Incidental Mutation 'R8165:Vrk2'
ID 633733
Institutional Source Beutler Lab
Gene Symbol Vrk2
Ensembl Gene ENSMUSG00000064090
Gene Name vaccinia related kinase 2
Synonyms 2810003O05Rik
MMRRC Submission 067591-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.235) question?
Stock # R8165 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 26421398-26544006 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 26485575 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 138 (F138L)
Ref Sequence ENSEMBL: ENSMUSP00000077471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078362] [ENSMUST00000109504]
AlphaFold Q8BN21
Predicted Effect probably benign
Transcript: ENSMUST00000078362
AA Change: F138L

PolyPhen 2 Score 0.206 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077471
Gene: ENSMUSG00000064090
AA Change: F138L

DomainStartEndE-ValueType
Pfam:Pkinase 29 298 4.4e-18 PFAM
Pfam:Pkinase_Tyr 29 313 2e-11 PFAM
low complexity region 365 376 N/A INTRINSIC
transmembrane domain 480 502 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109504
AA Change: F138L

PolyPhen 2 Score 0.206 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000105130
Gene: ENSMUSG00000064090
AA Change: F138L

DomainStartEndE-ValueType
Pfam:Pkinase 29 302 2.8e-22 PFAM
Pfam:Pkinase_Tyr 29 313 1.3e-11 PFAM
low complexity region 365 376 N/A INTRINSIC
transmembrane domain 480 502 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C A 5: 64,055,289 (GRCm39) probably null Het
Amph A G 13: 19,279,007 (GRCm39) K161E probably benign Het
Aox1 A T 1: 58,348,088 (GRCm39) H602L probably benign Het
Areg A G 5: 91,291,492 (GRCm39) N145S probably damaging Het
Arhgap29 C T 3: 121,782,222 (GRCm39) T142I probably damaging Het
Bcar3 C T 3: 122,304,805 (GRCm39) probably benign Het
Brpf3 C T 17: 29,025,248 (GRCm39) A107V probably benign Het
Btnl2 T A 17: 34,587,682 (GRCm39) S509T possibly damaging Het
Cacna2d2 A G 9: 107,402,653 (GRCm39) probably null Het
Casz1 C T 4: 149,028,888 (GRCm39) P1111L probably damaging Het
Ccdc91 C T 6: 147,533,086 (GRCm39) T411I unknown Het
Chd9 A C 8: 91,767,769 (GRCm39) E2422A probably damaging Het
Clrn3 T C 7: 135,130,133 (GRCm39) I34V probably benign Het
Cnksr3 C T 10: 7,104,467 (GRCm39) D79N probably damaging Het
Cops8 A G 1: 90,539,729 (GRCm39) probably null Het
Cpa2 A G 6: 30,564,345 (GRCm39) K392R probably benign Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Dnase1l3 T C 14: 7,994,299 (GRCm38) probably benign Het
Gdpd5 A T 7: 99,105,689 (GRCm39) T502S probably benign Het
Gp2 A T 7: 119,049,375 (GRCm39) D387E probably damaging Het
Gpr179 A G 11: 97,242,364 (GRCm39) L160P probably benign Het
Hmcn1 G A 1: 150,522,409 (GRCm39) T3497M probably benign Het
Idh3b T A 2: 130,122,420 (GRCm39) T322S possibly damaging Het
Kit A T 5: 75,781,540 (GRCm39) N323I possibly damaging Het
Kng2 T C 16: 22,806,246 (GRCm39) S445G unknown Het
Lin54 A G 5: 100,602,358 (GRCm39) V393A probably benign Het
Lyst T A 13: 13,872,945 (GRCm39) W2715R probably damaging Het
Mad1l1 T C 5: 140,300,813 (GRCm39) T28A probably benign Het
Med7 T A 11: 46,332,073 (GRCm39) C223S probably benign Het
Megf8 T A 7: 25,053,298 (GRCm39) L1823Q probably damaging Het
Mga C A 2: 119,777,719 (GRCm39) Q1755K probably benign Het
Mgat4b A T 11: 50,101,801 (GRCm39) N22I probably benign Het
Ndufb6 C T 4: 40,270,665 (GRCm39) probably null Het
Neil3 A G 8: 54,042,129 (GRCm39) L490P probably benign Het
Nek9 C T 12: 85,350,417 (GRCm39) V886I probably benign Het
Nol4l A T 2: 153,262,473 (GRCm39) Y366* probably null Het
Nt5dc2 A G 14: 30,860,886 (GRCm39) T354A probably damaging Het
Or1j11 T A 2: 36,311,715 (GRCm39) Y102N probably damaging Het
Pde2a G A 7: 101,149,655 (GRCm39) probably null Het
Phf1 T C 17: 27,156,044 (GRCm39) F444L possibly damaging Het
Plin4 G A 17: 56,414,019 (GRCm39) T202I possibly damaging Het
Plk4 G C 3: 40,768,009 (GRCm39) V851L probably damaging Het
Pp2d1 A G 17: 53,822,257 (GRCm39) S270P probably damaging Het
Ripor1 C A 8: 106,347,520 (GRCm39) L1028M unknown Het
Scn9a A G 2: 66,370,874 (GRCm39) F569L probably damaging Het
Sel1l2 T A 2: 140,104,626 (GRCm39) L306F probably damaging Het
Spic A T 10: 88,513,428 (GRCm39) S86T probably damaging Het
Spmip10 T A 18: 56,722,547 (GRCm39) probably benign Het
Stkld1 A G 2: 26,836,668 (GRCm39) N278S probably benign Het
Taar7d T A 10: 23,903,495 (GRCm39) F126I probably benign Het
Tbc1d31 A G 15: 57,824,345 (GRCm39) E869G possibly damaging Het
Tbcd C T 11: 121,384,711 (GRCm39) T315M probably benign Het
Terf2 T C 8: 107,809,656 (GRCm39) K221E possibly damaging Het
Thsd7a T A 6: 12,468,962 (GRCm39) T539S Het
Tll2 A G 19: 41,077,313 (GRCm39) F818L possibly damaging Het
Tmem87a T C 2: 120,200,959 (GRCm39) T427A possibly damaging Het
Ush2a C A 1: 188,183,952 (GRCm39) Q1419K possibly damaging Het
Vill T A 9: 118,895,821 (GRCm39) F511Y probably damaging Het
Virma T A 4: 11,542,128 (GRCm39) D1521E probably benign Het
Vps13c A G 9: 67,766,072 (GRCm39) D63G probably benign Het
Zfp710 T C 7: 79,735,775 (GRCm39) I514T probably damaging Het
Zgrf1 T A 3: 127,357,032 (GRCm39) F753I possibly damaging Het
Other mutations in Vrk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01865:Vrk2 APN 11 26,485,560 (GRCm39) missense possibly damaging 0.73
IGL02011:Vrk2 APN 11 26,421,717 (GRCm39) missense probably benign 0.10
IGL02185:Vrk2 APN 11 26,485,638 (GRCm39) nonsense probably null
IGL02257:Vrk2 APN 11 26,484,266 (GRCm39) missense probably damaging 1.00
IGL02424:Vrk2 APN 11 26,426,564 (GRCm39) missense probably benign 0.00
macromacro UTSW 11 26,499,325 (GRCm39) missense probably damaging 1.00
R0127:Vrk2 UTSW 11 26,484,313 (GRCm39) splice site probably benign
R0184:Vrk2 UTSW 11 26,500,046 (GRCm39) missense probably damaging 0.98
R0670:Vrk2 UTSW 11 26,436,959 (GRCm39) critical splice donor site probably null
R0751:Vrk2 UTSW 11 26,433,331 (GRCm39) splice site probably benign
R0766:Vrk2 UTSW 11 26,485,522 (GRCm39) splice site probably benign
R1103:Vrk2 UTSW 11 26,499,325 (GRCm39) missense probably damaging 1.00
R1184:Vrk2 UTSW 11 26,433,331 (GRCm39) splice site probably benign
R1312:Vrk2 UTSW 11 26,485,522 (GRCm39) splice site probably benign
R2041:Vrk2 UTSW 11 26,497,914 (GRCm39) missense probably benign 0.01
R2857:Vrk2 UTSW 11 26,433,324 (GRCm39) missense possibly damaging 0.54
R2859:Vrk2 UTSW 11 26,433,324 (GRCm39) missense possibly damaging 0.54
R3615:Vrk2 UTSW 11 26,439,866 (GRCm39) missense possibly damaging 0.90
R3616:Vrk2 UTSW 11 26,439,866 (GRCm39) missense possibly damaging 0.90
R4163:Vrk2 UTSW 11 26,497,915 (GRCm39) missense probably benign 0.00
R4651:Vrk2 UTSW 11 26,439,803 (GRCm39) missense probably damaging 0.98
R4652:Vrk2 UTSW 11 26,439,803 (GRCm39) missense probably damaging 0.98
R4662:Vrk2 UTSW 11 26,421,611 (GRCm39) missense possibly damaging 0.95
R5262:Vrk2 UTSW 11 26,541,697 (GRCm39) missense possibly damaging 0.94
R5458:Vrk2 UTSW 11 26,448,919 (GRCm39) missense probably damaging 0.99
R5529:Vrk2 UTSW 11 26,449,036 (GRCm39) missense probably damaging 1.00
R5840:Vrk2 UTSW 11 26,484,314 (GRCm39) splice site probably benign
R5892:Vrk2 UTSW 11 26,484,372 (GRCm39) intron probably benign
R6054:Vrk2 UTSW 11 26,436,975 (GRCm39) missense probably benign 0.20
R6923:Vrk2 UTSW 11 26,439,893 (GRCm39) missense probably damaging 1.00
R6952:Vrk2 UTSW 11 26,485,597 (GRCm39) missense probably damaging 0.97
R7841:Vrk2 UTSW 11 26,421,457 (GRCm39) missense probably damaging 1.00
R9074:Vrk2 UTSW 11 26,543,917 (GRCm39) intron probably benign
R9583:Vrk2 UTSW 11 26,433,157 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGTCTGGTAGCAATAGTCAGC -3'
(R):5'- ACAGCTGCTTAGATGCCTTGG -3'

Sequencing Primer
(F):5'- ACAGCATAGCCTGTCATTGG -3'
(R):5'- AGATGCCTTGGCTATTAGGTAGAAG -3'
Posted On 2020-07-13