Incidental Mutation 'R8158:Cgrrf1'
ID 633392
Institutional Source Beutler Lab
Gene Symbol Cgrrf1
Ensembl Gene ENSMUSG00000055128
Gene Name cell growth regulator with ring finger domain 1
Synonyms 1810009H17Rik, CGR19, 1110038G02Rik
MMRRC Submission 067584-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8158 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 46832125-46854193 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 46853735 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 239 (S239P)
Ref Sequence ENSEMBL: ENSMUSP00000070548 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068532] [ENSMUST00000226861]
AlphaFold Q8BMJ7
Predicted Effect probably benign
Transcript: ENSMUST00000068532
AA Change: S239P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000070548
Gene: ENSMUSG00000055128
AA Change: S239P

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
low complexity region 233 246 N/A INTRINSIC
RING 274 308 2.26e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000226861
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl2 T A 1: 156,642,069 (GRCm38) S968T probably benign Het
Adcy8 T C 15: 64,783,806 (GRCm38) D608G probably benign Het
Adgb C T 10: 10,378,734 (GRCm38) V1162M probably benign Het
Agrn A G 4: 156,173,889 (GRCm38) V1040A probably benign Het
Amer3 A T 1: 34,587,660 (GRCm38) T327S possibly damaging Het
Apaf1 C T 10: 91,059,658 (GRCm38) C426Y probably benign Het
Bsn T C 9: 108,110,033 (GRCm38) D2840G unknown Het
Camsap1 A T 2: 25,944,428 (GRCm38) C406* probably null Het
Cbr2 A T 11: 120,730,297 (GRCm38) M158K probably damaging Het
Clnk C A 5: 38,794,911 (GRCm38) probably null Het
Csad T C 15: 102,177,762 (GRCm38) M445V probably damaging Het
Dnajb7 T A 15: 81,407,399 (GRCm38) N246Y probably damaging Het
Dok6 T C 18: 89,473,947 (GRCm38) I169V probably benign Het
H2bc14 T C 13: 21,722,461 (GRCm38) Y122H probably benign Het
Il1f10 T G 2: 24,291,255 (GRCm38) I11R possibly damaging Het
Irs1 C T 1: 82,289,533 (GRCm38) V321M probably damaging Het
Itga9 T C 9: 118,877,143 (GRCm38) F938L probably damaging Het
Kif7 T C 7: 79,704,694 (GRCm38) D781G probably damaging Het
Klhl41 A T 2: 69,671,161 (GRCm38) N322I probably damaging Het
Krtap31-1 T G 11: 99,908,075 (GRCm38) C35G possibly damaging Het
Lsm11 A T 11: 45,933,997 (GRCm38) D234E probably benign Het
Med6 T C 12: 81,573,903 (GRCm38) K223R probably benign Het
Mfsd4b2 G A 10: 39,922,068 (GRCm38) T97I probably benign Het
Mrgpra1 A T 7: 47,335,456 (GRCm38) C158* probably null Het
Nr2e1 T C 10: 42,582,885 (GRCm38) T8A probably benign Het
Oas2 T C 5: 120,749,773 (GRCm38) M1V probably null Het
Or13a27 T C 7: 140,345,249 (GRCm38) I247V probably benign Het
Or14a260 T A 7: 86,335,677 (GRCm38) I240F probably benign Het
Or1e33 T A 11: 73,847,871 (GRCm38) M85L probably benign Het
Or8k17 T C 2: 86,236,160 (GRCm38) Y218C probably damaging Het
Or8w1 T A 2: 87,634,889 (GRCm38) N286I probably damaging Het
Otof C T 5: 30,380,194 (GRCm38) G1257D probably benign Het
Phf2 T C 13: 48,817,760 (GRCm38) T479A probably benign Het
Pik3c2a T C 7: 116,342,997 (GRCm38) N1516S probably benign Het
Qrich1 C A 9: 108,556,037 (GRCm38) T622K probably damaging Het
Rasip1 A G 7: 45,632,519 (GRCm38) K482R probably damaging Het
Rgl2 T C 17: 33,936,944 (GRCm38) F698L probably benign Het
Scarb1 T C 5: 125,303,137 (GRCm38) D124G probably benign Het
Sclt1 A G 3: 41,671,482 (GRCm38) I350T probably benign Het
Sec23ip T G 7: 128,767,640 (GRCm38) V696G probably damaging Het
Serpina1e G T 12: 103,951,095 (GRCm38) T105K probably benign Het
Sin3a A G 9: 57,113,544 (GRCm38) probably null Het
Slc34a2 A G 5: 53,060,840 (GRCm38) T154A probably damaging Het
Slc9a3 T C 13: 74,155,122 (GRCm38) L178P probably damaging Het
Smarca2 A C 19: 26,682,048 (GRCm38) I913L probably benign Het
Spaca7b T A 8: 11,665,056 (GRCm38) D46V probably damaging Het
Tcea3 G A 4: 136,273,716 (GRCm38) probably null Het
Tektl1 G C 10: 78,748,675 (GRCm38) Q338E probably benign Het
Tmcc1 T A 6: 116,043,474 (GRCm38) H339L Het
Trpm2 G T 10: 77,947,897 (GRCm38) H247Q probably damaging Het
Tyr T A 7: 87,472,516 (GRCm38) D356V probably damaging Het
Vmn2r54 A T 7: 12,615,961 (GRCm38) C565S probably damaging Het
Vmn2r82 A C 10: 79,377,802 (GRCm38) N74T probably benign Het
Zcchc4 T C 5: 52,815,918 (GRCm38) Y375H probably damaging Het
Zfhx3 T A 8: 108,948,721 (GRCm38) D2134E possibly damaging Het
Zfhx4 T A 3: 5,398,950 (GRCm38) Y1414* probably null Het
Zfp282 A T 6: 47,890,692 (GRCm38) E267D possibly damaging Het
Zfp442 A T 2: 150,409,176 (GRCm38) C269S possibly damaging Het
Zp3 T A 5: 135,985,564 (GRCm38) S246T probably benign Het
Other mutations in Cgrrf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Cgrrf1 APN 14 46,832,322 (GRCm38) missense probably damaging 0.99
IGL02507:Cgrrf1 APN 14 46,853,444 (GRCm38) nonsense probably null
IGL03298:Cgrrf1 APN 14 46,846,321 (GRCm38) missense probably benign 0.08
R0152:Cgrrf1 UTSW 14 46,853,913 (GRCm38) missense probably damaging 1.00
R1477:Cgrrf1 UTSW 14 46,853,438 (GRCm38) missense probably benign 0.12
R2020:Cgrrf1 UTSW 14 46,830,445 (GRCm38) unclassified probably benign
R2107:Cgrrf1 UTSW 14 46,853,376 (GRCm38) splice site probably benign
R3010:Cgrrf1 UTSW 14 46,853,766 (GRCm38) missense probably benign
R3801:Cgrrf1 UTSW 14 46,832,363 (GRCm38) missense probably damaging 1.00
R4296:Cgrrf1 UTSW 14 46,832,355 (GRCm38) missense probably damaging 0.99
R4681:Cgrrf1 UTSW 14 46,853,826 (GRCm38) missense probably benign 0.00
R4884:Cgrrf1 UTSW 14 46,853,455 (GRCm38) missense possibly damaging 0.82
R6010:Cgrrf1 UTSW 14 46,853,701 (GRCm38) missense probably damaging 0.99
R6299:Cgrrf1 UTSW 14 46,840,190 (GRCm38) missense probably damaging 1.00
R6861:Cgrrf1 UTSW 14 46,832,328 (GRCm38) missense probably damaging 1.00
R6932:Cgrrf1 UTSW 14 46,853,722 (GRCm38) missense probably benign 0.09
R6986:Cgrrf1 UTSW 14 46,832,129 (GRCm38) unclassified probably benign
R7132:Cgrrf1 UTSW 14 46,853,864 (GRCm38) missense probably damaging 1.00
R7152:Cgrrf1 UTSW 14 46,853,477 (GRCm38) nonsense probably null
R7694:Cgrrf1 UTSW 14 46,853,958 (GRCm38) missense possibly damaging 0.79
R8081:Cgrrf1 UTSW 14 46,854,011 (GRCm38) missense probably benign 0.03
R9028:Cgrrf1 UTSW 14 46,853,743 (GRCm38) missense probably benign 0.01
R9430:Cgrrf1 UTSW 14 46,853,874 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTTATAGAGATCAAGGAGTGGCTG -3'
(R):5'- ACTGCTTGAAGTAGCGCACAC -3'

Sequencing Primer
(F):5'- ATCAAGGAGTGGCTGTTTTTAAAGAG -3'
(R):5'- CTTGAAGTAGCGCACACAGCTG -3'
Posted On 2020-06-30