Incidental Mutation 'R8172:Scgb2b3'
ID634193
Institutional Source Beutler Lab
Gene Symbol Scgb2b3
Ensembl Gene ENSMUSG00000078754
Gene Namesecretoglobin, family 2B, member 3
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #R8172 (G1)
Quality Score225.009
Status Validated
Chromosome7
Chromosomal Location31359038-31362072 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 31359051 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Arginine at position 109 (K109R)
Ref Sequence ENSEMBL: ENSMUSP00000103725 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108090]
Predicted Effect possibly damaging
Transcript: ENSMUST00000108090
AA Change: K109R

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000103725
Gene: ENSMUSG00000078754
AA Change: K109R

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Feld-I_B 25 91 4.6e-34 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 100% (53/53)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931409K22Rik T C 5: 24,543,610 M803V probably benign Het
Adcy5 T A 16: 35,157,057 L320Q probably damaging Het
Adgre4 A T 17: 55,797,769 L278F probably benign Het
Agfg2 C A 5: 137,667,169 R108L probably damaging Het
Arap2 A T 5: 62,621,981 probably null Het
Ascl2 G T 7: 142,968,599 N37K possibly damaging Het
Baiap3 C A 17: 25,244,122 D1043Y probably damaging Het
Ccdc18 T C 5: 108,163,774 probably null Het
Cemip T A 7: 83,997,225 D205V probably damaging Het
Cenpn G A 8: 116,931,594 G93D probably benign Het
Clpsl2 T A 17: 28,549,582 S23R possibly damaging Het
Cnot3 T A 7: 3,658,725 I672N possibly damaging Het
Crygs A G 16: 22,806,542 Y50H probably damaging Het
Cyp4x1 T C 4: 115,111,677 T403A possibly damaging Het
Dnajc28 G A 16: 91,616,907 R150* probably null Het
Fam184b C T 5: 45,584,367 G174D possibly damaging Het
Fat2 T A 11: 55,287,812 D1474V probably damaging Het
Flg2 T A 3: 93,201,161 D165E possibly damaging Het
Fpr-rs7 A T 17: 20,114,181 F16I probably benign Het
Gpr176 G A 2: 118,284,134 T65I probably damaging Het
H2-Q10 C T 17: 35,471,099 T206I probably null Het
Hadha C G 5: 30,145,287 A88P probably damaging Het
Hlcs A T 16: 94,267,626 L245Q probably damaging Het
Hnrnph1 T C 11: 50,379,905 V113A probably damaging Het
Hsd3b7 G A 7: 127,802,374 V224M probably damaging Het
Igha T C 12: 113,259,972 D88G Het
Kdm7a T C 6: 39,149,031 K610R probably benign Het
Krt83 C T 15: 101,485,403 C474Y probably benign Het
Lrrc74a T A 12: 86,741,756 L170H probably damaging Het
Lyg2 T C 1: 37,907,667 T178A probably benign Het
Map2k2 T A 10: 81,123,608 probably null Het
Mast4 C T 13: 102,953,125 probably null Het
Mgea5 C T 19: 45,776,900 R156H probably damaging Het
Mtmr14 T A 6: 113,239,568 D8E probably benign Het
Neu2 C T 1: 87,596,911 P206L probably damaging Het
Olfr1202 A T 2: 88,817,642 Q157L probably damaging Het
Olfr122 A G 17: 37,772,435 T261A probably benign Het
Poc1b C A 10: 99,144,476 probably null Het
Proser1 T A 3: 53,478,851 V718E possibly damaging Het
Ptgr2 T A 12: 84,314,009 L351Q possibly damaging Het
Ptprf A G 4: 118,211,078 Y1754H probably benign Het
Scn2a1 A T 2: 65,690,328 H556L probably benign Het
Scn7a A T 2: 66,675,847 M1566K possibly damaging Het
Slco5a1 A T 1: 12,990,266 L77* probably null Het
Spert T A 14: 75,591,801 probably null Het
Stk31 T C 6: 49,417,327 F208L possibly damaging Het
Tbcd C T 11: 121,493,885 T315M probably benign Het
Tbx4 A G 11: 85,911,107 I189V probably benign Het
Tia1 T A 6: 86,427,700 Y306N probably benign Het
Ttc21b T A 2: 66,252,156 Y33F probably benign Het
Usp47 T A 7: 112,087,926 L677* probably null Het
Other mutations in Scgb2b3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1664:Scgb2b3 UTSW 7 31359039 makesense probably null
R1772:Scgb2b3 UTSW 7 31360196 missense possibly damaging 0.95
R3862:Scgb2b3 UTSW 7 31362005 critical splice donor site probably null
R5819:Scgb2b3 UTSW 7 31360214 missense possibly damaging 0.67
R6433:Scgb2b3 UTSW 7 31359067 missense probably benign 0.15
R7135:Scgb2b3 UTSW 7 31360214 missense possibly damaging 0.67
R7145:Scgb2b3 UTSW 7 31360148 missense probably benign 0.00
R7553:Scgb2b3 UTSW 7 31360248 missense possibly damaging 0.84
R7908:Scgb2b3 UTSW 7 31362014 missense probably damaging 0.98
R8350:Scgb2b3 UTSW 7 31362060 missense probably damaging 1.00
X0027:Scgb2b3 UTSW 7 31360256 missense probably benign 0.00
Z1186:Scgb2b3 UTSW 7 31359121 missense probably benign
Z1186:Scgb2b3 UTSW 7 31360167 missense probably benign
Predicted Primers PCR Primer
(F):5'- ACCTCACATGATTCCTGTTCAGG -3'
(R):5'- CCTGTGTATAAGGGGCAGTC -3'

Sequencing Primer
(F):5'- TTCCTGTTCAGGACATAGACACAGG -3'
(R):5'- ATAAGGGGCAGTCTCTTTGTG -3'
Posted On2020-07-13