Incidental Mutation 'R8146:Or51l4'
ID 632807
Institutional Source Beutler Lab
Gene Symbol Or51l4
Ensembl Gene ENSMUSG00000050281
Gene Name olfactory receptor family 51 subfamily L member 4
Synonyms Olfr630, MOR17-1, GA_x6K02T2PBJ9-6483085-6482126
MMRRC Submission 067574-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R8146 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 103403357-103406557 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103404510 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 94 (I94T)
Ref Sequence ENSEMBL: ENSMUSP00000102493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106880]
AlphaFold Q9EQQ7
Predicted Effect probably damaging
Transcript: ENSMUST00000106880
AA Change: I94T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102493
Gene: ENSMUSG00000050281
AA Change: I94T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 37 305 3.7e-8 PFAM
Pfam:7tm_1 43 294 8.4e-25 PFAM
Pfam:7tm_4 144 287 9e-29 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 98.6%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik T G 2: 19,498,814 (GRCm39) E393A possibly damaging Het
4930550C14Rik A G 9: 53,334,270 (GRCm39) D171G probably damaging Het
Abca13 T C 11: 9,347,829 (GRCm39) Y3561H probably damaging Het
Adgra2 T A 8: 27,604,202 (GRCm39) V464D probably damaging Het
Adgrl1 C A 8: 84,657,618 (GRCm39) T408N possibly damaging Het
Anks1b G A 10: 90,143,560 (GRCm39) R523Q probably damaging Het
Anks6 C A 4: 47,043,605 (GRCm39) A375S unknown Het
Bbs10 T A 10: 111,136,396 (GRCm39) I503K probably benign Het
Birc2 A G 9: 7,818,797 (GRCm39) I598T probably damaging Het
Cbl A T 9: 44,076,171 (GRCm39) D339E probably damaging Het
Cdh4 C A 2: 179,515,871 (GRCm39) Q350K possibly damaging Het
Cep78 A G 19: 15,933,727 (GRCm39) L617P probably damaging Het
Cnbd2 T G 2: 156,170,281 (GRCm39) V122G probably damaging Het
Crem A T 18: 3,288,007 (GRCm39) N158K possibly damaging Het
Cul1 T C 6: 47,472,027 (GRCm39) V56A possibly damaging Het
Dop1b T A 16: 93,546,827 (GRCm39) I277N possibly damaging Het
Exoc3 T C 13: 74,340,784 (GRCm39) D340G probably benign Het
Exoc6b A C 6: 84,885,176 (GRCm39) D254E probably benign Het
Fyttd1 A G 16: 32,722,862 (GRCm39) K268E probably damaging Het
Gbp8 T A 5: 105,178,844 (GRCm39) N157I probably benign Het
Hacd1 T A 2: 14,049,605 (GRCm39) S118C probably damaging Het
Hcn4 A C 9: 58,731,027 (GRCm39) E78A unknown Het
Inpp5e T A 2: 26,289,274 (GRCm39) T549S probably benign Het
Kcnh4 T C 11: 100,646,105 (GRCm39) N281S probably damaging Het
Kdm5b A G 1: 134,552,864 (GRCm39) D1280G probably benign Het
Lrfn3 A G 7: 30,059,304 (GRCm39) V307A probably benign Het
Mafb A G 2: 160,208,298 (GRCm39) L100P probably damaging Het
Med24 C T 11: 98,608,940 (GRCm39) G119R probably benign Het
Mvp G T 7: 126,586,171 (GRCm39) P866Q probably benign Het
Phykpl T C 11: 51,476,408 (GRCm39) Y43H probably damaging Het
Prag1 T G 8: 36,571,364 (GRCm39) L649R probably damaging Het
Ptgdr2 T C 19: 10,918,361 (GRCm39) F293L probably damaging Het
Rasip1 T G 7: 45,279,704 (GRCm39) S316A possibly damaging Het
Rlf G A 4: 121,004,429 (GRCm39) S1627L probably benign Het
Rtl1 T C 12: 109,557,145 (GRCm39) R1565G probably benign Het
Sart3 G A 5: 113,886,018 (GRCm39) T572M probably damaging Het
Sec24b G T 3: 129,789,573 (GRCm39) S816* probably null Het
Slamf1 C T 1: 171,619,887 (GRCm39) P279L probably benign Het
Slc18a1 C A 8: 69,495,401 (GRCm39) V368F possibly damaging Het
Tap1 A T 17: 34,408,206 (GRCm39) D194V probably damaging Het
Tuba1c A G 15: 98,935,496 (GRCm39) Y319C probably damaging Het
Unc79 T A 12: 103,036,416 (GRCm39) I579N probably damaging Het
Zbtb22 G T 17: 34,135,956 (GRCm39) V34L probably damaging Het
Other mutations in Or51l4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Or51l4 APN 7 103,404,213 (GRCm39) missense probably damaging 1.00
IGL01111:Or51l4 APN 7 103,404,580 (GRCm39) missense probably benign 0.07
IGL02456:Or51l4 APN 7 103,404,700 (GRCm39) missense possibly damaging 0.94
IGL03173:Or51l4 APN 7 103,404,183 (GRCm39) missense probably benign 0.00
R1104:Or51l4 UTSW 7 103,404,183 (GRCm39) missense probably benign 0.00
R1507:Or51l4 UTSW 7 103,404,228 (GRCm39) missense probably benign 0.00
R1695:Or51l4 UTSW 7 103,404,131 (GRCm39) nonsense probably null
R1966:Or51l4 UTSW 7 103,404,375 (GRCm39) missense probably damaging 1.00
R1971:Or51l4 UTSW 7 103,404,527 (GRCm39) nonsense probably null
R2696:Or51l4 UTSW 7 103,404,735 (GRCm39) missense probably damaging 0.96
R4943:Or51l4 UTSW 7 103,404,503 (GRCm39) missense probably benign 0.12
R5622:Or51l4 UTSW 7 103,404,376 (GRCm39) missense probably damaging 0.99
R6365:Or51l4 UTSW 7 103,404,402 (GRCm39) missense probably benign 0.00
R7592:Or51l4 UTSW 7 103,404,279 (GRCm39) missense probably damaging 1.00
R8283:Or51l4 UTSW 7 103,404,019 (GRCm39) missense possibly damaging 0.51
R8867:Or51l4 UTSW 7 103,403,893 (GRCm39) nonsense probably null
R8875:Or51l4 UTSW 7 103,404,462 (GRCm39) missense probably damaging 1.00
R9658:Or51l4 UTSW 7 103,404,028 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCTGAGCAGAGCAGCAGTTC -3'
(R):5'- TGGCTATGAGGAATTTCATCACTG -3'

Sequencing Primer
(F):5'- GAGCAGCAGTTCCAATCTTG -3'
(R):5'- GAGGAATTTCATCACTGGATTTCC -3'
Posted On 2020-06-30