Incidental Mutation 'R8165:Kng2'
ID 633744
Institutional Source Beutler Lab
Gene Symbol Kng2
Ensembl Gene ENSMUSG00000060459
Gene Name kininogen 2
Synonyms Kininogen-II
MMRRC Submission 067591-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8165 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 22804602-22847851 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22806246 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 445 (S445G)
Ref Sequence ENSEMBL: ENSMUSP00000046867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039338] [ENSMUST00000100046] [ENSMUST00000115349] [ENSMUST00000160243]
AlphaFold Q6S9I3
Predicted Effect unknown
Transcript: ENSMUST00000039338
AA Change: S445G
SMART Domains Protein: ENSMUSP00000046867
Gene: ENSMUSG00000060459
AA Change: S445G

DomainStartEndE-ValueType
CY 18 126 3.72e-19 SMART
CY 140 248 2.57e-22 SMART
CY 262 370 2.06e-35 SMART
low complexity region 376 390 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100046
SMART Domains Protein: ENSMUSP00000097623
Gene: ENSMUSG00000060459

DomainStartEndE-ValueType
CY 18 126 3.72e-19 SMART
CY 140 248 2.57e-22 SMART
CY 262 370 2.06e-35 SMART
low complexity region 376 390 N/A INTRINSIC
low complexity region 478 506 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115349
SMART Domains Protein: ENSMUSP00000111006
Gene: ENSMUSG00000060459

DomainStartEndE-ValueType
CY 18 126 3.72e-19 SMART
CY 140 248 2.57e-22 SMART
CY 262 370 2.06e-35 SMART
low complexity region 376 390 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160243
SMART Domains Protein: ENSMUSP00000124161
Gene: ENSMUSG00000060459

DomainStartEndE-ValueType
CY 18 126 3.72e-19 SMART
Blast:CY 140 171 2e-15 BLAST
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (65/65)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C A 5: 64,055,289 (GRCm39) probably null Het
Amph A G 13: 19,279,007 (GRCm39) K161E probably benign Het
Aox1 A T 1: 58,348,088 (GRCm39) H602L probably benign Het
Areg A G 5: 91,291,492 (GRCm39) N145S probably damaging Het
Arhgap29 C T 3: 121,782,222 (GRCm39) T142I probably damaging Het
Bcar3 C T 3: 122,304,805 (GRCm39) probably benign Het
Brpf3 C T 17: 29,025,248 (GRCm39) A107V probably benign Het
Btnl2 T A 17: 34,587,682 (GRCm39) S509T possibly damaging Het
Cacna2d2 A G 9: 107,402,653 (GRCm39) probably null Het
Casz1 C T 4: 149,028,888 (GRCm39) P1111L probably damaging Het
Ccdc91 C T 6: 147,533,086 (GRCm39) T411I unknown Het
Chd9 A C 8: 91,767,769 (GRCm39) E2422A probably damaging Het
Clrn3 T C 7: 135,130,133 (GRCm39) I34V probably benign Het
Cnksr3 C T 10: 7,104,467 (GRCm39) D79N probably damaging Het
Cops8 A G 1: 90,539,729 (GRCm39) probably null Het
Cpa2 A G 6: 30,564,345 (GRCm39) K392R probably benign Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Dnase1l3 T C 14: 7,994,299 (GRCm38) probably benign Het
Gdpd5 A T 7: 99,105,689 (GRCm39) T502S probably benign Het
Gp2 A T 7: 119,049,375 (GRCm39) D387E probably damaging Het
Gpr179 A G 11: 97,242,364 (GRCm39) L160P probably benign Het
Hmcn1 G A 1: 150,522,409 (GRCm39) T3497M probably benign Het
Idh3b T A 2: 130,122,420 (GRCm39) T322S possibly damaging Het
Kit A T 5: 75,781,540 (GRCm39) N323I possibly damaging Het
Lin54 A G 5: 100,602,358 (GRCm39) V393A probably benign Het
Lyst T A 13: 13,872,945 (GRCm39) W2715R probably damaging Het
Mad1l1 T C 5: 140,300,813 (GRCm39) T28A probably benign Het
Med7 T A 11: 46,332,073 (GRCm39) C223S probably benign Het
Megf8 T A 7: 25,053,298 (GRCm39) L1823Q probably damaging Het
Mga C A 2: 119,777,719 (GRCm39) Q1755K probably benign Het
Mgat4b A T 11: 50,101,801 (GRCm39) N22I probably benign Het
Ndufb6 C T 4: 40,270,665 (GRCm39) probably null Het
Neil3 A G 8: 54,042,129 (GRCm39) L490P probably benign Het
Nek9 C T 12: 85,350,417 (GRCm39) V886I probably benign Het
Nol4l A T 2: 153,262,473 (GRCm39) Y366* probably null Het
Nt5dc2 A G 14: 30,860,886 (GRCm39) T354A probably damaging Het
Or1j11 T A 2: 36,311,715 (GRCm39) Y102N probably damaging Het
Pde2a G A 7: 101,149,655 (GRCm39) probably null Het
Phf1 T C 17: 27,156,044 (GRCm39) F444L possibly damaging Het
Plin4 G A 17: 56,414,019 (GRCm39) T202I possibly damaging Het
Plk4 G C 3: 40,768,009 (GRCm39) V851L probably damaging Het
Pp2d1 A G 17: 53,822,257 (GRCm39) S270P probably damaging Het
Ripor1 C A 8: 106,347,520 (GRCm39) L1028M unknown Het
Scn9a A G 2: 66,370,874 (GRCm39) F569L probably damaging Het
Sel1l2 T A 2: 140,104,626 (GRCm39) L306F probably damaging Het
Spic A T 10: 88,513,428 (GRCm39) S86T probably damaging Het
Spmip10 T A 18: 56,722,547 (GRCm39) probably benign Het
Stkld1 A G 2: 26,836,668 (GRCm39) N278S probably benign Het
Taar7d T A 10: 23,903,495 (GRCm39) F126I probably benign Het
Tbc1d31 A G 15: 57,824,345 (GRCm39) E869G possibly damaging Het
Tbcd C T 11: 121,384,711 (GRCm39) T315M probably benign Het
Terf2 T C 8: 107,809,656 (GRCm39) K221E possibly damaging Het
Thsd7a T A 6: 12,468,962 (GRCm39) T539S Het
Tll2 A G 19: 41,077,313 (GRCm39) F818L possibly damaging Het
Tmem87a T C 2: 120,200,959 (GRCm39) T427A possibly damaging Het
Ush2a C A 1: 188,183,952 (GRCm39) Q1419K possibly damaging Het
Vill T A 9: 118,895,821 (GRCm39) F511Y probably damaging Het
Virma T A 4: 11,542,128 (GRCm39) D1521E probably benign Het
Vps13c A G 9: 67,766,072 (GRCm39) D63G probably benign Het
Vrk2 A G 11: 26,485,575 (GRCm39) F138L probably benign Het
Zfp710 T C 7: 79,735,775 (GRCm39) I514T probably damaging Het
Zgrf1 T A 3: 127,357,032 (GRCm39) F753I possibly damaging Het
Other mutations in Kng2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00851:Kng2 APN 16 22,847,580 (GRCm39) missense probably damaging 1.00
IGL01319:Kng2 APN 16 22,847,584 (GRCm39) missense probably damaging 0.99
IGL01469:Kng2 APN 16 22,818,577 (GRCm39) missense probably damaging 1.00
IGL01681:Kng2 APN 16 22,815,767 (GRCm39) splice site probably benign
IGL01830:Kng2 APN 16 22,806,801 (GRCm39) missense probably damaging 0.97
IGL01903:Kng2 APN 16 22,806,540 (GRCm39) missense possibly damaging 0.80
IGL02146:Kng2 APN 16 22,806,582 (GRCm39) missense probably damaging 0.97
IGL02305:Kng2 APN 16 22,819,374 (GRCm39) unclassified probably benign
IGL02429:Kng2 APN 16 22,830,829 (GRCm39) missense probably damaging 0.99
FR4548:Kng2 UTSW 16 22,819,302 (GRCm39) nonsense probably null
R0020:Kng2 UTSW 16 22,816,046 (GRCm39) missense probably benign 0.02
R0047:Kng2 UTSW 16 22,806,313 (GRCm39) missense possibly damaging 0.83
R0245:Kng2 UTSW 16 22,830,931 (GRCm39) splice site probably benign
R0610:Kng2 UTSW 16 22,819,344 (GRCm39) missense possibly damaging 0.96
R0646:Kng2 UTSW 16 22,806,486 (GRCm39) missense probably benign 0.10
R0666:Kng2 UTSW 16 22,815,872 (GRCm39) splice site probably benign
R1552:Kng2 UTSW 16 22,806,270 (GRCm39) missense probably damaging 1.00
R1765:Kng2 UTSW 16 22,806,993 (GRCm39) critical splice donor site probably null
R1833:Kng2 UTSW 16 22,830,802 (GRCm39) missense possibly damaging 0.95
R1997:Kng2 UTSW 16 22,843,626 (GRCm39) missense possibly damaging 0.84
R2025:Kng2 UTSW 16 22,819,325 (GRCm39) missense probably benign 0.15
R2056:Kng2 UTSW 16 22,806,703 (GRCm39) intron probably benign
R2137:Kng2 UTSW 16 22,816,076 (GRCm39) intron probably benign
R2517:Kng2 UTSW 16 22,807,065 (GRCm39) missense probably benign 0.24
R3438:Kng2 UTSW 16 22,830,821 (GRCm39) missense probably benign 0.23
R3439:Kng2 UTSW 16 22,830,821 (GRCm39) missense probably benign 0.23
R3551:Kng2 UTSW 16 22,830,745 (GRCm39) critical splice donor site probably null
R4389:Kng2 UTSW 16 22,843,618 (GRCm39) missense possibly damaging 0.91
R4538:Kng2 UTSW 16 22,806,813 (GRCm39) missense probably benign 0.00
R4684:Kng2 UTSW 16 22,806,391 (GRCm39) missense possibly damaging 0.93
R4978:Kng2 UTSW 16 22,806,666 (GRCm39) missense probably damaging 1.00
R5658:Kng2 UTSW 16 22,815,770 (GRCm39) splice site probably null
R6074:Kng2 UTSW 16 22,819,346 (GRCm39) missense probably benign 0.03
R6216:Kng2 UTSW 16 22,806,343 (GRCm39) missense probably damaging 1.00
R6271:Kng2 UTSW 16 22,822,698 (GRCm39) missense probably benign 0.33
R6459:Kng2 UTSW 16 22,830,865 (GRCm39) missense probably damaging 1.00
R7124:Kng2 UTSW 16 22,830,805 (GRCm39) missense probably damaging 1.00
R7310:Kng2 UTSW 16 22,806,522 (GRCm39) missense probably benign 0.00
R7532:Kng2 UTSW 16 22,845,794 (GRCm39) splice site probably null
R7667:Kng2 UTSW 16 22,806,982 (GRCm39) missense probably damaging 0.99
R7787:Kng2 UTSW 16 22,818,598 (GRCm39) missense probably damaging 1.00
R8092:Kng2 UTSW 16 22,806,672 (GRCm39) missense probably benign 0.00
R8814:Kng2 UTSW 16 22,822,761 (GRCm39) missense probably benign 0.00
R9019:Kng2 UTSW 16 22,847,546 (GRCm39) missense probably damaging 0.99
R9048:Kng2 UTSW 16 22,806,522 (GRCm39) missense probably benign 0.00
R9531:Kng2 UTSW 16 22,830,907 (GRCm39) missense possibly damaging 0.81
R9708:Kng2 UTSW 16 22,815,801 (GRCm39) missense probably damaging 0.99
R9764:Kng2 UTSW 16 22,822,737 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGCTCCTTACCAGAGCAG -3'
(R):5'- AGCCAGATAGCCTTTCATTTAAGC -3'

Sequencing Primer
(F):5'- CTCCTTACCAGAGCAGTGGATTTTG -3'
(R):5'- GCTGATATCTGATTTTCCAGAAGC -3'
Posted On 2020-07-13