Incidental Mutation 'R8168:Vmn1r174'
ID |
633903 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r174
|
Ensembl Gene |
ENSMUSG00000090411 |
Gene Name |
vomeronasal 1 receptor 174 |
Synonyms |
V1rd22 |
MMRRC Submission |
067594-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.051)
|
Stock # |
R8168 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
23453336-23454277 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 23454096 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Valine
at position 254
(D254V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126478
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167551]
|
AlphaFold |
E9PYW5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000167551
AA Change: D254V
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000126478 Gene: ENSMUSG00000090411 AA Change: D254V
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
8 |
300 |
4e-9 |
PFAM |
Pfam:V1R
|
43 |
300 |
5e-19 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
Validation Efficiency |
100% (44/44) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ano4 |
A |
G |
10: 88,816,857 (GRCm39) |
I652T |
probably damaging |
Het |
Arhgef1 |
A |
G |
7: 24,624,831 (GRCm39) |
T862A |
probably benign |
Het |
Atp6v1b2 |
T |
C |
8: 69,560,983 (GRCm39) |
S404P |
possibly damaging |
Het |
Catsperz |
A |
G |
19: 6,900,020 (GRCm39) |
S162P |
possibly damaging |
Het |
Cfap410 |
G |
A |
10: 77,818,778 (GRCm39) |
A150T |
probably benign |
Het |
Cfap54 |
A |
T |
10: 92,744,739 (GRCm39) |
S2170T |
unknown |
Het |
Copa |
A |
T |
1: 171,927,239 (GRCm39) |
H204L |
probably damaging |
Het |
Cwc22 |
A |
C |
2: 77,757,615 (GRCm39) |
V171G |
probably damaging |
Het |
Dock5 |
A |
T |
14: 68,007,646 (GRCm39) |
|
probably null |
Het |
Flrt1 |
G |
A |
19: 7,074,002 (GRCm39) |
L182F |
probably damaging |
Het |
Foxf1 |
T |
C |
8: 121,811,901 (GRCm39) |
V255A |
probably damaging |
Het |
Gnptab |
G |
T |
10: 88,254,995 (GRCm39) |
A194S |
probably benign |
Het |
Gzf1 |
C |
T |
2: 148,526,686 (GRCm39) |
R386C |
probably damaging |
Het |
H2-Aa |
T |
A |
17: 34,506,695 (GRCm39) |
T16S |
possibly damaging |
Het |
Hdgfl2 |
T |
C |
17: 56,389,282 (GRCm39) |
F52S |
probably damaging |
Het |
Htt |
A |
G |
5: 35,040,300 (GRCm39) |
N2154S |
probably benign |
Het |
Ifi207 |
A |
C |
1: 173,557,504 (GRCm39) |
S411R |
probably benign |
Het |
Jcad |
A |
T |
18: 4,675,094 (GRCm39) |
D952V |
probably benign |
Het |
Lama3 |
T |
A |
18: 12,639,999 (GRCm39) |
W65R |
probably null |
Het |
Mef2c |
G |
T |
13: 83,804,469 (GRCm39) |
L356F |
probably damaging |
Het |
Mrgprb2 |
A |
T |
7: 48,201,767 (GRCm39) |
S319R |
probably benign |
Het |
Mtrr |
C |
T |
13: 68,720,732 (GRCm39) |
V288I |
probably benign |
Het |
Myo18a |
T |
A |
11: 77,711,968 (GRCm39) |
I713N |
probably damaging |
Het |
Nelfa |
A |
T |
5: 34,079,251 (GRCm39) |
N107K |
possibly damaging |
Het |
Nim1k |
A |
T |
13: 120,174,288 (GRCm39) |
V202D |
probably damaging |
Het |
Nlrc4 |
T |
C |
17: 74,752,206 (GRCm39) |
T726A |
probably benign |
Het |
Or4p8 |
T |
A |
2: 88,727,120 (GRCm39) |
M274L |
probably benign |
Het |
Or9m1 |
T |
A |
2: 87,733,543 (GRCm39) |
H159L |
probably damaging |
Het |
Phaf1 |
C |
T |
8: 105,975,401 (GRCm39) |
P330L |
probably benign |
Het |
Prdm10 |
G |
A |
9: 31,258,263 (GRCm39) |
A514T |
probably benign |
Het |
Prg4 |
T |
A |
1: 150,331,601 (GRCm39) |
E357D |
unknown |
Het |
Ptp4a3 |
T |
G |
15: 73,628,695 (GRCm39) |
Y152D |
probably damaging |
Het |
Raph1 |
A |
G |
1: 60,538,779 (GRCm39) |
C389R |
unknown |
Het |
Rcc1 |
T |
C |
4: 132,063,096 (GRCm39) |
E170G |
probably benign |
Het |
Spag17 |
C |
T |
3: 99,942,300 (GRCm39) |
T775M |
possibly damaging |
Het |
Srcap |
T |
A |
7: 127,141,695 (GRCm39) |
V1825D |
probably damaging |
Het |
Tshr |
T |
A |
12: 91,478,739 (GRCm39) |
H195Q |
probably benign |
Het |
Vps13a |
A |
C |
19: 16,726,912 (GRCm39) |
I244M |
probably benign |
Het |
|
Other mutations in Vmn1r174 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00331:Vmn1r174
|
APN |
7 |
23,453,958 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL00950:Vmn1r174
|
APN |
7 |
23,453,911 (GRCm39) |
missense |
possibly damaging |
0.96 |
IGL01484:Vmn1r174
|
APN |
7 |
23,453,749 (GRCm39) |
nonsense |
probably null |
|
IGL02014:Vmn1r174
|
APN |
7 |
23,453,583 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02190:Vmn1r174
|
APN |
7 |
23,454,252 (GRCm39) |
missense |
unknown |
|
IGL03265:Vmn1r174
|
APN |
7 |
23,453,898 (GRCm39) |
nonsense |
probably null |
|
IGL03335:Vmn1r174
|
APN |
7 |
23,453,937 (GRCm39) |
missense |
probably benign |
0.41 |
R0529:Vmn1r174
|
UTSW |
7 |
23,453,622 (GRCm39) |
missense |
probably benign |
0.00 |
R1489:Vmn1r174
|
UTSW |
7 |
23,453,981 (GRCm39) |
nonsense |
probably null |
|
R1645:Vmn1r174
|
UTSW |
7 |
23,453,777 (GRCm39) |
missense |
possibly damaging |
0.87 |
R1691:Vmn1r174
|
UTSW |
7 |
23,453,337 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R1753:Vmn1r174
|
UTSW |
7 |
23,453,622 (GRCm39) |
missense |
probably benign |
0.00 |
R1939:Vmn1r174
|
UTSW |
7 |
23,453,532 (GRCm39) |
missense |
probably damaging |
0.99 |
R1988:Vmn1r174
|
UTSW |
7 |
23,454,050 (GRCm39) |
missense |
probably damaging |
0.98 |
R2299:Vmn1r174
|
UTSW |
7 |
23,453,429 (GRCm39) |
missense |
probably benign |
0.08 |
R4429:Vmn1r174
|
UTSW |
7 |
23,453,565 (GRCm39) |
missense |
probably benign |
0.02 |
R4516:Vmn1r174
|
UTSW |
7 |
23,453,768 (GRCm39) |
missense |
probably benign |
0.01 |
R4589:Vmn1r174
|
UTSW |
7 |
23,454,204 (GRCm39) |
nonsense |
probably null |
|
R5175:Vmn1r174
|
UTSW |
7 |
23,454,153 (GRCm39) |
missense |
probably benign |
0.03 |
R5392:Vmn1r174
|
UTSW |
7 |
23,454,227 (GRCm39) |
missense |
unknown |
|
R5503:Vmn1r174
|
UTSW |
7 |
23,453,562 (GRCm39) |
missense |
probably benign |
0.03 |
R5568:Vmn1r174
|
UTSW |
7 |
23,453,919 (GRCm39) |
missense |
probably damaging |
0.96 |
R6705:Vmn1r174
|
UTSW |
7 |
23,453,851 (GRCm39) |
missense |
probably benign |
0.25 |
R8190:Vmn1r174
|
UTSW |
7 |
23,453,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R8523:Vmn1r174
|
UTSW |
7 |
23,454,182 (GRCm39) |
missense |
probably damaging |
1.00 |
R8555:Vmn1r174
|
UTSW |
7 |
23,453,970 (GRCm39) |
missense |
possibly damaging |
0.84 |
R8913:Vmn1r174
|
UTSW |
7 |
23,453,375 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8979:Vmn1r174
|
UTSW |
7 |
23,453,892 (GRCm39) |
missense |
possibly damaging |
0.92 |
R8990:Vmn1r174
|
UTSW |
7 |
23,453,956 (GRCm39) |
missense |
possibly damaging |
0.71 |
X0011:Vmn1r174
|
UTSW |
7 |
23,453,906 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- GTCCACGATGCCATATTCATCAG -3'
(R):5'- CAGATGTTCTACCCAGGTTTATTGAG -3'
Sequencing Primer
(F):5'- CGATGCCATATTCATCAGCATCATGG -3'
(R):5'- CCCAGGTTTATTGAGTATCAGTGAC -3'
|
Posted On |
2020-07-13 |