Incidental Mutation 'R8165:Nek9'
ID 633738
Institutional Source Beutler Lab
Gene Symbol Nek9
Ensembl Gene ENSMUSG00000034290
Gene Name NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms C130021H08Rik
MMRRC Submission 067591-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8165 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 85346288-85386136 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85350417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 886 (V886I)
Ref Sequence ENSEMBL: ENSMUSP00000049056 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040992] [ENSMUST00000059341]
AlphaFold Q8K1R7
Predicted Effect probably benign
Transcript: ENSMUST00000040992
AA Change: V886I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000049056
Gene: ENSMUSG00000034290
AA Change: V886I

DomainStartEndE-ValueType
low complexity region 19 49 N/A INTRINSIC
S_TKc 52 308 1.07e-73 SMART
Pfam:RCC1 389 441 1.2e-9 PFAM
Pfam:RCC1_2 428 457 1.5e-8 PFAM
Pfam:RCC1 444 495 3.6e-13 PFAM
Pfam:RCC1_2 482 511 3.6e-11 PFAM
Pfam:RCC1 499 547 7.6e-14 PFAM
Pfam:RCC1 615 665 4.2e-8 PFAM
Pfam:RCC1_2 652 681 4.4e-7 PFAM
low complexity region 752 767 N/A INTRINSIC
low complexity region 889 900 N/A INTRINSIC
low complexity region 910 927 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000059341
SMART Domains Protein: ENSMUSP00000051664
Gene: ENSMUSG00000045064

DomainStartEndE-ValueType
low complexity region 93 106 N/A INTRINSIC
coiled coil region 207 254 N/A INTRINSIC
Pfam:zf-C2HC_2 378 402 3.6e-10 PFAM
low complexity region 433 444 N/A INTRINSIC
Pfam:zf-C2HC_2 489 513 3.1e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C A 5: 64,055,289 (GRCm39) probably null Het
Amph A G 13: 19,279,007 (GRCm39) K161E probably benign Het
Aox1 A T 1: 58,348,088 (GRCm39) H602L probably benign Het
Areg A G 5: 91,291,492 (GRCm39) N145S probably damaging Het
Arhgap29 C T 3: 121,782,222 (GRCm39) T142I probably damaging Het
Bcar3 C T 3: 122,304,805 (GRCm39) probably benign Het
Brpf3 C T 17: 29,025,248 (GRCm39) A107V probably benign Het
Btnl2 T A 17: 34,587,682 (GRCm39) S509T possibly damaging Het
Cacna2d2 A G 9: 107,402,653 (GRCm39) probably null Het
Casz1 C T 4: 149,028,888 (GRCm39) P1111L probably damaging Het
Ccdc91 C T 6: 147,533,086 (GRCm39) T411I unknown Het
Chd9 A C 8: 91,767,769 (GRCm39) E2422A probably damaging Het
Clrn3 T C 7: 135,130,133 (GRCm39) I34V probably benign Het
Cnksr3 C T 10: 7,104,467 (GRCm39) D79N probably damaging Het
Cops8 A G 1: 90,539,729 (GRCm39) probably null Het
Cpa2 A G 6: 30,564,345 (GRCm39) K392R probably benign Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Dnase1l3 T C 14: 7,994,299 (GRCm38) probably benign Het
Gdpd5 A T 7: 99,105,689 (GRCm39) T502S probably benign Het
Gp2 A T 7: 119,049,375 (GRCm39) D387E probably damaging Het
Gpr179 A G 11: 97,242,364 (GRCm39) L160P probably benign Het
Hmcn1 G A 1: 150,522,409 (GRCm39) T3497M probably benign Het
Idh3b T A 2: 130,122,420 (GRCm39) T322S possibly damaging Het
Kit A T 5: 75,781,540 (GRCm39) N323I possibly damaging Het
Kng2 T C 16: 22,806,246 (GRCm39) S445G unknown Het
Lin54 A G 5: 100,602,358 (GRCm39) V393A probably benign Het
Lyst T A 13: 13,872,945 (GRCm39) W2715R probably damaging Het
Mad1l1 T C 5: 140,300,813 (GRCm39) T28A probably benign Het
Med7 T A 11: 46,332,073 (GRCm39) C223S probably benign Het
Megf8 T A 7: 25,053,298 (GRCm39) L1823Q probably damaging Het
Mga C A 2: 119,777,719 (GRCm39) Q1755K probably benign Het
Mgat4b A T 11: 50,101,801 (GRCm39) N22I probably benign Het
Ndufb6 C T 4: 40,270,665 (GRCm39) probably null Het
Neil3 A G 8: 54,042,129 (GRCm39) L490P probably benign Het
Nol4l A T 2: 153,262,473 (GRCm39) Y366* probably null Het
Nt5dc2 A G 14: 30,860,886 (GRCm39) T354A probably damaging Het
Or1j11 T A 2: 36,311,715 (GRCm39) Y102N probably damaging Het
Pde2a G A 7: 101,149,655 (GRCm39) probably null Het
Phf1 T C 17: 27,156,044 (GRCm39) F444L possibly damaging Het
Plin4 G A 17: 56,414,019 (GRCm39) T202I possibly damaging Het
Plk4 G C 3: 40,768,009 (GRCm39) V851L probably damaging Het
Pp2d1 A G 17: 53,822,257 (GRCm39) S270P probably damaging Het
Ripor1 C A 8: 106,347,520 (GRCm39) L1028M unknown Het
Scn9a A G 2: 66,370,874 (GRCm39) F569L probably damaging Het
Sel1l2 T A 2: 140,104,626 (GRCm39) L306F probably damaging Het
Spic A T 10: 88,513,428 (GRCm39) S86T probably damaging Het
Spmip10 T A 18: 56,722,547 (GRCm39) probably benign Het
Stkld1 A G 2: 26,836,668 (GRCm39) N278S probably benign Het
Taar7d T A 10: 23,903,495 (GRCm39) F126I probably benign Het
Tbc1d31 A G 15: 57,824,345 (GRCm39) E869G possibly damaging Het
Tbcd C T 11: 121,384,711 (GRCm39) T315M probably benign Het
Terf2 T C 8: 107,809,656 (GRCm39) K221E possibly damaging Het
Thsd7a T A 6: 12,468,962 (GRCm39) T539S Het
Tll2 A G 19: 41,077,313 (GRCm39) F818L possibly damaging Het
Tmem87a T C 2: 120,200,959 (GRCm39) T427A possibly damaging Het
Ush2a C A 1: 188,183,952 (GRCm39) Q1419K possibly damaging Het
Vill T A 9: 118,895,821 (GRCm39) F511Y probably damaging Het
Virma T A 4: 11,542,128 (GRCm39) D1521E probably benign Het
Vps13c A G 9: 67,766,072 (GRCm39) D63G probably benign Het
Vrk2 A G 11: 26,485,575 (GRCm39) F138L probably benign Het
Zfp710 T C 7: 79,735,775 (GRCm39) I514T probably damaging Het
Zgrf1 T A 3: 127,357,032 (GRCm39) F753I possibly damaging Het
Other mutations in Nek9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01431:Nek9 APN 12 85,361,361 (GRCm39) missense probably benign 0.23
IGL01595:Nek9 APN 12 85,361,194 (GRCm39) missense probably damaging 1.00
IGL01603:Nek9 APN 12 85,352,379 (GRCm39) missense probably damaging 1.00
IGL01893:Nek9 APN 12 85,383,174 (GRCm39) missense probably damaging 1.00
IGL02017:Nek9 APN 12 85,376,697 (GRCm39) missense probably damaging 1.00
IGL02197:Nek9 APN 12 85,354,704 (GRCm39) missense probably null
IGL02207:Nek9 APN 12 85,350,257 (GRCm39) nonsense probably null
IGL02749:Nek9 APN 12 85,352,281 (GRCm39) missense probably benign 0.02
IGL02756:Nek9 APN 12 85,358,110 (GRCm39) critical splice donor site probably null
IGL03343:Nek9 APN 12 85,350,383 (GRCm39) missense probably damaging 1.00
Rose_colored UTSW 12 85,350,311 (GRCm39) missense probably damaging 1.00
R0048:Nek9 UTSW 12 85,348,673 (GRCm39) missense probably benign 0.17
R0331:Nek9 UTSW 12 85,374,149 (GRCm39) splice site probably benign
R0499:Nek9 UTSW 12 85,348,657 (GRCm39) missense probably benign 0.09
R1484:Nek9 UTSW 12 85,348,622 (GRCm39) missense probably damaging 1.00
R1760:Nek9 UTSW 12 85,357,184 (GRCm39) missense probably benign 0.00
R1760:Nek9 UTSW 12 85,352,364 (GRCm39) missense possibly damaging 0.71
R1883:Nek9 UTSW 12 85,379,330 (GRCm39) missense probably damaging 1.00
R1884:Nek9 UTSW 12 85,379,330 (GRCm39) missense probably damaging 1.00
R1999:Nek9 UTSW 12 85,376,677 (GRCm39) missense probably damaging 1.00
R2046:Nek9 UTSW 12 85,367,481 (GRCm39) splice site probably benign
R2096:Nek9 UTSW 12 85,361,322 (GRCm39) missense probably benign 0.00
R2150:Nek9 UTSW 12 85,376,677 (GRCm39) missense probably damaging 1.00
R2368:Nek9 UTSW 12 85,376,661 (GRCm39) missense possibly damaging 0.89
R2570:Nek9 UTSW 12 85,379,320 (GRCm39) nonsense probably null
R4381:Nek9 UTSW 12 85,376,632 (GRCm39) missense probably damaging 1.00
R4570:Nek9 UTSW 12 85,367,508 (GRCm39) missense probably damaging 1.00
R4661:Nek9 UTSW 12 85,367,666 (GRCm39) missense possibly damaging 0.78
R4669:Nek9 UTSW 12 85,360,978 (GRCm39) missense probably benign 0.00
R4993:Nek9 UTSW 12 85,357,194 (GRCm39) missense probably damaging 1.00
R5071:Nek9 UTSW 12 85,374,233 (GRCm39) missense possibly damaging 0.70
R5090:Nek9 UTSW 12 85,376,616 (GRCm39) critical splice donor site probably null
R5248:Nek9 UTSW 12 85,355,751 (GRCm39) missense probably damaging 1.00
R5521:Nek9 UTSW 12 85,374,219 (GRCm39) missense probably benign 0.09
R5734:Nek9 UTSW 12 85,350,289 (GRCm39) missense probably benign
R6039:Nek9 UTSW 12 85,359,859 (GRCm39) missense probably benign 0.08
R6039:Nek9 UTSW 12 85,359,859 (GRCm39) missense probably benign 0.08
R6269:Nek9 UTSW 12 85,379,103 (GRCm39) splice site probably null
R6353:Nek9 UTSW 12 85,348,603 (GRCm39) missense probably damaging 0.96
R6406:Nek9 UTSW 12 85,385,946 (GRCm39) missense probably damaging 0.97
R6744:Nek9 UTSW 12 85,376,703 (GRCm39) missense probably benign 0.09
R6922:Nek9 UTSW 12 85,350,311 (GRCm39) missense probably damaging 1.00
R7603:Nek9 UTSW 12 85,350,288 (GRCm39) missense probably benign 0.00
R7686:Nek9 UTSW 12 85,350,433 (GRCm39) missense probably benign 0.01
R7905:Nek9 UTSW 12 85,352,370 (GRCm39) missense probably damaging 1.00
R7964:Nek9 UTSW 12 85,385,787 (GRCm39) missense probably benign 0.02
R8330:Nek9 UTSW 12 85,376,727 (GRCm39) missense probably damaging 1.00
R8802:Nek9 UTSW 12 85,374,192 (GRCm39) missense probably benign 0.19
R8859:Nek9 UTSW 12 85,353,120 (GRCm39) missense probably damaging 1.00
R8997:Nek9 UTSW 12 85,367,565 (GRCm39) missense probably benign 0.00
R9055:Nek9 UTSW 12 85,348,616 (GRCm39) missense probably damaging 0.99
R9261:Nek9 UTSW 12 85,359,841 (GRCm39) missense probably damaging 1.00
R9661:Nek9 UTSW 12 85,361,253 (GRCm39) missense possibly damaging 0.96
X0052:Nek9 UTSW 12 85,368,801 (GRCm39) critical splice donor site probably null
Z1177:Nek9 UTSW 12 85,380,819 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGGATGTTCTCACCTGCTGG -3'
(R):5'- AAATAGATGATTCTGCAGCAGC -3'

Sequencing Primer
(F):5'- GGCCTCCTTCCAATTTCTTGTTGAG -3'
(R):5'- TTTGTACTGGGGAGCCAT -3'
Posted On 2020-07-13