Incidental Mutation 'R0692:Or5m3b'
ID 63368
Institutional Source Beutler Lab
Gene Symbol Or5m3b
Ensembl Gene ENSMUSG00000045392
Gene Name olfactory receptor family 5 subfamily M member 3B
Synonyms GA_x6K02T2Q125-47516301-47517233, Olfr1033, MOR199-2
MMRRC Submission 038877-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R0692 (G1)
Quality Score 98
Status Not validated
Chromosome 2
Chromosomal Location 85850984-85875152 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85872516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 286 (M286V)
Ref Sequence ENSEMBL: ENSMUSP00000151539 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111589] [ENSMUST00000213496] [ENSMUST00000213774] [ENSMUST00000213865] [ENSMUST00000214546] [ENSMUST00000215682] [ENSMUST00000218397]
AlphaFold Q8VFK5
Predicted Effect probably benign
Transcript: ENSMUST00000111589
AA Change: M286V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000107216
Gene: ENSMUSG00000042796
AA Change: M286V

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213364
Predicted Effect probably benign
Transcript: ENSMUST00000213496
Predicted Effect probably benign
Transcript: ENSMUST00000213774
Predicted Effect probably benign
Transcript: ENSMUST00000213865
AA Change: M286V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000214546
AA Change: M286V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000215682
AA Change: M286V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000218397
AA Change: M286V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add3 T A 19: 53,205,383 (GRCm39) D44E probably damaging Het
Bpifb5 T C 2: 154,076,616 (GRCm39) V421A probably benign Het
Clk4 C T 11: 51,172,155 (GRCm39) R273* probably null Het
Cmya5 A T 13: 93,230,357 (GRCm39) L1577* probably null Het
Col14a1 G C 15: 55,205,134 (GRCm39) G88A unknown Het
Helz2 A G 2: 180,882,674 (GRCm39) C40R probably benign Het
Kcng1 T A 2: 168,104,683 (GRCm39) I388F probably damaging Het
Krt35 T C 11: 99,983,896 (GRCm39) E368G possibly damaging Het
Krt81 T C 15: 101,358,053 (GRCm39) D400G possibly damaging Het
Mcm3ap T C 10: 76,319,003 (GRCm39) C744R probably damaging Het
Pde6c A T 19: 38,168,698 (GRCm39) Y788F probably damaging Het
Plxnc1 A G 10: 94,673,362 (GRCm39) probably null Het
Rflnb T C 11: 75,918,279 (GRCm39) D62G probably benign Het
Sema4f CCAGCAGCAGCAGCAGCAGC CCAGCAGCAGCAGCAGC 6: 82,916,511 (GRCm39) probably benign Het
Slc12a1 T A 2: 125,036,082 (GRCm39) Y651* probably null Het
Srbd1 T C 17: 86,443,888 (GRCm39) T113A probably benign Het
Svopl A T 6: 37,994,131 (GRCm39) L300Q probably damaging Het
Trim41 C T 11: 48,699,077 (GRCm39) probably null Het
Vmn1r23 C A 6: 57,903,110 (GRCm39) E223* probably null Het
Other mutations in Or5m3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:Or5m3b APN 2 85,872,441 (GRCm39) missense probably damaging 1.00
IGL01745:Or5m3b APN 2 85,872,381 (GRCm39) missense possibly damaging 0.74
IGL02317:Or5m3b APN 2 85,871,913 (GRCm39) missense probably damaging 0.99
IGL02400:Or5m3b APN 2 85,872,420 (GRCm39) missense probably benign 0.00
R1629:Or5m3b UTSW 2 85,871,766 (GRCm39) missense probably damaging 0.99
R2105:Or5m3b UTSW 2 85,871,674 (GRCm39) missense probably damaging 0.97
R2288:Or5m3b UTSW 2 85,872,377 (GRCm39) nonsense probably null
R4451:Or5m3b UTSW 2 85,872,303 (GRCm39) missense probably damaging 1.00
R4512:Or5m3b UTSW 2 85,871,913 (GRCm39) missense probably damaging 0.99
R4878:Or5m3b UTSW 2 85,871,799 (GRCm39) missense probably benign 0.08
R5442:Or5m3b UTSW 2 85,872,295 (GRCm39) missense probably benign 0.29
R5867:Or5m3b UTSW 2 85,871,795 (GRCm39) missense probably benign 0.01
R7849:Or5m3b UTSW 2 85,871,949 (GRCm39) missense probably benign 0.00
R7881:Or5m3b UTSW 2 85,871,814 (GRCm39) missense probably benign 0.03
Z1088:Or5m3b UTSW 2 85,872,063 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGAATGCGCTCAGCAGAAGG -3'
(R):5'- CGAAGGCATTAGACAGGTCAAGGTC -3'

Sequencing Primer
(F):5'- CTCAGCAGAAGGCAGGC -3'
(R):5'- atttaaCCTACTTGCCTAAGAGTTCC -3'
Posted On 2013-07-30