Incidental Mutation 'R0692:Vmn1r23'
| ID |
63374 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r23
|
| Ensembl Gene |
ENSMUSG00000093376 |
| Gene Name |
vomeronasal 1 receptor 23 |
| Synonyms |
V1rc24 |
| MMRRC Submission |
038877-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.124)
|
| Stock # |
R0692 (G1)
|
| Quality Score |
88 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
57902868-57903776 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 57903110 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Stop codon
at position 223
(E223*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135676
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000175817]
|
| AlphaFold |
Q8R2D0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000175817
AA Change: E223*
|
| SMART Domains |
Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: E223*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
3.1e-57 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Add3 |
T |
A |
19: 53,205,383 (GRCm39) |
D44E |
probably damaging |
Het |
| Bpifb5 |
T |
C |
2: 154,076,616 (GRCm39) |
V421A |
probably benign |
Het |
| Clk4 |
C |
T |
11: 51,172,155 (GRCm39) |
R273* |
probably null |
Het |
| Cmya5 |
A |
T |
13: 93,230,357 (GRCm39) |
L1577* |
probably null |
Het |
| Col14a1 |
G |
C |
15: 55,205,134 (GRCm39) |
G88A |
unknown |
Het |
| Helz2 |
A |
G |
2: 180,882,674 (GRCm39) |
C40R |
probably benign |
Het |
| Kcng1 |
T |
A |
2: 168,104,683 (GRCm39) |
I388F |
probably damaging |
Het |
| Krt35 |
T |
C |
11: 99,983,896 (GRCm39) |
E368G |
possibly damaging |
Het |
| Krt81 |
T |
C |
15: 101,358,053 (GRCm39) |
D400G |
possibly damaging |
Het |
| Mcm3ap |
T |
C |
10: 76,319,003 (GRCm39) |
C744R |
probably damaging |
Het |
| Or5m3b |
A |
G |
2: 85,872,516 (GRCm39) |
M286V |
probably benign |
Het |
| Pde6c |
A |
T |
19: 38,168,698 (GRCm39) |
Y788F |
probably damaging |
Het |
| Plxnc1 |
A |
G |
10: 94,673,362 (GRCm39) |
|
probably null |
Het |
| Rflnb |
T |
C |
11: 75,918,279 (GRCm39) |
D62G |
probably benign |
Het |
| Sema4f |
CCAGCAGCAGCAGCAGCAGC |
CCAGCAGCAGCAGCAGC |
6: 82,916,511 (GRCm39) |
|
probably benign |
Het |
| Slc12a1 |
T |
A |
2: 125,036,082 (GRCm39) |
Y651* |
probably null |
Het |
| Srbd1 |
T |
C |
17: 86,443,888 (GRCm39) |
T113A |
probably benign |
Het |
| Svopl |
A |
T |
6: 37,994,131 (GRCm39) |
L300Q |
probably damaging |
Het |
| Trim41 |
C |
T |
11: 48,699,077 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r23 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01563:Vmn1r23
|
APN |
6 |
57,903,061 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01980:Vmn1r23
|
APN |
6 |
57,903,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02934:Vmn1r23
|
APN |
6 |
57,902,914 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03153:Vmn1r23
|
APN |
6 |
57,902,917 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0410:Vmn1r23
|
UTSW |
6 |
57,903,175 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0452:Vmn1r23
|
UTSW |
6 |
57,903,469 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0590:Vmn1r23
|
UTSW |
6 |
57,903,349 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0647:Vmn1r23
|
UTSW |
6 |
57,903,169 (GRCm39) |
missense |
probably benign |
|
|
R1674:Vmn1r23
|
UTSW |
6 |
57,903,046 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1744:Vmn1r23
|
UTSW |
6 |
57,902,910 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1774:Vmn1r23
|
UTSW |
6 |
57,903,675 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2101:Vmn1r23
|
UTSW |
6 |
57,903,437 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2202:Vmn1r23
|
UTSW |
6 |
57,903,604 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2204:Vmn1r23
|
UTSW |
6 |
57,903,604 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2205:Vmn1r23
|
UTSW |
6 |
57,903,604 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4282:Vmn1r23
|
UTSW |
6 |
57,903,452 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4408:Vmn1r23
|
UTSW |
6 |
57,903,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4532:Vmn1r23
|
UTSW |
6 |
57,902,914 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4690:Vmn1r23
|
UTSW |
6 |
57,903,010 (GRCm39) |
missense |
probably benign |
|
|
R4700:Vmn1r23
|
UTSW |
6 |
57,903,190 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4894:Vmn1r23
|
UTSW |
6 |
57,903,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6164:Vmn1r23
|
UTSW |
6 |
57,903,040 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6930:Vmn1r23
|
UTSW |
6 |
57,903,130 (GRCm39) |
missense |
probably benign |
|
|
R7129:Vmn1r23
|
UTSW |
6 |
57,903,061 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7731:Vmn1r23
|
UTSW |
6 |
57,903,319 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7877:Vmn1r23
|
UTSW |
6 |
57,903,541 (GRCm39) |
missense |
probably benign |
|
|
R8751:Vmn1r23
|
UTSW |
6 |
57,903,452 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8809:Vmn1r23
|
UTSW |
6 |
57,903,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGGGATAGGCATTCACCACAAAC -3'
(R):5'- GTGTGTTCCAGGCTGTCACTATCAG -3'
Sequencing Primer
(F):5'- CAAACTTCTGAACAGTCAGGATG -3'
(R):5'- GGCTGTCACTATCAGTCCCAG -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation