|Institutional Source||Beutler Lab|
|Gene Name||fibronectin leucine rich transmembrane protein 1|
|Is this an essential gene?||Probably non essential (E-score: 0.164)|
|Stock #||R8168 (G1)|
|Chromosomal Location||7092014-7105729 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 7096637 bp|
|Amino Acid Change||Leucine to Phenylalanine at position 182 (L182F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000109010 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000040261] [ENSMUST00000113383]|
|Predicted Effect||probably benign
|Predicted Effect||probably damaging
AA Change: L182F
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: L182F
|Coding Region Coverage||
|Validation Efficiency||100% (44/44)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Flrt1||
(F):5'- TGAAGGTGTCGTCGGCAATG -3'
(R):5'- TCATCTACCTGTATGAGAATGACCTG -3'
(F):5'- CGGCAATGCGCTGGTTG -3'
(R):5'- GAATGACCTGGACGAGTTCCCTATC -3'