Incidental Mutation 'R8171:Kcnt2'
| ID |
634078 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kcnt2
|
| Ensembl Gene |
ENSMUSG00000052726 |
| Gene Name |
potassium channel, subfamily T, member 2 |
| Synonyms |
E330038N15Rik |
| MMRRC Submission |
067597-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R8171 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
140173896-140539805 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 140437203 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 545
(N545K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113333
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119786]
[ENSMUST00000120709]
[ENSMUST00000120796]
|
| AlphaFold |
D3Z649 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119786
AA Change: N495K
PolyPhen 2
Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000113535
Gene: ENSMUSG00000052726
AA Change: N495K
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.6e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
476 |
2.3e-16 |
PFAM |
|
low complexity region
|
598 |
613 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
699 |
714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120709
AA Change: N545K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000112887
Gene: ENSMUSG00000052726
AA Change: N545K
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.7e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
764 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120796
AA Change: N545K
PolyPhen 2
Score 0.128 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000113333
Gene: ENSMUSG00000052726
AA Change: N545K
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193606
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele are viable with normal pain and itch responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
G |
T |
14: 32,383,982 (GRCm39) |
A661E |
probably benign |
Het |
| Abhd14a |
T |
A |
9: 106,317,960 (GRCm39) |
T142S |
probably benign |
Het |
| Actn1 |
A |
G |
12: 80,243,167 (GRCm39) |
|
probably null |
Het |
| Adss2 |
T |
C |
1: 177,623,917 (GRCm39) |
N15S |
probably benign |
Het |
| Alpk2 |
A |
G |
18: 65,439,054 (GRCm39) |
S780P |
probably benign |
Het |
| Asap1 |
G |
T |
15: 63,982,815 (GRCm39) |
L830M |
probably damaging |
Het |
| Atic |
T |
C |
1: 71,609,032 (GRCm39) |
V319A |
possibly damaging |
Het |
| Atp8a2 |
A |
T |
14: 60,283,493 (GRCm39) |
I87N |
probably damaging |
Het |
| Bace2 |
G |
T |
16: 97,225,786 (GRCm39) |
V407L |
possibly damaging |
Het |
| Bltp1 |
T |
C |
3: 37,029,862 (GRCm39) |
V2423A |
probably benign |
Het |
| Bmp3 |
A |
T |
5: 99,020,528 (GRCm39) |
Y317F |
probably damaging |
Het |
| Ccdc159 |
A |
G |
9: 21,845,007 (GRCm39) |
E291G |
possibly damaging |
Het |
| Cct8l1 |
T |
A |
5: 25,721,552 (GRCm39) |
L89Q |
probably damaging |
Het |
| Cep83 |
T |
A |
10: 94,604,797 (GRCm39) |
N503K |
possibly damaging |
Het |
| Ces4a |
A |
G |
8: 105,873,839 (GRCm39) |
Y436C |
probably damaging |
Het |
| Cftr |
T |
A |
6: 18,258,287 (GRCm39) |
D579E |
probably damaging |
Het |
| Chd9 |
T |
A |
8: 91,752,015 (GRCm39) |
V1751D |
possibly damaging |
Het |
| Clasp2 |
A |
T |
9: 113,732,974 (GRCm39) |
T937S |
possibly damaging |
Het |
| Clock |
T |
A |
5: 76,414,261 (GRCm39) |
D17V |
possibly damaging |
Het |
| Cpm |
T |
C |
10: 117,519,220 (GRCm39) |
L376P |
probably damaging |
Het |
| Crocc2 |
T |
C |
1: 93,116,723 (GRCm39) |
|
probably null |
Het |
| Csnk1g2 |
A |
G |
10: 80,475,636 (GRCm39) |
D401G |
probably damaging |
Het |
| Cyb5r4 |
C |
T |
9: 86,924,863 (GRCm39) |
L206F |
possibly damaging |
Het |
| Cyp1a1 |
T |
A |
9: 57,607,479 (GRCm39) |
W36R |
probably benign |
Het |
| Cyp3a59 |
A |
T |
5: 146,022,584 (GRCm39) |
H30L |
probably damaging |
Het |
| Dab2 |
G |
A |
15: 6,453,407 (GRCm39) |
V182I |
probably benign |
Het |
| Dnah1 |
G |
T |
14: 31,019,067 (GRCm39) |
F1342L |
probably damaging |
Het |
| Draxin |
A |
T |
4: 148,200,123 (GRCm39) |
L109Q |
possibly damaging |
Het |
| Elfn1 |
G |
A |
5: 139,957,112 (GRCm39) |
V39M |
probably damaging |
Het |
| Erlin1 |
A |
G |
19: 44,057,768 (GRCm39) |
I19T |
probably benign |
Het |
| F830016B08Rik |
T |
A |
18: 60,433,150 (GRCm39) |
S78T |
possibly damaging |
Het |
| Fer1l4 |
A |
G |
2: 155,890,151 (GRCm39) |
V258A |
probably benign |
Het |
| Fgb |
T |
C |
3: 82,949,822 (GRCm39) |
D445G |
probably damaging |
Het |
| Fgd6 |
T |
C |
10: 93,910,194 (GRCm39) |
|
probably null |
Het |
| Frem3 |
T |
A |
8: 81,341,869 (GRCm39) |
D1387E |
probably damaging |
Het |
| Gdf3 |
T |
C |
6: 122,586,862 (GRCm39) |
T22A |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,593,167 (GRCm39) |
A511V |
probably benign |
Het |
| Gldc |
A |
T |
19: 30,111,161 (GRCm39) |
N538K |
probably benign |
Het |
| Glipr1l1 |
C |
T |
10: 111,914,289 (GRCm39) |
P217S |
probably benign |
Het |
| Gpr161 |
A |
G |
1: 165,134,005 (GRCm39) |
N89S |
probably damaging |
Het |
| Gypa |
T |
A |
8: 81,236,092 (GRCm39) |
S166T |
probably benign |
Het |
| Hcar1 |
A |
G |
5: 124,017,152 (GRCm39) |
S180P |
probably damaging |
Het |
| Hcn1 |
T |
C |
13: 117,739,270 (GRCm39) |
S11P |
unknown |
Het |
| Hectd4 |
A |
G |
5: 121,456,819 (GRCm39) |
E728G |
possibly damaging |
Het |
| Ints14 |
A |
T |
9: 64,880,532 (GRCm39) |
H213L |
possibly damaging |
Het |
| Itih1 |
A |
T |
14: 30,659,047 (GRCm39) |
M323K |
possibly damaging |
Het |
| Ivl |
A |
G |
3: 92,479,085 (GRCm39) |
S327P |
probably damaging |
Het |
| Kdm4b |
A |
T |
17: 56,696,534 (GRCm39) |
R417W |
probably damaging |
Het |
| Kif13a |
T |
C |
13: 46,932,444 (GRCm39) |
E1083G |
probably damaging |
Het |
| Klhl40 |
A |
T |
9: 121,607,623 (GRCm39) |
H261L |
probably benign |
Het |
| Kpnb1 |
A |
G |
11: 97,066,573 (GRCm39) |
|
probably null |
Het |
| Lamc3 |
C |
A |
2: 31,804,983 (GRCm39) |
T621N |
probably benign |
Het |
| Lingo3 |
T |
C |
10: 80,670,595 (GRCm39) |
H445R |
probably benign |
Het |
| Ly75 |
G |
A |
2: 60,144,572 (GRCm39) |
T1297I |
possibly damaging |
Het |
| Lypd6 |
C |
T |
2: 50,080,759 (GRCm39) |
T149M |
possibly damaging |
Het |
| Mcrs1 |
A |
T |
15: 99,146,613 (GRCm39) |
D139E |
probably damaging |
Het |
| Muc5b |
G |
A |
7: 141,414,737 (GRCm39) |
S2561N |
unknown |
Het |
| Mybpc1 |
C |
T |
10: 88,358,865 (GRCm39) |
G1095R |
probably damaging |
Het |
| Myh1 |
A |
G |
11: 67,093,398 (GRCm39) |
Y163C |
probably damaging |
Het |
| Notch4 |
T |
A |
17: 34,801,483 (GRCm39) |
C1110* |
probably null |
Het |
| Nt5el |
T |
A |
13: 105,246,291 (GRCm39) |
V284E |
probably benign |
Het |
| Or12j2 |
A |
T |
7: 139,916,143 (GRCm39) |
I123F |
probably damaging |
Het |
| Or2ag1 |
C |
T |
7: 106,313,825 (GRCm39) |
S21N |
probably benign |
Het |
| Or2ag1 |
T |
A |
7: 106,313,826 (GRCm39) |
S21C |
|
Het |
| Or4c10b |
A |
G |
2: 89,711,409 (GRCm39) |
I80V |
probably benign |
Het |
| Pcsk1 |
T |
A |
13: 75,238,210 (GRCm39) |
C10* |
probably null |
Het |
| Pdlim5 |
A |
T |
3: 142,017,948 (GRCm39) |
S107T |
probably benign |
Het |
| Plac8l1 |
T |
A |
18: 42,313,445 (GRCm39) |
D99V |
probably damaging |
Het |
| Plin2 |
A |
T |
4: 86,575,349 (GRCm39) |
V400E |
probably damaging |
Het |
| Plxna1 |
G |
A |
6: 89,334,102 (GRCm39) |
P176S |
probably benign |
Het |
| Pnn |
A |
G |
12: 59,117,223 (GRCm39) |
K238R |
probably damaging |
Het |
| Pou5f1 |
A |
G |
17: 35,820,933 (GRCm39) |
E231G |
probably benign |
Het |
| Ppara |
A |
T |
15: 85,682,077 (GRCm39) |
M258L |
probably benign |
Het |
| Prune2 |
G |
A |
19: 17,097,882 (GRCm39) |
D1129N |
probably damaging |
Het |
| Rai14 |
G |
A |
15: 10,633,249 (GRCm39) |
T47M |
probably damaging |
Het |
| Rdh5 |
T |
C |
10: 128,753,969 (GRCm39) |
I117V |
probably benign |
Het |
| Rpain |
G |
A |
11: 70,864,724 (GRCm39) |
C137Y |
probably damaging |
Het |
| Scn3a |
A |
G |
2: 65,361,154 (GRCm39) |
V126A |
possibly damaging |
Het |
| Senp7 |
G |
T |
16: 55,932,089 (GRCm39) |
L129F |
probably damaging |
Het |
| Setd1a |
A |
G |
7: 127,390,399 (GRCm39) |
D1025G |
unknown |
Het |
| Sirt4 |
A |
T |
5: 115,621,082 (GRCm39) |
V30E |
probably damaging |
Het |
| Slit1 |
C |
A |
19: 41,715,512 (GRCm39) |
R113L |
probably damaging |
Het |
| Stxbp5l |
G |
A |
16: 37,028,416 (GRCm39) |
T549I |
noncoding transcript |
Het |
| Sytl2 |
A |
G |
7: 90,058,678 (GRCm39) |
M926V |
probably damaging |
Het |
| Tgfbr2 |
C |
T |
9: 115,959,074 (GRCm39) |
W113* |
probably null |
Het |
| Tmem86a |
A |
G |
7: 46,703,512 (GRCm39) |
Y213C |
probably damaging |
Het |
| Tpo |
T |
A |
12: 30,154,045 (GRCm39) |
Y220F |
probably damaging |
Het |
| Ttc6 |
C |
A |
12: 57,720,096 (GRCm39) |
A889E |
probably damaging |
Het |
| Tyw1 |
A |
G |
5: 130,328,855 (GRCm39) |
D547G |
probably benign |
Het |
| Ubtfl1 |
A |
G |
9: 18,320,523 (GRCm39) |
K17R |
probably benign |
Het |
| Usp46 |
T |
A |
5: 74,163,354 (GRCm39) |
I331F |
probably benign |
Het |
| Vmn2r111 |
T |
C |
17: 22,792,073 (GRCm39) |
H61R |
probably benign |
Het |
| Wdr75 |
T |
A |
1: 45,861,706 (GRCm39) |
N715K |
probably benign |
Het |
| Wdr97 |
C |
A |
15: 76,247,819 (GRCm39) |
F1614L |
|
Het |
| Zfp772 |
A |
T |
7: 7,207,096 (GRCm39) |
C198* |
probably null |
Het |
|
| Other mutations in Kcnt2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Kcnt2
|
APN |
1 |
140,450,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00673:Kcnt2
|
APN |
1 |
140,523,789 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL00806:Kcnt2
|
APN |
1 |
140,450,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01135:Kcnt2
|
APN |
1 |
140,282,293 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL01412:Kcnt2
|
APN |
1 |
140,498,155 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01777:Kcnt2
|
APN |
1 |
140,523,736 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01780:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02134:Kcnt2
|
APN |
1 |
140,304,121 (GRCm39) |
missense |
probably benign |
|
|
IGL02350:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02357:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02481:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02866:Kcnt2
|
APN |
1 |
140,352,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02891:Kcnt2
|
APN |
1 |
140,502,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03007:Kcnt2
|
APN |
1 |
140,282,245 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03024:Kcnt2
|
APN |
1 |
140,498,193 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03231:Kcnt2
|
APN |
1 |
140,461,740 (GRCm39) |
intron |
probably benign |
|
|
BB002:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
BB012:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R0230:Kcnt2
|
UTSW |
1 |
140,174,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0367:Kcnt2
|
UTSW |
1 |
140,278,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Kcnt2
|
UTSW |
1 |
140,437,218 (GRCm39) |
nonsense |
probably null |
|
|
R0543:Kcnt2
|
UTSW |
1 |
140,537,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Kcnt2
|
UTSW |
1 |
140,435,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1123:Kcnt2
|
UTSW |
1 |
140,501,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1156:Kcnt2
|
UTSW |
1 |
140,356,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1425:Kcnt2
|
UTSW |
1 |
140,310,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1530:Kcnt2
|
UTSW |
1 |
140,411,970 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Kcnt2
|
UTSW |
1 |
140,359,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1728:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1862:Kcnt2
|
UTSW |
1 |
140,353,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1887:Kcnt2
|
UTSW |
1 |
140,511,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1889:Kcnt2
|
UTSW |
1 |
140,512,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Kcnt2
|
UTSW |
1 |
140,353,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2005:Kcnt2
|
UTSW |
1 |
140,480,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2044:Kcnt2
|
UTSW |
1 |
140,302,892 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2115:Kcnt2
|
UTSW |
1 |
140,480,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2135:Kcnt2
|
UTSW |
1 |
140,356,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Kcnt2
|
UTSW |
1 |
140,437,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2212:Kcnt2
|
UTSW |
1 |
140,458,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Kcnt2
|
UTSW |
1 |
140,501,421 (GRCm39) |
splice site |
probably null |
|
|
R2442:Kcnt2
|
UTSW |
1 |
140,304,091 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R3121:Kcnt2
|
UTSW |
1 |
140,356,622 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3176:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3276:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3704:Kcnt2
|
UTSW |
1 |
140,461,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Kcnt2
|
UTSW |
1 |
140,512,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Kcnt2
|
UTSW |
1 |
140,537,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4201:Kcnt2
|
UTSW |
1 |
140,353,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4501:Kcnt2
|
UTSW |
1 |
140,480,718 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4502:Kcnt2
|
UTSW |
1 |
140,435,485 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4632:Kcnt2
|
UTSW |
1 |
140,450,886 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4758:Kcnt2
|
UTSW |
1 |
140,446,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4790:Kcnt2
|
UTSW |
1 |
140,282,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4892:Kcnt2
|
UTSW |
1 |
140,440,763 (GRCm39) |
nonsense |
probably null |
|
|
R4973:Kcnt2
|
UTSW |
1 |
140,537,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5154:Kcnt2
|
UTSW |
1 |
140,278,994 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5296:Kcnt2
|
UTSW |
1 |
140,537,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5353:Kcnt2
|
UTSW |
1 |
140,354,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Kcnt2
|
UTSW |
1 |
140,502,481 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5806:Kcnt2
|
UTSW |
1 |
140,437,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Kcnt2
|
UTSW |
1 |
140,353,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Kcnt2
|
UTSW |
1 |
140,461,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5961:Kcnt2
|
UTSW |
1 |
140,435,440 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6123:Kcnt2
|
UTSW |
1 |
140,290,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6225:Kcnt2
|
UTSW |
1 |
140,354,661 (GRCm39) |
nonsense |
probably null |
|
|
R6248:Kcnt2
|
UTSW |
1 |
140,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6351:Kcnt2
|
UTSW |
1 |
140,302,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6380:Kcnt2
|
UTSW |
1 |
140,437,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6532:Kcnt2
|
UTSW |
1 |
140,511,844 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6693:Kcnt2
|
UTSW |
1 |
140,278,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6817:Kcnt2
|
UTSW |
1 |
140,173,931 (GRCm39) |
unclassified |
probably benign |
|
|
R6856:Kcnt2
|
UTSW |
1 |
140,523,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Kcnt2
|
UTSW |
1 |
140,511,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6971:Kcnt2
|
UTSW |
1 |
140,440,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Kcnt2
|
UTSW |
1 |
140,310,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7138:Kcnt2
|
UTSW |
1 |
140,523,778 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7261:Kcnt2
|
UTSW |
1 |
140,282,255 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7474:Kcnt2
|
UTSW |
1 |
140,498,216 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7524:Kcnt2
|
UTSW |
1 |
140,511,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7541:Kcnt2
|
UTSW |
1 |
140,304,122 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7558:Kcnt2
|
UTSW |
1 |
140,450,928 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7651:Kcnt2
|
UTSW |
1 |
140,498,199 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7730:Kcnt2
|
UTSW |
1 |
140,446,686 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7875:Kcnt2
|
UTSW |
1 |
140,501,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Kcnt2
|
UTSW |
1 |
140,450,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7925:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R8040:Kcnt2
|
UTSW |
1 |
140,377,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8041:Kcnt2
|
UTSW |
1 |
140,537,398 (GRCm39) |
missense |
probably benign |
|
|
R8268:Kcnt2
|
UTSW |
1 |
140,450,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8905:Kcnt2
|
UTSW |
1 |
140,435,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8927:Kcnt2
|
UTSW |
1 |
140,356,535 (GRCm39) |
splice site |
probably null |
|
|
R8988:Kcnt2
|
UTSW |
1 |
140,356,587 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9020:Kcnt2
|
UTSW |
1 |
140,512,049 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9109:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9167:Kcnt2
|
UTSW |
1 |
140,506,200 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9232:Kcnt2
|
UTSW |
1 |
140,411,931 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9297:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9298:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9318:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9404:Kcnt2
|
UTSW |
1 |
140,353,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kcnt2
|
UTSW |
1 |
140,440,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1088:Kcnt2
|
UTSW |
1 |
140,511,896 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Kcnt2
|
UTSW |
1 |
140,501,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kcnt2
|
UTSW |
1 |
140,304,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Kcnt2
|
UTSW |
1 |
140,537,386 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTCCCTAGTTCTATTATTTGATG -3'
(R):5'- AATTCCAATGAGTTTGTACTGACCC -3'
Sequencing Primer
(F):5'- TTTTGTTCTGTTTAATTAGAGTTGGC -3'
(R):5'- TACTGACCCATGCTGGCAATG -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation