Incidental Mutation 'R8145:Tagap1'
ID 632784
Institutional Source Beutler Lab
Gene Symbol Tagap1
Ensembl Gene ENSMUSG00000052031
Gene Name T cell activation GTPase activating protein 1
Synonyms 2610315E15Rik
MMRRC Submission 067573-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8145 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 7222410-7228555 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 7223526 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 390 (I390N)
Ref Sequence ENSEMBL: ENSMUSP00000070466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063683]
AlphaFold P0CAX8
Predicted Effect probably damaging
Transcript: ENSMUST00000063683
AA Change: I390N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000070466
Gene: ENSMUSG00000052031
AA Change: I390N

DomainStartEndE-ValueType
low complexity region 2 12 N/A INTRINSIC
low complexity region 141 152 N/A INTRINSIC
low complexity region 250 269 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 90.4%
Validation Efficiency 100% (79/79)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg6 A T 4: 99,634,564 (GRCm39) D273V probably damaging Het
Ankk1 T A 9: 49,327,097 (GRCm39) H694L possibly damaging Het
Asb7 G T 7: 66,309,696 (GRCm39) N173K probably benign Het
Atp10b A T 11: 43,092,949 (GRCm39) Q428L probably damaging Het
Bag3 A G 7: 128,147,612 (GRCm39) E409G possibly damaging Het
Bltp1 T C 3: 37,052,416 (GRCm39) S3039P probably damaging Het
Bpifb2 T A 2: 153,733,232 (GRCm39) V398E probably damaging Het
Btf3l4b A T 13: 96,217,649 (GRCm39) D63E probably benign Het
Ccr6 T C 17: 8,474,945 (GRCm39) V50A probably benign Het
Cdcp3 G T 7: 130,898,045 (GRCm39) V2088L unknown Het
Cdx1 T C 18: 61,152,995 (GRCm39) N204D probably damaging Het
Ciao1 T C 2: 127,087,726 (GRCm39) D203G possibly damaging Het
Cldn7 A T 11: 69,856,892 (GRCm39) Y47F possibly damaging Het
Col6a1 A T 10: 76,559,305 (GRCm39) D110E possibly damaging Het
Cpne6 C A 14: 55,752,025 (GRCm39) Q261K probably benign Het
Crebbp T C 16: 3,946,389 (GRCm39) T497A probably benign Het
Cyp2s1 A G 7: 25,507,467 (GRCm39) probably null Het
Ddx42 A T 11: 106,130,887 (GRCm39) I454F possibly damaging Het
Ddx5 G T 11: 106,672,911 (GRCm39) A538E probably benign Het
Dnajb1 T A 8: 84,336,944 (GRCm39) V238D probably damaging Het
Dntt A G 19: 41,044,224 (GRCm39) Y463C probably damaging Het
Eif4b A G 15: 102,001,423 (GRCm39) T437A unknown Het
Eppk1 T C 15: 75,990,900 (GRCm39) T1994A possibly damaging Het
Fbxw15 A T 9: 109,384,658 (GRCm39) C381S probably benign Het
Fosl2 T A 5: 32,310,412 (GRCm39) V287D probably damaging Het
Gdpd4 A G 7: 97,690,077 (GRCm39) T590A probably benign Het
Gm49368 A G 7: 127,712,487 (GRCm39) E877G probably null Het
Grin2b C T 6: 135,709,497 (GRCm39) A1350T probably benign Het
Gzmk A G 13: 113,308,430 (GRCm39) L257P probably damaging Het
Has2 T A 15: 56,545,175 (GRCm39) K142N probably benign Het
Hectd1 T C 12: 51,831,016 (GRCm39) E944G possibly damaging Het
Hmcn1 T C 1: 150,629,411 (GRCm39) R949G probably benign Het
Hmcn2 A G 2: 31,313,117 (GRCm39) E3442G probably damaging Het
Irf9 T A 14: 55,843,255 (GRCm39) C152* probably null Het
Itga3 A G 11: 94,943,290 (GRCm39) W936R probably damaging Het
Klhl11 G T 11: 100,354,740 (GRCm39) D360E probably damaging Het
Lnx1 G A 5: 74,846,060 (GRCm39) T130I probably benign Het
Lrrc36 C T 8: 106,170,396 (GRCm39) P82L probably damaging Het
Map4k4 T C 1: 40,039,694 (GRCm39) C29R Het
Mki67 T C 7: 135,296,065 (GRCm39) K2990E probably benign Het
Mnt G A 11: 74,733,799 (GRCm39) A477T unknown Het
Mroh9 A G 1: 162,890,096 (GRCm39) S214P probably benign Het
Mrps18b C A 17: 36,225,293 (GRCm39) R94L possibly damaging Het
Myh6 T A 14: 55,191,382 (GRCm39) I820F probably benign Het
Nphp3 A G 9: 103,913,050 (GRCm39) T943A probably benign Het
Or51a25 C A 7: 102,372,937 (GRCm39) L253F probably damaging Het
Or52b4i A G 7: 102,191,830 (GRCm39) H229R probably benign Het
Papolb T C 5: 142,514,353 (GRCm39) D430G probably benign Het
Pdzd2 T C 15: 12,407,458 (GRCm39) H334R probably benign Het
Pkd1l2 T A 8: 117,781,742 (GRCm39) M768L probably benign Het
Pklr G T 3: 89,052,795 (GRCm39) R547L probably benign Het
Pla2g4a T C 1: 149,716,394 (GRCm39) Y697C probably benign Het
Prkcd T C 14: 30,324,019 (GRCm39) T435A probably benign Het
Rfx1 C T 8: 84,800,657 (GRCm39) P86L probably benign Het
Rnf19b C A 4: 128,977,862 (GRCm39) A693D probably benign Het
Scn9a A G 2: 66,317,754 (GRCm39) I1578T probably damaging Het
Slamf9 A G 1: 172,303,942 (GRCm39) S96G probably benign Het
Slc17a8 T C 10: 89,412,233 (GRCm39) D584G probably benign Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Slc2a7 C A 4: 150,252,818 (GRCm39) T486K probably damaging Het
Slc6a20a G A 9: 123,466,065 (GRCm39) A592V probably damaging Het
Spz1 T C 13: 92,711,609 (GRCm39) D289G probably benign Het
Sspo G A 6: 48,444,683 (GRCm39) C2226Y possibly damaging Het
Taf4b T G 18: 14,963,085 (GRCm39) D608E probably damaging Het
Tcp11l2 A G 10: 84,444,480 (GRCm39) N430D probably damaging Het
Thsd7b T C 1: 129,688,036 (GRCm39) L649P probably damaging Het
Tmprss15 C T 16: 78,757,473 (GRCm39) G956R probably damaging Het
Tnc G T 4: 63,935,716 (GRCm39) Q407K probably benign Het
Tti1 C A 2: 157,849,509 (GRCm39) E577* probably null Het
Vmn2r79 A T 7: 86,686,862 (GRCm39) M748L probably benign Het
Zbtb37 C T 1: 160,847,654 (GRCm39) R451Q probably damaging Het
Zfp1002 T C 2: 150,096,455 (GRCm39) K325E probably benign Het
Zfp566 A T 7: 29,777,785 (GRCm39) I132N probably benign Het
Zik1 C T 7: 10,223,930 (GRCm39) G389E probably damaging Het
Zzef1 A T 11: 72,799,295 (GRCm39) K2382* probably null Het
Other mutations in Tagap1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01384:Tagap1 APN 17 7,224,282 (GRCm39) missense probably benign 0.00
IGL02138:Tagap1 APN 17 7,223,485 (GRCm39) missense probably damaging 1.00
IGL02475:Tagap1 APN 17 7,223,826 (GRCm39) missense probably benign 0.41
IGL02955:Tagap1 APN 17 7,223,781 (GRCm39) missense probably damaging 1.00
R1494:Tagap1 UTSW 17 7,224,210 (GRCm39) missense probably damaging 1.00
R1824:Tagap1 UTSW 17 7,223,425 (GRCm39) missense probably benign 0.02
R1990:Tagap1 UTSW 17 7,224,285 (GRCm39) missense probably benign 0.00
R2067:Tagap1 UTSW 17 7,224,259 (GRCm39) missense probably benign 0.00
R2086:Tagap1 UTSW 17 7,224,102 (GRCm39) missense probably benign 0.00
R2111:Tagap1 UTSW 17 7,224,259 (GRCm39) missense probably benign 0.00
R4425:Tagap1 UTSW 17 7,223,511 (GRCm39) missense probably benign 0.00
R5271:Tagap1 UTSW 17 7,223,495 (GRCm39) nonsense probably null
R5728:Tagap1 UTSW 17 7,224,420 (GRCm39) missense probably benign 0.30
R7100:Tagap1 UTSW 17 7,224,111 (GRCm39) missense possibly damaging 0.83
R9627:Tagap1 UTSW 17 7,224,327 (GRCm39) missense probably benign 0.09
R9698:Tagap1 UTSW 17 7,228,477 (GRCm39) missense probably damaging 0.99
Z1177:Tagap1 UTSW 17 7,224,016 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAGTGCTCAGTCACAGAAG -3'
(R):5'- AGCATTGGGTCTGAGAAATCC -3'

Sequencing Primer
(F):5'- GTGCTCAGTCACAGAAGACAATC -3'
(R):5'- GGGTCTGAGAAATCCAAAGACTTTTC -3'
Posted On 2020-06-30