Incidental Mutation 'R8163:Kynu'
ID 633605
Institutional Source Beutler Lab
Gene Symbol Kynu
Ensembl Gene ENSMUSG00000026866
Gene Name kynureninase
Synonyms L-kynurenine hydrolase, 4432411A05Rik
MMRRC Submission 067589-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8163 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 43445341-43572734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 43518966 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Valine at position 245 (G245V)
Ref Sequence ENSEMBL: ENSMUSP00000028223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028223] [ENSMUST00000050511] [ENSMUST00000112826]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000028223
AA Change: G245V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028223
Gene: ENSMUSG00000026866
AA Change: G245V

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 400 3.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000050511
AA Change: G245V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061775
Gene: ENSMUSG00000026866
AA Change: G245V

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 307 7.8e-12 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000112826
AA Change: G245V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108445
Gene: ENSMUSG00000026866
AA Change: G245V

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 405 8.4e-17 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930022D16Rik A G 11: 109,304,883 (GRCm39) I11V unknown Het
Ago3 G T 4: 126,262,377 (GRCm39) T391K probably benign Het
Asap1 A G 15: 63,963,899 (GRCm39) W1100R probably damaging Het
Bbof1 T C 12: 84,473,536 (GRCm39) S289P possibly damaging Het
Cd3d T C 9: 44,896,952 (GRCm39) F109L probably benign Het
Cebpd A T 16: 15,705,841 (GRCm39) E218V probably damaging Het
Cfl1 T C 19: 5,543,528 (GRCm39) probably benign Het
Cpa2 A C 6: 30,564,350 (GRCm39) I394L probably damaging Het
Ddx50 C A 10: 62,475,678 (GRCm39) V348F possibly damaging Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Echs1 A G 7: 139,692,357 (GRCm39) V130A possibly damaging Het
Eif2s2 A G 2: 154,734,621 (GRCm39) S2P probably benign Het
Fastk A G 5: 24,649,273 (GRCm39) I38T probably benign Het
Fat3 G A 9: 15,871,055 (GRCm39) R3779C probably damaging Het
Fat4 A T 3: 39,033,881 (GRCm39) N2511I possibly damaging Het
Fbxw13 G A 9: 109,012,122 (GRCm39) T315I probably benign Het
Fzd5 A T 1: 64,774,352 (GRCm39) Y470N probably damaging Het
G530012D18Rik C G 1: 85,504,935 (GRCm39) D113E unknown Het
Gpr25 T C 1: 136,187,596 (GRCm39) D339G probably damaging Het
Igsf9b T A 9: 27,233,907 (GRCm39) probably null Het
Il5 T A 11: 53,614,813 (GRCm39) M125K possibly damaging Het
Iqub G A 6: 24,449,714 (GRCm39) T717I probably benign Het
Katnb1 T C 8: 95,823,014 (GRCm39) F403S probably damaging Het
Krt26 T C 11: 99,220,498 (GRCm39) I451V probably benign Het
Krt88 T C 15: 101,351,389 (GRCm39) L132P probably damaging Het
Lap3 C T 5: 45,669,389 (GRCm39) R513* probably null Het
Lin9 C T 1: 180,486,691 (GRCm39) R126W probably damaging Het
Lrrc37 A T 11: 103,506,688 (GRCm39) I1760K unknown Het
Lrrtm2 C T 18: 35,346,777 (GRCm39) R175H probably damaging Het
N4bp2l2 A G 5: 150,584,774 (GRCm39) L60P probably damaging Het
Ncr1 T C 7: 4,343,828 (GRCm39) F142S probably damaging Het
Nktr TAGAAG TAG 9: 121,579,929 (GRCm39) probably benign Het
Or5b95 A G 19: 12,657,552 (GRCm39) I27V probably benign Het
Parp16 T A 9: 65,137,231 (GRCm39) H152Q probably damaging Het
Plaa C G 4: 94,457,640 (GRCm39) V777L probably benign Het
Prnp A G 2: 131,778,908 (GRCm39) T187A probably benign Het
Pzp T G 6: 128,489,157 (GRCm39) I485L probably benign Het
Rc3h1 T A 1: 160,782,629 (GRCm39) Y703N probably damaging Het
Rngtt G A 4: 33,325,109 (GRCm39) C110Y probably damaging Het
Rps10 G A 17: 27,853,085 (GRCm39) R95C probably benign Het
Scn9a T A 2: 66,314,745 (GRCm39) I1658F probably damaging Het
Sec16a A T 2: 26,306,433 (GRCm39) W702R Het
Taf6 G T 5: 138,180,238 (GRCm39) Q339K possibly damaging Het
Tbcd C T 11: 121,384,711 (GRCm39) T315M probably benign Het
Tmem198 C T 1: 75,459,671 (GRCm39) P209S possibly damaging Het
Vmn2r78 G A 7: 86,603,660 (GRCm39) A613T probably damaging Het
Vps13c G A 9: 67,857,720 (GRCm39) E2651K probably benign Het
Wdfy4 C T 14: 32,873,545 (GRCm39) V255I Het
Zfhx3 A G 8: 109,675,925 (GRCm39) D2325G probably damaging Het
Zfp36l2 T C 17: 84,494,551 (GRCm39) N29D possibly damaging Het
Zfp692 T A 11: 58,201,199 (GRCm39) probably null Het
Other mutations in Kynu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Kynu APN 2 43,561,394 (GRCm39) missense possibly damaging 0.91
IGL01974:Kynu APN 2 43,571,352 (GRCm39) unclassified probably benign
R0099:Kynu UTSW 2 43,519,065 (GRCm39) critical splice donor site probably null
R0304:Kynu UTSW 2 43,569,893 (GRCm39) missense probably damaging 0.99
R1681:Kynu UTSW 2 43,569,837 (GRCm39) missense probably damaging 1.00
R1799:Kynu UTSW 2 43,494,169 (GRCm39) missense possibly damaging 0.65
R2016:Kynu UTSW 2 43,494,289 (GRCm39) nonsense probably null
R2345:Kynu UTSW 2 43,471,397 (GRCm39) missense probably damaging 1.00
R3085:Kynu UTSW 2 43,492,312 (GRCm39) missense probably benign 0.00
R3825:Kynu UTSW 2 43,571,451 (GRCm39) missense probably benign
R4091:Kynu UTSW 2 43,569,884 (GRCm39) missense possibly damaging 0.94
R4241:Kynu UTSW 2 43,571,422 (GRCm39) missense probably benign 0.00
R4594:Kynu UTSW 2 43,569,902 (GRCm39) missense probably benign 0.00
R4673:Kynu UTSW 2 43,569,815 (GRCm39) missense probably damaging 1.00
R4871:Kynu UTSW 2 43,569,830 (GRCm39) missense possibly damaging 0.58
R5371:Kynu UTSW 2 43,479,406 (GRCm39) missense probably benign 0.00
R6272:Kynu UTSW 2 43,525,001 (GRCm39) missense probably benign 0.01
R6342:Kynu UTSW 2 43,571,463 (GRCm39) missense probably benign 0.09
R6866:Kynu UTSW 2 43,453,122 (GRCm39) nonsense probably null
R7203:Kynu UTSW 2 43,571,365 (GRCm39) missense probably damaging 1.00
R9024:Kynu UTSW 2 43,490,807 (GRCm39) missense possibly damaging 0.62
R9089:Kynu UTSW 2 43,489,620 (GRCm39) missense probably damaging 1.00
R9303:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9305:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9506:Kynu UTSW 2 43,571,414 (GRCm39) missense probably damaging 1.00
R9702:Kynu UTSW 2 43,479,469 (GRCm39) missense probably damaging 1.00
R9759:Kynu UTSW 2 43,569,881 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AAGTAGTTTTGCGAAGATGGC -3'
(R):5'- AACTTTATATGCCCCAGTACAGG -3'

Sequencing Primer
(F):5'- CTTTTGTCTAGAGGGCTGCCTAAAG -3'
(R):5'- GACTTTTGGTATAGCATTGGAAATG -3'
Posted On 2020-07-13