Incidental Mutation 'R8168:Or4p8'
ID 633893
Institutional Source Beutler Lab
Gene Symbol Or4p8
Ensembl Gene ENSMUSG00000075114
Gene Name olfactory receptor family 4 subfamily P member 8
Synonyms MOR225-4, Olfr1208, GA_x6K02T2Q125-50372411-50371485
MMRRC Submission 067594-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R8168 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88726918-88727992 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 88727120 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 274 (M274L)
Ref Sequence ENSEMBL: ENSMUSP00000097398 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099810]
AlphaFold Q8VG47
Predicted Effect probably benign
Transcript: ENSMUST00000099810
AA Change: M274L

PolyPhen 2 Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000097398
Gene: ENSMUSG00000075114
AA Change: M274L

DomainStartEndE-ValueType
Pfam:7tm_4 28 302 1.9e-48 PFAM
Pfam:7tm_1 38 284 2.6e-17 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano4 A G 10: 88,816,857 (GRCm39) I652T probably damaging Het
Arhgef1 A G 7: 24,624,831 (GRCm39) T862A probably benign Het
Atp6v1b2 T C 8: 69,560,983 (GRCm39) S404P possibly damaging Het
Catsperz A G 19: 6,900,020 (GRCm39) S162P possibly damaging Het
Cfap410 G A 10: 77,818,778 (GRCm39) A150T probably benign Het
Cfap54 A T 10: 92,744,739 (GRCm39) S2170T unknown Het
Copa A T 1: 171,927,239 (GRCm39) H204L probably damaging Het
Cwc22 A C 2: 77,757,615 (GRCm39) V171G probably damaging Het
Dock5 A T 14: 68,007,646 (GRCm39) probably null Het
Flrt1 G A 19: 7,074,002 (GRCm39) L182F probably damaging Het
Foxf1 T C 8: 121,811,901 (GRCm39) V255A probably damaging Het
Gnptab G T 10: 88,254,995 (GRCm39) A194S probably benign Het
Gzf1 C T 2: 148,526,686 (GRCm39) R386C probably damaging Het
H2-Aa T A 17: 34,506,695 (GRCm39) T16S possibly damaging Het
Hdgfl2 T C 17: 56,389,282 (GRCm39) F52S probably damaging Het
Htt A G 5: 35,040,300 (GRCm39) N2154S probably benign Het
Ifi207 A C 1: 173,557,504 (GRCm39) S411R probably benign Het
Jcad A T 18: 4,675,094 (GRCm39) D952V probably benign Het
Lama3 T A 18: 12,639,999 (GRCm39) W65R probably null Het
Mef2c G T 13: 83,804,469 (GRCm39) L356F probably damaging Het
Mrgprb2 A T 7: 48,201,767 (GRCm39) S319R probably benign Het
Mtrr C T 13: 68,720,732 (GRCm39) V288I probably benign Het
Myo18a T A 11: 77,711,968 (GRCm39) I713N probably damaging Het
Nelfa A T 5: 34,079,251 (GRCm39) N107K possibly damaging Het
Nim1k A T 13: 120,174,288 (GRCm39) V202D probably damaging Het
Nlrc4 T C 17: 74,752,206 (GRCm39) T726A probably benign Het
Or9m1 T A 2: 87,733,543 (GRCm39) H159L probably damaging Het
Phaf1 C T 8: 105,975,401 (GRCm39) P330L probably benign Het
Prdm10 G A 9: 31,258,263 (GRCm39) A514T probably benign Het
Prg4 T A 1: 150,331,601 (GRCm39) E357D unknown Het
Ptp4a3 T G 15: 73,628,695 (GRCm39) Y152D probably damaging Het
Raph1 A G 1: 60,538,779 (GRCm39) C389R unknown Het
Rcc1 T C 4: 132,063,096 (GRCm39) E170G probably benign Het
Spag17 C T 3: 99,942,300 (GRCm39) T775M possibly damaging Het
Srcap T A 7: 127,141,695 (GRCm39) V1825D probably damaging Het
Tshr T A 12: 91,478,739 (GRCm39) H195Q probably benign Het
Vmn1r174 A T 7: 23,454,096 (GRCm39) D254V probably damaging Het
Vps13a A C 19: 16,726,912 (GRCm39) I244M probably benign Het
Other mutations in Or4p8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01340:Or4p8 APN 2 88,727,321 (GRCm39) missense probably damaging 1.00
IGL02132:Or4p8 APN 2 88,727,503 (GRCm39) missense probably benign
IGL02374:Or4p8 APN 2 88,727,803 (GRCm39) missense probably damaging 1.00
R1378:Or4p8 UTSW 2 88,727,370 (GRCm39) missense probably benign 0.01
R1570:Or4p8 UTSW 2 88,727,290 (GRCm39) missense probably damaging 1.00
R2056:Or4p8 UTSW 2 88,727,105 (GRCm39) missense probably damaging 1.00
R2092:Or4p8 UTSW 2 88,727,611 (GRCm39) missense probably damaging 0.99
R2185:Or4p8 UTSW 2 88,727,047 (GRCm39) missense probably damaging 0.99
R5223:Or4p8 UTSW 2 88,727,678 (GRCm39) missense probably benign 0.03
R5479:Or4p8 UTSW 2 88,727,035 (GRCm39) missense probably benign 0.13
R6463:Or4p8 UTSW 2 88,727,462 (GRCm39) missense probably benign 0.00
R6859:Or4p8 UTSW 2 88,727,278 (GRCm39) missense probably benign
R7347:Or4p8 UTSW 2 88,727,615 (GRCm39) missense possibly damaging 0.51
R7352:Or4p8 UTSW 2 88,727,062 (GRCm39) missense probably damaging 1.00
R7544:Or4p8 UTSW 2 88,727,705 (GRCm39) missense probably damaging 1.00
R7713:Or4p8 UTSW 2 88,728,122 (GRCm39) start gained probably benign
R7842:Or4p8 UTSW 2 88,727,305 (GRCm39) missense possibly damaging 0.89
R7869:Or4p8 UTSW 2 88,727,408 (GRCm39) missense probably benign 0.00
R8137:Or4p8 UTSW 2 88,727,013 (GRCm39) makesense probably null
R8556:Or4p8 UTSW 2 88,727,382 (GRCm39) nonsense probably null
R8967:Or4p8 UTSW 2 88,727,844 (GRCm39) nonsense probably null
R9092:Or4p8 UTSW 2 88,727,321 (GRCm39) missense probably damaging 1.00
R9221:Or4p8 UTSW 2 88,727,255 (GRCm39) missense probably benign
Z1176:Or4p8 UTSW 2 88,727,405 (GRCm39) missense probably damaging 1.00
Z1177:Or4p8 UTSW 2 88,727,144 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGCTATGCACCATCTTGTTATC -3'
(R):5'- GGGTGATGTCCATTCTGACC -3'

Sequencing Primer
(F):5'- CAAAGAGTTTGTCTTGGCAC -3'
(R):5'- CATTCTGACCTTTGTTGCATTGG -3'
Posted On 2020-07-13