Incidental Mutation 'R8159:Or51v14'
ID 633436
Institutional Source Beutler Lab
Gene Symbol Or51v14
Ensembl Gene ENSMUSG00000045132
Gene Name olfactory receptor family 51 subfamily V member 14
Synonyms MOR4-1, Olfr620, GA_x6K02T2PBJ9-6335095-6334154
MMRRC Submission 067585-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R8159 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 103260617-103261558 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 103261347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 71 (T71I)
Ref Sequence ENSEMBL: ENSMUSP00000061764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052152]
AlphaFold E9PZ66
Predicted Effect possibly damaging
Transcript: ENSMUST00000052152
AA Change: T71I

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000061764
Gene: ENSMUSG00000045132
AA Change: T71I

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 1.6e-137 PFAM
Pfam:7tm_1 43 294 4.5e-19 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.6%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 C A 3: 59,843,843 (GRCm39) P179Q probably damaging Het
Abcc1 C T 16: 14,290,794 (GRCm39) T1468I probably damaging Het
Adrb3 A C 8: 27,718,099 (GRCm39) C117G probably benign Het
Aff4 A T 11: 53,302,721 (GRCm39) S1065C possibly damaging Het
Agrn G A 4: 156,256,825 (GRCm39) A1260V probably benign Het
Auts2 A G 5: 131,488,963 (GRCm39) probably null Het
BC005537 T A 13: 24,993,916 (GRCm39) H159Q probably benign Het
Cacna2d4 A G 6: 119,274,488 (GRCm39) D625G probably benign Het
Cd72 A G 4: 43,450,174 (GRCm39) Y245H probably damaging Het
Ceacam20 G T 7: 19,710,109 (GRCm39) V378L probably damaging Het
Chpf C T 1: 75,455,436 (GRCm39) R105K probably null Het
Chst9 A T 18: 15,585,365 (GRCm39) Y399* probably null Het
Cntn5 A G 9: 10,145,386 (GRCm39) I108T possibly damaging Het
Col14a1 A G 15: 55,291,324 (GRCm39) T931A unknown Het
D630045J12Rik T C 6: 38,105,410 (GRCm39) H1890R probably damaging Het
Dkk2 T C 3: 131,880,739 (GRCm39) I128T probably benign Het
Ece2 C T 16: 20,430,534 (GRCm39) P54S probably damaging Het
Fhip2a T C 19: 57,372,697 (GRCm39) probably null Het
Fry A T 5: 150,322,998 (GRCm39) T1050S probably benign Het
Gfra2 A G 14: 71,133,397 (GRCm39) K76E probably damaging Het
Gigyf1 A T 5: 137,520,457 (GRCm39) D423V unknown Het
Gpr180 G A 14: 118,391,302 (GRCm39) G235R probably damaging Het
Herc1 A G 9: 66,369,003 (GRCm39) Q403R probably null Het
Hes5 A G 4: 155,045,502 (GRCm39) N17S probably benign Het
Insrr T A 3: 87,707,735 (GRCm39) L59H probably damaging Het
Irs1 A C 1: 82,266,290 (GRCm39) I642S probably damaging Het
Mettl22 T C 16: 8,306,633 (GRCm39) V363A probably benign Het
Notch2 A G 3: 98,028,238 (GRCm39) H983R possibly damaging Het
Nynrin T G 14: 56,100,587 (GRCm39) S126A probably damaging Het
Nynrin A T 14: 56,102,517 (GRCm39) M729L probably benign Het
Or7e178 A C 9: 20,226,015 (GRCm39) I67S possibly damaging Het
Otof C T 5: 30,537,538 (GRCm39) G1257D probably benign Het
Pals2 A T 6: 50,171,527 (GRCm39) E392V probably benign Het
Pcdhgc5 A G 18: 37,954,175 (GRCm39) E483G probably benign Het
Phldb2 T C 16: 45,680,747 (GRCm39) E20G possibly damaging Het
Ptprz1 A G 6: 23,001,662 (GRCm39) I1251V probably benign Het
Rfx2 A T 17: 57,110,605 (GRCm39) M127K probably benign Het
Slc9a3 A G 13: 74,312,407 (GRCm39) N668S probably benign Het
Smg6 G A 11: 74,929,465 (GRCm39) V965M probably damaging Het
Spen A T 4: 141,202,314 (GRCm39) H2104Q possibly damaging Het
Svep1 C T 4: 58,069,396 (GRCm39) E2797K possibly damaging Het
Svep1 T C 4: 58,087,815 (GRCm39) S1755G probably benign Het
Sycp2 A C 2: 177,996,770 (GRCm39) S1144R probably damaging Het
Tsen54 T A 11: 115,711,804 (GRCm39) L407* probably null Het
Uba1y T A Y: 828,806 (GRCm39) I538K possibly damaging Het
Vil1 C A 1: 74,463,136 (GRCm39) H440N probably benign Het
Other mutations in Or51v14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02807:Or51v14 APN 7 103,261,198 (GRCm39) missense probably benign 0.34
R0496:Or51v14 UTSW 7 103,261,204 (GRCm39) missense probably benign 0.09
R0834:Or51v14 UTSW 7 103,261,444 (GRCm39) missense probably benign 0.00
R1957:Or51v14 UTSW 7 103,260,618 (GRCm39) makesense probably null
R1958:Or51v14 UTSW 7 103,260,618 (GRCm39) makesense probably null
R2158:Or51v14 UTSW 7 103,261,443 (GRCm39) missense possibly damaging 0.66
R3797:Or51v14 UTSW 7 103,260,654 (GRCm39) missense probably benign 0.37
R5389:Or51v14 UTSW 7 103,260,797 (GRCm39) nonsense probably null
R6292:Or51v14 UTSW 7 103,261,386 (GRCm39) missense probably damaging 0.99
R6374:Or51v14 UTSW 7 103,261,128 (GRCm39) missense probably benign 0.23
R6422:Or51v14 UTSW 7 103,261,221 (GRCm39) missense probably damaging 1.00
R6586:Or51v14 UTSW 7 103,261,183 (GRCm39) missense possibly damaging 0.81
R7234:Or51v14 UTSW 7 103,261,089 (GRCm39) missense probably damaging 0.97
R7393:Or51v14 UTSW 7 103,261,198 (GRCm39) missense possibly damaging 0.90
R7855:Or51v14 UTSW 7 103,260,979 (GRCm39) missense possibly damaging 0.88
R7900:Or51v14 UTSW 7 103,260,900 (GRCm39) missense possibly damaging 0.82
R8265:Or51v14 UTSW 7 103,261,048 (GRCm39) missense possibly damaging 0.95
R8314:Or51v14 UTSW 7 103,261,254 (GRCm39) missense probably damaging 1.00
R9182:Or51v14 UTSW 7 103,261,063 (GRCm39) missense possibly damaging 0.57
Predicted Primers PCR Primer
(F):5'- TGGCCACTCCGATTTTCAGG -3'
(R):5'- CACTAGTTCTAGGTTTGCTCTGAC -3'

Sequencing Primer
(F):5'- CCGATTTTCAGGATCCTGTCATTGG -3'
(R):5'- GCTCTGACTGGTTTCCCTGG -3'
Posted On 2020-07-13