibly damaging |
Het |
| Asb7 |
G |
T |
7: 66,309,696 (GRCm39) |
N173K |
probably benign |
Het |
| Atp10b |
A |
T |
11: 43,092,949 (GRCm39) |
Q428L |
probably damaging |
Het |
| Bag3 |
A |
G |
7: 128,147,612 (GRCm39) |
E409G |
possibly damaging |
Het |
| Bltp1 |
T |
C |
3: 37,052,416 (GRCm39) |
S3039P |
probably damaging |
Het |
| Bpifb2 |
T |
A |
2: 153,733,232 (GRCm39) |
V398E |
probably damaging |
Het |
| Btf3l4b |
A |
T |
13: 96,217,649 (GRCm39) |
D63E |
probably benign |
Het |
| Ccr6 |
T |
C |
17: 8,474,945 (GRCm39) |
V50A |
probably benign |
Het |
| Cdcp3 |
G |
T |
7: 130,898,045 (GRCm39) |
V2088L |
unknown |
Het |
| Cdx1 |
T |
C |
18: 61,152,995 (GRCm39) |
N204D |
probably damaging |
Het |
| Ciao1 |
T |
C |
2: 127,087,726 (GRCm39) |
D203G |
possibly damaging |
Het |
| Cldn7 |
A |
T |
11: 69,856,892 (GRCm39) |
Y47F |
possibly damaging |
Het |
| Col6a1 |
A |
T |
10: 76,559,305 (GRCm39) |
D110E |
possibly damaging |
Het |
| Cpne6 |
C |
A |
14: 55,752,025 (GRCm39) |
Q261K |
probably benign |
Het |
| Crebbp |
T |
C |
16: 3,946,389 (GRCm39) |
T497A |
probably benign |
Het |
| Cyp2s1 |
A |
G |
7: 25,507,467 (GRCm39) |
|
probably null |
Het |
| Ddx42 |
A |
T |
11: 106,130,887 (GRCm39) |
I454F |
possibly damaging |
Het |
| Ddx5 |
G |
T |
11: 106,672,911 (GRCm39) |
A538E |
probably benign |
Het |
| Dnajb1 |
T |
A |
8: 84,336,944 (GRCm39) |
V238D |
probably damaging |
Het |
| Dntt |
A |
G |
19: 41,044,224 (GRCm39) |
Y463C |
probably damaging |
Het |
| Eif4b |
A |
G |
15: 102,001,423 (GRCm39) |
T437A |
unknown |
Het |
| Eppk1 |
T |
C |
15: 75,990,900 (GRCm39) |
T1994A |
possibly damaging |
Het |
| Fbxw15 |
A |
T |
9: 109,384,658 (GRCm39) |
C381S |
probably benign |
Het |
| Fosl2 |
T |
A |
5: 32,310,412 (GRCm39) |
V287D |
probably damaging |
Het |
| Gdpd4 |
A |
G |
7: 97,690,077 (GRCm39) |
T590A |
probably benign |
Het |
| Gm49368 |
A |
G |
7: 127,712,487 (GRCm39) |
E877G |
probably null |
Het |
| Grin2b |
C |
T |
6: 135,709,497 (GRCm39) |
A1350T |
probably benign |
Het |
| Gzmk |
A |
G |
13: 113,308,430 (GRCm39) |
L257P |
probably damaging |
Het |
| Has2 |
T |
A |
15: 56,545,175 (GRCm39) |
K142N |
probably benign |
Het |
| Hectd1 |
T |
C |
12: 51,831,016 (GRCm39) |
E944G |
possibly damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,629,411 (GRCm39) |
R949G |
probably benign |
Het |
| Hmcn2 |
A |
G |
2: 31,313,117 (GRCm39) |
E3442G |
probably damaging |
Het |
| Irf9 |
T |
A |
14: 55,843,255 (GRCm39) |
C152* |
probably null |
Het |
| Itga3 |
A |
G |
11: 94,943,290 (GRCm39) |
W936R |
probably damaging |
Het |
| Klhl11 |
G |
T |
11: 100,354,740 (GRCm39) |
D360E |
probably damaging |
Het |
| Lnx1 |
G |
A |
5: 74,846,060 (GRCm39) |
T130I |
probably benign |
Het |
| Lrrc36 |
C |
T |
8: 106,170,396 (GRCm39) |
P82L |
probably damaging |
Het |
| Map4k4 |
T |
C |
1: 40,039,694 (GRCm39) |
C29R |
|
Het |
| Mki67 |
T |
C |
7: 135,296,065 (GRCm39) |
K2990E |
probably benign |
Het |
| Mnt |
G |
A |
11: 74,733,799 (GRCm39) |
A477T |
unknown |
Het |
| Mroh9 |
A |
G |
1: 162,890,096 (GRCm39) |
S214P |
probably benign |
Het |
| Mrps18b |
C |
A |
17: 36,225,293 (GRCm39) |
R94L |
possibly damaging |
Het |
| Myh6 |
T |
A |
14: 55,191,382 (GRCm39) |
I820F |
probably benign |
Het |
| Nphp3 |
A |
G |
9: 103,913,050 (GRCm39) |
T943A |
probably benign |
Het |
| Or51a25 |
C |
A |
7: 102,372,937 (GRCm39) |
L253F |
probably damaging |
Het |
| Or52b4i |
A |
G |
7: 102,191,830 (GRCm39) |
H229R |
probably benign |
Het |
| Papolb |
T |
C |
5: 142,514,353 (GRCm39) |
D430G |
probably benign |
Het |
| Pdzd2 |
T |
C |
15: 12,407,458 (GRCm39) |
H334R |
probably benign |
Het |
| Pkd1l2 |
T |
A |
8: 117,781,742 (GRCm39) |
M768L |
probably benign |
Het |
| Pklr |
G |
T |
3: 89,052,795 (GRCm39) |
R547L |
probably benign |
Het |
| Pla2g4a |
T |
C |
1: 149,716,394 (GRCm39) |
Y697C |
probably benign |
Het |
| Prkcd |
T |
C |
14: 30,324,019 (GRCm39) |
T435A |
probably benign |
Het |
| Rfx1 |
C |
T |
8: 84,800,657 (GRCm39) |
P86L |
probably benign |
Het |
| Rnf19b |
C |
A |
4: 128,977,862 (GRCm39) |
A693D |
probably benign |
Het |
| Scn9a |
A |
G |
2: 66,317,754 (GRCm39) |
I1578T |
probably damaging |
Het |
| Slamf9 |
A |
G |
1: 172,303,942 (GRCm39) |
S96G |
probably benign |
Het |
| Slc17a8 |
T |
C |
10: 89,412,233 (GRCm39) |
D584G |
probably benign |
Het |
| Slc1a7 |
G |
A |
4: 107,869,473 (GRCm39) |
V513M |
probably benign |
Het |
| Slc2a7 |
C |
A |
4: 150,252,818 (GRCm39) |
T486K |
probably damaging |
Het |
| Slc6a20a |
G |
A |
9: 123,466,065 (GRCm39) |
A592V |
probably damaging |
Het |
| Spz1 |
T |
C |
13: 92,711,609 (GRCm39) |
D289G |
probably benign |
Het |
| Sspo |
G |
A |
6: 48,444,683 (GRCm39) |
C2226Y |
possibly damaging |
Het |
| Taf4b |
T |
G |
18: 14,963,085 (GRCm39) |
D608E |
probably damaging |
Het |
| Tagap1 |
A |
T |
17: 7,223,526 (GRCm39) |
I390N |
probably damaging |
Het |
| Tcp11l2 |
A |
G |
10: 84,444,480 (GRCm39) |
N430D |
probably damaging |
Het |
| Thsd7b |
T |
C |
1: 129,688,036 (GRCm39) |
L649P |
probably damaging |
Het |
| Tmprss15 |
C |
T |
16: 78,757,473 (GRCm39) |
G956R |
probably damaging |
Het |
| Tnc |
G |
T |
4: 63,935,716 (GRCm39) |
Q407K |
probably benign |
Het |
| Tti1 |
C |
A |
2: 157,849,509 (GRCm39) |
E577* |
probably null |
Het |
| Zbtb37 |
C |
T |
1: 160,847,654 (GRCm39) |
R451Q |
probably damaging |
Het |
| Zfp1002 |
T |
C |
2: 150,096,455 (GRCm39) |
K325E |
probably benign |
Het |
| Zfp566 |
A |
T |
7: 29,777,785 (GRCm39) |
I132N |
probably benign |
Het |
| Zik1 |
C |
T |
7: 10,223,930 (GRCm39) |
G389E |
probably damaging |
Het |
| Zzef1 |
A |
T |
11: 72,799,295 (GRCm39) |
K2382* |
probably null |
Het |
|
| Other mutations in Vmn2r79 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01401:Vmn2r79
|
APN |
7 |
86,686,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01675:Vmn2r79
|
APN |
7 |
86,645,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01760:Vmn2r79
|
APN |
7 |
86,651,366 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn2r79
|
APN |
7 |
86,686,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01843:Vmn2r79
|
APN |
7 |
86,686,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01914:Vmn2r79
|
APN |
7 |
86,686,571 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01980:Vmn2r79
|
APN |
7 |
86,686,290 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02438:Vmn2r79
|
APN |
7 |
86,651,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02740:Vmn2r79
|
APN |
7 |
86,653,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03052:Vmn2r79
|
UTSW |
7 |
86,652,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4445001:Vmn2r79
|
UTSW |
7 |
86,651,408 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Vmn2r79
|
UTSW |
7 |
86,652,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Vmn2r79
|
UTSW |
7 |
86,651,287 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0418:Vmn2r79
|
UTSW |
7 |
86,651,611 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1070:Vmn2r79
|
UTSW |
7 |
86,652,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1234:Vmn2r79
|
UTSW |
7 |
86,653,307 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1459:Vmn2r79
|
UTSW |
7 |
86,687,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Vmn2r79
|
UTSW |
7 |
86,686,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1624:Vmn2r79
|
UTSW |
7 |
86,653,247 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1633:Vmn2r79
|
UTSW |
7 |
86,687,042 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1676:Vmn2r79
|
UTSW |
7 |
86,651,839 (GRCm39) |
missense |
probably benign |
|
|
R1781:Vmn2r79
|
UTSW |
7 |
86,651,555 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1794:Vmn2r79
|
UTSW |
7 |
86,650,621 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1823:Vmn2r79
|
UTSW |
7 |
86,687,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r79
|
UTSW |
7 |
86,653,289 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2018:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2019:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2177:Vmn2r79
|
UTSW |
7 |
86,645,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2984:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3719:Vmn2r79
|
UTSW |
7 |
86,651,245 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3798:Vmn2r79
|
UTSW |
7 |
86,651,402 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3969:Vmn2r79
|
UTSW |
7 |
86,652,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4183:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4245:Vmn2r79
|
UTSW |
7 |
86,651,624 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4301:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4391:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4393:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4394:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4396:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4397:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4592:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4697:Vmn2r79
|
UTSW |
7 |
86,687,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Vmn2r79
|
UTSW |
7 |
86,650,675 (GRCm39) |
missense |
probably benign |
|
|
R5016:Vmn2r79
|
UTSW |
7 |
86,686,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Vmn2r79
|
UTSW |
7 |
86,651,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Vmn2r79
|
UTSW |
7 |
86,651,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6078:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6079:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6138:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6257:Vmn2r79
|
UTSW |
7 |
86,651,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6260:Vmn2r79
|
UTSW |
7 |
86,686,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r79
|
UTSW |
7 |
86,686,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Vmn2r79
|
UTSW |
7 |
86,650,522 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6374:Vmn2r79
|
UTSW |
7 |
86,651,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6530:Vmn2r79
|
UTSW |
7 |
86,651,252 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6546:Vmn2r79
|
UTSW |
7 |
86,652,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6682:Vmn2r79
|
UTSW |
7 |
86,653,370 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6858:Vmn2r79
|
UTSW |
7 |
86,686,580 (GRCm39) |
missense |
probably benign |
|
|
R6965:Vmn2r79
|
UTSW |
7 |
86,651,100 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7130:Vmn2r79
|
UTSW |
7 |
86,651,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7156:Vmn2r79
|
UTSW |
7 |
86,686,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7604:Vmn2r79
|
UTSW |
7 |
86,652,592 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7691:Vmn2r79
|
UTSW |
7 |
86,687,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8055:Vmn2r79
|
UTSW |
7 |
86,686,541 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8070:Vmn2r79
|
UTSW |
7 |
86,651,336 (GRCm39) |
missense |
probably benign |
|
|
R8073:Vmn2r79
|
UTSW |
7 |
86,651,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8263:Vmn2r79
|
UTSW |
7 |
86,686,726 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Vmn2r79
|
UTSW |
7 |
86,686,741 (GRCm39) |
nonsense |
probably null |
|
|
R8400:Vmn2r79
|
UTSW |
7 |
86,651,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Vmn2r79
|
UTSW |
7 |
86,651,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8862:Vmn2r79
|
UTSW |
7 |
86,645,712 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9146:Vmn2r79
|
UTSW |
7 |
86,650,681 (GRCm39) |
nonsense |
probably null |
|
|
R9276:Vmn2r79
|
UTSW |
7 |
86,687,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9361:Vmn2r79
|
UTSW |
7 |
86,652,822 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9676:Vmn2r79
|
UTSW |
7 |
86,686,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U15987:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0054:Vmn2r79
|
UTSW |
7 |
86,653,270 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Vmn2r79
|
UTSW |
7 |
86,651,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,686,377 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,651,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAAGACTGAGGTGGCTGCTAC -3'
(R):5'- TGCACTGGAGGCCAAGATAC -3'
Sequencing Primer
(F):5'- GCTACTTTCAGGAGCACCTAATTAC -3'
(R):5'- GAGGCCAAGATACAGAAGACCTC -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation