Incidental Mutation 'R8153:Lnx2'
ID 633132
Institutional Source Beutler Lab
Gene Symbol Lnx2
Ensembl Gene ENSMUSG00000016520
Gene Name ligand of numb-protein X 2
Synonyms
MMRRC Submission 067579-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R8153 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 146953465-147013385 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 146964906 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 439 (N439S)
Ref Sequence ENSEMBL: ENSMUSP00000016664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016664]
AlphaFold Q91XL2
Predicted Effect probably benign
Transcript: ENSMUST00000016664
AA Change: N439S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000016664
Gene: ENSMUSG00000016520
AA Change: N439S

DomainStartEndE-ValueType
RING 51 88 2.06e-6 SMART
low complexity region 103 114 N/A INTRINSIC
PDZ 242 317 2.25e-17 SMART
PDZ 348 421 2.97e-17 SMART
PDZ 474 553 7.37e-13 SMART
PDZ 606 683 1.27e-16 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T A 7: 41,275,157 (GRCm39) S287T probably benign Het
Abca15 T C 7: 119,999,812 (GRCm39) S1429P probably damaging Het
Arfgef2 GTGTGCAGAAACT GT 2: 166,676,383 (GRCm39) 92 probably null Het
C1qb A G 4: 136,607,877 (GRCm39) V162A possibly damaging Het
Cachd1 G T 4: 100,845,835 (GRCm39) probably null Het
Cfap61 T C 2: 146,042,704 (GRCm39) I1159T probably benign Het
Csf1 T A 3: 107,656,020 (GRCm39) D337V probably damaging Het
Ddhd2 T A 8: 26,240,816 (GRCm39) T251S probably benign Het
Dnah5 A G 15: 28,384,576 (GRCm39) T3107A probably damaging Het
Dnph1 T C 17: 46,809,965 (GRCm39) V169A probably benign Het
Ebf2 T C 14: 67,627,914 (GRCm39) V303A probably damaging Het
Eif4a3l2 A T 6: 116,528,968 (GRCm39) I282F probably damaging Het
Enpp3 A G 10: 24,685,777 (GRCm39) F206S probably damaging Het
Fam151b G T 13: 92,614,410 (GRCm39) T26K probably damaging Het
Fga T C 3: 82,938,164 (GRCm39) S180P probably damaging Het
Fpr-rs3 A G 17: 20,844,685 (GRCm39) L152P probably damaging Het
Gen1 C A 12: 11,310,948 (GRCm39) G95W probably damaging Het
Ggta1 T A 2: 35,313,333 (GRCm39) T3S possibly damaging Het
Gm4884 T A 7: 40,692,582 (GRCm39) C184S probably benign Het
Gpr137b T C 13: 13,533,991 (GRCm39) Y355C Het
Gsx2 T C 5: 75,237,716 (GRCm39) S223P probably damaging Het
Hnf4g C T 3: 3,699,250 (GRCm39) probably benign Het
Iqub A C 6: 24,450,789 (GRCm39) Y603* probably null Het
Klhl22 A G 16: 17,610,414 (GRCm39) N555S probably damaging Het
Lama5 T C 2: 179,829,724 (GRCm39) D1928G probably benign Het
Lamb2 C T 9: 108,357,845 (GRCm39) R123W probably damaging Het
Lamc2 CATCAGCTA CA 1: 152,999,850 (GRCm39) probably null Het
Lgr4 T A 2: 109,830,645 (GRCm39) F255I probably damaging Het
Lztr1 G T 16: 17,336,439 (GRCm39) probably null Het
Mtcl3 G T 10: 29,024,235 (GRCm39) E384* probably null Het
Nfkb2 G T 19: 46,296,455 (GRCm39) R241L probably damaging Het
Nrcam T C 12: 44,631,755 (GRCm39) F1103L probably benign Het
Or2g1 A G 17: 38,106,367 (GRCm39) I11V probably benign Het
Or5k17 A G 16: 58,746,149 (GRCm39) S262P possibly damaging Het
Or8d2 A G 9: 38,759,631 (GRCm39) I74V possibly damaging Het
Or8g52 A G 9: 39,630,954 (GRCm39) M144V possibly damaging Het
Otof C A 5: 30,546,079 (GRCm39) A425S probably damaging Het
Parg T A 14: 31,984,777 (GRCm39) L774H probably damaging Het
Pcnx1 C T 12: 81,965,593 (GRCm39) R59* probably null Het
Pcnx4 T A 12: 72,603,017 (GRCm39) F426L probably benign Het
Pde5a T G 3: 122,646,225 (GRCm39) S805R probably benign Het
Pde5a T A 3: 122,646,227 (GRCm39) M806K probably damaging Het
Plekhh1 T C 12: 79,125,812 (GRCm39) S1283P probably benign Het
Ppp1r12a A G 10: 107,998,303 (GRCm39) K15E probably damaging Het
Prkdc A T 16: 15,482,108 (GRCm39) M384L probably damaging Het
Ptchd4 A G 17: 42,814,787 (GRCm39) D896G probably benign Het
Rsf1 GGC GGCTACGGCCGC 7: 97,229,113 (GRCm39) probably benign Het
Slmap T C 14: 26,254,488 (GRCm39) S65G probably benign Het
Snta1 C A 2: 154,222,722 (GRCm39) L298F probably damaging Het
Sphkap T G 1: 83,255,730 (GRCm39) N673T possibly damaging Het
St8sia5 T G 18: 77,340,807 (GRCm39) probably null Het
Tgm6 T C 2: 129,986,975 (GRCm39) V481A probably benign Het
Thada T C 17: 84,700,855 (GRCm39) N1217S possibly damaging Het
Tia1 C G 6: 86,397,314 (GRCm39) H107D probably damaging Het
Ttn A G 2: 76,746,956 (GRCm39) Y4698H probably benign Het
Ube3c T C 5: 29,811,929 (GRCm39) Y390H possibly damaging Het
Ubqln5 A G 7: 103,778,011 (GRCm39) I271T possibly damaging Het
Vmn2r109 A G 17: 20,784,969 (GRCm39) V17A probably benign Het
Xkr9 A G 1: 13,754,363 (GRCm39) D119G probably benign Het
Zfp236 C T 18: 82,648,152 (GRCm39) C1003Y probably damaging Het
Other mutations in Lnx2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02593:Lnx2 APN 5 146,969,825 (GRCm39) missense possibly damaging 0.81
IGL02657:Lnx2 APN 5 146,964,984 (GRCm39) missense probably damaging 1.00
IGL02820:Lnx2 APN 5 146,978,877 (GRCm39) missense probably damaging 0.98
R0051:Lnx2 UTSW 5 146,966,163 (GRCm39) missense probably damaging 0.96
R0389:Lnx2 UTSW 5 146,955,850 (GRCm39) missense possibly damaging 0.51
R0482:Lnx2 UTSW 5 146,955,771 (GRCm39) missense probably damaging 0.99
R1601:Lnx2 UTSW 5 146,970,329 (GRCm39) missense probably damaging 0.99
R1604:Lnx2 UTSW 5 146,966,135 (GRCm39) missense probably benign 0.02
R1647:Lnx2 UTSW 5 146,964,152 (GRCm39) missense probably benign 0.04
R3001:Lnx2 UTSW 5 146,955,825 (GRCm39) missense probably benign 0.00
R3002:Lnx2 UTSW 5 146,955,825 (GRCm39) missense probably benign 0.00
R4734:Lnx2 UTSW 5 146,965,947 (GRCm39) missense probably damaging 1.00
R4960:Lnx2 UTSW 5 146,955,850 (GRCm39) missense probably benign 0.09
R5387:Lnx2 UTSW 5 146,964,964 (GRCm39) missense probably benign 0.00
R5689:Lnx2 UTSW 5 146,965,961 (GRCm39) missense probably damaging 1.00
R5950:Lnx2 UTSW 5 146,961,160 (GRCm39) critical splice donor site probably null
R6161:Lnx2 UTSW 5 146,978,836 (GRCm39) splice site probably null
R6623:Lnx2 UTSW 5 146,961,297 (GRCm39) missense probably damaging 1.00
R7086:Lnx2 UTSW 5 146,956,988 (GRCm39) splice site probably null
R7320:Lnx2 UTSW 5 146,956,943 (GRCm39) missense possibly damaging 0.71
R7701:Lnx2 UTSW 5 146,961,333 (GRCm39) missense probably damaging 1.00
R7887:Lnx2 UTSW 5 146,955,853 (GRCm39) missense probably damaging 1.00
R8267:Lnx2 UTSW 5 146,965,901 (GRCm39) missense probably damaging 1.00
R8298:Lnx2 UTSW 5 146,961,327 (GRCm39) missense probably benign 0.05
R8384:Lnx2 UTSW 5 146,966,138 (GRCm39) missense probably benign 0.01
R8446:Lnx2 UTSW 5 146,970,169 (GRCm39) missense probably benign
R8971:Lnx2 UTSW 5 146,970,236 (GRCm39) missense probably benign
R9378:Lnx2 UTSW 5 146,961,180 (GRCm39) missense probably benign 0.16
R9468:Lnx2 UTSW 5 146,979,289 (GRCm39) start gained probably benign
R9711:Lnx2 UTSW 5 146,961,376 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAATGACAGCCTGCATTTCAG -3'
(R):5'- CCTTGGGCTACTCAGTGAGAAC -3'

Sequencing Primer
(F):5'- CCAAACAAAACCAAAAAGACCTG -3'
(R):5'- GCTACTCAGTGAGAACTTGCC -3'
Posted On 2020-06-30