Incidental Mutation 'R8162:Gm13741'
ID 633557
Institutional Source Beutler Lab
Gene Symbol Gm13741
Ensembl Gene ENSMUSG00000090018
Gene Name predicted gene 13741
Synonyms
MMRRC Submission 067588-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # R8162 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87656511-87658457 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 87486446 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 273 (M273R)
Ref Sequence ENSEMBL: ENSMUSP00000097443 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099857]
AlphaFold no structure available at present
Predicted Effect noncoding transcript
Transcript: ENSMUST00000099854
AA Change: M273R
SMART Domains Protein: ENSMUSP00000097440
Gene: ENSMUSG00000075154
AA Change: M273R

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000099857
AA Change: M273R

PolyPhen 2 Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000097443
Gene: ENSMUSG00000111747
AA Change: M273R

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.8%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol7b T A 15: 77,307,430 (GRCm39) Q355L probably benign Het
Asb14 A T 14: 26,633,945 (GRCm39) Q383H probably benign Het
Ash1l T G 3: 88,977,553 (GRCm39) M2661R probably damaging Het
Cacna1e G T 1: 154,577,313 (GRCm39) probably null Het
Ccdc40 G T 11: 119,150,870 (GRCm39) probably null Het
Cd27 T A 6: 125,210,188 (GRCm39) probably null Het
Ces3b T C 8: 105,817,385 (GRCm39) L371S possibly damaging Het
Clec4a2 T A 6: 123,117,711 (GRCm39) Y210N probably damaging Het
Cpeb2 A T 5: 43,394,681 (GRCm39) H553L Het
Cpne8 T C 15: 90,503,881 (GRCm39) I95V probably benign Het
D630039A03Rik T C 4: 57,910,525 (GRCm39) T96A probably benign Het
Dand5 C A 8: 85,543,147 (GRCm39) G110C probably damaging Het
Erich3 C T 3: 154,470,210 (GRCm39) T1554M unknown Het
Evi5l T C 8: 4,241,300 (GRCm39) S278P probably damaging Het
Farp2 C A 1: 93,548,325 (GRCm39) H1003Q probably damaging Het
G530012D18Rik C G 1: 85,504,935 (GRCm39) D113E unknown Het
Gm28363 T A 1: 117,626,641 (GRCm39) D26E unknown Het
Gm8674 A T 13: 50,054,407 (GRCm39) D700E noncoding transcript Het
Gtf3c4 G A 2: 28,724,593 (GRCm39) Q380* probably null Het
Idh2 GGTCCCAG GG 7: 79,748,077 (GRCm39) probably benign Het
Il1a A T 2: 129,148,477 (GRCm39) S78T possibly damaging Het
Kdm2b A T 5: 123,072,856 (GRCm39) Y341N probably damaging Het
Mcc T C 18: 44,582,508 (GRCm39) probably null Het
Met A G 6: 17,547,061 (GRCm39) D898G probably damaging Het
Mogs T C 6: 83,092,863 (GRCm39) V101A probably damaging Het
Mrgpra4 A T 7: 47,631,221 (GRCm39) Y127N probably damaging Het
Ms4a18 A G 19: 10,991,071 (GRCm39) S8P probably benign Het
Muc4 A T 16: 32,569,197 (GRCm39) T148S unknown Het
Nutm1 G A 2: 112,078,817 (GRCm39) L1033F probably benign Het
Ocstamp G T 2: 165,239,787 (GRCm39) A133D probably damaging Het
Or1ab2 T G 8: 72,864,253 (GRCm39) V281G noncoding transcript Het
Or5p63 T C 7: 107,810,995 (GRCm39) H247R probably damaging Het
Or8g17 T A 9: 38,930,249 (GRCm39) D196V probably benign Het
Or9s18 G A 13: 65,300,734 (GRCm39) R232Q probably damaging Het
Phf12 C A 11: 77,915,651 (GRCm39) P46Q probably damaging Het
Prf1 A G 10: 61,138,749 (GRCm39) T236A probably damaging Het
Ptcd3 A G 6: 71,884,798 (GRCm39) V47A probably benign Het
Rapgef1 A T 2: 29,626,011 (GRCm39) N1071Y probably damaging Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rnf26rt C A 6: 76,473,558 (GRCm39) A353S probably benign Het
Tango6 C T 8: 107,409,882 (GRCm39) P33L possibly damaging Het
Tasor2 G T 13: 3,649,691 (GRCm39) T36N probably damaging Het
Tbc1d2b C T 9: 90,089,937 (GRCm39) R864H probably damaging Het
Tent2 A G 13: 93,304,432 (GRCm39) probably null Het
Trav10n A T 14: 53,359,929 (GRCm39) I69L probably benign Het
Tsks A G 7: 44,603,296 (GRCm39) Q366R probably damaging Het
Vcan G T 13: 89,853,106 (GRCm39) S618* probably null Het
Vwf T A 6: 125,622,799 (GRCm39) probably null Het
Zfp827 T A 8: 79,787,206 (GRCm39) L124* probably null Het
Other mutations in Gm13741
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0981:Gm13741 UTSW 2 87,486,578 (GRCm39) missense probably benign 0.01
R1423:Gm13741 UTSW 2 87,486,674 (GRCm39) missense possibly damaging 0.95
R1612:Gm13741 UTSW 2 87,486,431 (GRCm39) missense probably damaging 1.00
Z1088:Gm13741 UTSW 2 87,487,221 (GRCm39) missense probably benign 0.01
Z1088:Gm13741 UTSW 2 87,486,765 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CTCATTACATGCAATTCTCAGTAGG -3'
(R):5'- GGGATTAGCATTGTCACCGTC -3'

Sequencing Primer
(F):5'- TTAGTTCACATAAACACAGTCTCAG -3'
(R):5'- ATTAGCATTGTCACCGTCCTTCTATC -3'
Posted On 2020-07-13